Supplemental Table S3:Functional Analysis of the Differentially Expressed Genes Identified

Supplemental Table S3:Functional analysis of the differentially expressed genes identified in WTIR vs. Nox2-/-IRcomparison

Relevant Functions / P Value / No of Molecules
Antimicrobial Response / 3.41E-18-1.44E-03 / DHX58, SOCS1, LCN2,IFNB1, ZC3HAV1, MX1, CCL5, TGTP1, IFI44, IRF7, CD40, DDX58, EIF2AK2, STAT1, ISG20
Inflammatory Response / 3.41E-18-5.29E-03 / SOCS1, IFI47, GDNF, IFNB1, TNFSF10, C1QA, SERPINA3, CASP4, CCL5, CXCL10, EDN2, IRGM, CD274, STAT1, DHX58, ARNTL, C3, CXCL9, LCN2, ZC3HAV1, MX1, TGTP1, ISG15, IFI44, IRF7, CD40, DDX58, C4A, EIF2AK2, PML, ISG20
Infectious Disease / 8.11E-12-4.24E-03 / TRIM56, IGTP, C3, CXCL9, IFI47, LCN2, IFNB1, TNFSF10, C1QA, CASP4, CCL5, PARP9, CXCL10, CD40, SRPK3, IRGM, DDX58, CD274, EIF2AK2, IFIT2, PML, STAT1, TRIM30
Infection Mechanism / 2.32E-09-4.24E-03 / IGTP, ARNTL, CXCL9, C3, RSAD2, ZC3HAV1, IFNB1, TNFSF10, C1QA, MX1, CCL5, ISG15, CXCL10, UBA7, SRPK3, CD40, IRGM, DDX58, EIF2AK2, CTNNB1, STAT1, PML, ISG20
Immunological Disease / 7.76E-09-5.78E-03 / SOCS1, C12ORF35, ZNFX1, SAMD9L, IFNB1, TNFSF10, C1QA, SERPINA3, CASP4, CCL5, TREX1 (includes EG:11277), CXCL10, G0S2, CAMK2D, PDLIM5, CD274, STAT1, CXCL9, C3, MAST4, HBA1, RNF213, DAXX, CD40, PRIC285 (includes EG:85441), SLFN12L, C4A, EIF2AK2, CYP2B6, IFIT2,PML
Cellular Development / 3.47E-07-5.45E-03 / SOCS1, DYNLT1, GDNF, IFI16, IFNB1, TNFSF10, SERPINA3, C1QC,CCL5, ACIN1, CXCL10, HBB (includes EG:3043), CD274, CTNNB1, STAT1, NRN1, HEY1, C3, HBA1, LCN2, TTN, IRF7, CD40, SNAI2, CYP2B6, EIF2AK2, PML, MYO1E
Cell Death / 5.3E-07-5.78E-03 / SOCS1, IGTP, GDNF, IFI16, IFNB1, TNFSF10, CASP4, SERPINA3, C1QA, CCL5, USP2, EDA2R, CXCL10, ACIN1, CAMK2D, G0S2, UBA7, STX8, CD274, STAT1, CTNNB1, HEY1, CXCL9, C3, LCN2, HBA1, MX1, ISG15, DAXX, CD40, SNAI2, DDX58, BIK, EIF2AK2, PML
Antigen Presentation / 5.7E-07-5.29E-03 / SOCS1, CXCL9, C3, LCN2, IFNB1, TNFSF10, C1QA, CCL5, CXCL10, CD40, EDN2, IRGM, DDX58, C4A, STAT1
Cellular Movement / 5.7E-07-5.29E-03 / SOCS1, C3, CXCL9, GDNF, LCN2, IFNB1, TNFSF10, MX1, SERPINA3, CCL5, PARP9, CXCL10, CD40, EDN2, SNAI2, IRGM, C4A, SP100, CD274, CTNNB1, STAT1, HEY1
Hematological System Development and Function / 5.7E-07-4.98E-03 / SOCS1, IFI16, IFNB1, TNFSF10, C1QA, C1QC, SERPINA3, CCL5, CXCL10, HBB (includes EG:3043), EDN2, IRGM, CD274, CTNNB1, STAT1, ARNTL, C3, CXCL9, HBA1, LCN2, ISG15, DAXX, IRF7, CD40, SNAI2, C4A, EIF2AK2, PML, MYO1E, ISG20
Immune Cell Trafficking / 5.7E-07-5.29E-03 / SOCS1, CXCL9, C3, LCN2, IFNB1, TNFSF10, C1QA, SERPINA3, CCL5, CXCL10, CD40, EDN2, IRGM, C4A, CD274, PML, STAT1
Neurological Disease / 7.28E-07-4.08E-03 / ARNTL, C3, GDNF, IFNB1, TNFSF10, SERPINA3, C1QA, CASP4, CCL5, CXCL10, CD40, PDLIM5, C4A, STAT1
Organismal Survival / 1.19E-06-1.44E-03 / DHX58, SOCS1, IGTP, CXCL9, C3, GDNF, IFI47, IFI16, IFNB1, TNFSF10, MX1, MYH7, ISG15, CXCL10, IRF7, HBB (includes EG:3043), CD40, IRGM, DDX58, C4A, CD274, STAT1
Skeletal and Muscular System Development and Function / 1.98E-06-5.78E-03 / SOCS1, C3, IFI16, IFNB1, TNFSF10, MYH7, CCL5, MYOT, TTN, CXCL10, CAMK2D, CD40, SRPK3, TRIM63, EDN2, C4A, EIF2AK2, STAT1, CTNNB1, HEY1, TMOD4
Tissue Morphology / 1.98E-06-5.51E-03 / SOCS1, GDNF, IFNB1, TNFSF10, C1QA, MYOT, CCL5, CXCL10, CAMK2D, HBB (includes EG:3043), EDN2, CD274, STAT1, CTNNB1, ARNTL, C3, MYH7, TTN, ISG15, CD40, TRIM63, C4A, BIK, PML, TMOD4
Gene Expression / 2.07E-06-4.97E-03 / SOCS1, ARNTL, IFI16, IFNB1, TNFSF10, MX1, RAMP1, DAXX, IRF7, CAMK2D, SRPK3, CD40, PRIC285 (includes EG:85441), SNAI2, DDX58, SP100, SOX18, EIF2AK2, CTNNB1, PML, STAT1, ISG20, HEY1
Cell-To-Cell Signaling and Interaction / 2.35E-06-5.78E-03 / SOCS1, CXCL9, C3, GDNF, LCN2, IFNB1, TNFSF10, C1QA, RAMP1, CCL5, CXCL10, CD40, EDN2, IRGM, DDX58, C4A, CD274, EIF2AK2, CTNNB1, PML, STAT1
Hematopoiesis / 3.59E-06-3.76E-03 / SOCS1, CXCL9, C3, IFI16, HBA1, LCN2, IFNB1, TNFSF10, C1QC, CCL5, CXCL10, IRF7, HBB (includes EG:3043), CD40, SNAI2, CD274, PML, STAT1, CTNNB1, MYO1E
Cellular Growth and Proliferation / 3.68E-06-5.45E-03 / SOCS1, GDNF, IFI16, IFNB1, TNFSF10, CCL5, CXCL10, ACIN1, CAMK2D, EDN2, CD274, CTNNB1, STAT1, NRN1, HEY1, CXCL9, C3, LCN2, ISG15, DAXX, CD40, SNAI2, SLFN12L, CYP2B6, EIF2AK2, PML, ISG20
Humoral Immune Response / 3.68E-06-3.76E-03 / C3, CD40, C4A, IFNB1, TNFSF10, C1QA, CTNNB1
Tissue Development / 3.68E-06-5.7E-03 / CXCL9, C3, IFI16, IFNB1, TNFSF10, MYH7, C1QA, CCL5, TTN, CXCL10, CD40, SRPK3, SNAI2, IRGM, C4A, CD274, PML, CTNNB1, HEY1
Inflammatory Disease / 4.12E-06-5.78E-03 / SOCS1, C12ORF35, SAMD9L, IFNB1, TNFSF10, SERPINA3, C1QA, CASP4, CCL5, TREX1 (includes EG:11277), CXCL10, UBA7, G0S2, CAMK2D, STX8, CD274, CTNNB1, STAT1, DHX58, ARNTL, CXCL9, C3, RNF213, RAMP1, DAXX, CD40, PRIC285 (includes EG:85441), DDX58, SLFN12L, C4A, BIK, EIF2AK2, CYP2B6
Cellular Function and Maintenance / 5.68E-06-3.76E-03 / DAXX, SOCS1, CD40,IFI16, IFNB1, TNFSF10, CD274, EIF2AK2, CCL5, PML, CTNNB1, STAT1
Connective Tissue Disorders / 6.38E-06-5.78E-03 / SOCS1, C12ORF35, SAMD9L, IFNB1, TNFSF10, SERPINA3, C1QA , CCL5, TREX1 (includes EG:11277), CXCL10, G0S2, CAMK2D, CD274, STAT1, CTNNB1, ARNTL, C3, CXCL9, RNF213, DAXX, CD40, PRIC285 (includes EG:85441), DDX58, SLFN12L, C4A, CYP2B6
Skeletal and Muscular Disorders / 6.38E-06-5.78E-03 / SOCS1, DYNLT1, GDNF, C12ORF35, SAMD9L, IFNB1, TNFSF10, C1QA, SERPINA3, MYOT, CCL5, TOR3A, USP2, TREX1 (includes EG:11277), CXCL10, G0S2, CAMK2D, CD274, CTNNB1, STAT1, ARNTL, C3, CXCL9, LCN2, RNF213, MYH7, TTN, DAXX, CD40, TRIM63, PRIC285 (includes EG:85441), SLFN12L, C4A, CYP2B6
Organismal Injury and Abnormalities / 8.95E-06-5.29E-03 / SOCS1, IFIT3, CXCL9, C3, TNFSF10, MX1, C1QA, MYH7, CXCL10, IRF7, HBB (includes EG:3043), DDX58, C4A, EIF2AK2, STAT1, CTNNB1
Cell Cycle / 2.27E-05-5.78E-03 / SOCS1, C3, GDNF, IFI16, IFNB1, TNFSF10, TTN, CXCL10, DAXX, IRF7, CAMK2D, CD40, BIK, CD274, EIF2AK2, STAT1, CTNNB1, PML
Cell Morphology / 3.3E-05-3.67E-03 / SOCS1, CXCL9, GDNF, LCN2, CCL5, TTN, ISG15, CXCL10, HBB (includes EG:3043), CD40, TRIM63, SNAI2, IRGM, CD274, CTNNB1, NRN1
Cellular Assembly and Organization / 3.3E-05-3.3E-03 / TRIM63, TNFSF10, MYH7, MYOT, PML, CTNNB1, TTN
Hypersensitivity Response / 3.3E-05-4.24E-03 / CXCL10, C3, CXCL9, C4A, CCL5
Lymphoid Tissue Structure and Development / 3.3E-05-3.54E-03 / CXCL10, SOCS1, C3, CXCL9, CD40, EDN2, CCL5
Gastrointestinal Disease / 5.3E-05-5.78E-03 / CXCL10, SOCS1, C3, DDX58, TNFSF10, PML, STAT1, CTNNB1
Hepatic System Disease / 5.3E-05-3.19E-03 / CXCL10, SOCS1, C3, DDX58, BIK, TNFSF10, PML, CTNNB1, STAT1
Cell-mediated Immune Response / 5.31E-05-4.57E-03 / CXCL10, SOCS1, C3, CXCL9, CD40, IFNB1, TNFSF10, CD274, CCL5, CTNNB1, STAT1
Ophthalmic Disease / 8.06E-05-2.36E-03 / SOCS1, C3, CCL5, STAT1
Cancer / 8.08E-05-4.8E-03 / SOCS1, GDNF, IFNB1, TNFSF10, CASP4, SERPINA3, CCL5, USP2, CXCL10, BDH1, HBB (includes EG:3043), ARL5B, CD274, CTNNB1, STAT1, NRN1, HEY1, IFIT3, DPEP1, CXCL9, C3, HBA1, LCN2, MX1, ISG15, IFI44, CD40, SNAI2, C4A, EIF2AK2, PML, ISG20
Renal and Urological Disease / 8.67E-05-3.36E-03 / SOCS1, C3, GDNF, LCN2, HBA1, C4A, C1QA, SERPINA3, CCL5, CTNNB1, PML
Cardiovascular Disease / 2.21E-04-2.25E-03 / DAXX, ARNTL, C3, GDNF, CD40, TRIM63, IFNB1, C1QA, MYH7, STAT1, TTN
Hematological Disease / 2.48E-04-3.76E-03 / SOCS1, C3, CXCL9, LCN2, IFNB1, C1QA, CCL5, CXCL10, CAMK2D, HBB (includes EG:3043), CD40, SNAI2, IRGM, CD274, EIF2AK2, PML, CTNNB1
Molecular Transport / 3.03E-04-3.03E-04 / C3, C4A, CCL5
Renal and Urological System Development and Function / 3.03E-04-1.94E-03 / CXCL10, CXCL9, GDNF, LCN2, CCL5
Small Molecule Biochemistry / 3.03E-04-3.93E-03 / CXCL10, SOCS1, CXCL9, HBB (includes EG:3043), C3, CD40, EDN2, IFNB1, C4A, TNFSF10, CCL5, STAT1
Connective Tissue Development and Function / 6.07E-04-5.29E-03 / SOCS1, CD40, IFI16, STX8, IFNB1, TNFSF10, EIF2AK2, CCL5, CTNNB1, PML, STAT1, NRN1
DNA Replication, Recombination, and Repair / 6.44E-04-2.33E-03 / CXCL10, ACIN1, CD40, GDNF, EDN2, IFNB1, BIK, TNFSF10, EIF2AK2, CTNNB1, PML, ISG20
Carbohydrate Metabolism / 6.8E-04-6.8E-04 / SOCS1, EDN2
Cell Signaling / 6.8E-04-5.03E-03 / CXCL10, SOCS1, CXCL9, CD40, GDNF, EDN2, IFNB1, TNFSF10, CD274, STAT1
Nucleic Acid Metabolism / 6.8E-04-6.8E-04 / CXCL10, CXCL9
Reproductive System Development and Function / 6.8E-04-6.8E-04 / GDNF, BIK
Cellular Compromise / 7.45E-04-2.87E-03 / BIK, TNFSF10, CCL5
Nervous System Development and Function / 7.92E-04-4.75E-03 / CXCL10, C3, CXCL9, GDNF, IFNB1, STAT1
Drug Metabolism / 8.35E-04-5.78E-03 / HBB (includes EG:3043), CD40, EDN2, TNFSF10, CYP2B6
Lipid Metabolism / 8.35E-04-3.93E-03 / CXCL10, HBB (includes EG:3043), C3, CD40, EDN2, TNFSF10
Embryonic Development / 9.03E-04-9.03E-04 / GDNF, LCN2
Dermatological Diseases and Conditions / 1.44E-03-5.78E-03 / SOCS1, TNFSF10, EIF2AK2, CCL5, SOX18, STAT1
Hepatic System Development and Function / 1.44E-03-2.22E-03 / C3, TNFSF10, CTNNB1, PML, STAT1
Respiratory Disease / 1.44E-03-3.76E-03 / SOCS1, CXCL9, C3, GDNF, LCN2, IFNB1, CCL5, CXCL10, HBB (includes EG:3043), CAMK2D, CD274, STAT1, PML
Endocrine System Disorders / 1.54E-03-5.78E-03 / C3, RSAD2, LCN2, SERPINA3, CTNNB1
Metabolic Disease / 1.54E-03-1.54E-03 / C3, RSAD2, LCN2, SERPINA3
Tumor Morphology / 1.69E-03-2.47E-03 / CXCL10, CXCL9, CD40, CD274, PML
Genetic Disorder / 1.75E-03-5.78E-03 / SOCS1, SOX18, CTNNB1
Developmental Disorder / 2.47E-03-5.78E-03 / CTNNB1, PML
Reproductive System Disease / 4.05E-03-4.05E-03 / LCN2, C4A, CD274, CTNNB1, STAT1
Cardiovascular System Development and Function / 5.51E-03-5.51E-03 / SOX18, MYO1E, HEY1
Organismal Development / 5.51E-03-5.51E-03 / SOX18, MYO1E, HEY1
RNA Post-Transcriptional Modification / 5.78E-03-5.78E-03 / EIF2AK2