02/03/2016 / Juillet 2016 Timing– V1

6thInternational Symposium Europe China

Molecular, cellular and tissue engineering,and clinical applications

First meeting of the CNRS GDRI France-China

“Mesenchymal Stem Cells and Regenerative Medicine”

July 11 -13, 2016

Faculté de Médecine, Vandœuvre-lès-Nancy (France)

Withfundingsupports of the Fédération de Recherche 3209 Molecular, Cellular BioEngineering and Therapeutics,CNRS, Région Alsace-Lorraine-Champagne-Ardenne.

With supports of MedicalFaculty of Nancy, UMR 7365 CNRS-UL “Ingénierie Moléculaire, Physiopathologie Articulaire”, Université de Lorraine.

Contact: JF Stoltz (); J Magdalou ()

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Provisional programme (March 2016)

14h-14h30 / Monday July 11 Afternoon
Welcomeopening ceremony. Presentation by the CNRS, University, Faculty of Medicine, CHU, CUGN, ALCA representatives
Session 1: Cell engineering – Chairmen: HanZC (Beijing – China), Mallein-GerinF (Lyon - France)
14h30-14h50 / Han ZC (Beijing – China) Mesenchymal stem cells and applications
14h50-15h10 / Tatullo M (Crotone – Italy) MSCs and their translational applications
15h10-15h25 / Cucchiarini M (Homburg – Germany) New cell engineering approaches for cartilage regenerative medicine
15h25-15h40 / Farges JC, DucretM, Fabre H, Celle A, Perrier-Groult E, Mallein-Gerin F (Lyon – France). Production of mesenchymal stromal cells to bring teeth back to life.
15h40-16h / Branlant C (Nancy – France) Non-coding RNA and mRNA splicing events as biomarkers of diseases and cell control quality tools
16h-16h20 / Discussion
16h20-16h40 / Coffee Break
16h40-16h55 / Yiou R (Créteil – France) Cell therapy and erectile dysfunction after prostatectomy
16h55-17h10 / Li Y et al.(Wuhan – China)Regulation of TLR4 signaling on the biological function of BMSC and its crosstalk with Notch signaling.
17h10-17h25 / Group of Y. Rémond (Strasbourg –France)MultiscaleMechanobiology of human tissue: Experiment and Modeling
17h25-17h40 / Ferry N. European regulations
17h40-18h00 / Discussion
Tuesday July 12 morning
Session 2: Immunotherapy and Hematology – Chairmen: KPerrucio (Perugia – Italy), V Decot (Nancy – France)
8h30-8h50 / Perruccio K, (Perugia – Italy). Cell therapy and hematological disorders
8h50-9h10 / Feuchtinger T (Munich - Deutchland). CTL antivirus
9h10-9h25 / Bensoussan D et al. (Nancy – France). Anti CTLImmunothérapy.
9h25-9h40 / Rubio ML (Nancy – France). NK T
9h40-9h55 / Xie X, Liu H, Wu J, Li Y, Chen Y, De Isla N, He X, Li X. Rat BMSC infusion is unable to ameliorate tissue injury in mice with LPS-induced endotoxemia.
9h55-10h10 / Decot V et al. (Nancy – France) NK cells and anti-tumor immunity
10h10-10h25 / D’Aveni M. CD 34+ Monocytes
10h25-10h40 / Coffee break
Tuesday July 12 Morning
Session 3: Miscellaneous clinical applications – Chairmen : Rémond (Strasburg – France), WangH (Wuhan – China)
10h40-11h00 / He B, Zhang XY, Wang GH, Magdalou J, Wang H (Wuhan, China / Nancy, France). Effect and molecular mechanism of high glucocorticoids on hepatocyte differentiation of Wharton’s jelly derived mesenchymal stem cells in vitro
11h00-11h20 / Zhang L, YE JS, Guan Z. (Kunming – China). Development on liver tissue engineering.
11h20-11h40 / Han S, He X, et al. (Wuhan – China) Peptide lead compounds research targeting Kv1.3 channel for the therapy of multiple sclerosis.
11h40-12h00 / Group of Y. Rémond (Strasbourg) Liver: Experiment and Modeling – CNRS Strasbourg
12h00-12h15 / Li N, Yi X, Ranran H, Jia L, Jie Z, Juan C, YiMin HJ, Stoltz JF (Beijing – China / Nancy – France) miR 22 improve the tube formation of human umbilical cord endothelial cell via up regulation of eNOS
12h15-12h25 / LatailladeMesenchymal stem cells and skin repair
12h25-12h45 / Discussion
Lunch
Tuesday July 12Afternoon
Session 4: Osteoarticular applications - Chairmen: ChenL (Wuhan – China), HenrotinY (Liège – Belgium), Kirkpatrick CJ (Mainz – Germany)
14h00-14h20 / Du WJ, Reppel L, Huselstein C, Bensoussan D, Carosella ED, Han ZC, Rouas-Freiss N (Paris, Nancy – France). Mesenchymal Stem Cells derived from Bone Marrow and Adipose Tissue maintain their immunosuppressive properties after chondrogenic differentiation: role of HLA-G.
14h20-14h35 / Chen L, Tian W, Tong T, Li Y, Yu H, Huselstein C, Chen Y. (Wuhan – China / Nancy – France)Tissue engineering scaffolds based on regenerated cellulose/soy protein composite beads fabricated by high-voltage electrostatic technique.
14h35-15h05 / Henrotin Y. (Liège – Belgium) Chitosan: a promising polymer for cartilage repair and tribosupplementation.
15h05-15h20 / Keller L, Wagner Q, Pugliano M, Schwinté P, Benkirane-Jessel N. (Strasbourg – France) Double compartmented and hybrid implant outfitted with well-organized 3D stem cells for osteochondral regenerative nanomedecine.
15h20-15h40 / Kirkpatrick J. (Mainz, Germany). Developing human in vitro models to stimulate regenerative processes in the skeletal system.
15h40-16h00 / Gomes ME (Univ MINHO – Portugal) Engineering skeletal tissues with adipose derived stem cells and natural origin scaffolds
16h-16h30 / Coffee break
16h30-16h50 / Yong-jianQi1,2, Bin Li 1, Bo He 2, Zheng He 2, Jacques Magdalou3, Jean Stoltz3, Hui Wang 2, Liao-bin Chen1,2* (Wuhan China / Nancy France)
Effect andmolecular mechanism of high glucocorticoids on chondrocyte differentiation of Wharton`s jelly derived mesenchymal stem cells in vitro
16h50-17h10 / Mallein-Gerin F, Bougault C, Trunfio-Sfarghiu AM, Matteo M, LopaS, Mayer N, Perrier-Groult E.(Lyon – France)Mechanical modulation of the chondrocyte phenotype: impact on the cartilage matrix properties.
17h10-17h30 / NoelD . (Montpellier-France)Mesenchymal stem cells for modulation of inflammation and cartilage regeneration in arthritis.
17h30-17h45 / Rodriguez-MerchanEC (Madrid – Spain)MSC et régénération du cartilage
17h45-17h55 / Pinzano A (Nancy, France). Tissue engineering of cartilage: from conception to bio-integration.
17h55-18h15 / Discussion
Wednesday, July 13Morning
Session 5: Cardiovascular applications – Chairmen: LiN (Beijing – China), VilquinJT (Paris – France)
9h00-9h20 / Vilquin JT (Paris – France) Cellular therapy and muscular dystrophy
9h20-9h40 / Dan P, Velot E, Francius G, Decot V, Menu P (Wuhan, China / Nancy, France).Wharton’s jelly extracellular matrix as biomaterial in vascular tissue engineering
9h40-10h00 / Li N, Xin Y,Huang R, Li J, Zhou J, Chen J, Huang YM, STOLTZ JF. (Beijing – China / Nancy – France)Biocompatible stem cell cardiac patch improves heart function after the ischemia reperfusion injury in rats
10h00-10h20 / Adipocytes et cardiovasculaire
10h20-10h40 / Uzan G (Villejuif – France). Circulating endothelial progenitors in vascular repair
10h40-11h00 / Discussion
11h00-11h15 / Concluding remarks: Magdalou J ,. Bensoussan D
POSTERS
P1 / Caunday O (Nancy – France). European Regulations JACIE
P2 / N. De Isla, I. Bhem, L. Targa, Y. Li, X. Liu, L. Zhang, N. Charif, JF Stoltz. (Nancy – France / Wuhan – Chine) Aging of MSC
P3 / Arnold G, Labat R, Rahouadj R (Nancy- France) Tendon mechanical behavior in the case of tendinitis and Low Level Laser Therapy.
P4 / Soltz JF, Zhang L, YE JS, De Isla N. (Nancy – France / Kunming – Chine) Organ reconstruction: dream or clinical reality for the future
P5 / Dostert G, Mesure B, Galvanin A, Jouan-HureauxV,Louis H, Decot V, Motorine I, Menu P, Velot E. .(Nancy-France) Mesenchymal stem cell exosomes preservation: a new opportunity for regenerative medicine?
P6 / Real-Time Multiscale Modeling of Vascularized Liver for Augmented Reality Surgery
P7 / Substitution of animal vessels by artificial vessels for microsurgery training
P8 / Mecanobiology of Bone Reconstruction for children cleft palate : effect of applied pressure in surgical procedure
P9 / Mesure B, Charon C, Francius G, Menu P, Velot E..(Nancy-France) Layer by layer polyelectrolyte films: effects of chitosan and hyaluronic acid crosslinking on the culture of Wharton’s jelly mesenchymal stem cells.
P10 / Wagner Q, Eap s, Schiavi J, Schwinté P, Benkirane-Jessel N, Keller L. (Strasbourg – France) A living think nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration.
P11 / Bone Remodeling during orthodontic tooth displacement : Multiscale kinetic modeling
P12 / Yang X, Léger L., Vincourt JB, Chen LB, Wang H., Magdalou J (Wuhan – Chine / Nancy – France) Effect of nicotine on human chondrocyte and on the proliferationand differentiation of Wharton’s jelly mesenchymal stem cells.
P13 / Yu H, Cauchois G, Six JL, Louvet N, Chen Y, Rahouadj R, Huselstein C. .(Nancy-France) Evaluation of physiochemical and biological properties of alginate / hyaluronicavichydrogel after UV sterilisation
P14 / Neybecker P, Henrionnet C, Galois L, Mainard D, Gillet P, Pinzano A.(Nancy-France)Chondrogenic potentialities of mesenchymal stem cells from synovium versus bone marrow for cartilage tissue engineering.
P15 / Multiphysics and Multiscale Modeling of Bone Regeneration : A Mechanobiological Approach
P16 / Tian W. (Wuhan-China). Advance in bioactive polymer nanocarriers in drug delivery systems