Name Surname1,*, Name Surname2, and Name Surname2

<This is the manuscript template for Carcinogenesis. Instructions are included in red at relevant places in the text. Please delete this text before submitting your manuscript>

Manuscript title <the title must be clearly intelligible to a non-specialist. The use of jargon and non-standard abbreviations in the title is not permitted.Please provide a short title of the paper to be used as a running head. It should be no more than 50 characters, including spaces.

Name Surname1,*, Name Surname2, † and Name Surname2, †

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Abstract< The abstract should be a single paragraph, not exceeding 250 words. URLs and references to figures or schemes should NOT be included and abbreviations (unless commonly known) should be spelled out in full. References should not be included in the abstract>

The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog

Summary

The Editors of Carcinogenesis have introduced the addition of a 'Summary', which summarises an article's main point (<40 words), for all accepted manuscripts. This is used to highlight an article in the contents list on-line and in e-mail alerts. A summary is not compulsory, but is likely to encourage readers browsing the table of contents to read an article. If you wish to provide a summary please include here and also in the appropriate box at time of submission.

Introduction

The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.
The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Materials and methods

The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.
The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Second level heading
The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Third level heading.The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.
Results

The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.
The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Second level heading
The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Third level heading. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Discussion

The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.
The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Supplementary material

Supplementary Figures 1 and 2 can be found at

Funding

Details of all funding sources for the work should be given. An example is shown below.

The following rules should be followed:

• The full official funding agency name should be given, i.e. ‘National Institutes of Health’, not ‘NIH’ (full RIN-approved list of UK funding agencies) Grant numbers should be given in brackets as follows: ‘(grant number xxxx)’
• Multiple grant numbers should be separated by a comma as follows: ‘(grant numbers xxxx, yyyy)’
• Agencies should be separated by a semi-colon
• Where individuals need to be specified for certain sources of funding the following text should be added after the relevant agency or grant number '(to [author initials])'>

Funding
National Institutes of Health (AA123456 to A.B., BB123456 to C.D.);Alcohol & Education Research Council (abcde123456).

Acknowledgements

The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Conflict of Interest Statement: None declared. <If authors declare a conflict of interest, add details here and refer to authors by their closed up initials, e.g. A.B.S.: Received grant-in-aid from…

References

<These should be cited in the text by sequential number only, in order of appearance, and listed numerically in the References section. Online references should be cited as example 5, below. Please see example 8 for a paper that has been published online but not yet in print. The initial version of a paper published in this way can be cited by the Digital Object Identifier (doi). Papers not yet published should not appear in the reference list, they should be cited in the text as follows: Shackelford,D.A. and Smith,A, unpublished results/submitted for publication/in preparation (delete as appropriate). Authors should check all references carefully, and in particular ensure that all references in the Reference section are cited in the text. Note that multiple references or page spans under one number are not allowed. Citations should conform to the following examples. Journal names should be abbreviated in the style of the ISI ( If there is more than one author in the reference, only include the first author name followed by et al. NOTE THAT FULL TITLES OF JOURNAL ARTICLES MUST BE PROVIDED>

1. Stafforini,D.M. et al. (2003) Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. Crit. Rev. Cl Lab. Sci., 40, 643–672.

2. Kufe,D.W.P. et al. (2001) Cancer Medicine. 6th edn. Oxford University Press, New York, NY.

3. McMichael,A.J. et al. (1987) T-cell antigens: new and previously defined clusters. In Cooper,C.S. and Grover,P.I. (eds) Leukocyte Typing III. Vol. 2. Springer-Verlag, Heidelberg, Germany, pp. 63–102.

4. Fragopoulou,E. et al. (2005) Characterization of acetyl-CoA: lyso-PAF acetyltransferase of human mesangial cells. Mediators Inflamm., 2004, 263–272.

5. Public Health Laboratory Service. Antimicrobial Resistance in 2000: England and Wales. January 2004, date last accessed).

6. Sun,H.-P. (2006) Mechanisms of Toxicity and Carcinogenicity of Three Alkylanilines. Ph.D. Thesis, Massachusetts Institute of Technology, Cambridge, MA.

7. WHO (2000) Obesity, Preventing & Managing the Global Epidemic. WHO Technical Report Series no 894 Geneva: NIH Publication No.: 83-1790. Washington, DC, pp. 7–15

8. Zhang,Y. (2011) The 1,2-benzenedithiole-based cyclocondensation assay, a valuable tool for measurement of chemopreventive isothiocyanates. Crit. Rev. Food Sci. Nutr. in press, doi: 10.1080/10408398.2010.503288.

TABLE AND FIGURES LEGENDS

Explain all symbols that appear in figures and tables in the legends

TABLE AND FIGURES LEGENDS

Table 1. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.

Fig. 1. The quick brown fox jumps over the lazy dog. (A) The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. (B) The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. (C) The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog. The quick brown fox jumps over the lazy dog.If figure contains different panels, each should be marked with (A), (B), (C) etc in the caption, as above.>

Style Points

• Use asterisks to represent statistical significance of P values in figures, e.g. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.
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• Please provide a short title of the paper to be used as a running head. It should be no more than 50 characters, including spaces.