Table S1AMultivariate analysis of adjuvant anthracycline treated triple negative breast cancer patients(AC group, n=147) revealed that BCL2 expression, tumor size, and nodal status all had independent predictive significancefor RFS (likelihood ratio test for the whole model, p=0.00303), BCSS (likelihood ratio test for the whole model, p=0.01626) and OS (likelihood ratio test for the whole model, p=0.00063).Each Cox regressionmodel included BCL2 status, age, tumor size, nodal status, and histopathological grade as variables.
Factors / RFS / BCSS / OSHR / 95% CI / p / HR / 95% CI / p / HR / 95% CI / p
age / 1.2 / 0.981 - 1.054 / 0.35863 / 1.1 / 0.967 - 1.054 / 0.6676 / 1.2 / 0.975 - 1.060 / 0.45323
pT / 1.70 / 0.918 - 3.153 / 0.09128 / 2.4 / 0.927 - 4.498 / 0.0766 / 2.65 / 1.365 - 5.150 / 0.00401
pN / 1.95 / 1.255 - 3.029 / 0.00300 / 2.069 / 1.189 - 3.599 / 0.0101 / 2.9 / 1.259 - 3.453 / 0.00429
G / 1.28 / 0.167 - 9.802 / 0.81382 / 0.71 / 0.089 - 5.681 / 0.7460 / 0.73 / 0.091 - 5.896 / 0.77059
BCL2 (ref. LOW) / 3.73 / 1.474 - 9.445 / 0.00545 / 4.25 / 1.372 - 13.174 / 0.0122 / 4.32 / 1.469 - 12.717 / 0.00785
Table S1B Multivariate analysis of adjuvant anthracycline treated triple negative breast cancer patients (AC group, BASAL-LIKE TNBC, n=95) revealed that BCL2 expression, tumor size, and nodal status all had independent predictive significance for RFS (likelihood ratio test for the whole model, p=0.00125), BCSS (likelihood ratio test for the whole model, p=0.00035) and OS (likelihood ratio test for the whole model, p=0.00063). Each Cox regression model (with Firth’s penalized maximum likelihood) included BCL2 status, age, tumor size, nodal status, and histopathological grade as variables.
Factors / RFS / BCSS / OSHR / 95% CI / p / HR / 95% CI / p / HR / 95% CI / p
age / 1,0148 / 0,9723-1,0591 / 0,4839 / 1,0164 / 0,9722-1,0626 / 0,4527 / 1,0158 / 0,9736-1,0599 / 0,4499
pT / 3,8799 / 1,2597-11,9501 / 0,0131 / 4,3114 / 1,3197-14,085 / 0,0106 / 3,3254 / 1,1241-9,8373 / 0,0236
pN / 2,2711 / 1,3435-3,8391 / 0,0034 / 2,4866 / 1,4179-4,3609 / 0,002 / 2,399 / 1,3736-4,1899 / 0,0029
G / 1,4356 / 0,0696-29,6115 / 0,7945 / 1,6694 / 0,0762-36,5682 / 0,7095 / 1,5895 / 0,0749-33,7336 / 0,736
BCL2 (ref. LOW) / 3,1671 / 1,0529-9,5268 / 0,029 / 3,521 / 1,1646-10,6453 / 0,0174 / 4,0287 / 1,3541-11,9861 / 0,0071
Table S1C Multivariate analysis of adjuvant anthracycline treated triple negative breast cancer patients (AC group, NON BASAL-LIKE TNBC, n=39) revealed that no factor was a significant predictor for RFS (likelihood ratio test for the whole model, p=0.96), BCSS (likelihood ratio test for the whole model, p=0.6236) and OS (likelihood ratio test for the whole model, p=0.1919). Each Cox regression model included BCL2 status, age, tumor size, nodal status, and histopathological grade as variables.
Factors / RFS / BCSS* / OSHR / 95% CI / p / HR / 95% CI / p / HR / 95% CI / p
age / 1,0197 / 0,9477-1,0971 / 0,6017 / 0,947 / 0,8271-1,0844 / 0,3423 / 0,9701 / 0,8457-1,1129 / 0,6652
pT / 0,9446 / 0,2831-3,1517 / 0,9261 / 1,1034 / 0,0683-17,8189 / 0,946 / 6,9046 / 0,7256-65,7053 / 0,0928
pN / 1,4229 / 0,5302-3,8181 / 0,4838 / 0,4112 / 0,0121-13,9959 / 0,5798 / 1,8323 / 0,4069-8,2501 / 0,4302
G / 0,5864 / 0,0508-6,7681 / 0,6689 / 0,072 / 0,0009-6,0758 / 0,0997 / 0,0227 / 0,0001-5,1063 / 0,1707
BCL2 (ref. LOW) / 1,862 / 0,3081-11,253 / 0,4982 / 3,1153 / 0,0607-159,8405 / 0,4588 / 6,9608 / 0,0708-684,2454 / 0,4072
* Calculated by Cox regression with Firth’s penalized maximum likelihood method.
Table S1DMultivariate analysis of adjuvant anthracycline treated triple negative breast cancer patients (AC group, n=134) revealed that BCL2 expression, tumor size, and nodal status all had independent predictive significance for BCSS (likelihood ratio test for the whole model, p=0.00393) and OS (likelihood ratio test for the whole model, p=0.00028), and BCL2 expression and nodal status had independent predictive significance for RFS (likelihood ratio test for the whole model, p=0.0262). Each Cox regression model included BCL2 status, age, tumor size, nodal status, basal-like status and histopathological grade as variables.
Factors / RFS / BCSS / OSHR / 95% CI / p / HR / 95% CI / p / HR / 95% CI / p
age / 1,0159 / 0,979-1,0543 / 0,4034 / 1,0109 / 0,9692-1,0543 / 0,6153 / 1,0171 / 0,9764-1,0594 / 0,4167
pT / 1,6819 / 0,8335-3,394 / 0,1466 / 2,7066 / 1,0807-6,7785 / 0,0335 / 3,4998 / 1,5989-7,6606 / 0,0017
pN / 1,8579 / 1,1707-2,9485 / 0,0086 / 2,0329 / 1,1637-3,5511 / 0,0127 / 2,1031 / 1,2738-3,4724 / 0,0037
G / 1,1411 / 0,1464-8,8966 / 0,8997 / 0,7021 / 0,0855-5,7654 / 0,742 / 0,7432 / 0,091-6,0709 / 0,7818
BCL2 (ref. LOW) / 3,1261 / 1,2123-8,0612 / 0,0184 / 3,9836 / 1,359-11,6769 / 0,0118 / 4,0569 / 1,4543-11,3171 / 0,0075
basal-like status / 1,1076 / 0,4066-3,017 / 0,8416 / 4,9143 / 0,9948-24,2775 / 0,0508 / 3,5241 / 0,9583-12,9594 / 0,058