receiving nocturnal inhalation of iloprost
Parameter / Iloprost / Placebo / P-value
Time in bed, min / 207 (190, 229) / 208 (174, 219) / 0.92
Total sleep time, min / 175 ± 27 / 171 ± 33 / 0.6
Sleep latency, min / 5 (2, 12) / 7 (3, 23) / 0.29
Latency to S3, min / 47 (26, 71) / 46 (29, 63) / 0.57
Stage 1/TST, % / 17 (12, 22) / 18 (13, 25) / 0.98
Stage 2/TST, % / 39 ± 14 / 37 ± 13 / 0.57
Stage 3/TST, % / 31 ± 17 / 31 ± 16 / 0.50
REM/TST, % / 12 ± 9 / 12 ± 7 / 0.95
Arousals/TST, n / 25 ± 13 / 27 ± 12 / 0.28
Respiratory arousals/TST, n / 6 (3, 11) / 5 (2, 10) / 0.98
Desaturation arousals/TST, n / 5 (2, 12) / 6 (4, 17) / 0.54
Systolic blood pressure, mmHg / 120 ± 23 / 123 ± 24 / 0.23
Diastolic blood pressure, mmHg / 69 ± 19 / 71 ± 22 / 0.57
Longest apnea, sed / 26.7 ± 13.4 / 23.5 ± 11.3 / 0.11
Longest hypopnea, sec / 41.7 ± 12.9 / 43.8 ± 21.3 / 0.70
Obstructive apnea index, /h / 0.3 (0.0, 1.4) / 0.4 (0.0, 1.4) / 0.43
Mixed apnea index, /h / 0.3 (0.0, 2.9) / 0.7 (0.0, 1.4) / 0.13
Central apnea index, /h / 13.1 (10.3, 16.0) / 13.0 (11.1, 17.0) / 0.56
Obstructive hypopnea index, /h / 7.0 (0.0, 19.0) / 8.9 (4.0, 12.0) / 0.55
Central hypopnea index, /h / 12.7 (6.7, 17.7) / 12.0 (7.4, 20.0) / 0.93
Apnea-hypopnea index, /h / 34.9 ± 21.9 / 33.3 ± 19.4 / 0.55
Desaturations, /h / 25.1 (9.3, 40.9) / 23.2 (12.7, 45.9) / 0.77
Time with oxygen saturation <90%, % / 3.0 (0.3, 16.2) / 1.5 (0.0, 11.1) / 0.31
Average oxygen saturation, % / 93 (92, 95) / 94 (92, 95) / 1.00
Minimum oxygen saturation, % / 86 (82, 89) / 86 (83, 89) / 0.29
Average oxygen desaturation, % / 4.6 ± 1.4 / 4.6 ± 1.6 / 0.97
Cycle length, sec / 48.0 ± 2.5 / 46.9 ± 2.7 / 0.44
Ventilation length, sec / 30.1 ± 7.9 / 29.8 ± 8.1 / 0.81
Apnea length, sec / 17.9 ± 3.1 / 17.1 ± 3.9 / 0.24
Circulatory delay, sec / 31.8 ± 8.6 / 32.9 ± 8.4 / 0.44
Time to peak ventilation, sec / 13.8 ± 3.8 / 13.2 ± 3.8 / 0.48
Values are mean ± standard deviation or median (interquartile range)
REM, rapid eye movement; TST, total sleep time.