Supplementary Table2. Univariable analysis of RTDS based on the data obtained before re-hepatectomy

Variable / Initial stage / Recurrent stage
Number / P / Number / P
Age,years, ≤50 / >50 / 360/275 / 0.985 / 291/344 / 0.435
Sex, male / female / 547/88 / 0.744 / 547/88 / 0.601
Diabetes, yes / no / 28/607 / 0.755 / 70/565 / 0.453
Drinking, yes / no / 152/483 / 0.072 / 70/565 / 0.544
Anti-viral treatment, yes/no / 23/612 / 0.367 / 177/458 / 0.053
HBsAg, negative / positive / 41/594 / 0.944 / 61/574 / 0.456
HBeAg, negative / positive / 437/198 / 0.133 / 449/186 / 0.102
HBV-DNA, IU/ml, <1000 / ≥1000 / 292/343 / 0.051 / 411/224 / 0.001
TBIL, umol/L, ≤17.1 / >17.1 / 450/185 / 0.312 / 460/175 / 0.657
ALB, g/l, ≤35 / >35 / 30/605 / 0.673 / 34/601 / 0.899
ALT, IU/l, ≤40 / >40 / 293/342 / 0.081 / 383/252 / 0.331
AST, IU/l, ≤40 / >40 / 346/289 / 0.061 / 451/184 / 0.089
PT, seconds, ≤12 / >12 / 230/405 / 0.835 / 239/396 / 0.508
PLT, 109/l, ≤100 / >100 / 129/506 / 0.492 / 203/432 / 0.081
GGT, IU/l, ≤60 / >60 / 416/219 / 0.318 / 516/119 / 0.016
AFP, ng/ml, ≤200 / >200 / 151/484 / 0.045 / 329/306 / 0.011
Varices, yes/ no / 127/508 / 0.086 / 173/462 / 0.071
Tumor number (imaging) *,
single/multiple / -/- / N/A / 539/96 / 0.001
Tumor diameter (imaging) *,cm,
≤3 / 3-5 /5 / -/-/- / N/A / 367/185/83 / 0.004
Hepatectomy, anatomical / non-anatomical / 363/272 / 0.231 / -/- / N/A
Blood loss, ml, ≤400 / >400 / 552/83 / 0.032 / -/- / N/A
Blood transfusion, no / yes / 564/71 / 0.003 / -/- / N/A
Tumor diameter (pathology) **,cm,
≤5 / 5-10 /10 / 374/183/78 / 0.006 / -/-/- / N/A
Tumor numbers(pathology) **,
single / multiple / 474/161 / 0.001 / -/- / N/A
Surgical margin**,cm, ≤1 / >1 / 361/274 / 0.258 / -/- / N/A
Tumor capsule**, absence / presence / 429/206 / 0.071 / -/- / N/A
MVI**, absence / presence / 317/318 / 0.145 / -/- / N/A
Edmondson-Steiner, I-II / III-IV / 124/511 / 0.017 / -/- / N/A
Cirrhosis**, no / yes / 331/304 / 0.555 / -/- / N/A
TTR, months, ≤12 / 12-24 / >24 / 164/151/320 / < 0.001 / -/- / N/A

Abbreviation: HBsAg, hepatitis Bsurface antigen; HBeAg, hepatitis Be antigen;HBV-DNA, hepatitis Bvirus-deoxyribonucleic acid; TBIL, total bilirubin;ALB, albumin;ALT, alanine aminotransferase; AST, aspartate aminotransferase; PT, prothrombin time; PLT, platelet count; GGT, gamma-glutamyltransferase;AFP, alpha-fetoprotein; MVI, microvascular invasion; TTR, time to recurrence; N/A, not applicable.

*: Identified with contrast-enhanced CT scan or/and MRI.

**: Identified with post-operative pathological examination.