Family History: Father Had PC and Skin Cancer

PC Digest as of 1/05/11

Norman F. Haard

DOB: 12/4/41, Age 68,

Family history: father had PC and skin cancer

Past surgeries: tonsillectomy, appendectomy, hernia repairs(5), 5x by-pass, radical prostatechtomy, defribrillater, stents

Other health problems: type 2 diabetes controlled w diet & exercise, heart disease, over weight

Exercise: moderate

Diet: moderate

9/01-Lump identified by DRE; PSA 4.1; Bx equivocal

2/03 –lump confirmed; PSA 5.5; Bx showed PC (80% of cores positive), GS (4+3), DX PC

4/03- bPSA 6.5, RP, GS (4+3), margins free of tumor, no spread to pelvic nodes

5/03- nadir PSA 0.15 ( 2 weeks post RP)

6/03- PSA 0.15 (1 month post RP)

7/03- PSA 0.17

10/03-PSA 0.22

12/03-PSA 0.40

1/04- PSA 0.45

2/04- prostacint scan negative

2//04- Consultation with Eric Small, UCSF; recommended Lupron & radiation of pelvis combo

2/04- Transrectal Ultrasound/Dr Shinohara, UCSF- negative

3/04- PSA 0.75

3/04-5/04- Dr Baird/Chico; radiation of pelvic region, computerized tomography of the pelvis

4/04- PSA 0.55

6/04- PSA 0.60

9/04- PSA 0.80

12/04- PSA 1.70

2/05- PSA 2.85

3/05- PSA 4.10

3/05- pain in right lower pelvic bone; bone scan and CT showed tumor in right inferior pubic ramus; Dx metastatic bone; cancer not confirmed by Bx; CS D2

6/05- PSA 5.50

6/05- start 3 month Lupron injections

8/05- pain in right lower pelvic bone gone

9/05- PSA nd

10/05- pain at base of spine/pelvic area; moderated with 6 advil/day

12/05- PSA 0.10

1/06- PSA 0.30

1/06- testosterone 48 ng

2/06- S. Strum: Testosterone should be lower; recommended check LH, DHEA-S, androstendione;

3/3/06- PSA 0.8

3/3/06- Pain in pelvic area has returned

3/06- bone scan and CT confirmed tumor in right inferior pubic ramus; similar size but different shape and more dense

3/5/06- take 9 enriched n-3 capsules/day

3/16/06- increase fish oil dose to 12 tablets, 10 g/day(about 5.5g EPA + DHA)

3/17/06- DHEA-S=351(high); androstendione=;129 testosterone= 57

3/18/06- Start Casodex(50 mg/day); pain in pelvic area where tumor ID has progressed rapidly.

3/22/06- subcutaneous Zoladexinjection(3 month)

3/22/06-PSA=0.9; testosterone=0.22; red cell count=4.05; hematocrit=38.1; MCH=33.4

4/06- pain in pelvic tumor area mostly gone

4/29/06-PSA=0.1

5/30/06- PSA < 0.1

6/1/06- Zoladex injection (3 month)

7/06- Bone density scan indicated ostopenia in lumbar region. Start Ca/Vit D supplement and Fosamex

8/06 Start 8 oz pomegranate juice/day

9/06- new pain in left pelvic area associated with joint during walking(relieved by Tylenol)

9/18/06-PSA=0.2

9/27/06- Zoladex injection (3 month)

10/20/06-Pain from right inferior pubic ramus tumor has returned when sit for > 1 h

11/14/06 -PSA = 0.7

12/12/06-PSA= 0.9

12/20/06-Zoladex injection (3 month)

12/27/06-Bone scan , confirmed tumor in right inferior pubic ramus; similar size but different shape and more dense,

1/29/07-PSA=1.5

3/12/07-PSA= 2.8

3/12/07- stop taking Casodex; Zoladex injection (3 month)

4/30/07- PSA= 7.7; tumor associated pain has progressively increased in past several months

5/29/07-PSA=9.2; on vicodin continuously w morphine as needed

6/12/07- zometa infusion

6/17/07- partial reduction in tumor pain

6/20/07-3 month zoladex injection

7/2/07-zometa infusion #2

7/4/07-start prednisone

7/6/07-Taxotere infusion #1; PSA= 15.3

7/8/07-Neulasta injection

7/9/07- significant reduction in tumor pain, no morphine necessary for 3 days;

7/11 start avinza, 60 mg/day for pain and oxycodone for breakthrough pain

7/15 Tumor pain gone

7/27 taxotere (#2) and zometa (#3) infusion; PSA= 4.3

8/24 taxotere #3, Zometa #4; PSA= 2.4

9/14 taxotere #4, Zometa #5, PSA=0.8

9/19 90 day Zoladex injection

10/5 taxotere #5; zometa #6; PSA=0.8

10/26 taxotere #6; zometa #7; PSA=0.4

11/16 taxotere #7; zometa #8; PSA=0.4

11/20/07 90 day Zoladex injection

12/21/07 taxotere#8; zometa# 9; PSA=0.2; tumor pain returned, < 7/6/07

12/29/07-stop avinza because of severe constipation(oxydodone or morphine used for break through pain).

1/11/08 taxotere #9, zometa# 10; PSA=0.4

2/1/08 taxotere #10, zometa# 11; PSA=0.4

2/7/08 bone scan (about same), spot in neck may be arthritis

2/29/08 zometa#12; PSA=0.5

3/24/08 Zoladex2/24/08

3/213/21/08; zometa #13; PSA=2.5; tumor pain continues to increase but <7/06/07

4/2/08 PSA=3.7

4/11/08 PSA=3.8

4/25 /08 zometa infusion #14;

5/5/08 PSA=7.6

5/23/08 zometa #15; PSA=12.1; stop prednisone

5/28/08 mAb interleukin 6, CNTO 328(clinical trial start)

6/11/08 CNTO 328 infusion; PSA= 11.3

6/20/08 Zometa #16; PSA=14.5

6/25/08 CNTO infusion 328; PSA= 9.1

7/2/08 Bone scan and CT scan (no change)

7/7/08 PSA= 14.5

7/9/08 CNTO 328 infusion

7/28/08 PSA= 12.8; Zometa #17; PSA=14.5

8/6/08 CNTO 328 infusion

8/20/08 PSA= 14.4; CNTO 328 infusion

8/22/08 Zometa #18; PSA=14.5

8/23/08 PSA=14.6,

8/25/08 Bone scan and CT scan- new metastatic foci in left pubic bone, 1 cm

8/29/08 PSA= 18.6; CNTO 328 trial discontinued

9/15/08 PSA=16.0; zometa #19 & Zoladex(90 day)

9/19/08 PSA=14.3

9/22/08 Startabiraterone trial

10/13/08 Zometa #20; PSA= 10.9

11/14/08 Zometa #21

11/19/08 PSA=9.7 (Abiraterone trial)

11/20/08 PSA= 9.6(Enloe Cancer Center)

12/11/08 Bone scan and CT scan indicate minor progression of tumors

12/12/08 Zometa #22; PSA= 7.7

12/18/08 PSA=7.8; testosterone=22

1/17/09 Zometa # 23; PSA=16.5

2/20/09 Zometa # 24; PSA=11.0

3/4/09 Bone scan and CT scans showed minor progression and one suspect new metastases

3/11/09 PSA= 14.3

3/20/09 Zometa #25; PSA=13.7

4/17/09 Zometa #26 ; PSA=13.0

5/8/09 PSA=24

5/15/09 Zometa #27, PSA=18.9

5/28/09 Bone scan; CT scan-numerous new metastases in pelvis and spine

6/1/09 PSA= 29.9

6/12 PSA= 24.9; zometa #28

7/10 Zometa #29

7/10/09 PSA=

8/14 creatinine =1.7(no zometa)

8/14 PSA=20.7

8/20/09 Bone scan; CT scan- new metastases in pelvis and spine, ribs

9/11/09 Zometa#29 ,PSA=23.1

10/10/09 Zometa,#30, PSA=38.1, creatinine =1.1

11/10/09 zometa #31, PSA=45.5, creatinine = 1.0

11/19/09 PSA = 40.9; Bone scan; CT scan- new metastases in pelvis and spine, ribs

12/18/09 PSA=110.5; start Mitoxantrone/Leukine /silybinphytosome; Zometa #32

1/8/10 Skip Novantrone, PSA=111.5

1/29/10 Novantrone #2, Zometa#33, PSA= 113.5

2/19/10Novantrone #3, Zometa #33, PSA= 97.1

3/17/10Novantrone #4, Zometa #34, PSA= 153

4/28/10 Zometa#35, PSA= 255.4, [hgh=9.7, HCT=28.9,RBC=3.1]

5/26/10Zometa #36, PSA=195

6/23/10Zometa 37, PSA=129

7/22/10/Zometa #38, PSA= 69.6

8/19/10Zometa #39; PSA=48.6; tumor pain increase

9/17/10 Zometa #40; PSA=54.9

10/15/10,Zometa #41; PSA=87.6, creatinine-0.8

11/1/10 Start Fentanylpatch(75mcg/h), methadone(4x 10mg/d), dilaudid(as needed)

11/3/10 Samarium155 treatment

12/10/10 PSA=64.5; zometa #42

2/5/11PSA=267.8; zometea#43

3/15/11 PSA= 136; zometa

4/15/11 PSA=146;zometa

5/18/11 Zometa, PSA=246