Supplementary Figures

Supplementary Figures.

Figure S1

Time-activity curves (TACs) of [11C]AZ10419369 in three brain regions and five conditions. Averaged TACs (n = 4) under the Cont (A), Fen (B), Ket (C), Ket+Fen (D), and Ket+NBQX (E) conditions are shown. Radioactivity is expressed as the standardized uptake value (SUV) normalized to the injected dose and body weight. The following regions are shown: the globus pallidus (GP), occipital cortex (Occ), and cerebellum (CRB).

Figure S2

Details of the coronal section autoradiograms showing [11C]AZ10419369 binding to the 5-HT1B receptor. Binding sites in the nucleus accumbens (A, Acb), ventral pallidum (B, VP), external (B and C, GPe) and internal segments (C, GPi) of the globus pallidus, substantia nigra (D, SN), lateral geniculate nucleus (D, LGN), and occipital cortex (E, Occ) are shown. Photographs of a cross section of a frozen brain sample are shown on the right.

Figure S3

Time-activity curves (TACs) of [11C]DASB in five brain regions and three conditions. The averaged TACs (n = 4) for the Cont (A), Ket (B), and Ket+NBQX (C) conditions are shown. Radioactivity is expressed as the standardized uptake value (SUV). The following regions are shown: the thalamus (Tha), nucleus accumbens (Acb), globus pallidus (GP), occipital cortex (Occ), and cerebellum (CRB).

Figure S4

Spatially normalized parametric images of [11C]DASB fused onto the rhesus MRI template in each condition. Averaged BPND images (n = 4) in the Cont (A), Ket (B), and Ket+NBQX (C) conditions were superimposed on a parasagittal slice of MRI (bottom right). The BPND images are shown in color, whereas the template MRIs are shown in grayscale. Acb, nucleus accumbens; GP, globus pallidus; A, anterior; P, posterior.