2017 Tumour Microenvironment, Basic Science To Novel Therapies (including 3D Models Workshop)
14th-16th June 2017
Nottingham Conference Centre, Burton Street, Nottingham
3D Models Workshop
Wednesday 14th June
09:00 – 09:30 Registration
09:30 – 09:40 Introduction and Welcome
09:40 – 10:10 Dr Katharina Wittmann (Ithaca NY, USA) “Tissue engineering with fabrication technologies to look at the role of micro environmental conditions in tumourigenesis”.
10:10 -10:40 Dr Craig Murdoch (University of Sheffield) Development of tissue engineered models of oral dysplasia.
10:40 – 11:00 Coffee break
11:00 – 11:15 Discussion of previous talks (Chaired by Dr Neil Cross, Sheffield Hallam University)
11:15 – 11.45 Dr Anna Grabowska (University of Nottingham) “3D models using patient-derived xenografts for drug sensitivity screening – the importance of human stromal cells”
11.45 – 12:30 Dr Penelope Ottewell (University of Sheffield) “Clinically relevant 3D models of human breast cancer bone metastasis”.
Selected talks from abstracts
12:30 – 12.45 Kendelle Murphy (The Kinghorn Cancer Centre, Auistralia) “Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/Abraxane”
12:45 – 13:00 Ander Abarrategi (The Francis Crick Institute) “Scaffold-based humanized microenvironment approach for the study of human normal and leukemic hematopoiesis”
13:00 -13:30 Lunch and poster viewing
13:30-13:50 Discussion of previous talks (Chaired by Dr Craig Murdoch, University of Sheffield)
13:50 – 14:20 Prof. Marilena Loizidou (UCL, London) “3D colorectal cancer models, efficiency of cholesterol liposomes and micelles as nanocarriers”.
Selected talks from abstracts
14:20 – 14:35 Philip Bland (The Institute of Cancer Research) “The use of the mouse intraductal model (MIND) to investigate invasive growth and ductal carcinomas in situ (DCIS) progression”
14:35 – 14:50 Ferran Valderrama (University of London) “Investigating tumour angiogenesis in a 3D model of prostate cancer”
14:50 – 15:05 Amy Harding (University of Sheffield) “Novel tissue-engineered constructs to elucidate the role of fibroblast-derived extracellular matrix in oral cancer progression”
15:05 – 15:20 Pamela Collier (University of Nottingham) “Interaction in a 3D tumour microenvironment influences the ability of mesenchymal cells to differentiate into cancer-associated fibroblasts capable of promoting cancer cell growth”
15:20 – 15:30 Coffee break
15:30 – 16:00 Dr Jos Jonkers (Netherlands Cancer Institute) “Use of genetically engineered mouse models and PDX to model breast cancer development and response to therapies”.
16:00 – 16:30 Open floor discussion and closing remarks (delegates can ask questions from any of the speakers. (Chaired by Dr Penelope Ottewell, University of Sheffield and Dr Anna Grabowska, University of Nottingham).
Tumour Microenvironment, Basic Science To Novel Therapies
Wednesday 14th June 2017
17:00-18:00 registration (drinks reception/canapes at 17:00)
18:00pm-19:00pm
Opening Keynote.
Robert Kerbel (Sunybrook Health Sciences Centre, Toronto), “Experimental therapeutics in preclinical mouse models of metastatic disease: lessons learned, discoveries made”
Thursday 15th June 2017
Stroma
09:00-09:30 Jeff Pollard (University of Edinburgh) “Tumour-associated macrophages from mechanism to therapy”
09:30-10:00 Ian Tomlinson (University of Oxford) “Cancer predisposition resulting from micro environmental differences”
10:00-10:30 Ingunn Holen (University of Sheffield) “The role of the microenvironment in bone metastasis development and response to therapy”
10:30-11:00 Coffee break
Speakers from selected abstracts
11:00-11:15 Jai Prakash (University of Twente) “Targeting integrin alpha5 in pancreatic stellate cells. A novel strategy to abolish stoma-induced tumor growth”
11:15-11:30 Nicola Ferrari (Institute of Cancer Research) “DKK3 is new regulator of the pro-tumourigenic functions of cancer associated fibroblasts”
11:30-11:45 Alex Shepard (University of Cardiff) “Heparin Sulphate Proteoglycans (HSPGs) as regulators of exosome-induced stromal cell differentiation”
11:45-12:00 Angelica Santiago Gomez (University of Manchester) “Investigating NOTCH signalling effects on breast cancer stem cell dormancy in the metastatic niche”
12:00-12:15 Jonas Schnittert (University of Twente) “Lipoxin A4 inhibits pancreatic stellate cell differentiation and inhibits pancreatic tumour growth in vivo”
12:15-12.30 Massimiliano Mellone (University of Southampton) “New role for the DNA Damage Response pathway in tumour microenvironment”
12:30-14:00 Trade Stands and lunch
Hypoxia and metabolism
14:00-14:30 Michael Potente (MPI Bad Neuheim) “Regulation of angiogenesis by endothelial metabolism”
14:30-15:00 Max Mazzone (University of Leuven) “Tumour-associated macrophages orchestrate blood vessels and lymphatics”
15:00-15:30 Ester Hammond Hypoxia (University of Oxford). “Targeting hypoxia-induced replication stress”
Selected speakers from abstracts
15:30-15:45 Victoria Tessyman (University of Manchester) “Monitoring pharmacodynamics response to hypoxia-modifying therapy using non-invasive positron emission tomography and magnetic resonance imaging”
15:45-16:00 Sara Zanivan (University of Glasgow) “From chloride channel to secreted oxidoreductase:the role of secreted CLIC3 in cancer progression and angiogenesis”
16:00-16:30 Tea
16:30-17:30 Keynote lecture
Peter Carmeliet – (KU Leuven) “Endothelial metabolic function as a regulator of angiogenesis”
17:30 – 19:30 Posters and drinks
19:30 BACR dinner
Friday 16th June 2017
Tumour angiogenesis
Opening Keynote.
09:00-09:30 Kari Alitalo (University of Helsinki) “Targeting the angiopoietin & VEGF pathways”
09:30-10:00 Kairbaan Hodivala Dilke (Queen Mary University of London) “Tumour microenvironment – New ways for old roads”
10:00-10:30 Gordon Jayson (University of Manchester) “Response biomarkers for VEGF inhibitors”
10:30-11:00 Coffee
Cancer and the Immune system
11:00-11:30 Lisa Coussens (Oregon Health and Science University, OHSU). “Dynamic interactions between myeloid and lymphoid cells regulate response to cytotoxic therapy in solid tumours”
11:30-12:00 Jamie Honeychurch (University of Manchester) “Radiotherapy and immunotherapy combinations to modify the tumour microenvironment and overcome adaptive resistance”
12:00-12:30 Poulam Patel (University of Nottingham) “Immuno-oncology: checkpoint inhibitors and beyond!”
Selected speakers from abstracts
12:30-12:45 Rachel Evans (Kings College) “Dual functionality of TGFb1 signalling during macrophage induced lymphatic dissemination in breast cancer”
12:45-13:00 Anna Pires (University of Cardiff) “The composition of the tumour extracellular matrix is associated with responsiveness to immunotherapy”
13:00-14:00 Lunch
The interstitial-stem cell niche
14:00-14:30 Jan Kitajewski (Columbia University, New York) “Regulation of tumor angiogenesis by cell fate determination pathways”
14:30-15:00 Axel Behrens (Crick Institute, London) “Molecular mechanisms of pancreatic cancer development”
15:00-15:30 Roy Bicknell (University of Birmingham), “CLEC14A and multimerin2 in the endothelial extracellular matrix”
15:30-16.00 Tea
Closing Lecture
16.00-17:00 David Bates (University of Nottingham) “Interaction in the micro-environment – Synergy between immuno-oncology and anti-angiogenesis”