EUR J NUCL MED MOLEC IMAGING
BRAIN 18F-DOPA PET AND COGNITION IN DE NOVO PARKINSON’S DISEASE
1Agnese Picco*, 2Silvia Morbelli*, 3Arnoldo Piccardo, 1Dario Arnaldi, 1,4Nicola Girtler, 1Andrea Brugnolo, 2Irene Bossert, 5Lucio Marinelli, 6Antonio Castaldi, 7Fabrizio De Carli,8Claudio Campus,5Giovanni Abbruzzese, 1Flavio Nobili.
Corresponding author:
FlavioNobili, MD
Clinical Neurology (DINOGMI), University of Genoa
Largo P Daneo, 3; 16132 Genoa, Italy
Ph: +39 0103537568
Fax: +39 0105556893
e-mail:
SUPPLEMENTAL METHODS, INCLUDING REFERENCES
Subjects: PD group. The neuropsychological battery included: i) verbal and visuo-spatial short working memory by Digit Span and Corsi Block Tapping Test [1] ii) verbal learning and delayed recall by the Rey Auditory Verbal Learning Test (RAVLT)[2]iii) visuomotor abilities, divided and attentional shifting by the Trail Making Test, forms A (TMTA) and B (TMTB) [3] with the computation of B-A score iv) psychomotor speed, attention/integration by the Symbol Digit Test [3]v) visuoconstructional abilities by a test involving copying figures, including simple copy and copying with guiding landmarks [4] vi) attentional flexibility by the Stroop Color Word Test [5] vii) executive function (abstract thinking, mental flexibility) by the Wisconsin Card Sorting Test (WCST) [6] viii) language function by the categorical and phonological verbal fluency test [7]. Depressive and neuropsychiatric symptoms were assessed with the 15-item Geriatric Depression Scale (GDS) [8] and the Neuropsychiatric Inventory [9], respectively.
Magnetic Reseonance Imaging was obtained by means of a 1.5 T superconductive system (Signa™ HDxt, GE Healthcare, Milwaukee, WI), including a sagittal T1-FFE sequence with the following parameters: TR 8.7 ms, TE 4.1 ms, flip angle 8°, FOV 256 mm, matrix 256×256, 150 sagittal slices (1.0-mm thick), and voxel size 0.98×0.98×1.6.
White matter hyperintensities were graded according to the Whalund’s scale [10] and no subject scored more than 1 in each brain region with the exception of basal ganglia that must score 0.
REFERENCES
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