Michael M. Lipsky, Ph.D. 04/20/2015
CURRICULUM VITAE
Michael M. Lipsky, Jr., Ph,D., RQAP-GLP
Professor, Department of Pathology
University of Maryland, School of Medicine
Date:April 20, 2015
Personal Information:
Business Address:University of Maryland School of Medicine
Department of Pathology
HSF-1 Room 646A
Baltimore, Maryland 21201
Phone Number:(410) 706-1415
Education:
B.S. / Villanova University / 1973Ph.D. / University of Maryland
School of Medicine / 1979
Major Research Interests
During the past 7 years I have been active in establishing and operating GLP compliant animal facility operations in the Comparative Medicine Program. I have served as the Veterinary Resources manager for Quality Control and Quality Assurance/ GLP compliance.We developed GLP capabilities, in house, through a rigorous development, implementation and training program. I have extensive experience in developing GLP-compliant SOPs, including work-capture forms and data forms. I have developed and coordinate in-house GLP training programs for Comparative Medicine staff and maintain staff training files for all personnel. Currently I serve as the director of the Quality Assurance Unit for a large contract on thedevelopment of therapeutic interventions for neurotoxicity. I am also working to expand GLP research/testing within the Comparative Medicine program.
My general research interests include: The basic Patho-Toxicology of heavy metals, including the molecular mechanisms of metal carcinogenesis; specifically lead-induced renal neoplasia in rats and arsenite-induced hepatocarcinogenesis using human liver epithelial cells and cell lines. This research is establishing relationships between lead-induced chronic toxicity, renal epithelial cell mitogenesis, apoptosis and other molecular events and the development of preneoplastic and neoplastic renal alterations.We are also interested in environmental toxicology and pathology including effects xenobiotics in aquatic animals, as well as the development of in vitro model systems for toxicologic evaluation and mechanistic studies.
Employment History:
Assistant Professor of PathologyUniversity of Maryland
School of Medicine / 19791983
Associate Professor of Pathology
University of Maryland
School of Medicine / 19831994
Volunteer Research Scientist
Laboratory of Human Carcinogenesis
National Cancer Institute / 19902000
Professor
University of Maryland
School of Medicine / 1994-present
Major Academic Tasks:
ChairmanAnimal Care and Use Committee
University of Maryland
School of Medicine / 19881994
Faculty
Program of Toxicology
University of Maryland / 1988
present
CoChairman
American Cancer Society Institutional Cancer Grant Program (IN 174A) / 19901995
Chairman
Department of Pathology Promotions Committee / 1995-2008
Director
Graduate Program in Pathology / 1995-1999
Animal Facility Administrator 2013 - present
Department of Medical and Research Technology2015-present
Secondary appointment
Additional Training Experience:
Sabbatical leave, Molecular Carcinogenesis1995-1996
Laboratory of Human Carcinogenesis
National Cancer Institute
Dr. Curtis Harris, Mentor
Molecular Biology1993
Summer Laboratory Course
University of Maryland Baltimore County
Clinical Proteomics Training2004
FDA/NCI Clinical Proteomics Program
Registered Quality Assurance Professional-GLP2012
Certification
Professional Memberships:
American Association for the Advancement of Science / 1979presentMaryland Society for Medical Research / 19881997
Society of Toxicologic Pathologists / 1994-1998
Society of Quality Assurance / 2010- present
Honors and Awards:
Graduate School FellowshipUniversity of Maryland, Baltimore / 19761977
Faculty Teaching Award in Pathophysiology & Therapeutics Course (Oncology-Pulmonary-Epidemiology Unit), Class of 2005 / 2002-2003
1
Michael M. Lipsky, Ph.D. 04/20/2015
Administrative Service
Institutional Service
Advanced Accelerated Program in Pathology Committee / 19801985Pathology Graduate Committee / 19802004
Associate Member, University of Maryland Graduate Faculty / 19791982
Member of M.S. and Ph.D. Thesis and Dissertation Committees (Listed by the candidate)
J. Hickey, M.S., 1981; J. Resau, Ph.D.,1984; K. Vitek, M.S., 1985; C. BurgKurland, Ph.D., 1986; H. Marshall, M.S., 1986; M. Pogar, M.S., 1987; M. Borys, M.S., 1987; K. HoldernessCole, Ph.D., 1987; Q. Yu, Ph.D., 1987; M. Huang, Ph.D., 1987; K. Elliget, Ph.D., 1988; M. Borges, M.S., 1988; C. Knobloch, M.S., 1988; S. Corin, M.S., 1989; H. Zhang, M.S., 1990; P. Brown, Ph.D. 1991: H. Lee, Ph.D., 1991; E. Conner, Ph.D., 1992; M. Czerwinski, Ph.D., 1992; Y. Lin, Ph.D., 1993; W. Chi, Ph.D., 1993, J. Chen, Ph.D., 1994; Michael Abshire, Ph.D., 1995; Christopher Zhao, Ph.D., 1996; Adel Taalat, Ph..D.1997; Frank Neuman, M.S. 1998; Patrick Devine, Ph.D. 1999; S. Srinivas, Ph.D. 1999; Current Ph.D. Quingq Jiang, Ph.D. 1999; P. DeValle, Ph.D. 1999; L. Melewski, M.S., 2001; current S. Basu, Ph.D., E. Madden, Ph.D., C. Stine, M.S., M. Chen, Ph.D., X. Li, Ph.D., M.A. Whittaker, G. Wang / 1980present
Member, University of Maryland Graduate Faculty / 1982present
University of Maryland Cancer Center Laboratory Review Committee / 1982
Reviewer, American Cancer Society, Institutional
Cancer Grant( #1N174A ) Program / 19821987
Search Committee, Director of University of Maryland Cancer Center / 1982
Institutional Animal Care and Use Committee / 19821994
Committee for Development of Core Cancer Curriculum / 1984
University of Maryland Cancer Center Research and Development Committee / 19841985
Member, University of Maryland Cancer Center / 1985-1998
Search Committee, Director of Laboratory Animal Resources, School of Medicine / 1987
Cochairman, ACS Institutional Cancer Grant (#1N174A ) Program / 19871995
Member, Faculty Rewards Subcommittee of the Curriculum Revision Committee / 1993-1994
Member, School of Medicine Retrenchment Committee / 1993
Member, School of Medicine SRIS/DRIF Committee / 1994-1995
Member, Pathology Department Promotions Committee / 1994-2013
Major Consultant and
National Activities
Consultant, Universities Associated for Research and Education in Pathology, Inc., "The Renal Toxicity of Unleaded Gasoline." / 19821983Consultant, Review of policy document for U.S.E.P.A. Risk Assessment Forum, "Carcinogenicity Study of Unleaded Gasoline Vapor," ICAIR Life Systems, Inc., Highpoint, Ohio. / 1984
Consultant, Universities Associated for Research and Education in Pathology, Inc. "The Health Effects of NTA in Detergents." / 19841985
Consultant and author, support document for U.S.E.P.A. Risk Assessment Forum" The Biology of Mouse Liver Neoplasia," ICAIR Life Systems, Inc. / 19871988
Consultant, review of policy document for U.S.E.P.A. Risk Assessment Forum, "Alpha2uglobulin: Association with Renal Toxicity and Neoplasia in the Rat." Done through Eastern Research Group. / 19891990
Consultant and author, support document for U.S.E.P.A. Risk Assessment Forum, "Excreted Nacetyl glucosaminidase in Renal Toxicity and Risk Assessment.” / 19901991
Participating scientist and consultant, Pathology Working Groups, National Toxicology Program/ National Institute of Environmental Health Sciences. / 19861996
NIH/OPRR Site Visit Participant (Animal Care and Use Programs, Yale University) / 1994
Editorial Tasks
Editorial board, Toxicologic Pathology / 19941996Reviewer, Toxicologic Pathology / 1990-2010
Reviewer, Carcinogenesis / 19832003
Reviewer, Cancer Research / 19842003
Reviewer, In Vitro Cell and Developmental Biology / 19872001
Reviewer, Journal of the National Cancer Institute / 19922005
Reviewer, Environmental Research / 1994-2010
Reviewer, Hepatology / 1996-2004
Reviewer, American Journal of Pathology / 1998-2010
Local Service
Member, Governor's Task Force on the use of experimental animals for toxicity testing of cosmetic and household products. State of Maryland. / 1989Member, Maryland Council on the Scientific Use of Animals. / 19901994
Teaching Responsibilities
Current University of Maryland School of Medicine
TOXI 600, Principles of Toxicology, Lecturer (5-10 graduate students) / 1988present
Advisor for M.S. and Ph.D. research / 1979
present
Course Director, MEDT 451, Cell and Molecular Biology
(20-25 undergraduate students) Dept. Medical and Research Technology / 2009- present
Past University of Maryland School of Medicine
Host Defenses and Infectious Diseases Course, Year 2 Medical students, Lecturer and Small group instructor (150 /16 students) 1997-2011
Pathophysiology and Therapeutics Course, Year 2 Medical Students, Lecturerand Small group instructor - Neoplasia (150/16 students) 1998-2011
Path 605, Pathobiology of Aquatic Organisms, Lecturer (6-12 graduate/undergraduate students)Path 760, Biology of Cancer, Lecturer (20 graduate students)PATH 702, Introduction to Pathology, Lecturer (1015 graduate students) / 19792007
Preceptor, Medical Student Research Projects (1-4 students) / 19792001
/ 1996-2005
Pathophysiology and Therapeutics Course, Sophomore Year Medical Students, Unit Leader - Neoplasia (150-175 medical and graduate students) / 1995-1997
PATH 601602, Sophomore Pathology, System Chairman, Neoplasia and Environmental Pathobiology Section (150175 medical and graduate students ), Small Group instructor (45 students) / 19791995
Advisor, Independent Electives for Medical Students / 19801995
PATH 713, Advanced General and Cellular Pathobiology, Course Director (612 graduate students) / 19861988
PATH 514, Course Director, Environmental Pathobiology (812 medical and graduate students) / 19801982
PATH 527, Topics in Cancer Prevention, Lecturer (3550 medical students) / 19811988
Path 527, Topics in Cancer Prevention, CoCourse director (3550 medical students) / 19881991
PATH 532, Biochemical Pathology, Lecturer / 19791989
PATH 524 Neoplastic Diseases Seminar, Cocourse director Medical School, PATH 619 Graduate School, (2550 medical and graduate students) / 19801994
Pharm 502, Principles of Drug Action (810 graduate students) / 19931994
PATH 713, Advanced General and Cellular Pathobiology, Lecturer (612 graduate students) / 19791986
Graduate Students
Renate Reimschuessel , V.M.D., Ph.D. 1989 - Toxicity, Regeneration and Nephron Development in the Goldfish Kidney Following a SublethalDose of Hexachlorobutadiene / 1986-1989
Andrew Kane, Ph.D. 1993.3-Trifluoromethyl -4- nitrophenol (TFM) Toxicity and UDP-Glucuronyltransferase Kinetics in Three Bullfrog Life Stages and Fish, with Relevance to Warmwater Aquaculture. / 1988-1993
Christina Råbergh, Ph.D. 1995. ToxicologyInduction of P450!A and Toxicity of Carbon Tetrachloride and Chloroform in primary cultures of rainbow trout hepatocytes. / 19931995
Deidra Murphy, Ph.D. 1995. Bioaccumulation of Chlordane by Channel Catfish (Ictalurus punctatus) and Toxicity to a Human Liver Epithelial Cell Line. / 19921995
Anne Marie Enright , Ph.D. 1995. Carbon Tetrachloride and Chloroform Induced Toxicity and DNA Strand Breaks in Primary Fischer 344 Rat, B6C3F1 Mouse, and Human Hepatocytes and Three Immortalized Human Liver Epithelial cell Lines. / 19901995
Shankarananarayana Srinivas, Ph.D. 1999 - hHGF/SCID and hHGF/RAG Mice: Novel Animal Models for In Vivo Hepatocellular Transplantation. / 1994-1999
Mary Skinner M.S. / 1987-1990
Linda Wilmot M.S / 1981-1984
David Tanner M.S / 1979-1982
Grant Support
Current
None
Pending Grants
None
Publications
Chapters
1. / Hinton, D.E., Lipsky, M.M., Klaunig, J.E., and Kolaja, J.: Hepatic morphology of the bushbaby (Galapagos): A light and electron microscopic study. In: Lesser Galapagos as an Animal Model: Selected Topics, Vol. 12 (D.E. Haines, Vol. ed.). In: Primates in Medicine (E.J. Goldsmith and J. Moor Janckowski, Series ed.). S. Karger, Basel., 1982.2. / Hinton, D.E., Klaunig, J.E., Lipsky, M.M., Jack, R., Kahng, M.W., Sanefuji, H., Jones, R.T., and Trump, B.F.: Chemical carcinogenesis in fish: Induction of hepatic drug metabolizing enzymes and bacterial mutagenesis with polycyclic aromatic hydrocarbons (PAH). Proceedings of the International Symposium on Polycyclic Aromatic Hydrocarbons in the Marine Environment, EPA6001982013, pp. 110123, 1982.
3. / Hinton, D.E., Klaunig, J.E., Jack, R.M., Lipsky, M.M., and Trump, B.F.: In vitro evaluation of the channel catfish Ictalurus punctatus (rafinesque) as a test species in chemical carcinogenesis study. Aquatic Toxicology and Hazard Assessment. ATSDR. Raven Press, N.Y., pp. 226238, 1982.
4. / Trump, B.F., Lipsky, M.M., Jones, T.W., Heatfield, B.M., Higginson, J., Endicott, K., and Hess, H.B.: An evaluation of the significance of experimental hydrocarbon toxicity to man. In: Hemstreet, G.P., Thorpe, J.J., and Kane, M.L., editors. Proceedings of the Workshop on the Kidney Effects of Hydrocarbons. Washington, D.C.: American Petroleum Institute, pp. 415436, 1983.
5. / Lipsky, M.M.: A brief review of the toxicity and carcinogenicity of selected chlorinated hydrocarbons. In: Hemstreet, G.P., Thorpe, J.J., and Kane, M.L., editors. Proceedings of the Workshop on the Kidney Effects of Hydrocarbons. Washington, D.C.: American Petroleum Institute, pp. 415436, 1983.
6. / Lipsky, M.M., Hinton, D.E., Tanner, D.T., and Trump, B.F.: Reversibility, persistence and progression of safroleinduced mouse liver lesions following cessation of exposure. In: Popp, J., editor. Current Perspectives of Mouse Liver Neoplasia. Washington, D.C.: Hemisphere Publishing, pp. 161171, 1984.
7. / Lipsky, M.M., and Trump, B.F.: Chemicallyinduced renal epithelial neoplasia in experimental animals. In: Richter, J.W., and Solez, K., editors. International Review of Experimental Pathology, Academic Press, New York, pp. 357385, 1988.
8. / Lipsky, M.M., and Trump, B.F.: Light hydrocarbon nephropathy and renal carcinoma. In: Bach, P.H., and Loch, E.A., editors. Nephrotoxicity In the Experimental and the Clinical Situation, Part 2. MTP Press, Lancaster, U.K., pp. 463473, 1988.
9. / Lipsky, M.M., Cole, K.E., Hsu, I.C., Kahng, M.W., Jones, T.W., and Trump, B.F.: Interspecies comparisons of in vitro hepatocarcinogenesis. In: Stevenson, D.E., Popp, J.A., Ward, J.A., McClain,P.M., Slaga, T.J., Pitot, H.C., editors. Mouse Liver Carcinogenesis. Alan R. Liss, New York, pp. 395408, 1990.
10. / Fowler, B.A., Gandley, P.E., Akerman, M., Lipsky, M.M., and Smith, M.A.: Proximal tubule cell injury: Metallothionine in Biology and Medicine. Klassen, C.D. and Sufuki, K.T., editors. CRC Press, Boca Raton, FL. , pp. 322-331, 1995.
11. / Lipsky, M.M. and Trump, B.F.: Toxic and carcinogenic chemicals. In: Craighead J.E., editor. Pathology of Environmental and Occupational Disease. Mosby-Year Book, Inc. St. Louis, 1995.
Journal Articles (Peer Reviewed)
1. / Lipsky, M.M., Klaunig, J.E., and Hinton, D.E.: Comparison of acute response to polychlorinated biphenyls in liver of rat and channel catfish: A biochemical and morphological study. J. Toxicol. Env. Health 4: 107121, 1978.2. / Hinton, D.E., Klaunig, J.E., and Lipsky, M.M.: PCB induced alterations in teleost liver: A model for environmental disease in fish. Marine Fisheries Review 40: 4750, 1978.
3. / Klaunig, J.E., Lipsky, M.M., Trump, B.F., and Hinton, D.E.: Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB. J. Environ. Pathol. Toxicol. 2: 953963, 1979.
4. / Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Goldblatt, P.J., and Trump, B.F.: Iron negative foci and nodules in safroleexposed mouse liver made siderotic by irondextran injection. Pathol. Res. Pract. 164: 178185, 1979.
5. / Hinton, D.E., Lipsky, M.M., Heatfield, B.M., and Trump, B.F.: Opposite effects of lead on chemical carcinogenesis in kidney and liver of rats. Bull. Environ. Contam. Toxicol. 23: 464469, 1979.
6. / Pool, C.R. and Lipsky, M.M.: A simple ferrocyanide method for semithin sections of eponembedded tissues. Stain Technol. 54: 226227, 1979. Pool, C.R. and Lipsky, M.M.: A simple ferrocyanide method for semithin sections of eponembedded tissues. Stain Technol. 54: 226227, 1979.
7. / Hinton, D.E., Heatfield, B.M., Lipsky, M.M., and Trump, B.F.: Chemicallyinduced renal tubular
carcinoma. Am. J. Pathol.100: 317320, 1980.
8. / Lipsky, M.M., Hinton, D.E., Goldblatt, P.J., Klaunig, J.E., and Trump, B.F.: Gamma glutamyl transpeptidase in safroleinduced presumptive premalignant mouse hepatocytes. Carcinogenesis1: 151156, 1980.
9. / Lipsky, M.M., Hinton, D.E., Klaunig, J.E., and Trump, B.F.: Biology of hepatocellular neoplasia in the mouse. I. The histogenesis of safroleinduced hepatocellular carcinoma. JNCI 67: 365376, 1981.
10. / Lipsky, M.M., Hinton, D.E., Klaunig, J.E., and Trump, B.F.: Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of Balb/c mouse liver during safroleinduced carcinogenesis JNCI67: 377392, 1981.
11. / Lipsky, M.M., Hinton, D.E., Klaunig, J.E., and Trump, B.F.: Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safroleinduced hepatocellular adenomas and hepatocellular carcinomas. JNCI67: 393405, 1981.
12. / Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Chacko, J., and Trump, B.F.: Mouse liver cell culture. I. Hepatocyte isolation. In Vitro. 17: 913925, 1981.
13. / Klaunig, J.E., Goldblatt, P.J., Lipsky, M.M., Hinton, D.E., and Trump, B.F.: Mouse liver cell culture. II. Primary culture. In Vitro. 17: 926934, 1981.
14. / Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M, and Trump, B.F.: Mouse liver cell culture. III. Light and electron microscopy of liver cells in primary culture. Anat. Rec. 204: 231243, 1982.
15. / Trump, B.F., Lipsky, M.M., Jones, T.W., Heatfield, B.M., Higginson, J., Endicott, K., and Hess, H.B.: An evaluation of the significance of experimental hydrocarbon toxicity to man. Adv. Modern Environ. Toxicol. 7: 273288, 1984.
16. / Lipsky, M.M.: A brief review of the toxicity and carcinogenicity of selected chlorinated hydrocarbons. Adv. Modern Environ. Toxicol. 7: 141153, 1984.
17. / Tanner, D.C. and Lipsky, M.M. Effect of lead acetate on N(4fluoro4biphenyl) acetamideinduced renal carcinogenesis in rats. Carcinogenesis 5: 11091113, 1984.
18. / Klaunig, J.E., Goldblatt, A.J., Hinton, D.E., Lipsky, M.M. and, Trump, B.F. : Carcinogeninduced unscheduled DNA synthesis (UDS) in mouse hepatocytes. Toxicol. Pathol.12: 119125, 1984.
19. / Trump, B.F., Berezesky, I.K., Lipsky, M.M., and Jones, T.W. Heterogenecity of the nephron: Significance to nephrotoxicity. Monographs Appl. Toxicol. 2: 3142, 1985.
20. / Trump, B.F., Jones, T.W., and Lipsky, M.M. Light hydrocarbon nephropathy. Monographs Appl. Toxicol.2: 493504, 1985.
21. / Hsu, I.C., Lipsky, M.M., Cole, K.E., Su, C.H., and Trump, B.F. Isolation and culture of hepatocytes from human liver of immediate autopsy. In Vitro Cell.& Develop. Biol. 21:154160, 1985.
22. / Lipsky, M.M., Sheridan, T.R., Bennett, R.O., and May, E.B.: Comparison of trout hepatocyte culture on different substrates. In Vitro Cell. Dev. Biol.22: 360362, 1986.
23. / Hsu, I.C., Harris, C.C., Lipsky, M.M., Snyder, S., and Trump, B.F.: Cell and species differences in metabolic activation of chemical carcinogens. Mutat. Res.177: 17, 1987.
24. / May, E.B., Lukacovic, R., King, H., and Lipsky, M.M.: Hyperplastic and neoplastic alterations in the livers of white perch (Morone americana) from the Chesapeake Bay. JNCI79: 137143, 1987.
25. / Reimschuessel, R., Bennett, R.O., May, E.B., and Lipsky, M.M.: Eosinophilic granular cell response to a microsporedian infection in a sergeant major fish (Abudefduf saxatilis) (Lennaeus). J. Fish Diseases10: 321322, 1987.
26. / May, E.B., Bennett, R.O., Lipsky, M.M., and Reimschuessel, R.: The application of laboratory technology to fish as models in biomedical research, Part I. Lab. Animal 16(4): 2328, 1987.
27. / May, E.B., Bennett, R.O., Lipsky, M.M., and Reimscheussel, R.: The application of laboratory technology to fish as models in biomedical research, Part II. Lab. Animal16(4): 2532, 1987.
28. / Bennett, R.O., Kraeuter, J.N., Woods, L.C., III, Lipsky, M.M., and May, E.B.: Histological evaluations on swim bladder noninflation in striped bass larvae (Morone saxatilix). Diseases Aquatic Organisms3: 9195, 1987.
29. / Reimschuessel, R., May, E.B., Bennett, R.O., and Lipsky, M.M.: Necropsy examination of fish. The Vet Clinics of N. Am. 18: 427435, 1988.
30. / Cole, K.E., Jones, T.W., Lipksy, M.M., Trump, B.F., and Hsu, I.C.: In vitro binding of aflatoxin B1 and acetylaminofluorene to rat, mouse, and human hepatocytes DNArelationship of DNA binding to carcinogenicity. Carcinogenesis9: 711716, 1988.
31. / Yu, Q.C., Lipsky, M.M., Trump, B.F., and Marzella, L.: Response of human hepatocyte lysosomes to postmortem anoxia. Human Pathol. 19: 11741180, 1988.
32. / Lipsky, M.M., Trump, B.F., and Hinton, D.E., Histogenesis of dieldrin and DDTinduced hepatocellular carcinoma in BALB/c mice. J. Pathol. Toxicol. Oncol. 9: 7983, 1989.
33. / Cole, K.E., Jones, T.W., Lipsky, M.M., Trump, B.F., and Hsu, I.C.: Comparative ultrastructural effect of three carcinogens on human, rat, and mouse hepatocytes. Carcinogenesis10: 139143, 1989.
34. / Reimschuessel, R., May, E.B., Bennett, R.O. and Lipsky, M.M: Renal histopathologic changes in the goldfish (Carassius auratus) after sublethal exposure to hexachlorobutadiene. Aquatic Toxicology15: 169180, 1989.
35. / Reimschuessel, R., Bennett, R.O., May, E.B., and Lipsky, M.M.: Retinoblastoma in a porkfish (Anisotremus virginicus, Linnaeus) and a brown bullhead (Ictalurus nebulosus, Lesuerur). J. Comp. Pathol. 101: 215220, 1989.
36. / Muhvich, A.G., Reimschuessel, R., Lipsky, M.M., and Bennett, R.O.: Fusarium solani isolated from newborn bonnethead sharks, Sphyrna tiburo (L.). J. Fish Diseases12: 5762, 1989.
37. / Reimschuessel, R., Bennett, R.O., May, E.B., and Lipsky, M.M.: Development of newly formed nephrons in the goldfish kidney following hexachlorobutadieneinduced nephrotoxicity. Toxicol. Pathol.18: 3238, 1990.
38. / Zang, S. Z., Lipsky, M.M., Trump, B.F., and Hsu, I.C.: Neutral Red (NR) assay for cell viability and xenobiotic induced cytotoxicity in primary cultures of human and rat hepatocytes. Cell Biol. Toxicol. 6: 219234, 1990.
39. / Reimschuessel, R., Bennett, R.O., May, E.B., and Lipsky, M.M.: Renal tubular cell regeneration and chronic nephrotoxicity in the goldfish ( Crassus Auratus ) following exposure to a single sublethal dose of hexachlorobutadiene. Dis. Aquatic Org. 8: 211224, 1990.
40. / Aoki, Y., Lipsky, M.M. and Fowler, B.A.: Alteration in protein synthesis in primary culture of rat kidney proximal tubule epithelial cells by exposure to gallium, indium and arsenic. Toxicol. Appl. Pharmacol. 106: 462468, 1990.
41. / Kane,A.S., Bennett, R.O., Resau, J.R., Cottrell, J.R., Reimschuessel, R., May, E.B., Streb,M., Hutchenson, R. and Lipsky, M.M.: Comparison of cell, tissue and whole organism bioassays to assess inorganic metal toxicity in the aquatic environment. Alt. Methods Toxicol. 8: 409424, 1991
42. / Reimschuessel, R., Bennett, R.O., May, E.B. and Lipsky, M.M.: Ultrastructural injury and regeneration in the goldfish nephron following sublethal exposure to hexachlorobutadiene. J. Aquatic Anim. Health.3 : 115, 1991
43. / Reimschuessel, R., Bennett, R.O., and Lipsky, M.M.: A histological lesion classification system. J. Aquatic Anim. Health. 4: 135143, 1992
44. / Kane, A.S., Reimschuessel, R. and Lipsky, M.M.: Impact of Tadpoles on warmwater fish pond production. Fisheries.17: 3639, 1992.
45. / Pfeiffer, M.A., Cole, K.E., Smoot, D.T., Weston, A., Groopman, J.D., Shields, P.G., Vignaud, J.M., Lipsky, M.M., Trump, B.F., Lechner, J.F. and Harris, C.C.: SV40 Tantigen immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. PNAS. 90: 51235127, 1993.
46. / Kane A.E., Day, W., Reimschuessel, R. and Lipsky, M.M. 3Trifluoromethyl4nitrophenol (TFM) toxicity and hepatic microsomal UDPglucuronyltransferase activity in larval and adult bullfrogs. Aquatic Toxicol., 27: 5160, 1993.
47. / Reimschuessel, R., Bennett, R.O., May, E.B. and Lipsky, M.M. Pathological alterations and new nephron development in rainbow trout Oncorhynchus mykiss following tetrachloroethylene contamination. J. Zool. Wildlife, 24: 503507, 1993.
48. / Reimschuessel, R., Kane, A.S., Muhvich, A.G. and Lipsky, M.M. Recovery of histological lesions in the gills of brown bullheads exposed to copper. Marine Environ. Res. 35:198-199, 1993.
49. / Lipsky, M.M., Skinner, M and O'Connell, C.: Effects of chloroform and bromodichloromethane on DNA synthesis in male Fischer344 rat kidney. Environ. Health Persp. 101:249-252, 1994.
50. / Kane, A.E., Kahng, M.W., Reimschuessel, R., Nhamburo, P.T. and Lipsky, M.M. UDPGlucuronyltransferase kinetics for 3trifluoromethyl4nitrophenol and pnitrophenol in fish. Trans. Am. Fish. Soc.123:217-222,1994.
51. / Råbergh, C.M.I., Ziegler, K., Isomaa, B., Lipsky, M.M. and Eriksson, J.E. Uptake of taurocholic acid and cholic acid in isolated hepatocytes from rainbow trout. Am. J. Physiol. 267: G380-G386, 1994.
52. / Tokiwa, T., Lipsky, M.M., Smoot, D.T. and Lechner, J.F. A method for transforming human liver epithelial cells by transfection using a plasmid containing SV40 early region gene. Meth. Cell Sci. 16:57-60, 1994
53. / Pfeifer, A., M., Mace, K., Tromvoukis, Y. and Lipsky, M.M. High efficiency establishment of immortalized cells from adult human liver. Meth. Cell Sci. 17:83-89, 1995.
54. / Rabergh, C.M., Kane, A.S., Reimschuessel, R. and Lipsky, M.M. Viability and induction of tyrosine aminotransferase in rainbow trout hepatocytes cultured on laminin and polylysine in a serum-free medium. Meth. Cell Sci. 17:207-215, 1995.
55. / Houk, H., Lipsky, M.M., Marzella, L. and Burnett, J. W. Toxicity of sea nettle (Chrysaora Quinquecirrha) fishing tentacle nematocyst venom in cultured rat hepatocytes. Toxicon. 34:771-778, 1996.
56. / Lin, J., Squibb, K.S., Ackerman, M., Nordberg, G.F., Lipsky, M., and Fowler, B.A.: Cytotoxicity, zinc protection and stress protein induction in rat proximal tubule cells exposed to cadmium chloride in primary cell culture. Renal Failure 18:867-882, 1996.
57. / Rabergh, C.M., and Lipsky, M.M. Toxicity of chloroform and carbon tetrachloride in primary cultures of rainbow trout hepatocytes. Aquatic Toxicol. 37:169-182, 1997.
58. / Trifillis, A., Del Valle, P. Cui, X., Lipsky, M.M., Ruegg, C. and Kane, A. Cultured rabbit renal proximal straight tubular cells are more susceptible to mercuric chloride than convoluted tubular cells. In Vitro Toxicol. 11:133-138, 1998.
59. / Jiang, Q., DeTolla, L., Van Rooijen, N., Singh, I.S., Fitzgerald, B., Lipsky, M.M., Kane, A.S., Cross, A.S., and Hasday, J.S.: Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. Infection and Immunity 67: 1539-1546, 1999.
60. / Råbergh, C.M., Vrolijk, N.H., Lipsky, M.M., and Chen, T.T.: Differential expression of two Cyp1A genes in rainbow trout (Oncorhynchys mykiss). Toxicol. Appl. Pharmacol. 165:195-205, 2000.
61. / Stine, C.B., Smith, D.L., Vogelbein, W.K., Harshbarger, J.C., Gudla, P.R., Lipsky, M.M., and Kane, A.S.: Morphometry of hepatic neoplasms and altered foci in the mummichog, Fundulus heteroclitus. Toxicol. Pathol., 32: 1-9, 2004.
62. / Fowler, B.A., Whittaker, M.A., Lipsky, M.M., Wang, G., and Chen, X.Q.: Oxidative stress induced by lead, cadmium and arsenic mixtures. 30-day, 90-day and 180-day drinking water studies in rats: an overview. Proceedings of the International Symposium on Health Impact of Cadmium Exposure and its Prevention in China. Shanghai, China. Biometals, 17:567, 2004.
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66. / Karaolis, D.K., Cheng, K., Lipsky, M. M., Elnabawi, A., Hayakawa, Y. and Raufman, J.P.: 3’,5’-Diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated Human Colon Cancer Cell proliferation. Biochem.Biophys Res.Commun. 329: 40-45, 2005.
64.X.Ma, Norsworthy, N., Kundu, W.H., Rodgers, P., Gimotty, O., Goloubeva, M., Lipsky, M.M., Li, D., Holt, D. and Fulton, A. CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model. Molecular Cancer Therapeutics.8(3): 490-498, 2009.
Weidong Jiang, Xin Wei Wang, Tamar Unger, Marshonna Forgues, Christian Brechot, Jin Woo Kim, Perwez Hussain, Elise Bowman, Elise Spillare, Michael M. Lipsky, Jeanne M. Meck, Luciane R. Cavalli, Bassem R. Haddad, Curtis C. Harris. Cooperation of tumor-derived HBx mutants and p53-249ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized human hepatocyte-derived cell line. Int J Cancer. 127(5):1011-1020, 2010.
Whittaker, M, Wang, G, Chen, XQ, Lipsky M, Smith, D, Gwiazda, R and Fowler B. Exposure to Pb, Cd and As Mixtures Potentiates the Production of Oxidative Stress Precursors: 30 Day, 90 Day and 180 Day Drinking Water Studies in Rats. Toxicol. Appl. Pharmacol. 254: 154-166, 2011
67.Elizabeth P. Smith, Kathleen Shanks, Michael M Lipsky, Louis J. DeTolla, Achsah D Keegan, Svetlana P. Chapovel. Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor. BMC Immunology. May 19,12:30 2011.