Supplemental Table 1: Correlation between the initial interpretation & pathological review of biopsy specimens and details on surgical specimens (FEA: flat epithelial atypia, ADH: atypical ductal hyperplasia, ALH: atypical lobular hyperplasia, LCIS: lobular carcinoma in situ, ILC: invasive lobular carcinoma, IDC: invasive ductal carcinoma, DCIS: ductal carcinoma in situ; RS: radial scar)

Initial
interpretation / Pathological review / % of concordance (or ratio) / Surgical specimen
Details
Type / Number / Number and type
FEA alone / 35 / 13 FEA alone
16 FEA+ADH
2 FEA+ALH
1 no atypia
1 FEA+ADH+ALH
1 ALH+LCIS
1 ALH alone / 37.1% / 3 IDC (3FEA+ADH)
1 ILC (FEA alone)
4 DCIS (1FEA alone and 3FEA+ADH)
ADH alone / 63 / 32 ADH alone
20 ADH+FEA
4 no tissue for review
2 no atypia
1 ADH+ALH+LCIS+FEA
1 FEA alone
1 LCIS alone
1 ALH + LCIS
1 DCIS / 50.8% / 5 IDC (4 ADH alone and 1 ADH+FEA)
1 ILC (ALH+LCIS)
9 DCIS (2 no tissue left, 6 ADH alone, 1 ADH+FEA)
LCIS alone / 26 / 11 LCIS alone
12 LCIS+ALH
1 ADH+ALH+LCIS
1 ALH alone
1 no tissue for review / 42.3% / 3 IDC (1 LCIS alone, 2 LCIS+ALH)
4 ILC (2LCIS alone, 2 LCIS+ALH)
ALH alone / 23 / 21 ALH alone
2 ALH+LCIS / 91.3% / 3 IDC (3ALH alone)
1 ILC (ALH+LCIS)
LCIS+RS / 2 / 2 LCIS +RS / 2/2 / 1 IDC (LCIS+RS)
FEA+ADH / 19 / 16 FEA+ADH
1 ADH+RS
1 FEA+ADH+ALH+RS
1 FEA+ALH+ADH / 84.2% / 1 IDC (1FEA+ADH)
2 DCIS (2FEA+ADH)
ADH+ALH / 8 / 3 ADH+ALH
3 ADH+ALH+FEA
1 LCIS alone
1 no tissue for review / 37.5% / 3 IDC (1ADH+ALH, 1 LCIS alone, 1 ALH+ADH+FEA )
1 DCIS (ADH+ALH)
LCIS+ALH / 9 / 7 LCIS+ALH
2 ALH alone / 77.8% / 1 IDC (LCIS+ALH)
1 ILC (LCIS+ALH)
ADH+RS / 4 / 3 ADH+RS
1 RS alone / 3/4 / 0
FEA+LCIS / 2 / 1 FEA+LCIS
1 FEA+LCIS+ADH+ALH / 1/2 / 0
ADH+LCIS / 2 / 1 ADH+ALH+LCIS
1 no tissue for review / 2 DCIS (1 ADH+ALH+ILC
1 no tissue left)
FEA+ALH / 3 / 3 FEA+ALH+ADH / 0/3 / 0
ALH+RS / 1 / 1 ALH+RS / 1/1 / 0
ALH+LCIS+RS / 1 / 1 ALH+ADH+LCIS+RS / 0/1 / 0
FEA+ALH+LCIS / 1 / 1 FEA+ALH+ADH+LCIS / 0/1 / 0
FEA+ADH+ALH / 2 / 2 FEA+ADH+ALH / 2/2 / 1 ILC (FEA+ADH+ALH)
ADH+ALH+LCIS / 3 / 1 ALH+LCIS
2 ADH+ALH+LCIS+FEA / 0/3 / 2 DCIS (2 ADH+ALH+LCIS+FEA)
Total:
35 FEA alone, 63 ADH alone, 26 LCIS,
23 ALH alone
57 mixed / 204 / 14 FEA alone
32 ADH alone
13 LCIS
25 ALH alone
1 RS alone
108 Mixed
1 DCIS
3 no atypia
7 no tissue for review / 54.9%