Table 2 Electronic supplementary data of hemodynamic and locomotor activity in male BPN/3 and BPN/2 mice.
Period / Parameter / BPH/2 / BPN/3
P value
24 h / Mean / SAP / (mm Hg) / 148.2 / ± / 1.1 / 127.8 / ± / 1.8 / 1.E-06
1% / SAP / (mm Hg) / 117.1 / ± / 1.4 / 100.3 / ± / 2.5 / 2.E-04
99% / SAP / (mm Hg) / 183.5 / ± / 3.2 / 163.1 / ± / 3.2 / 8.E-04
99-1% / SAP / (mm Hg) / 66.4 / ± / 4.3 / 62.8 / ± / 3.7 / 5.E-01
Mean / MAP / (mm Hg) / 130.2 / ± / 1.2 / 112.8 / ± / 1.5 / 1.E-06
1% / MAP / (mm Hg) / 102.6 / ± / 1.1 / 85.9 / ± / 1.8 / 1.E-05
99% / MAP / (mm Hg) / 162.7 / ± / 4.1 / 144.9 / ± / 2.8 / 3.E-03
99-1% / MAP / (mm Hg) / 60.1 / ± / 4.5 / 59.0 / ± / 3.8 / 9.E-01
Mean / DAP / (mm Hg) / 111.5 / ± / 2.1 / 96.2 / ± / 2.1 / 3.E-04
1% / DAP / (mm Hg) / 85.5 / ± / 1.8 / 70.2 / ± / 1.8 / 8.E-05
99% / DAP / (mm Hg) / 143.9 / ± / 5.6 / 126.0 / ± / 3.1 / 1.E-02
99-1% / DAP / (mm Hg) / 58.4 / ± / 5.1 / 55.8 / ± / 3.6 / 7.E-01
Mean / PP / (mm Hg) / 36.8 / ± / 2.2 / 31.6 / ± / 2.4 / 2.E-01
1% / PP / (mm Hg) / 24.8 / ± / 4.0 / 22.6 / ± / 2.5 / 6.E-01
99% / PP / (mm Hg) / 46.8 / ± / 1.8 / 40.8 / ± / 2.6 / 1.E-01
99-1% / PP / (mm Hg) / 21.9 / ± / 3.5 / 18.2 / ± / 0.9 / 2.E-01
Mean / HR / (beats min-1) / 656.3 / ± / 4.9 / 554.2 / ± / 11.8 / 1.E-05
1% / HR / (beats min-1) / 517.2 / ± / 9.8 / 400.8 / ± / 8.4 / 6.E-07
99% / HR / (beats min-1) / 783.1 / ± / 6.1 / 703.1 / ± / 10.3 / 6.E-05
99-1% / HR / (beats min-1) / 265.9 / ± / 10.1 / 302.4 / ± / 5.2 / 4.E-03
Inactive time / Activity / % / 57.6 / ± / 1.1 / 69.3 / ± / 2.0 / 6.E-04
#>0 / Activity / (a.u.) / 1220.0 / ± / 31.8 / 883.3 / ± / 56.2 / 6.E-04
Mean / Activity / (a.u.) / 11.9 / ± / 0.9 / 5.2 / ± / 0.6 / 4.E-05
Log(Act>0) / Activity / 1.2 / ± / 0.0 / 1.0 / ± / 0.0 / 4.E-04
HR(Act=0) / Activity / (beats min-1) / 615.3 / ± / 7.9 / 527.9 / ± / 11.3 / 7.E-05
HR(Act>0) / Activity / (beats min-1) / 712.0 / ± / 5.1 / 614.3 / ± / 11.5 / 2.E-05
DAP(Act=0) / Activity / (mm Hg) / 103.9 / ± / 2.7 / 91.8 / ± / 2.0 / 3.E-03
DAP(Act>0) / Activity / (mm Hg) / 121.8 / ± / 2.3 / 105.4 / ± / 2.1 / 2.E-04
MAP(Act=0) / Activity / (mm Hg) / 122.0 / ± / 1.6 / 108.0 / ± / 1.5 / 3.E-05
MAP(Act>0) / Activity / (mm Hg) / 141.5 / ± / 1.8 / 123.0 / ± / 1.8 / 1.E-05
SAP(Act=0) / Activity / (mm Hg) / 139.1 / ± / 1.2 / 122.6 / ± / 1.9 / 2.E-05
SAP(Act>0) / Activity / (mm Hg) / 160.6 / ± / 1.9 / 138.7 / ± / 2.3 / 1.E-05
PP(Act=0) / Activity / (mm Hg) / 35.2 / ± / 2.5 / 30.8 / ± / 2.4 / 2.E-01
PP(Act>0) / Activity / (mm Hg) / 38.8 / ± / 2.1 / 33.4 / ± / 2.4 / 1.E-01
Light Period / Mean / SAP / (mm Hg) / 140.5 / ± / 1.2 / 122.3 / ± / 1.8 / 5.E-06
1% / SAP / (mm Hg) / 116.2 / ± / 1.4 / 98.8 / ± / 2.6 / 2.E-04
99% / SAP / (mm Hg) / 178.6 / ± / 2.2 / 158.4 / ± / 3.1 / 3.E-04
99 - 1% / SAP / (mm Hg) / 62.5 / ± / 2.8 / 59.6 / ± / 3.8 / 6.E-01
Mean / MAP / (mm Hg) / 123.1 / ± / 1.0 / 107.5 / ± / 1.2 / 5.E-07
1% / MAP / (mm Hg) / 101.6 / ± / 1.1 / 84.2 / ± / 1.9 / 1.E-05
99% / MAP / (mm Hg) / 157.5 / ± / 2.4 / 140.4 / ± / 2.9 / 1.E-03
99 - 1% / MAP / (mm Hg) / 55.9 / ± / 2.8 / 56.2 / ± / 4.0 / 1.E+00
Mean / DAP / (mm Hg) / 105.0 / ± / 2.0 / 91.3 / ± / 1.8 / 2.E-04
1% / DAP / (mm Hg) / 84.6 / ± / 1.8 / 68.6 / ± / 1.8 / 4.E-05
99% / DAP / (mm Hg) / 138.1 / ± / 3.5 / 122.6 / ± / 3.1 / 7.E-03
99 - 1% / DAP / (mm Hg) / 53.5 / ± / 3.0 / 54.0 / ± / 3.8 / 9.E-01
Mean / PP / (mm Hg) / 35.5 / ± / 2.4 / 31.0 / ± / 2.5 / 2.E-01
1% / PP / (mm Hg) / 25.0 / ± / 4.1 / 22.5 / ± / 2.6 / 6.E-01
99% / PP / (mm Hg) / 46.1 / ± / 2.0 / 40.3 / ± / 2.6 / 1.E-01
99 - 1% / PP / (mm Hg) / 21.1 / ± / 3.6 / 17.8 / ± / 0.9 / 3.E-01
Mean / HR / (beats min-1) / 620.3 / ± / 6.9 / 523.6 / ± / 9.9 / 7.E-06
1% / HR / (beats min-1) / 508.5 / ± / 10.4 / 393.4 / ± / 7.7 / 5.E-07
99% / HR / (beats min-1) / 766.2 / ± / 8.3 / 682.0 / ± / 9.5 / 3.E-05
99 - 1% / HR / (beats min-1) / 257.7 / ± / 13.0 / 288.6 / ± / 7.9 / 5.E-02
Mean / Activity / 5.5 / ± / 0.8 / 3.2 / ± / 0.4 / 2.E-02
Inactive time / Activity / % / 72.5 / ± / 1.8 / 78.6 / ± / 1.4 / 2.E-02
#>0 / Activity / (a.u.) / 396.2 / ± / 25.6 / 308.7 / ± / 19.7 / 2.E-02
Mean / Activity / (a.u.) / 5.5 / ± / 0.8 / 3.2 / ± / 0.4 / 2.E-02
Log(Act>0) / Activity / 1.0 / ± / 0.0 / 0.9 / ± / 0.0 / 1.E-01
HR(Act=0) / Activity / 595.9 / ± / 8.3 / 505.7 / ± / 10.5 / 3.E-05
HR(Act>0) / Activity / 684.5 / ± / 4.0 / 588.4 / ± / 11.0 / 1.E-05
DAP(Act=0) / Activity / (mm Hg) / 100.3 / ± / 2.3 / 87.8 / ± / 1.9 / 1.E-03
DAP(Act>0) / Activity / (mm Hg) / 117.5 / ± / 1.4 / 103.7 / ± / 2.2 / 4.E-04
MAP(Act=0) / Activity / (mm Hg) / 117.9 / ± / 1.1 / 103.6 / ± / 1.4 / 6.E-06
MAP(Act>0) / Activity / (mm Hg) / 137.0 / ± / 1.1 / 121.1 / ± / 2.0 / 4.E-05
SAP(Act=0) / Activity / (mm Hg) / 134.6 / ± / 1.0 / 118.1 / ± / 2.0 / 2.E-05
SAP(Act>0) / Activity / (mm Hg) / 156.0 / ± / 1.6 / 137.0 / ± / 2.5 / 9.E-05
PP(Act=0) / Activity / (mm Hg) / 34.4 / ± / 2.6 / 30.3 / ± / 2.5 / 3.E-01
PP(Act>0) / Activity / (mm Hg) / 38.5 / ± / 2.2 / 33.3 / ± / 2.5 / 2.E-01
Dark Period / Mean / SAP / (mm Hg) / 156.0 / ± / 1.6 / 133.3 / ± / 2.1 / 3.E-06
1% / SAP / (mm Hg) / 122.5 / ± / 2.5 / 106.4 / ± / 2.2 / 4.E-04
99% / SAP / (mm Hg) / 185.7 / ± / 3.4 / 166.8 / ± / 3.6 / 3.E-03
99 - 1% / SAP / (mm Hg) / 63.2 / ± / 4.9 / 60.4 / ± / 3.4 / 6.E-01
Mean / MAP / (mm Hg) / 137.4 / ± / 1.8 / 118.1 / ± / 1.9 / 9.E-06
1% / MAP / (mm Hg) / 107.5 / ± / 2.5 / 93.0 / ± / 1.5 / 2.E-04
99% / MAP / (mm Hg) / 164.9 / ± / 4.6 / 147.5 / ± / 3.0 / 5.E-03
99 - 1% / MAP / (mm Hg) / 57.4 / ± / 5.7 / 54.5 / ± / 3.1 / 6.E-01
Mean / DAP / (mm Hg) / 118.0 / ± / 2.6 / 101.1 / ± / 2.5 / 5.E-04
1% / DAP / (mm Hg) / 90.0 / ± / 3.3 / 77.4 / ± / 1.8 / 3.E-03
99% / DAP / (mm Hg) / 145.7 / ± / 6.1 / 128.2 / ± / 3.1 / 1.E-02
99 - 1% / DAP / (mm Hg) / 55.6 / ± / 5.8 / 50.8 / ± / 2.9 / 4.E-01
Mean / PP / (mm Hg) / 38.0 / ± / 2.1 / 32.3 / ± / 2.4 / 1.E-01
1% / PP / (mm Hg) / 26.0 / ± / 3.9 / 23.4 / ± / 2.2 / 5.E-01
99% / PP / (mm Hg) / 47.0 / ± / 1.8 / 41.2 / ± / 2.7 / 1.E-01
99 - 1% / PP / (mm Hg) / 21.0 / ± / 3.4 / 17.9 / ± / 1.0 / 3.E-01
Mean / HR / (beats min-1) / 692.3 / ± / 4.2 / 584.9 / ± / 14.5 / 6.E-05
1% / HR / (beats min-1) / 538.9 / ± / 13.9 / 433.1 / ± / 15.4 / 4.E-04
99% / HR / (beats min-1) / 785.2 / ± / 6.2 / 710.5 / ± / 10.0 / 9.E-05
99 - 1% / HR / (beats min-1) / 246.3 / ± / 13.8 / 277.4 / ± / 11.2 / 1.E-01
Mean / Activity / (a.u) / 18.4 / ± / 1.6 / 7.3 / ± / 1.1 / 5.E-05
Inactive time / Activity / % / 42.8 / ± / 1.3 / 60.1 / ± / 3.4 / 2.E-03
Mean / Activity / (a.u.) / 823.8 / ± / 18.5 / 574.7 / ± / 49.2 / 2.E-03
Mean / Activity / (a.u.) / 18.4 / ± / 1.6 / 7.3 / ± / 1.1 / 5.E-05
Log(Act>0) / Activity / 1.3 / ± / 0.0 / 1.0 / ± / 0.0 / 6.E-05
HR(Act=0) / Activity / 647.8 / ± / 8.3 / 557.4 / ± / 13.9 / 3.E-04
HR(Act>0) / Activity / 724.8 / ± / 6.1 / 627.3 / ± / 12.4 / 4.E-05
DAP(Act=0) / Activity / (mm Hg) / 110.0 / ± / 3.5 / 97.3 / ± / 2.4 / 8.E-03
DAP(Act>0) / Activity / (mm Hg) / 123.8 / ± / 2.7 / 106.2 / ± / 2.2 / 2.E-04
MAP(Act=0) / Activity / (mm Hg) / 128.8 / ± / 2.7 / 113.8 / ± / 1.7 / 3.E-04
MAP(Act>0) / Activity / (mm Hg) / 143.5 / ± / 2.1 / 123.9 / ± / 1.8 / 1.E-05
SAP(Act=0) / Activity / (mm Hg) / 146.6 / ± / 2.4 / 128.6 / ± / 1.9 / 5.E-05
SAP(Act>0) / Activity / (mm Hg) / 162.7 / ± / 2.2 / 139.7 / ± / 2.3 / 9.E-06
PP(Act=0) / Activity / (mm Hg) / 36.6 / ± / 2.4 / 31.4 / ± / 2.4 / 2.E-01
PP(Act>0) / Activity / (mm Hg) / 39.0 / ± / 2.1 / 33.4 / ± / 2.4 / 1.E-01
Dark - Light / Mean / SAP / (mm Hg) / -15.5 / ± / 1.6 / -11.0 / ± / 1.4 / 6.E-02
Difference / 1% / SAP / (mm Hg) / -6.3 / ± / 2.6 / -7.6 / ± / 1.1 / 6.E-01
99% / SAP / (mm Hg) / -7.1 / ± / 2.1 / -8.4 / ± / 1.1 / 5.E-01
99 - 1% / SAP / (mm Hg) / -0.7 / ± / 2.6 / -0.8 / ± / 1.7 / 1.E+00
Mean / MAP / (mm Hg) / -14.3 / ± / 1.5 / -10.7 / ± / 1.3 / 9.E-02
1% / MAP / (mm Hg) / -5.8 / ± / 2.3 / -8.8 / ± / 1.1 / 2.E-01
99% / MAP / (mm Hg) / -7.4 / ± / 2.5 / -7.1 / ± / 1.0 / 9.E-01
99 - 1% / MAP / (mm Hg) / -1.5 / ± / 3.2 / 1.6 / ± / 1.7 / 4.E-01
Mean / DAP / (mm Hg) / -13.0 / ± / 1.8 / -9.8 / ± / 1.2 / 1.E-01
1% / DAP / (mm Hg) / -5.4 / ± / 1.8 / -8.8 / ± / 1.3 / 1.E-01
99% / DAP / (mm Hg) / -7.6 / ± / 2.9 / -5.6 / ± / 1.0 / 5.E-01
99 - 1% / DAP / (mm Hg) / -2.1 / ± / 3.0 / 3.2 / ± / 1.7 / 1.E-01
Mean / PP / (mm Hg) / -2.5 / ± / 1.0 / -1.3 / ± / 0.6 / 3.E-01
1% / PP / (mm Hg) / -1.1 / ± / 1.2 / -0.9 / ± / 0.7 / 9.E-01
99% / PP / (mm Hg) / -0.9 / ± / 0.6 / -0.9 / ± / 0.5 / 1.E+00
99 - 1% / PP / (mm Hg) / 0.1 / ± / 1.1 / 0.0 / ± / 0.9 / 9.E-01
Mean / HR / (beats min-1) / -72.0 / ± / 5.9 / -61.3 / ± / 7.4 / 3.E-01
1% / HR / (beats min-1) / -30.4 / ± / 6.5 / -39.7 / ± / 10.1 / 5.E-01
99% / HR / (beats min-1) / -19.0 / ± / 10.7 / -28.5 / ± / 6.4 / 4.E-01
99 - 1% / HR / (beats min-1) / 11.4 / ± / 11.2 / 11.2 / ± / 9.0 / 1.E+00
Mean / Activity / (a.u.) / -12.9 / ± / 1.8 / -4.1 / ± / 0.9 / 4.E-04
a.u., arbitrary units; DAP, diastolic pressure; HR, heart rate; MAP, mean arterial pressure; PP, pulse pressurel SAP, systolic arterial pressure. P value determined by Student's unpaired t-test. n=6 BPH/2 and n=9 BPN/3.