Neurobiology of Disease 4340/6340

Spring 2016 MWF 11:00-11:50, Jones102

James Cronin, PhD, , 1003 Stern

Office Hours: Tues/Thurs, 11-1, or by appointment. It is best to let me know if you are coming so I’ll be at my desk.

This class surveys several of the significant diseases and/or conditions addressed by Neuroscience. For each disease, a general outline of the clinical presentation will be given, followed by a review of recent research papers in the field. Emphasis is placed on original publications elucidating either mechanisms of the disease or potential interventions.

Readings for the class will be taken from book chapters, review papers, and original research papers. I will either provide copies of articles/chapters in class, or will post the readings as PDF files on Black Board. Lectures will be in the form of PowerPoint presentations, which will also be posted on Black Board.

Graduate students will conduct assigned presentationsduring the course of the semester relating to and reinforcing the class material. The schedule and readings may be modified as the semester progresses depending on student interest,as I discover additional material, and as new material is published. Additional information on the diseases discussed in this class can be found at: as well as at the websites of the various support societies for each disease

Exams are multiple choice, “fill-in-the-blanks”, and short answer. Make-up exams are only given for valid significant reasons (e.g. Medical/Dental/Graduate School interview). Arrangements must be made prior to the exam. In the event of illness, documentation is required for a make-up exam. Missed exams are counted as 0 points. Over the course of the semester there will be short “class participation” quizzes covering the reading material for that class, or other recent classes. These will not be difficult but rather will assess if the material was read and the level of understandingobtained from the readings. For undergraduate grades, quizzes are 5%, exams count for 95% of the final grade. Graduate students’ grades are calculated as based on5% quiz scores, 15% presentations, and 80% exams. Material presented during graduate student presentations can be included on tests- so pay attention. There are no extra-credit projects; please do not ask.

Tests scores are posted on BlackBoard, and test are typically reviewed the next class.

Do not send emails asking if I will look up your grade on a test, it is posted on Black Board. This is a waste of my time. Do not ask what score you need to make on a test to get a desired final grade. This is a waste of your time. Do not ask if you can take a test at a different time because you have other tests scheduled around the same time. This is unprofessional. Look at your syllabi and plan accordingly.

For testing and presentation purposes, the class material is divided into “Blocks”

BlockLectures

I1-10

II11-19

III20-27

IV28-37

Learning Objectives:

-Understanding of fundamentals of neuronal and membrane physiology, and how these relate to pathology.

-Familiarization with contemporary thought in the Neuroscience community regarding the underlying basis for the diseases and conditions discussed in the class.

-Familiarization with contemporary therapeutic treatments and interventions for the diseases discussed in the class, as well as the limitations and expected outcomes of those treatments.

-Familiarization with common research techniques and technologies used in Neuroscience.

Service Learning Component

An optional service-learning component is available with this course. Students wishing to participate in the Service Learning component must register for service learning separately from the lecture course. Participating students will choose one of the participating community partners to complete their service requirements. The specific regular duties will vary depending on the community partner, with whom the students will spend either 20 hour or 40 hours over the course of the semester. The 20 hour option is for 0 credit hours, the 40 hour option is for one credit hour. All students will

-Keep a daily journal of their experiences with the community partner in which they will record their activities while on-site. Copies of journals are provided to the instructor on Friday of every week as ‘progress reports’. Students are therefore required to keep their journals up-to-date. Entries should be written on the day of the service

-Each participating student will give two 10 minute presentationson their Service Learning experiences. Emphasis is placed on any correlates that can be drawn to the material discussed in class. These presentations are made to the other students participating in Service Learning and are to be scheduled outside of class-time. The first presentations will occur around mid-semester, while the second presentations are at the end of the semester. Students are also asked to reflect on ‘non-class room lessons learned’.

date / lecture / reading
1 / 1/11/2016 / 1. Introduction, Neuroscience Review/Membrane Physiology I
2 / 1/13/2016 / 2. Neuroscience Review/Membrane Physiology II
3 / 1/15/2016 / 3. Neuroscience Review/Synaptic Physiology I
4 / 1/18/2016 / No class, MLK day
5 / 1/20/2016 / 4. Neuroscience Review/Synaptic Physiology II/Myasthenia Gravis / Myasthenia and related disorders of the neuromuscular junction. J NeurolNeurosurg Psychiatry 2010;81:850-857.
6 / 1/22/2016 / 5. Neuromuscular Diseases; Parkinson’s I / Neuroscience, Chapter 17, Modulation of Movement by the Basal Ganglia. Parkinson’s Disease: Genetics and Pathogenesis. Ann.Rev. Path. Mech. Dis. Supplemental Reading: Cell Transportation…Mount Sinai J Med 78:126-158, 2011.2011(6):193-222
7 / 1/25/2016 / 6. Neuromuscular Diseases; Parkinson’s II / Cell transplantation and gene therapy in Parkinson’s Disease. 2011 Mount Sinai Journal of medicine 78:126-158.
8 / 1/27/2016 / 7. Neuromuscular Diseases II; Huntington’s/ Multiple Sclerosis / Huntington Disease, Nature Reviews Disease Primers 2015
Multiple Sclerosis, Journal of Clinical Investigation, 2012
9 / 1/29/2016 / 8. ALS / Amyotrophic Lateral Sclerosis. The Lancet Vol 377, March 12, 2011. 942-954
10 / 2/1/2016 / 9 Student presentation: Gene Therapy and RNAi Technology for Neuroscience Research and Therapeutics / Applications of CRISPR_Cas systems in neuroscience, Nature, January 2016.
Brain Research 1338(2010) 112-121.
11 / 2/3/2016 / 10 Student presentation: Stem Cells in Human Neurodegenerative Diseases. / Stem Cells in Human Neurodegenerative Disorders. Journal of Clinical Investigation 120(1) Jan 2010.
12 / 2/5/2016 / Test I
13 / 2/8-2/10 / No class- Mardi Gras
14 / 2/12/2016 / 11. Alzheimer’s I / Alzheimer’s Disease, Nature Reviews Disease Primers, 2015.
Supplemental Readings:
Alzheimer’s Mechanisms, Cell, March 2012. New Concepts in Neurobiology…Radiology, May 2012. Synapses and Alzheimer’s. Cold Spring Harbor, May 2012. Pathways Towards Alzheimer’s. Nature 2004
15 / 2/15/2016 / 12. Alzheimer’s II
16 / 2/17/2016 / 13. The Aging Brain / The Aging Cortical Synapse, Nature Reviews Neuroscience, April 2012
17 / 2/19/2016 / 14. Student Presentation: Lewy Body Disorder / 100 yrs of Lewy Pathology, Nature Reviews Neurology 2013.
The many faces of α-synuclein…Nature Reviews Neuroscience, 2013.
18 / 2/22/2016 / 15. Student presentation: Preventing Dementia. / Preventing Dementia. Current Opinion in Psychiatry 2013
19 / 2/24/2016 / 16. Stroke/Rehab / Plasticity during stroke recovery: from synapses to behavior. Nature Review Neuroscience Vol 10, December 2009.See also: Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacology and Therapeutics 132(2011)57-71 Neuroscience 2006 (7)628-638
20 / 2/26/2016 / 17. Spinal Cord Injuries / Glial inhibition of CNS Axon Regeneration, Nature Reviews Neuroscience 2006 (7)617-627. Therapeutic interventions after spinal cord injury, Nature Reviews. See also: Current and future therapeutic strategies for functional repair of spinal cord injury. Pharmacology and Therapeutics 132(2011)57-71. Neuroscience 2006 (7)628-638
21 / 2/29/2016 / 18. Epilepsy / Primary and secondary mechanisms of epileptogenesis…Current Review in Basic Science. Vol10, no5, 2010. See also: The neurobiology of Antiepileptic drugs. Nature Review neuroscience, Vol 5, July 2004.
22 / 3/2/2016 / 19. Student presentation: Obsessive-Compulsive Disorder / Obsessive-compulsive disorder, Nature Reviews Disease Primers, 2015
23 / 3/4/2016 / Test II
24 / 3/7/2016 / 20. Autism I / Autism Spectrum Disorders: Clinical Features and Diagnosis. PediatrClin N Am 59 (2012) 19–25. Neurobiological Basis of Autism. PediatrClin N Am 59 (2012) 45–61
25 / 3/9/2016 / 21. Autism II / An Epidemic of Fear, Wired, 2009. Prenatal and Infant Exposure to Thimersol… Pediatrics 2010; 126:4. 656-664. Population-based study of measles, mumps, and rubella vaccination and autism. New England journal of Medicine Vol347, No19, 2002
26 / 3/11/2016 / 22. Developmental and Neural Tube Disorders / Spina bifida, Nature Reviews Disease Primers, 2015.
Supplemental Reading: Neural tube defects: recent advances, unsolved questions,and controversies. The Lancet 2013
27 / 3/14/2016 / 23. Schizophrenia / Schizophrenia, Nature Reviews Disease Primers, 2015.
Supplemental Reading: Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia. CurrOpion in Neurobio 2013
28 / 3/16/2016 / 24. Plasticity and Recovery from Depression / Neuronal Network Plasticity and Recovery From Depression. JAMA Psychiatry 2013
29 / 3/18/2016 / 25. Student Presentation: ADHD / Attention-deficit/hyperactivity disorder, Nature Reviews Disease Primers, 2015.
ADHD Models. Trends in Cognitive Sciences 2012
30 / 3/21-3/28 / No Class / Easter/Spring Break
31 / 3/30/2016 / 26. Diabetic Neuropathy / Diabetic Neuropathy. Nature Reviews Endocrinology 2013
32 / 4/1/2016 / Test III
33 / 4/4/2016 / 27. Diseases of Vision and Hearing / TBD
34 / 4/6/2016 / 28. Addiction / Systems level neuroplasticity in drug addiction. Cold Spring Habor Perspectives in Medicine 2013
35 / 4/8/2016 / 29. PTSD / Post-traumatic stress disorder, Nature Reviews Disease Primers, 2015.
Supplemental reading: Biological studies of post-traumatic stress disorder. Nature Reviews Neuroscience, November 2012
36 / 4/11/2016 / 30. Migraine / Neurobiology of Migraine. Nature Reviews Neuroscience, 2003 (4)386-398.
Emerging migraine treatments and drug targets. Trends in Pharmacological Sciences. 2011
37 / 4/13/2016 / 31. Dyslexia / Overcoming Dyslexia, S Shaywitz. Chapters 3-7. Dyslexia, Science 325(280):2009
38 / 4/15/2016 / 32. Computer/Brain Interface / Neural interfaces for the brain and spinal cord…Nature Reviews Neurology 2012. Bionic Brains and Beyond, Wall Street Journal 2012
Targeted muscle innervations for real-time myoelectric control of multifunctional artificial arms. Journal of the American Medical Association, Feb 11 (301)6, 619-628.
39 / 4/18/2016 / 33. Brain Death / Death, Unconsciousness and the Brain. (2005) 6:899-909. Chronic Consciousness Disorders, Ann.Rev.Med. 2009
Essay on Animal Mind, The Economist December 2015
Awakening, The Atlantic, 2012
40 / 4/20/2016 / 34. Neuroscience of Gender / Why sex matters for neuroscience. Nat. Rev. Neurosci. 2006 Jun;7(6):477-84. Neurodevelopment of Human Sexual Orientation. Neuroscience & Biobehavioral Reviews 2005(29):1057-1066. Sexual Differentiation of the brain & behavior. Best Practices & Research, Clinical Endocrinology & Metabolism. 2007(21); 431-444. Psychosocial and psychosexual aspects of disorders of sex development. Best Practice & Research Clinical Endocrinology & Metabolism 24 (2010) 325–334. Sex differences in molecular neuroscience: from fruit flies to humans.
Nature Reviews Neuroscience 2010 (11)9-17.
The Weaker Sex, The Economist, May 2015
41 / 4/22/2016 / 35. Student Presentation: Anorexia and Eating Disorders / Anorexia, Nature Reviews Disease Primers, 2015
42 / 4/25/2016 / 36. Student Presentation: Cognitive Enhancement / Cognitive Enhancement. Trends in Cognitive Sciences, 2011. Brain Gain, New Yorker 4/2009

Final Wednesday May 4

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