Arch SocEspOftalmol.2005 Jul;80(7):387-94.
[A comparative study of 0.15% sodium hyaluronate versus polyvinyl alcohol in the treatment of dry eyes].
[Article in Spanish]
Vico E1,Quereda A,Benítez-Del-Castillo JM,Fernández C,García-Sánchez J.
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Abstract
PURPOSE:
To evaluate the efficacy of two artificial tears for the treatment of dry eyes: 0.15% sodium hyaluronate and polyvinyl alcohol.
METHODS:
The study included 60 dry eyes in 30 patients. Fifteen of the patients were treated with 0.15% sodium hyaluronate and 15 with polyvinyl alcohol. Five drops a day for one month was given in both groups. Visual acuity, Schirmer's test, tear clearance, dry eye symptoms questionnaire, fluorescein and rose bengal staining, corneal sensibility, bulbar hyperemia, tear detritus, meibomian gland plug, palpebral erythema and edema before and after treatment were evaluated.
RESULTS:
Symptoms as judged by the dry eye questionnaire, as well as both fluorescein and rose bengal staining, were significantly improved by 0.15% sodium hyaluronate. The polyvinyl alcohol treated patients did not show a significant improvement in any parameter.
CONCLUSION:
Sodium hyaluronate was more effective than polyvinyl alcohol in the treatment of patients with dry eyes (Arch SocEspOftalmol 2005; 80: 387-394).
Cornea.2010 Feb;29(2):167-71. doi: 10.1097/ICO.0b013e3181b11648.
Comparative analysis of carmellose 0.5% versus hyaluronate 0.15% in dry eye: a flow cytometric study.
Sanchez MA1,Torralbo-Jimenez P,Giron N,de la Heras B,HerreroVanrell R,Arriola-Villalobos P,Diaz-Valle D,Alvarez-Barrientos A,Benitez-Del-Castillo JM.
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Abstract
PURPOSE:
To compare the effects of Viscofresh 0.5% (carmellose sodium 0. 5%) versus Lubristil (sodium hyaluronate 0.15%) in dry eye syndrome and to study the influence of these two treatments on the expression of various inflammatory markers by flow cytometry in impression cytology specimens.
METHODS:
In this randomized, masked-observer, parallel group, single-center study, 15 patients with dry eye syndrome were randomized to sodium carmellose 0.5% or sodium hyaluronate 0.15% 1-month treatment after a 1-week washout period. Corneal staining with flurescein, breakup time, Schirmer 1 test with anesthesia (Jones test), and tear clearance were assessed. Besides, conjunctival impression cytology was performed to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using flow cytometry.
RESULTS:
Carmellose group shows statistical improvement compared with the hyaluronate group in breakup time, corneal staining, and HLA-DR. The two other inflammatory markers had also a tendency for a decreased expression in both groups, with no statistical significance. There were neither visual acuity loss nor other complications related to treatment.
CONCLUSION:
Both artificial tears improve dry eye signs and symptoms and inflammatory markers expression, with significant better results in carmellose group.