Rosen et al. (E) T-1. Behavioral abnormalities1 in six patients whose anatomical pattern was not predicted by their clinical syndrome2
Case
/
CDx
/
ADx
/
Del
/
Ha
/
Ag
/
Dep
/
Anx
/
Ela
/
Ap
/
Dis
/
Irr
/
AM
/
Slp
/

Eat

1 / SD / Fv / 0 / 0 / 1 / 1 / 1 / 0 / 1 / 1 / 0 / 1 / 1 / 1
2 / SD / Fv / 1 / 1 / 1 / 1 / 1 / 1 / 1 / 1 / 1 / 1 / 1 / 1

3

/

SD

/ Fv / 0 / 0 / 0 / 0 / 0 / 0 / 1 / 1 / 0 / 0 / 0 / 1
4 / FTD / Tv / 1 / 0 / 1 / 0 / 1 / 0 / 1 / 1 / 1 / 0 / 0 / 1
5 / FTD / Tv / 1 / 0 / 1 / 0 / 0 / 1 / 0 / 1 / 1 / 0 / 0 / 1
6 / FTD / Tv / 0 / 0 / 1 / 0 / 1 / 1 / 1 / 1 / 0 / 1 / 1 / 1
1. Del = Delusions, Ha = Hallucinations, Ag = Agitation, Dep = Depression, Anx = Anxiety, Ela = Elation, Ap = Apathy, Dis = Disinhibiton, Irr = Irritability, AM = Aberrant Motor Behavior, Slp = Sleep disorders, Eat = Eating disorders. 1 = Present, 0 = Absent.
2. CDx = clinical diagnosis, SD = Semantic dementia, ADx = Anatomical diagnosis, fv = fvFTD, tv = tvFTD

Rosen et al. (E) T-2. Patterns of atrophy1 in six patients whose anatomical pattern2 was not predicted by their clinical syndrome

Case3

/

Clinical Dx.

/

MMSE

/

Ratem Z

/

Latem Z

/

Rfr Z

/

Lfr Z

1 / SD / 23 / 0.33 / -1.963 / -2.978 / -3.508
2 / SD / 0 / -3.515 / -1.792 / -6.403 / -4.192

3

/

SD

/

22

/

-1.8

/

-2.543

/

-2.871

/

-3.825

4 / FTD / 20 / -3.276 / -4.502 / -1.038 / -2.596
5 / FTD / 27 / -3.258 / -4.146 / -0.439 / -2.827
6 / FTD / 24 / -3.563 / -2.861 / -2.256 / -0.888
1. Atrophy as indicated by z-score for measured region compared with same region in control subjects (see methods). Bolded region shows most negative z-score in that individual.
2. R = right, L = Left, fr = frontal cortex, atem = anterior temporal cortex
3. Cases are listed in the same order as in Table 3.

Rosen et al. (E) T-3. Comparison of findings from studies of behavior1 in FTD

Study (authors)

/ Measure2 /

FTD>AD4

/

tvFTD>fvFTD5

/

fvFTD>tvFTD5

1. Levy et al.a / NPI3 / Apathy
Disinhibition
Euphoria
Aberrant Motor Behavior / ND / ND

2. Bozeat et al.b

/ Locally constructed questionnaire (with NPI items included) / Use of catchphrases, and other stereotyped behavior
Eating disorders
Decreased self-care
Poor judgment
Reduction in conversation
Social withdrawal
Apathy / Mental rigidity
Depression / Disinhibition
3. Bathgate et al. c / Locally constructed questionnaire / Affect and social behavior (8 items differed)
Loss of awareness of pain
Eating and vegetative behaviors (10 items differed)
Repetitive, compulsive behaviors (6 items differed) /

ND

/

ND

4. Snowden et al. d / Locally constructed questionnaire / ND /

Selective food fads

Repetitive, compulsive themes and behaviors

Complex compulsions
Excessive worrying /

Loss of insight

Pervasive loss of emotion

Loss of interest/social contact
Exaggerated reaction to pain

Gluttony

tvFTD>AD

/

fvFTD>AD

5. Current Study / NPI3 / Elation
Disinhibition
Aberrant Motor Behavior
Eating Disorders (trend)
Sleep disorders / Elation
Disinhibition
Aberrant Motor Behavior
Eating Disorders
Apathy
Anxiety / Sleep disorders
Depression (trend) / Apathy
1. Only includes studies looking at multiple types of behavior across groups.
2. Studies 3 and 4 used the same questionnaire (69 items), which was different than the one used in Study 2 (39 items). For study 1, 3, and the current study, only general categories of behavior are listed, for studies 2 and 4, individual items are listed
3. Earlier version of NPI used in study 1 did not include eating disorders.
4. Studies 1 and 3 did not divide FTD into anatomical variants. Study 2 did, however data were analyzed as differences across three groups (AD, fvFTD, tvFTD). Items listed in 3rd column for study 2 appeared to be present in fvFTD and tvFTD more than AD, and were not listed by the authors as being different between FTD variants (4th and 5th columns).
5. Study 4 used clinical divisions, but made anatomical inferences. They included two clinical variants of FTD: apathetic and disinhibited. Items are listed here if they were more prevalent in either of these variants compared with SD.
ND = not done.
a = Levy ML, Miller BL, Cummings JL, Fairbanks LA, Craig A. Alzheimer disease and frontotemporal dementias. Behavioral distinctions. Arch Neurol 1996;53(7):687-690.
b = Bozeat S, Gregory CA, Ralph MA, Hodges JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? J Neurol Neurosurg Psychiatry 2000;69(2):178-186.
c = Bathgate D, Snowden JS, Varma A, Blackshaw A, Neary D. Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia. Acta Neurol Scand 2001;103(6):367-378.
d = Snowden JS, Bathgate D, Varma A, Blackshaw A, Gibbons ZC, Neary D. Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J Neurol Neurosurg Psychiatry 2001;70(3):323-332.

Please contact: Howard Rosen: for any questions regarding this data.