SUPPLEMENTARY MATERIALS
Distribution of patients
Participants in this study were recruited in 26 major psychiatric hospitals/psychiatric units of general hospitals [Peking University Institute of Mental Health (n = 223), Beijing Huilongguan Hospital (n = 70), Beijing Anding Hospital (n = 170), FirstAffiliatedHospitalof Harbin Medical University (n = 210), Psychiatric Hospital of Henan Province (n = 50), Qingdao Mental Health Center(n = 50), Fuzhou Psychiatric Hospital (n = 293), Shenzhen Kang Ning Hospital (n = 110), Guangdong General hospital (n = 182), Guangzhou Brain Hospital (n = 160), Third Hospital of Zhongshan University (n = 101), TongdeHospitalofZhejiangProvince (n = 160), Hangzhou Seventh People’s Hospital (n = 246), Second AffiliatedHospital, ZhejiangUniversity School of Medicine (n = 180), Nanjing Brain Hospital (n = 150), Ningbo Mental Hospital (n = 69), Suzhou Guangji Hospital (n = 200), Second People'sHospitalofTaizhouCity(n = 100), Shanghai Mental Health Center (n = 333), Hongkou District Mental Health Center of Shanghai (n = 100), FirstAffiliatedHospitalof Kunming Medical College (n = 100), First Hospital of Shanxi Medical University (n = 100), First Hospital of Chongqing Medical University (n = 150), West China Hospital (n = 149), Renmin Hospital of Wuhan University (n = 140), Second Xiangya Hospital of Central South University (n = 110)] located in north, south, east, west and central parts of China.
Table S1. Multinomial logistic regression of subtypes among bipolar disorders by different variables
I / Intercept / 0.040
Past history of mental health / 0.220 / 0.85 / 0.66-1.10
Age at first episode / 0.030 / 1.01 / 1.00-1.03
Age at entry / 0.001 / 0.98 / 0.97-0.99
Episode number (past 12 months) / 0.010 / 1.07 / 1.02-1.13
Episode types of first episode / 0.040 / 0.81 / 0.65-0.99
Episode types of last time / 0.010 / 1.28 / 1.08-1.52
[ATFB=1.0] / 0.001 / 1.88 / 1.39-2.55
[ATFB=2.0] / . / . / .
II / Intercept / 0.030
Past history of mental health / 0.100 / 0.82 / 0.65-1.04
Age at first episode / 0.240 / 1.01 / 0.99-1.02
Age at entry / 0.001 / 0.98 / 0.97-0.99
Episode number (past 12 months) / 0.001 / 1.08 / 1.03-1.13
Episode types of first episode / 0.420 / 0.93 / 0.77-1.11
Episode types of last time / 0.001 / 1.32 / 1.13-1.54
[ATFB=1.0] / 0.001 / 2.85 / 2.13-3.814
[ATFB=2.0] / . / . / .
III / Intercept / 0.560
Past history of mental health / 0.210 / 0.84 / 0.63-1.11
Age at first episode / 0.750 / 0.99 / 0.98-1.01
Age at entry / 0.001 / 0.98 / 0.96-0.99
Episode number (past 12 months) / 0.001 / 1.10 / 1.04-1.15
Episode types of first episode / 0.003 / 0.72 / 0.57-0.89
Episode types of last time / 0.001 / 1.41 / 1.18-1.69
[ATFB=1.0] / 0.001 / 1.80 / 1.32-2.48
[ATFB=2.0] / . / . / .
IV / Intercept / 0.001
Past history of mental health / 0.401 / 0.82 / 0.56-1.27
Age at first episode / 0.024 / 1.03 / 1.00-1.05
Age at entry / 0.009 / 0.98 / 0.96-0.99
Episode number (past 12 months) / 0.006 / 1.08 / 1.02-1.14
Episode types of first episode / 0.889 / 1.02 / 0.74-1.43
Episode types of last time / 0.001 / 3.93 / 3.16-4.89
[ATFB=1.0] / 0.024 / 0.65 / 0.45-0.95
[ATFB=2.0] / . / . / .
V / Intercept / 0.001
Past history of mental health / 0.010 / 1.71 / 1.14-2.56
Age at first episode / 0.330 / 0.99 / 0.97-1.01
Age at entry / 0.462 / 1.01 / 0.99-1.02
Episode number (past 12 months) / 0.003 / 1.09 / 1.03-1.12
Episode types of first episode / 0.008 / 0.59 / 0.40-0.87
Episode types of last time / 0.923 / 1.02 / 0.73-1.41
[ATF B=1.0] / 0.019 / 2.07 / 1.13-3.81
[ATF B=2.0] / . / . / .
The multinomial logistic regression was employed, and the subtype VI (remission state) was donated as the inner reference index. ATF B=1 was defined as Not-met the criteria, and ATF B=2 was defined as met the criteria. I, Hypomania; II, Mania without psychotic symptoms; III, Mania with psychotic symptoms; IV, Mixed state; V, Recurrent mania; VI, Remission.