Regulation and Function of Small GTPases
June 7 - 12, 2015
West Palm Beach, Florida
Organizers:
John F Hancock
University of Texas Health Science Center at Houston
Houston, Texas, USA
Heidi Welch
Babraham Institute
Cambridge, UK
Sunday, June 7, 2015
6:00PM-7:00PMWelcome Reception
7:00PM-8:00PMDinner
8:00PM-9:30PMPlenary Session
Channing Der, University of North Carolina
Ras and Ras-related GTPases in cancer biology
Monday, June 8, 2015
7:30AM-9:00AMBreakfast
9:00AM-12:15PMSession 1: Ras membrane interactions
Chair: Philippe Bastiaens
Max Planck Institute for Molecular Physiology, Dortmund, Germany
Mark R. Philips, NYU School of Medicine
The complexity of Ras membrane interactions and signal transduction
AlemeyahuGorfe, University of Texas Health Science Center at Houston
Rasnanoclustering: new insights from computation and simulation
Roland Winter, University of Dortmund, Germany
Reconstituting Ras membrane interactions on model membranes
Jay T Groves, University of California Berkeley
Ras dimerization: mechanisms and implications
**Plus Two Short Talks Chosen from Abstracts
12:30PM-1:30PMLunch and Meet the Speakers
1:30PM-2:30PMFree-time
2:30PM-5:30PM Session 2: GTPase regulators and signal transmission
Chair: Dafna Bar Sagi, NYU Langone Medical Center
John Sondek, University of North Carolina, School of Medicine
GTPase control of phospholipases
John Chernoff, Fox Chase Cancer Center, Philadelphia
Tracing Pak1 function in zebrafish development
Sonja Vermeren, University of Edinburgh, UK
ARAP3 in angiogenesis and migration
Keith Burridge, University of North Carolina, School of Medicine
Mechanical signals to Rho GTPases
**Short Talk Chosen from Abstracts
6:00PM-7:00PMDinner
7:00PM-9:00PMPoster Session I
Tuesday, June 9, 2013
7:30AM-9:00AMBreakfast
9:00AM-12:15PMSession 3: Cell migration and control of polarity
Chair: Linda Van Aelst, Cold Spring Harbor Laboratory, NY
Alan Hall, Memorial Sloan Kettering Cancer Center
Rho GTPases, epithelial morphogenesis and polarity
Ian Macara, Vanderbilt University Medical Center
Regulation of cell polarity
Erik Sahai, Cancer Research UK London Research Institute
The generation and maintenance of cancer-associated fibroblasts
Anne Ridley, Kings College London, UK
Rho proteins and leukocyte migration
**Two Short Talks Chosen from Abstracts
12:30PM-1:30PMLunch and Meet the Speakers
1:30PM-5:00PMFree-time
5:00PM-6:00PMMentoring discussion I: Writing your paper and getting it published
6:00PM-7:00PMDinner
7:00PM-9:45PMSession 4: The role of small GTPases in cancer
Chair: Eric Sahai, Cancer Research UK LRI
Dafna Bar Sagi, NYU Langone Medical Center
Ras signaling in pancreatic cancer
Kevin Haigis, Massachusetts General Hospital, Boston
Elucidating the distinct function of Ras isoforms in colon cancer
Richard Marais, Cancer Research UK, Manchester Institute**TBC
Rasoncogenesis
AngelikiMalliri, Cancer Research UK, Manchester Institute
Regulation of Tiam1 in Metastasis
**Short Talk Chosen from Abstracts
Wednesday, June 10, 2013
7:30AM-9:00AMBreakfast
9:00AM-12:15PM Session 5: Small GTPasesin cell biology
Chair: Heidi Welch, Babraham Institute, Cambridge, UK
Linda Van Aelst, Cold Spring Harbor Laboratory, NY
Regulation of neural development by Rho GTPases
Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Regulation of trafficking by Rab proteins
Kimberly Tolias, Baylor College of Medicine, Houston
Small GTPases in neuronal migration and plasticity
Xosé R. Bustelo, Centro de Investigación del Cáncer, Spain
The biology and function of VAV
**Two Short Talks Chosen from Abstracts
12:30PM-1:30PMLunch and Meet the Speakers
1:30PM-2:30PMFree-time
2:30PM-5:30PMSession 6: Signaling networks and targeting
Chair: John Hancock, University of Texas Health Science Center at Houston
Michael A. White, University of Texas Southwestern Medical Center
Therapeutic targeting of effector networks
Philippe Bastiaens, Max Planck Institute of Molecular Physiology, Dortmund Germany
The Ras spatial organizing system: control and inhibition
Julian Downward, London Research Institute, Cancer Research UK, London
Ras signaling and oncogenic mechanisms
Karen Cichowski, Harvard Medical School and Brigham and Women's Hospital, Boston
Co-targeting Ras effector pathways in cancer therapy
** Short Talk Chosen from Abstracts
5:30-6:00PMBusiness meeting to discuss next conference
6:00PM-7:00PMDinner
7:00PM-9:00PMPoster Session II
Thursday, June 11, 2013
7:30AM-9:00AMBreakfast
9:00AM-12:15PM Session 7:Progress in Ras drug development
Chair: Channing Der, University of North Carolina
Frank McCormick, University of California San Francisco
Ras inhibitors: targets, strategy and progress
Gaston Habets, Plexicon Inc., California
The complexity of BRAF inhibition
Xiadong Cheng, University of Texas Health Science Center at Houston
Drug discovery targeting EPAC/Rap Signaling
John F Hancock, University of Texas Health Science Center at Houston
Targeting of Ras plasma membrane interactions
**Two Short Talks Chosen from Abstracts
12:30PM-1:30PMLunch and Meet the Speakers
1:30PM-2:30PMMentoring discussion II: Getting your first grant
2:30PM-5:30PMSession 8:Biological probes, tools and GTPase imaging
Chair: Mark R. Philips, NYU School of Medicine
Klaus Hahn, University of North Carolina, School of Medicine
Peeking and poking at GTPase networks in vivo using designed protein probes
Michiyuki Matsuda, Kyoto University, Japan
Imaging Ras and Rho activation in real time
Paul Timpson, Garvan Institute, Sydney, Australia
In vivo imaging of GTPase activity in intact tumors
Jacqueline Cherflis, CNRS, Gif-sur-Yvette, France
Reconstituting Arf activation and signaling in vitro
** Short Talk Chosen from Abstracts
6:00PM-7:00PMDinner
Friday, June 12, 2013
7:30AM-9:00AMBreakfast
9:00AMDepartures