Department of Postgraduate Studies in Kaya Chikitsa

From,

Dr. REKHA. K.B.P.,

1st Year MD (Ayu),

Department of Postgraduate Studies in Kaya Chikitsa

AyurvedicMedicalCollege & PG Centre,

Davangere – 577 566.

To,

THE REGISTRAR,

RajivGandhiUniversity of Health Sciences,

Bangalore.

Through :

The Principal and head of the Department of Kaya Chikitsa,

AyurvedicMedicalCollege, Davangere – 577 566.

Respected Sir,

Subject: Submission of Dissertation synopsis of registration.

As desired by Rajiv Gandhi University of Health Sciences for the postgraduate studies I am forwarding herewith the synopsis dissertation topic in duplicates, in respect of M.D. (Ayurveda) Kaya Chikitsa specialty for the academic year 2008 – 2009.

Title of Dissertation:

“CLINICAL EVALUATION OF ANUBHUTA YOGA (INGUDI) IN THE MANAGEMENT OF KĀMALA”

This for your kind information, kindly acknowledge the same.

Thanking you,

Your’s faithfully

Place : Davangere

Date : (Dr. REKHA. K.B.P)

RAJIVGANDHIUNIVERSITY FO HEALTH SCIENCES

BANGALORE, KARNATAKA

ANNEXURE – II

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

1. Name of the candidate :DR. REKHAK.B.P.

1st YEAR MD (AYU),

DEPARTMENT OF POST GRADUATE STUDIES IN KAYACHIKITSA,

AYURVEDICMEDICALCOLLEGE & PG CENTRE,

DAVANGERE -577566.

DR. REKHA K.B.P.

W/O. MR. K. PRABHUDEVA,

134, 4TH CROSS, 4THMAIN,

NAGARABHAVI CIRCLE,

VIDHYAGIRI LAYOUT,

BANGALORE.

1. Name of the Institute :AYURVEDIC MEDICAL

COLLEGE & PG CENTRE, DAVANGERE.

1. Course of the Study and Subject:M.D(Ayu) KAYA CHIKITSA
2. Date of Admission to the Course: 04.06.2008
3. Title of the topic:CLINICAL EVALUATION

OF ANUBHUTA YOGA (INGUDI)

IN THE MANAGEMENT OF

KĀMALA

1. BRIEF RESUME OF INTENDED WORK :

6.1NEED FOR THE STUDY

Kāmala is one of the major causes of mortality and morbidity in developing countries. Kāmala has been observed to be shifting from sub clinical infection to rapidly producing chronic liver disease1. Its prevalence is more in India, as liver plays a central role in maintaining metabolic homeostasis and toxicity. So it is essential to study diseases and disordered metabolism. Dysfunction of Liver not only affects the metabolism but also the circulation and Haemopoetic activities of the body2.

Ayurveda acharyas explained Kāmala and its bhedas as swatantra and paratantra vyadhi to pandu roga and upadrava of other disease. It is commonly caused due to mithya ahara and vihara leading to dooshana of asthayi dhatus rasa and raktha all together3. This dushti of rasa and raktavaha srotas jointly produces Kāmala roga by affecting the raktavaha srotomoola yakruth and pleeha. Yakrut in particular helps in pachana kriya and production of pitta, which it secretes into grahani.

In this aspect there are so many medicines in use. Among them one is folklore medicine (Ingudi + Ela + Khanda Sarkara). The persons who are advicing this medicine is unaware about the mode of action of the drug. Present study is undertaken to evaluate the medicinal efficacy and mode of action on Kāmala disease.

6.2REVIEW OF LITERATURE

Kāmala is reviewed in

1.Samprapti, lakshana, bheda, mentioned in Charaka chikitsa sthana chapter No. 16, sloka No. 34, 35, 36, 37, Chikitsa in 124, 127, 130, 131, 132, 134, slokas4.

2.Lakshana, bheda, chikitsa, in Sushruta Samhita Chapter No. 44, sloka no: 11, 12, 13, 14, Chikitsa in 33, 34, 36, 375.

3.Chikitsa in Astanga Hrudaya in 16th chapter 40, 41, 42, 43, 51, 57 sloka6

Description of plants

4.Nighantu Adarsha volume – I & 2 by Bapalal Vaidya for reference of Ingudi and Ela7

5.Description of Ingudi and Ela -Dravya guna vignana by P V Sharma8

6.Indian Medicinal Plants by Kiritikar & Basu B D- Vol-1 & 4 -Description of Balanites Aegyptiaca and Elettaria cardamomum9

Hepatitis reviewed in

7.Hepatitis reviewed in Davidson’s principles and practice of medicines by Stanley Davidson10

8. Pathology of hepatitis is reviwed in Text book of pathology by Harsh

mohan

PREVIOUS WORK:

1998 – BU - Gupta S.K. - Clinical Evaluation of Some Indigenous Drugs in the treatment of Kāmala

2000 – BHU – Lavanya V.K.N. – Clinical Experimental Study on Viral Hepatitis (Kāmala) and its management with an Indigenous compound.

2003 – JP Yadav P.S. – Clinical Evaluation of Markandyadi Hima in the Management of Kāmala Roga with special reference to viral hepatitis.

2003 – HY – Pridhvi Raj – Effect of Darvyadi Choorna in Kāmala

6.3OBJECTIVES OF THE STUDY

Management of Kāmala by Anubhoota yoga as shamana aushada.

1. MATERIALS AND METHODS
2. Source of the data :

Patients attending the OPD / IPD of Ashwini Ayurvedic Medical College Hospital, Davangere and also from special camps conducted in Kottur, (Bellary district) will be selected for the study.

7.2.Method of Collection of data:

Patients presenting the classical symptoms of Kāmala will be selected for the study like Haridra twak netra, mootra, nakha, anana, daurabalya, aruchi, chardi, hrillasa.

INCLUSION CRITERIA:

1.Patients from age group 20–50 years irrespective of gender, occupation, and educational, economical and social status will be selected.

2.Bilirubin level 1 – 5mg/dl, 5 – 15mg/dl, more than 15mg/dl.

EXCLUSION CRITERIA:

1.Patients with complication of this disease will be excluded like Haleemaka and Kumba Kāmala.

2.Kāmala with other systemic disease, which hinders the course of treatment, will be excluded.

3.Chronic liver diseases, cirrhosis of liver, alcoholic liver diseases etc.

STUDY DESIGN

• Total number of cases selected for study is 30 and above.
• Single group study.
• To assess the severity, the following parameter is adopted.

Parameter mild moderate severe

Total serum bilirubin 1 – 5mg/dl 5 – 15mg/dl>15mg/dl

DRUG FORM AND POSOLOGY

• Kalka form (Ingudi + Ela + Khanda sarkara) in dosage of 5 gms in the morning and evening on empty stomach. Anupana is ushna jala.

DURATION

• 14 days
• 2 follow ups once in 15 days.

SUBJECTIVE PARAMETER

• Reduction in the symptoms of Kāmala i.e. haridra twak, nakha, nayana, mootra, daurbalya, daha, aruchi, hrillasa.

OBJECTIVE PARAMETER

Reduction in bilirubin level and symptoms.

7.3 DOES THE STUDY REQUIRE ANY INVESTIGATIONS OR INTERVENTIONS TO BE CONDUCTED OF PATIENTS OR ANIMALS ? IF SO PLEASE DESCRIBE BRIEFLY.

• The study will be human clinical study; no animal experimentation will be done.
• The study will be done on patients who match inclusive criteria only.

STATISTICAL ANALYSIS

Results will be analysed by using standard statistical test – unpaired (t- test).

INVESTIGATION

1. Hb%
2. LFT
3. Other investigations if necessary.

7.4 HAS THE ETHICAL CLEARANCE BEEN OBTAINED FROM YOUR INSTITUTION IN CASE OF 7.3?

Yes, however, consent will be taken from the patients before the treatment

1. LIST OF REFERENCES

1. CharakaSamhitaofAgnivesha Chikitsa Sthana 16 chapter, sloka no: 37, pg.no:462 revised by Charaka and Drudabala with vidyotini hindi commentary Introduction by Vaidhya by Samrath Sri. Satya Narayana Sastri Book by Pt. Kashinath Sastri Dr. Gorakha Nath, Chaturvedi.

1. Essentials of Medical Physiology chapter: 40, pg.no: 198, by K.Sembulingam, Prema Sembulingam.

1. Sushruta Samhita byMaharshiSushruta part II, Uttara tantra 44 chapter, sloka no: 11, pg no: 288, edited with Ayurveda Tattva Sandipika by Kaviraja Ambika Dutta Shastri.

1. CharakaSamhitaofAgnivesha Chikitsa Sthana 16 chapter, pg.no: 461 & 462, sloka no: 24, 35, 36, 37; pg.no: 505, 506, 507, sloka no: 124, 125, 126, 127, 130, 131, 132, 134 & 137; revised by Charaka and Drudabala with vidyotini hindi commentary Introduction by Vaidhya by Samrath Sri. Satya Narayana Sastri Book by Pt. Kashinath Sastri Dr. Gorakha Nath Chaturvedi.

1. Sushruta Samhita byMaharshiSushruta part II, Uttara tantra chapter-4, sloka no: 11, 12, 13, 14, 33, 34, and 35 pg no: 288, 289, 293,294; edited with Ayurveda Tattva Sandipika by Kaviraja Ambika Dutta Shastri.

1. Astanga Hrudaya by Srimad Vaghbata nidana sthana chapter no: 13, sloka no: 15 & 16; chikitsa sthana 16th chapter, sloka no: 40, 41, 43, 51, 57; with Nirmala hindi commentary by Brahmanand Tripati.

1. Nighantu Adarsha Vol –I & II, pg.no: 252 & 253 by Bapalal Vaidhya.

1. DravyagunaVignana Vol-II, pg no: 252 & 253 by P V Sharma.

1. Indian Medicinal Plants Vol-1, pg.no: 513; Vol-4, pg.no: 2442 by Kiritikar K R & Basu B D.

1. Davidson’s Principles and Practice of medicines chapter no: 23, pg. no: 935Author Sir Stanley Davidson Edited by Nicholas A. Bron. Nicki R. Colledge, Broan R.

1. Text book of Pathology, chapter no: 18; pg.no:569; 4th edition, by Harsh Mohan.

BIBLIOGRAPHY

SL.NO / TITLE OF THE BOOK / AUTHOR / PUBLISHER / EDITION & YEAR
1. / Astanga Hrudaya by Srimad Vaghbata / Brahmanand Tripati / Chaukambha Sanskrit Sansthan / 2007
2. / Charaka Samhita of Agnivesha / Kashinath Shastri & Dr.Gorakhnath Chaturvedi / ChaukambhaBharathiAcademy / 1994
20th Edition
3. / Davidson’s Principles and practice of medicine / Sir Stanley / Churchill Livingstone Elsevier / 2006
20th edition
4. / Dravya Guna Vignana / P V Sharma / ChaukambhaBharathiAcademy / 2001
5. / Essentials of Medical Physiology / K.Sembulingam
& Prema Sembulingam / Jaypee Publication / 2005
3rd Edition
6. / Indian Medicinal Plants / Kiritikar K R & Basu B D / International book distributor / 1987
2nd edition
7. / Nighantu Adarsha / Bapalal Vaidya / ChaukambhaBharatiAcademy / 2001
8. / Sushruta Samhita of Maharshi Sushruta / Kaviraj Ambika Dutt Shastri / Chaukambha sanskrith
Sansthan / 2007
9. / Textbook of Pathology / Harsh Mohan / Jaypee Publication / 2002
4th Edition