Systematic Reviews of Oral Complications from Cancer Therapies: Methodology

Appendix: Search Strategy (online access)

Radiotherapy Search Strategy

1. Cochrane Collection in Ovid:

The entire list of topic reviews from the following groups on April 15, 2005: Oral Health Group; Ear, Nose and Throat Disorders group; Pain, Palliative Care and Supportive Care Group. Only systematic reviews were considered; protocols were not considered. Nothing was found.

2. Best Evidence is now called simply ACP Journal Club:

Database: EBM Reviews - ACP Journal Club <1991 to March/April 2005>

Search Strategy:

------

1 ((oral or mouth or mucos$) and (radiat$ or radiotherapy or radioisotope$1 or radioprotect$ or radiochemo$ or irradiat$)).mp. [mp=title, abstract, full text, keywords, caption text] (12)

2 from 1 keep 2 (1)

3 from 2 keep 1 (1)

3. Medline:

Incidence of cancer-related oral manifestations of radiotherapy for head and neck cancer and oral care protocols pre- and during radiotherapy for head and neck cancer:

-searched for these two together because the search strategies overlap

-search strategy adapted from “highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE” in the Cochrane Reviewer’s Handbook[5]

Database: Ovid MEDLINE(R) <1966 to April Week 4 2005>

Search Strategy:

------

1 exp Radiotherapy/ (78537)

2 exp Radiation Injuries/ (37822)

3 exp Radioisotopes/ (198966)

4 exp "Head and Neck Neoplasms"/ (152334)

5 exp "Head and Neck Neoplasms"/rt [Radiotherapy] (19002)

6 stomatognathic diseases/ or jaw diseases/ or cherubism/ or granuloma, giant cell/ or exp jaw abnormalities/ or jaw cysts/ or nonodontogenic cysts/ or odontogenic cysts/ or dentigerous cyst/ or odontogenic cyst, calcifying/ or exp periodontal cyst/ or exp jaw, edentulous/ or mandibular diseases/ or exp craniomandibular disorders/ or prognathism/ or retrognathism/ or maxillary diseases/ or mouth diseases/ or behcet syndrome/ or bell palsy/ or burning mouth syndrome/ or candidiasis, oral/ or dry socket/ or facial hemiatrophy/ or facial neuralgia/ or facial paralysis/ or focal epithelial hyperplasia/ or hemifacial spasm/ or leukoedema, oral/ or lichen planus, oral/ or lip diseases/ or cheilitis/ or cleft lip/ or herpes labialis/ or ludwig's angina/ or melkersson-rosenthal syndrome/ or exp mouth abnormalities/ or exp mouth, edentulous/ or noma/ or exp oral fistula/ or exp oral hemorrhage/ or oral manifestations/ or oral submucous fibrosis/ or oral ulcer/ or exp periapical diseases/ or periodontal diseases/ or alveolar bone loss/ or furcation defects/ or gingival diseases/ or gingival hemorrhage/ or exp gingival overgrowth/ or gingival recession/ or exp gingivitis/ or pericoronitis/ or periodontal attachment loss/ or periodontal cyst/ or exp periodontitis/ or tooth loss/ or exp tooth migration/ or tooth mobility/ or ranula/ or salivary gland diseases/ or mikulicz' disease/ or parotid diseases/ or exp parotitis/ or salivary duct calculi/ or salivary gland calculi/ or salivary gland fistula/ or sialadenitis/ or sialometaplasia, necrotizing/ or sialorrhea/ or submandibular gland diseases/ or xerostomia/ or tongue diseases/ or glossalgia/ or exp glossitis/ or macroglossia/ or tongue, fissured/ or tongue, hairy/ or tuberculosis, oral/ or pharyngeal diseases/ or nasopharyngeal diseases/ or nasopharyngitis/ or peritonsillar abscess/ or pharyngitis/ or retropharyngeal abscess/ or tonsillitis/ or velopharyngeal insufficiency/ or exp stomatognathic system abnormalities/ or exp temporomandibular joint disorders/ or exp tooth diseases/ (221472)

7 exp stomatognathic system/ (224770)

8 exp *"Head and Neck Neoplasms"/rt or (exp *"Head and Neck Neoplasms"/ and (exp *Radiotherapy/ or exp *Radiation Injuries/ or exp *Radioisotopes/)) (12371)

9 8 and oral manifest$.ti. (3)

10 8 and exp *stomatognathic system/re (282)

11 8 and (*stomatognathic diseases/ or *jaw diseases/ or *cherubism/ or *granuloma, giant cell/ or exp *jaw abnormalities/ or *jaw cysts/ or *nonodontogenic cysts/ or *odontogenic cysts/ or *dentigerous cyst/ or *odontogenic cyst, calcifying/ or exp *periodontal cyst/ or exp *jaw, edentulous/ or *mandibular diseases/ or exp *craniomandibular disorders/ or *prognathism/ or *retrognathism/ or *maxillary diseases/ or *mouth diseases/ or *behcet syndrome/ or *bell palsy/ or *burning mouth syndrome/ or *candidiasis, oral/ or *dry socket/ or *facial hemiatrophy/ or *facial neuralgia/ or *facial paralysis/ or *focal epithelial hyperplasia/ or *hemifacial spasm/ or *leukoedema, oral/ or *lichen planus, oral/ or *lip diseases/ or *cheilitis/ or *cleft lip/ or *herpes labialis/ or *ludwig's angina/ or *melkersson-rosenthal syndrome/ or exp *mouth abnormalities/ or exp *mouth, edentulous/ or *noma/ or exp *oral fistula/ or exp *oral hemorrhage/ or *oral manifestations/ or *oral submucous fibrosis/ or *oral ulcer/ or exp *periapical diseases/ or *periodontal diseases/ or *alveolar bone loss/ or *furcation defects/ or *gingival diseases/ or *gingival hemorrhage/ or exp *gingival overgrowth/ or *gingival recession/ or exp *gingivitis/ or *pericoronitis/ or *periodontal attachment loss/ or *periodontal cyst/ or exp *periodontitis/ or *tooth loss/ or exp *tooth migration/ or *tooth mobility/ or *ranula/ or *salivary gland diseases/ or *mikulicz' disease/ or *parotid diseases/ or exp *parotitis/ or *salivary duct calculi/ or *salivary gland calculi/ or *salivary gland fistula/ or *sialadenitis/ or *sialometaplasia, necrotizing/ or *sialorrhea/ or *submandibular gland diseases/ or *xerostomia/ or *tongue diseases/ or *glossalgia/ or exp *glossitis/ or *macroglossia/ or *tongue, fissured/ or *tongue, hairy/ or *tuberculosis, oral/ or *pharyngeal diseases/ or *nasopharyngeal diseases/ or *nasopharyngitis/ or *peritonsillar abscess/ or *pharyngitis/ or *retropharyngeal abscess/ or *tonsillitis/ or *velopharyngeal insufficiency/ or exp *stomatognathic system abnormalities/ or exp *temporomandibular joint disorders/ or exp *tooth diseases/) (352)

12 8 and (xerostomia or dysphagia or dysgeusia or taste or mouth or cheilitis or lip or lips or candidiasis or burning or gingiv$ or periodont$ or tooth or teeth or dentition or dental or saliv$ or sial$ or parotid$ or tongue$ or gloss$ or pharyng$ or pharnyx or stomoatognathic).ti,ab. and (toxicit$ or dlt).ti,ab. (184)

13 9 or 10 or 11 or 12 (750)

14 oral care.ti. (216)

15 exp oral hygiene/ (10825)

16 exp dentistry/ (242181)

17 8 and (14 or exp *oral hygiene/ or exp *dentistry/) (168)

18 13 or 17 (870)

19 exp epidemiologic study characteristics/ or exp epidemiologic research design/ (1289646)

20 exp Morbidity/ (173284)

21 late effect$1.ti,ab. (2502)

22 8 and (20 or 21) (323)

23 18 or 22 (1152)

24 limit 23 to (humans and english language) (882)

25 limit 24 to (case reports or comment or letter or news or newspaper article) (118)

26 24 not 25 (764)

27 limit 26 to (clinical trial or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or consensus development conference or consensus development conference, nih or controlled clinical trial or guideline or meta analysis or multicenter study or practice guideline or randomized controlled trial or "review" or review, academic or "review literature" or review, multicase or "review of reported cases" or review, tutorial or "scientific integrity review" or technical report or twin study or validation studies) (239)

28 26 and (clinical trial$1 or (phase adj2 (study or studies or trial$1)) or (meta adj (analysis or analyses)) or randomized controlled trial$1 or (consensus adj2 conference$1) or guideline$1).ti,ab,hw. (88)

29 limit 26 to evidence based medicine reviews (15)

30 26 and 19 (325)

31 27 or 28 or 29 or 30 (450)

32 Comparative Study/ (1179342)

33 Placebos/ (23554)

34 research design/ (40149)

35 exp evaluation studies/ (514230)

36 ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab. (80159)

37 (control$ or prospectiv$ or volunteer$).ti,ab. (1514347)

38 (placebo$ or random$).ti,ab. (346771)

39 32 or 33 or 34 or 35 or 36 or 38 or 37 (2940396)

40 26 and 39 (366)

41 31 or 40 (530)

Chemotherapy Search Strategy

1. Cochrane Collection in Ovid:

The entire list of topic reviews from the following groups on April 6, 2005: Oral Health Group; Ear, Nose and Throat Disorders group; Pain, Palliative Care and Supportive Care Group. Only systematic reviews were selected; protocols were not selected.

2. Best Evidence is now called simply ACP Journal Club:

Database: EBM Reviews - ACP Journal Club <1991 to March/April 2005>

Search Strategy:

------

1 mucositis.mp. [mp=title, abstract, full text, keywords, caption text] (0)

2 stomatitis.mp. [mp=title, abstract, full text, keywords, caption text] (1)

3 ((oral or mouth or mucos$) and (chemotherapy or cytotoxic$ or cancer$1 or leukem$ or carcinoma$1 or neoplas$ or oncolog$)).mp. [mp=title, abstract, full text, keywords, caption text] (108)

4 from 3 keep 16 (1)

5 from 4 keep 1 (1)

3. Medline:

Incidence of cancer-related oral manifestations of chemotherapy and oral care protocols pre- and during chemotherapy:

-searched for these two (incidence of oral manifestations of chemo and oral care protocols pre-and during chemo) together because the search strategies overlap

-search strategy adapted from “highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE” in the Cochrane Reviewer’s Handbook[5]

Database: Ovid MEDLINE(R) <1966 to April Week 4 2005>

Search Strategy:

------

1 exp *neoplasms/dt (115510)

2 exp *neoplasms/ and (exp *immunosuppressive agents/ or *myeloablative agents/) (19045)

3 exp *antineoplastic agents/ (339476)

4 1 or 2 or 3 (369460)

5 4 and oral manifest$.ti. (12)

7 exp stomatognathic system/ (224770)

8 exp *stomatognathic system/de (6778)

9 4 and (*stomatognathic diseases/ci or *jaw diseases/ci or *cherubism/ci or *granuloma, giant cell/ci or exp *jaw abnormalities/ci or *jaw cysts/ci or *nonodontogenic cysts/ci or *odontogenic cysts/ci or *dentigerous cyst/ci or *odontogenic cyst, calcifying/ci or exp *periodontal cyst/ci or exp *jaw, edentulous/ci or *mandibular diseases/ci or exp *craniomandibular disorders/ci or *prognathism/ci or *retrognathism/ci or *maxillary diseases/ci or *mouth diseases/ci or *behcet syndrome/ci or *bell palsy/ci or *burning mouth syndrome/ci or *candidiasis, oral/ci or *dry socket/ci or *facial hemiatrophy/ci or *facial neuralgia/ci or *facial paralysis/ci or *focal epithelial hyperplasia/ci or *hemifacial spasm/ci or *leukoedema, oral/ci or *lichen planus, oral/ci or *lip diseases/ci or *cheilitis/ci or *cleft lip/ci or *herpes labialis/ci or *ludwig's angina/ci or *melkersson-rosenthal syndrome/ci or exp *mouth abnormalities/ci or exp *mouth, edentulous/ci or *noma/ci or exp *oral fistula/ci or exp *oral hemorrhage/ci or *oral manifestations/ci or *oral submucous fibrosis/ci or *oral ulcer/ci or exp *periapical diseases/ci or *periodontal diseases/ci or *alveolar bone loss/ci or *furcation defects/ci or *gingival diseases/ci or *gingival hemorrhage/ci or exp *gingival overgrowth/ci or *gingival recession/ci or exp *gingivitis/ci or *pericoronitis/ci or *periodontal attachment loss/ci or *periodontal cyst/ci or exp *periodontitis/ci or *tooth loss/ci or exp *tooth migration/ci or *tooth mobility/ci or *ranula/ci or *salivary gland diseases/ci or *mikulicz' disease/ci or *parotid diseases/ci or exp *parotitis/ci or *salivary duct calculi/ci or *salivary gland calculi/ci or *salivary gland fistula/ci or *sialadenitis/ci or *sialometaplasia, necrotizing/ci or *sialorrhea/ci or *submandibular gland diseases/ci or *xerostomia/ci or *tongue diseases/ci or *glossalgia/ci or exp *glossitis/ci or *macroglossia/ci or *tongue, fissured/ci or *tongue, hairy/ci or *tuberculosis, oral/ci or *pharyngeal diseases/ci or *nasopharyngeal diseases/ci or *nasopharyngitis/ci or *peritonsillar abscess/ci or *pharyngitis/ci or *retropharyngeal abscess/ci or *tonsillitis/ci or *velopharyngeal insufficiency/ci or exp *stomatognathic system abnormalities/ci or exp *temporomandibular joint disorders/ci or exp *tooth diseases/ci or exp *stomatognathic system/de) (522)

10 4 and (*stomatognathic diseases/ or *jaw diseases/ or *cherubism/ or *granuloma, giant cell/ or exp *jaw abnormalities/ or *jaw cysts/ or *nonodontogenic cysts/ or *odontogenic cysts/ or *dentigerous cyst/ or *odontogenic cyst, calcifying/ or exp *periodontal cyst/ or exp *jaw, edentulous/ or *mandibular diseases/ or exp *craniomandibular disorders/ or *prognathism/ or *retrognathism/ or *maxillary diseases/ or *mouth diseases/ or *behcet syndrome/ or *bell palsy/ or *burning mouth syndrome/ or *candidiasis, oral/ or *dry socket/ or *facial hemiatrophy/ or *facial neuralgia/ or *facial paralysis/ or *focal epithelial hyperplasia/ or *hemifacial spasm/ or *leukoedema, oral/ or *lichen planus, oral/ or *lip diseases/ or *cheilitis/ or *cleft lip/ or *herpes labialis/ or *ludwig's angina/ or *melkersson-rosenthal syndrome/ or exp *mouth abnormalities/ or exp *mouth, edentulous/ or *noma/ or exp *oral fistula/ or exp *oral hemorrhage/ or *oral manifestations/ or *oral submucous fibrosis/ or *oral ulcer/ or exp *periapical diseases/ or *periodontal diseases/ or *alveolar bone loss/ or *furcation defects/ or *gingival diseases/ or *gingival hemorrhage/ or exp *gingival overgrowth/ or *gingival recession/ or exp *gingivitis/ or *pericoronitis/ or *periodontal attachment loss/ or *periodontal cyst/ or exp *periodontitis/ or *tooth loss/ or exp *tooth migration/ or *tooth mobility/ or *ranula/ or *salivary gland diseases/ or *mikulicz' disease/ or *parotid diseases/ or exp *parotitis/ or *salivary duct calculi/ or *salivary gland calculi/ or *salivary gland fistula/ or *sialadenitis/ or *sialometaplasia, necrotizing/ or *sialorrhea/ or *submandibular gland diseases/ or *xerostomia/ or *tongue diseases/ or *glossalgia/ or exp *glossitis/ or *macroglossia/ or *tongue, fissured/ or *tongue, hairy/ or *tuberculosis, oral/ or *pharyngeal diseases/ or *nasopharyngeal diseases/ or *nasopharyngitis/ or *peritonsillar abscess/ or *pharyngitis/ or *retropharyngeal abscess/ or *tonsillitis/ or *velopharyngeal insufficiency/ or exp *stomatognathic system abnormalities/ or exp *temporomandibular joint disorders/ or exp *tooth diseases/) and ((incidence or prevalence or epidemiology or statistics or morbidity).mp. or ep.fs. or sn.fs.) [mp=title, original title, abstract, name of substance word, subject heading word] (134)

11 *stomatognathic diseases/pc, th, dt, rt, su, nu, dh or *jaw diseases/pc, th, dt, rt, su, nu, dh or *cherubism/pc, th, dt, rt, su, nu, dh or *granuloma, giant cell/pc, th, dt, rt, su, nu, dh or exp *jaw abnormalities/pc, th, dt, rt, su, nu, dh or *jaw cysts/pc, th, dt, rt, su, nu, dh or *nonodontogenic cysts/pc, th, dt, rt, su, nu, dh or *odontogenic cysts/pc, th, dt, rt, su, nu, dh or *dentigerous cyst/pc, th, dt, rt, su, nu, dh or *odontogenic cyst, calcifying/pc, th, dt, rt, su, nu, dh or exp *periodontal cyst/pc, th, dt, rt, su, nu, dh or exp *jaw, edentulous/pc, th, dt, rt, su, nu, dh or *mandibular diseases/pc, th, dt, rt, su, nu, dh or exp *craniomandibular disorders/pc, th, dt, rt, su, nu, dh or *prognathism/pc, th, dt, rt, su, nu, dh or *retrognathism/pc, th, dt, rt, su, nu, dh or *maxillary diseases/pc, th, dt, rt, su, nu, dh or *mouth diseases/pc, th, dt, rt, su, nu, dh or *behcet syndrome/pc, th, dt, rt, su, nu, dh or *bell palsy/pc, th, dt, rt, su, nu, dh or *burning mouth syndrome/pc, th, dt, rt, su, nu, dh or *candidiasis, oral/pc, th, dt, rt, su, nu, dh or *dry socket/pc, th, dt, rt, su, nu, dh or *facial hemiatrophy/pc, th, dt, rt, su, nu, dh or *facial neuralgia/pc, th, dt, rt, su, nu, dh or *facial paralysis/pc, th, dt, rt, su, nu, dh or *focal epithelial hyperplasia/pc, th, dt, rt, su, nu, dh or *hemifacial spasm/pc, th, dt, rt, su, nu, dh or *leukoedema, oral/pc, th, dt, rt, su, nu, dh or *lichen planus, oral/pc, th, dt, rt, su, nu, dh or *lip diseases/pc, th, dt, rt, su, nu, dh or *cheilitis/pc, th, dt, rt, su, nu, dh or *cleft lip/pc, th, dt, rt, su, nu, dh or *herpes labialis/pc, th, dt, rt, su, nu, dh or *ludwig's angina/pc, th, dt, rt, su, nu, dh or *melkersson-rosenthal syndrome/pc, th, dt, rt, su, nu, dh or exp *mouth abnormalities/pc, th, dt, rt, su, nu, dh or exp *mouth, edentulous/pc, th, dt, rt, su, nu, dh or *noma/pc, th, dt, rt, su, nu, dh or exp *oral fistula/pc, th, dt, rt, su, nu, dh or exp *oral hemorrhage/pc, th, dt, rt, su, nu, dh or *oral manifestations/pc, th, dt, rt, su, nu, dh or *oral submucous fibrosis/pc, th, dt, rt, su, nu, dh or *oral ulcer/pc, th, dt, rt, su, nu, dh or exp *periapical diseases/pc, th, dt, rt, su, nu, dh or *periodontal diseases/pc, th, dt, rt, su, nu, dh or *alveolar bone loss/pc, th, dt, rt, su, nu, dh or *furcation defects/pc, th, dt, rt, su, nu, dh or *gingival diseases/pc, th, dt, rt, su, nu, dh or *gingival hemorrhage/pc, th, dt, rt, su, nu, dh or exp *gingival overgrowth/pc, th, dt, rt, su, nu, dh or *gingival recession/pc, th, dt, rt, su, nu, dh or exp *gingivitis/pc, th, dt, rt, su, nu, dh or *pericoronitis/pc, th, dt, rt, su, nu, dh or *periodontal attachment loss/pc, th, dt, rt, su, nu, dh or *periodontal cyst/pc, th, dt, rt, su, nu, dh or exp *periodontitis/pc, th, dt, rt, su, nu, dh or *tooth loss/pc, th, dt, rt, su, nu, dh or exp *tooth migration/pc, th, dt, rt, su, nu, dh or *tooth mobility/pc, th, dt, rt, su, nu, dh or *ranula/pc, th, dt, rt, su, nu, dh or *salivary gland diseases/pc, th, dt, rt, su, nu, dh or *mikulicz' disease/pc, th, dt, rt, su, nu, dh or *parotid diseases/pc, th, dt, rt, su, nu, dh or exp *parotitis/pc, th, dt, rt, su, nu, dh or *salivary duct calculi/pc, th, dt, rt, su, nu, dh or *salivary gland calculi/pc, th, dt, rt, su, nu, dh or *salivary gland fistula/pc, th, dt, rt, su, nu, dh or *sialadenitis/pc, th, dt, rt, su, nu, dh or *sialometaplasia, necrotizing/pc, th, dt, rt, su, nu, dh or *sialorrhea/pc, th, dt, rt, su, nu, dh or *submandibular gland diseases/pc, th, dt, rt, su, nu, dh or *xerostomia/pc, th, dt, rt, su, nu, dh or *tongue diseases/pc, th, dt, rt, su, nu, dh or *glossalgia/pc, th, dt, rt, su, nu, dh or exp *glossitis/pc, th, dt, rt, su, nu, dh or *macroglossia/pc, th, dt, rt, su, nu, dh or *tongue, fissured/pc, th, dt, rt, su, nu, dh or *tongue, hairy/pc, th, dt, rt, su, nu, dh or *tuberculosis, oral/pc, th, dt, rt, su, nu, dh or *pharyngeal diseases/pc, th, dt, rt, su, nu, dh or *nasopharyngeal diseases/pc, th, dt, rt, su, nu, dh or *nasopharyngitis/pc, th, dt, rt, su, nu, dh or *peritonsillar abscess/pc, th, dt, rt, su, nu, dh or *pharyngitis/pc, th, dt, rt, su, nu, dh or *retropharyngeal abscess/pc, th, dt, rt, su, nu, dh or *tonsillitis/pc, th, dt, rt, su, nu, dh or *velopharyngeal insufficiency/pc, th, dt, rt, su, nu, dh or exp *stomatognathic system abnormalities/pc, th, dt, rt, su, nu, dh or exp *temporomandibular joint disorders/pc, th, dt, rt, su, nu, dh or exp *tooth diseases/pc, th, dt, rt, su, nu, dh (56999)

12 exp epidemiologic study characteristics/ or exp epidemiologic research design/ (1289646)

13 exp *immunosuppressive agents/ae or *myeloablative agents/ae or exp *antineoplastic agents/ae (32562)

14 4 and 13 and (*stomatognathic diseases/ or *jaw diseases/ or *cherubism/ or *granuloma, giant cell/ or exp *jaw abnormalities/ or *jaw cysts/ or *nonodontogenic cysts/ or *odontogenic cysts/ or *dentigerous cyst/ or *odontogenic cyst, calcifying/ or exp *periodontal cyst/ or exp *jaw, edentulous/ or *mandibular diseases/ or exp *craniomandibular disorders/ or *prognathism/ or *retrognathism/ or *maxillary diseases/ or *mouth diseases/ or *behcet syndrome/ or *bell palsy/ or *burning mouth syndrome/ or *candidiasis, oral/ or *dry socket/ or *facial hemiatrophy/ or *facial neuralgia/ or *facial paralysis/ or *focal epithelial hyperplasia/ or *hemifacial spasm/ or *leukoedema, oral/ or *lichen planus, oral/ or *lip diseases/ or *cheilitis/ or *cleft lip/ or *herpes labialis/ or *ludwig's angina/ or *melkersson-rosenthal syndrome/ or exp *mouth abnormalities/ or exp *mouth, edentulous/ or *noma/ or exp *oral fistula/ or exp *oral hemorrhage/ or *oral manifestations/ or *oral submucous fibrosis/ or *oral ulcer/ or exp *periapical diseases/ or *periodontal diseases/ or *alveolar bone loss/ or *furcation defects/ or *gingival diseases/ or *gingival hemorrhage/ or exp *gingival overgrowth/ or *gingival recession/ or exp *gingivitis/ or *pericoronitis/ or *periodontal attachment loss/ or *periodontal cyst/ or exp *periodontitis/ or *tooth loss/ or exp *tooth migration/ or *tooth mobility/ or *ranula/ or *salivary gland diseases/ or *mikulicz' disease/ or *parotid diseases/ or exp *parotitis/ or *salivary duct calculi/ or *salivary gland calculi/ or *salivary gland fistula/ or *sialadenitis/ or *sialometaplasia, necrotizing/ or *sialorrhea/ or *submandibular gland diseases/ or *xerostomia/ or *tongue diseases/ or *glossalgia/ or exp *glossitis/ or *macroglossia/ or *tongue, fissured/ or *tongue, hairy/ or *tuberculosis, oral/ or *pharyngeal diseases/ or *nasopharyngeal diseases/ or *nasopharyngitis/ or *peritonsillar abscess/ or *pharyngitis/ or *retropharyngeal abscess/ or *tonsillitis/ or *velopharyngeal insufficiency/ or exp *stomatognathic system abnormalities/ or exp *temporomandibular joint disorders/ or exp *tooth diseases/ or exp *stomatognathic system/) (430)

15 oral care.ti. (216)

16 exp oral hygiene/ (10825)

17 exp dentistry/ (242181)

18 4 and 11 (562)

19 4 and (15 or exp *oral hygiene/ or exp *dentistry/) (210)

20 18 or 19 (727)

21 limit 20 to (humans and english language) (480)

22 limit 21 to (case reports or comment or letter or news or newspaper article) (159)

23 21 not 22 (321)

24 limit 23 to (clinical trial or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or consensus development conference or consensus development conference, nih or controlled clinical trial or guideline or meta analysis or multicenter study or practice guideline or randomized controlled trial or "review" or review, academic or "review literature" or review, multicase or "review of reported cases" or review, tutorial or "scientific integrity review" or technical report or twin study or validation studies) (157)

25 23 and (clinical trial$1 or (phase adj2 (study or studies or trial$1)) or (meta adj (analysis or analyses)) or randomized controlled trial$1 or (consensus adj2 conference$1) or guideline$1).ti,ab,hw. (53)

26 limit 23 to evidence based medicine reviews (16)

27 23 and 12 (132)

28 24 or 25 or 26 or 27 (201)

29 4 and (xerostomia or dysphagia or dysgeusia or taste or mouth or cheilitis or lip or lips or candidiasis or burning or gingiv$ or periodont$ or tooth or teeth or dentition or dental or saliv$ or sial$ or parotid$ or tongue$ or gloss$ or pharyng$ or pharnyx or stomoatognathic).ti,ab. and (toxicit$ or dlt).ti,ab. (543)

30 5 or 9 or 10 or 14 or 29 (1314)

31 limit 30 to (humans and english language) (862)

32 limit 31 to (case reports or comment or letter or news or newspaper article) (157)

33 31 not 32 (705)

34 limit 33 to (clinical trial or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or consensus development conference or consensus development conference, nih or controlled clinical trial or guideline or meta analysis or multicenter study or practice guideline or randomized controlled trial or "review" or review, academic or "review literature" or review, multicase or "review of reported cases" or review, tutorial or "scientific integrity review" or technical report or twin study or validation studies) (372)

35 33 and (clinical trial$1 or (phase adj2 (study or studies or trial$1)) or (meta adj (analysis or analyses)) or randomized controlled trial$1 or (consensus adj2 conference$1) or guideline$1).ti,ab,hw. (231)