Potentially Explosive Compounds

Standard Operating Procedure

Potentially Explosive Compounds

Print a copy and insert into your
Laboratory Safety Manual and Chemical Hygiene Plan.

Department: / Chemistry /
Date SOP was written: / 12/5/2012 /
Date SOP was approved by PI/lab supervisor: / 1/13/2013 /
Principal Investigator: / Richmond Sarpong /
Internal Lab Safety Coordinator/Lab Manager: / Rebecca Murphy /
Lab Phone: / 510-643-2485 /
Office Phone: / 510-643-6312 /
Emergency Contact: / Richmond Sarpong, 626-644-2407 /
(Name and Phone Number)
Location(s) covered by this SOP: / Latimer Hall: 834, 836, 837, 838, 839, 842, 847, 849, 907 /
(Building/Room Number)

Type of SOP: Process Hazardous Chemical Hazardous Class

Purpose

This SOP applied to various chemicals that are potentially explosive compounds. See Table 1 below.

Physical & Chemical Properties/Definition of Chemical Group

Chemical classes of explosives - According to Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards (section 4.D.3.1 Explosive Hazards) The National Academies Press: Washington, DC, 2011.

"An explosive is any chemical compound or mechanical mixture that, when subjected to heat, impact, friction, detonation, or other suitable initiation, undergoes rapid chemical change, evolving large volumes of highly heated gases – typically nitrogen or CO2 – that exert pressure on the surrounding medium. The term applies to materials that either detonate or deflagrate.”

All compounds with bonds between electronegative atoms should be considered to be highly reactive, but the following functional groups should alert you to danger: peroxides (-O-O-, -O-O-O-), nitro compounds (O-NO2, N-NO2, and C-NO2), nitroso compounds (O-NO, N-NO), azo and related compounds (C=N2, R-N2+, -N=N-, -N3, -N=N-S-N=N-), hypohalites and haloamines (RCOO-X, N-X), oxyhalide salts (ClO4-, ClO3-, BrO3-, IO3-, ClO2, ClO-) and related metal salts (M-N3, M-CC-M, M-N=C=O, M-OClO3, picrates, dinitrophenolates).

Listed Chemicals/Compounds

The following chemicals/compounds are considered potentially explosive. It is important to remember that this list is not comprehensive and chemical/compound SDSs will need to be reviewed to determine if your chemical/compound is part of this class.

Table 1.

1. Potentially Explosive Lab Chemicals

Acetyl peroxide / Acetylene / Ammonium nitrate
Ammonium perchlorate / Ammonium picrate / Barium azide
Benzoyl peroxide / Bromopropyne / Butanone peroxide
Cumene peroxide / Diazodinitrophenol / Dinitrophenol
Dinitrophenylhydrazine / Dinitroresorcinol / Dipicryl amine
Dipicryl sulphide / Dodecanoyl peroxide / Ethylene oxide
Heavy metal azides / Lauric peroxide / Lead azide
Lithium azide / Methyl ethyl ketone peroxide / Mercury azide
Mercury fulminate / Nitrocellulose / Nitrogen trifluoride
Nitrogen triiodide / Nitroglycerine / Nitroguanidine
Nitromethane / Nitrourea / Organic azides
Picramide / Picric acid / Picryl chloride
Picryl sulphonic acid / Potassium azide / Propargyl bromide (neat)
Silver fulminate / Sodium azide / Sodium dinitrophenate
Succinic peroxide / Tetranitroaniline / Trinitroaniline
Trinitroanisole / Trinitrobenzene / Trinitrobenzenesulphonic acid
Trinitrobenzoic acid / Trinitrocresol / Trinitronaphthalene
Trinitrophenol / Trinitroresorcinol / Trinitrotoluene
Urea nitrate

1. Potentially Explosive Compound Classes

Acetylene (-C=C-) / Acyl hypohalites (RCO-OX) / Azide Organic (R-N3)
Azide Metal (M-N3) / Azo (-N=N-) / Diazo (=N=N)
Diazosulphide (-N=N-S-N=N-) / Diazonium salts (R-N2+) / Fulminate (-CNO)
Halogen Amine (=N-X) / Nitrate (-ONO2) / Nitro (-NO2)
Aromatic or Aliphatic Nitramine (=N-NO2) (-NH-NO2) / Nitrite (-ONO) / Nitroso (-NO)
Ozonides / Peracids (-CO-O-O-H) / Peroxide (-O-O-)
Hydroperoxide (-O-O-H) / Metal peroxide (M-O-O-M)

1. Explosive Salts

Bromate salts (BrO3-) / Chlorate salts (ClO3-) / Chlorite salts (Cl02-)
Perchlorate salts (Cl04-) / Picrate salts (2,4,6-trinitrophenoxide) / Picramate salts (2-amino-4,6-dinitrophenoxide)
Hypohalite salts (XO-) / Iodate salts (IO3-)

Potential Hazards/Toxicity

The danger of explosive compounds arises from lacerations due to shrapnel (metal, glass, ceramic, etc.) and burns due to fires that might accompany or follow the explosion.

An explosion might also lead to exposure to toxic chemicals. See the appropriate SOPs and MSDSs for any other chemicals used in tandem with potentially explosive chemicals to determine if there is the potential of exposure to toxic chemicals.

Engineering Controls

NOTE: Lab-specific information on engineering controls may be included in the Protocol/Procedure section.

Fume Hood

Reactions involving potentially explosive reagents, intermediates, or products should be conducted in a hood with the sash closed. Only those authorized to work with this class of chemical should be allowed near the hood.

Portable Blast Shield

When working with potentially explosive compounds the use ofa portable blast shield, inside the hood, is recommended.

Personal Protective Equipment (PPE)

NOTE: Lab-specific information on PPE selection may be included in the Protocol/Procedure section.

Respiratory protection

NOTE: Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S. This is a regulatory requirement.

Refer to 8 CCR 5144 for selection of respirators. A respiratory protection program that meets 8 CCR 5144 must be followed whenever workplace conditions warrant use of a respirator.

Respirators should be used only under any of the following circumstances:

• As a last line of defense (i.e., after engineering and administrative controls have been exhausted).
• When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will be exceeded.
• Regulations require the use of a respirator.
• An employer requires the use of a respirator.
• There is potential for harmful exposure due to an atmospheric contaminant (in the absence of PEL)
• As PPE in the event of a chemical spill clean-up process

Hand Protection

Gloves must be worn with when handling potentially explosive compounds. Ensure that the gloves to be used are appropriate (e.g. static free, etc.). Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Choose gloves that provide a balance between protection against lacerations (in case of an explosion) and the agility needed to work nimbly with potentially explosive compounds. Wash and dry hands after removal of gloves.

NOTE: Lab-specific and chemical-specific information on glove selection may be included in the Protocol/Procedure section. Refer to glove selection from the link below:

For glove selection, go to:

Eye Protection

Safety glasses with side shields ortightly fitting safety goggles. Use goggles and face shield (8-inch minimum) when appropriate. Only use equipment for eye protection tested and approved under appropriate government standards such as ANSI Z 87.1, NIOSH (US), or EN 166(EU).

Skin and Body Protection

Long pants, closed-toed and closed-heeled shoes, cotton-based clothing/attire (no exposed skin below waist),and flame resistant lab coat must be worn for protecting against chemical hazards. No exposed skin is allowed from waist down.

Hygiene Measures

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

First Aid Procedures

Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident.

Refer to specific chemical SOPs and SDSs for specific first aid procedures.

General First Aid Procedures

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Seek medical attention.

In case of skin contact

Remove contaminated clothing. Wash off with soap and plenty of water. Seek medical attention.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and Seek medical attention.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Seek medical attention.

Special Handling and Storage Requirements

NOTE: Laboratory-specific information on handling and storage may be included in the Protocol/Procedure section.

Refer to specific chemical SOPs and SDSs for specific handling and storage requirements.

Working alone

Certain extremely hazardous operations should not be performed if the PI or Lab Safety Contact(s) are not present. Never work alone with extremely hazardous materials/operations. See the Protocol/Procedure section for specific prohibitions (if any) on working alone.

Chemical factors that affect stability - Note that the explosive potential of any substance depends on several factors:

1. Dilution: Pure solids and pure liquids are much more dangerous than solutions. Dilution reduces the potential for explosive chain reactions.

2. Functional group density - The explosive hazard is increased when unstable functional groups make up most of the organic molecule. Trinitrotoluene is dangerous whereas nitrotoluene is not. Remember the azide rule: NEVER attempt to isolate an organic azide with a carbon-to-nitrogen ratio of less than 1.

Triggers - There are a variety of common triggers for chemical explosions: heat, impact, friction, catalysts, and even light.

• Heat facilitates explosive detonations. Store potentially dangerous away from heat sources this includes direct sunlight. Before heating any reaction that involves potentially explosive compounds, consult the PI.

• Shock-sensitive materials include metal acetylides, azides, nitrogen triiodide, nitrate esters, nitro compounds, metal perchlorates, many organic peroxides, and compounds containing diazo, halamine, nitroso, and ozonide functional groups.

• Many metal ions, including the iron in rust, can catalyze the violent decomposition of peroxides.

• Acids, bases, and other substances catalyze the explosive polymerization of acrolein.

Hydrogen and chlorine react explosively in the presence of light.

(refer to the SDS of your compound to determine potential triggers to avoid)

Designated Area

Designated area(s) for use and storage of potentially explosive chemicals must be established. These designated areas must have a sign that at a minimum states “EXPLOSION RISK”.

General Precautions

Get Permission: Attention! Federally regulated explosives are strictly controlled. Please refer to the most recent list from the Bureau of Alcohol, Tobacco, and Firearms to see if the material you are interested in buying or making a compound that is on their list: There are over 200 compounds and compound classes on the ATF list, including some surprisingly common reagents like dinitrophenylhydrazine. If you want to purchase or synthesize any of the explosives on the ATF list you must first contact EH&S. No exceptions! Familiarize yourself with the structural features of the common military explosives below; NEVER buy or synthesize anything that resembles any of these military explosives.

Purchases of potentially explosive chemicals should be restricted to ensure that these chemicals are used up completely. This requires careful experiment planning on behalf of researchers. Researchers should purchase no more material than is needed to complete an experiment.

Minimize the quantity of potentially explosive chemicals in the lab by tracking the potentially explosive compounds in the laboratory’s inventory and disposing of unused compounds.

Keep and store all potentially explosive chemicals away from all ignition sources such as heat, open flames, spark sources and direct sunlight.

When manipulating potentially explosive chemicals use equipment that will not generate static electricity, sparks or a area of friction. (e.g. use a Teflon-coated spatula instead of a regular metal spatula)

SpillResponse and Exposure Response

Beforebeginningwork withchemicals,reviewtherelevant SOPs, SafetyDataSheets,andother chemicalsafetyresources. Developspecificproceduresforemergencyresponseandchemical exposureorinjurytostaff,includinganyspecialfirstaidmeasuresrequiredfortherelevantchemicals.

Spill and Accident Procedure

Note: These responses may not apply to all potentially explosive chemicals. Please review specific chemical SOPs and SDSs for specific response to spills and accidents. Always dial 911 and 510-642-9090 for assistance.

Chemical Spill Dial 911

Spill – Assess the extent of danger. Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.). Dial 911 and 510-642-9090 for assistance.

Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident.

Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water from the emergency eyewash station for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident.

Medical Emergency Dial 911

Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911 or go to the nearest emergency room. Note: All serious injuries must be reported to EH&S within 8 hours. Follow up with a call to 510-642-9090 to report the incident.

Non-Life Threatening Emergency – Go to the Occupational Health Facility (Tang Health Center). After hours go to the nearest emergency room. Note: All serious injuries must be reported to EH&S within 8 hours. Follow up with a call to 510-642-9090 to report the incident.

Needle stick/punctureexposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Go to the Occupational Health Facility (Tang Health Center). After hours go to the nearest emergency room. Note: All needle stick/puncture exposures must be reported to EH&S within 8 hours. Follow up with a call to 510-642-9090 to report the incident.

Hazardous Waste Disposal

General hazardous waste disposal guidelines:

Label Waste

• Labelallcontainers withthelabelprovidedat See theEH&SFactSheet,“HazardousWaste Management”forgeneralinstructionsonprocedures fordisposingofhazardouswaste.

Dispose of Waste

• Dispose of regularly generated chemical waste within 6 months.
• Call EH&S for questions.

Safety Data Sheet (SDS) Location

SDS can be accessed online at

Potentially Explosive Compounds1Date: 01/02/2013

SOP Template developed by The UC Center for Laboratory Safety

Potentially Explosive Compounds1Date: 01/02/2013

SOP Template developed by The UC Center for Laboratory Safety

Documentation of Training (signature and initials of all users is required)

• Prior to conducting any work with peroxide forming chemicals, designated personnel must provide training to his/her laboratory personnel specific to the hazards involved in working with the specific chemical(s) used, work area decontamination, and emergency procedures.

• The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the SDS provided by the manufacturer.

I have read and understand the content of this SOP:

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Potentially Explosive Compounds1Date: 01/02/2013

SOP Template developed by The UC Center for Laboratory Safety