Table e-1. Relation of premorbid cognitive activity to rate of change in cognitive function in persons with no cognitive impairment, MCI, or AD: full weighted mixed-effects models*

Model A / Model B
Model Term / Estimate / SE / P Value / Estimate / SE / P Value
Intercept / 0.574 / 0.031 / <.001 / 0.489 / 0.048 / <.001
Age at diagnosis / -0.013 / 0.002 / <.001 / -0.015 / 0.002 / <.001
Age at diagnosis x time / -0.003 / 0.001 / <.001 / -0.003 / 0.001 / <.001
Sex / -0.083 / 0.026 / .002 / -0.082 / 0.025 / .001
Sex x time / 0.007 / 0.009 / .446 / 0.007 / 0.009 / .441
Education / 0.034 / 0.004 / <.001 / 0.034 / 0.004 / <.001
Education x time / -0.001 / 0.001 / .540 / -0.001 / 0.001 / .509
Race / -0.186 / 0.035 / <.001 / -0196 / 0.035 / <.001
Race x time / 0.029 / 0.010 / .005 / 0.027 / 0.010 / .008
MCI / -0.316 / 0.040 / <.001 / -0.313 / 0.039 / <.001
MCI x time / -0.036 / 0.012 / .002 / -0.035 / 0.012 / .003
AD / -0.884 / 0.066 / <.001 / -0.878 / 0.066 / <.001
AD x time / -0.124 / 0.018 / <.001 / -0.123 / 0.018 / <.001
Cognitive activity / 0.116 / 0.032 / <.001 / 0.109 / 0.032 / .001
Cognitive activity x time / 0.029 / 0.010 / .003 / 0.029 / 0.010 / .004
Cognitive activity x MCI / 0.040 / 0.062 / .520 / 0.045 / 0.061 / .468
Cognitive activity x MCI x time / -0.019 / 0.018 / .300 / -0.019 / 0.019 / .308
Cognitive activity x AD / 0.007 / 0.111 / .950 / -0.001 / 0.109 / .990
Cognitive activity x AD x time / -0.075 / 0.022 / .001 / -0.078 / 0.022 / .001
Temporal interval / 0.015 / 0.005 / .008
Temporal interval x time / 0.004 / 0.002 / .075

* MCI, mild cognitive impairment; AD, Alzheimer’s disease. Temporal interval is the time from cognitive activity assessment to diagnosis.