6th ECC ISTANBUL PROGRAM

Saturday, July7, 2006

10:00 AMRegistration of the participants

05:00 PM

02:00 PM E.C.A. Permanent Working Groups

Co-ordinator: E. Blennow

02:00-03:00Prenatal Diagnosis - Dolmabahçe A

Cytogenetics of Germ Cells, Pre-Implantation Cytogenetic Studies – Dolmabahçe B

European Association of Cytogenetic Technologists EATC- Dolmabahçe C

Eurogentest: European Cytogenetic National Representatives Meeting

(by invitation only) - Press room

03:00-04:00Cancer Cytogenetics, Solid Tumor Studies - Dolmabahçe A

Clinical and Molecular Approach of Cytogenetic Syndromes - Dolmabahçe B

Marker Chromosomes - Dolmabahçe C

Genetic Testing in Europe: A network for test development,

harmonisation, validation and standardisation - Pressroom.

04:00-05:00Cytogenetic Toxicology and Mutagenesis - Dolmabahçe A

Molecular Cytogenetics and Array CGH - Dolmabahçe B

Meiotic Studies - Dolmabahçe C

Cytogenetics and Society - Pressroom

05:00-06:00Applied Imaging International Satellite Symposium – Haliç

06:30 PMOpening ceremony – Anadolu Auditorium

Chaired by L. Larizza

A. Schinzel: How human chromosome aberrations are formed.

07:30 PM Transfer to the welcome receptıon at IstanbulUnıversıty rectorat

08:00 PMWelcome Reception.

Sunday, July8, 2006

08:30 AMPlenary sessions

Clinical cytogenetics I - Anadolu Auditorium (400)

Chaired by K. Madan, G. Lüleci

W. Bickmore:Nuclear organisation of chromatin and human disease.

K.H. Ørstavik: Skewed X-inactivation and human disease.

G. van Buggenhout: Chromosome aberrations in ageing mentally retarded persons.

Selected abstracts

S. Van Vooren: Literature Mining for Constitutional Cytogenetics.

A. Baumer: Trisomies represent risk factors for further independent non-disjunction events.

10:30 AMCoffeebreak and Trade Exhibition

11:00 AM Animal cytogenetics and karyotype evolution - Anadolu Auditorium (50)

Chaired by M. Rocchi, R. Stanyon

B. Dutrillaux: Meiosis in beetles: an example of biodiversity.

F. Yang: Comparative cytogenetics and karyotype evolution of muntjacs (Muntiacus).

L. Iannuzzi: Animal cytogenetics and karyotype evolution in Bovids.

Selected abstract

A. Cellamare: Progression Dynamics of Evolutionary-New Centromeres.

12:30 PM Lunch

01:00-02:00Abbott Satellite SymposiumHaliç

01:30 PM Poster session no. 1

02:30 PMConcurrent sessions

Chromosome instability in constitutional pathology and cancer

- Anadolu Auditorium (200)

Chaired by L. Larizza, J.P. Bureau

M. O'Driscoll: Cellular and clinical impact of genomic haploinsufficiency for genes involved in the ATR-dependent DNA damage response signalling pathway.

W. Saunders:Centrosomal amplification and multipolarity in cancer cells.

Selected abstracts:

I. Amir: Altered allelic replication timing in microdeleted genome.

I. Demidova: Evidences for increased level of mosaic aneuploidy involving chromosome 1 in the schizophrenia brain.

Gamete chromosomes – Topkapı A (150)

Chaired by J.M. Garcia-Sagredo

M. Garcia-Caldes: Maternal origin of human trisomy.

F. Pellestor: The study of chromosomal translocations in male gametes:segregation, interchromosomal effect and impact on fertility.

Selected abstracts:

J. Delhanty: Comprehensive analysis of human oocytes and 1st polar bodies by comparative genomic hybridisation (CGH).

E. Anton: Human reciprocal translocations: approximation to their segregation behavior using sperm FISH analysis.

04:00 PMCoffee break and Trade Exhibition

04:30 PMConcurrent sessions

New microdeletion syndromes, use of MLPA for cytogenetic diagnosis

- Anadolu Auditorium (200)

Chaired by A. Schinzel, S. Artan

B. de Vries: New microdeletion syndromes.

F. Kooy: Application of MLPA for cytogenetic diagnostics and research.

Selected abstract:

A. Delahaye: Evaluation of MLPA in routine diagnostics for the detection of subtelomeric rearrangements in 1040 patients with idiopathic mental retardation.

E. Andreucci: 6q24 duplication and transient neonatal diabetes: A possible differential diagnosis with Beckwith-Wiedemann syndrome?

Quality assessment in cytogenetics – Marmara (150)

Chaired by K. Miller, M. Alikasifoglu

U. Kristoffersson: Quality assessment and validation in clinical cytogenetic services.

S.J. Hamilton: Quality assessment in QF-PCR for rapid aneuploidy screening:The UK experience.

B. Quellhorst-Prawley: EQA in Europe.

05:45–06.45Agilent Satellite Symposium - Haliç

Monday, July9, 2006

08:30 AMPlenary sessions

Cancer cytogenetics- Anadolu Auditorium

Chaired by J. Limon, B. Young

B. Young: Linking cytogenetics to genotype analysis can uncover new eventsin leukaemia.

F. Speleman: Integration of molecular cytogenetics, arrayCGH and expression profiling in the study of neuroblastoma: implications for future therapy.

A. Geurts van Kessel: Cycle (de)regulation in t(X;1)(p11;q21)-positive renal cell Cancer.

Selected abstracts:

J. Suela: Combination of different genomic approaches to define a candidate deleted gene in AML.

L. Russell: Multiple novel genes are deregulated by IGH@ in B cell precursor acute lymphoblastic leukaemia including five members of the CEBP gene family.

P. Edwards: Array painting shows a number of balanced translocations that target cancer-relevant genes in breast cancer cell lines.

A. Elliott: MLPA analysis of neuroblastoma tumours.

10:30 AMCoffee break and Trade Exhibition

10:45 AMAffymetrix Satellite Symposium–Haliç

A. Dufke: Genomic copy number analysis using the Affymetrix 500K SNP arrays.

11:30 AMCytogenetics, biodiversity and plant evolution in Turkey

and the wider Middle East - Anadolu Auditorium (30)

Chaired by P. Heslop-Harrison

P. Heslop-Harrison: Chromosome evolution and centres of diversity of crops.

M. Ørgaard: Crocus cytogenetics, speciation and phylogeny.

A. Belyayev: Cereal Genomes and the evolution of diversity.

H. Ozkan: Genome changes and cereal ploidy.

D. Pignone: Germplasms, diversity, cytogenetics around the Mediterranean.

01:00-02:00Ikonysis Satellite Symposium:

Ikoniscope® Robotic Microscopy in Cytogenetics and Rare Cell Detection

- Haliç

J. Wauters: Fully automated FISH examination in prenatal and bladder cancer diagnosis.

Sir W. Bodmer: Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope (Ikoniscope®).

01:30 PM Poster session no. 2

02:30 PMConcurrent sessions

Microarrays linked to cytogenetic diagnosis - Anadolu Auditorium

Chaired by J. Wolstenholme

E. Maher: Microarrays in the diagnostic laboratory.

A. Reymond: Flanking gene expresion in microdeletion syndromes.

Selected abstracts:

R. Hochstenbach: Copy number variants complicate interpretation of pathogenic segmental aneuploidy.

N. de Leeuw: Diagnostic use of molecular karyotyping by tiling-resolution array CGH in patients with mental retardation.

Preimplantation genetic diagnosis – Topkapı A

Chaired by E. Blennow, M. Bahce

C. Le Caignec: Application of metaphase and array CGH to preimplantation genetic diagnosis.

C. Staessen: Review: PGD for chromosomal abnormalities with FISH.

Selected abstracts:

A. Mantzouratou: Evidence for variable aneuploidy mechanisms in embryos from couples with distinct indications for preimplantaion genetic screening (PGS).

E. Vanneste: Aneuploidy and aneusomy detection in human embryos by array CGH.

Y. Saglam: Preimplantation genetic diagnosis for HLAtyping.

04:00 PMCoffee break and Trade Exhibition

04:30 PMConcurrent sessions

Clinical cytogenetics II (evolution of phenotypes) - Anadolu Auditorium (300)

Chaired by G. Kosztolányi, A. Schinzel

G. Kosztolányi: Consequences of ring formation of human chromosomes.

E. Rossi: Array CGH findings of ring chromosomes.

Selected abstracts:

L. Backx: Array painting using microdissected chromosomes to map chromosomal breakpoints.

S. Cheung: Detection of somatic mosaicism by Targeted aCGH: Clinical experience of 5000 samples.

Architecture of the human genome - Marmara (150)

Chaired by M. Rocchi,

E. Eichler: The evolution of human segmental duplication architecture.

G. Bernardi: Molecular basis of chromosomal bands.

P. Stankiewicz: Mechanisms of DNA rearrangements underlying genomic disorders.

M. Rocchi: Human neocentromeres and evolutionary-new centromeres.

Selected abstract:

O. Uyguner: The formation of isochromosome 12p in 8 cases with Pallister-Killian syndrome.

06:00 PMGeneral Assembly of the European Cytogeneticists Association – Topkapı A (100)

08:30 PMConference Dinner

Tuesday, July 10, 2006

08:30 AMPlenary sessions

New developments in prenatal diagnosis– Anadolu Auditorium (200)

Chaired by S. Basaran, J. Vermeesch

H. Fiegler: Array CGH in prenatal diagnosis.

J. Crolla: To quit or not to quit prenatal cytogenetic diagnosis?

M. Rodriguez de Alba: Non-invasive prenatal diagnosis.

J. Wouters: Towards automated FISH screening.

Selected abstract:

B. Faas: MLPA for prenatal aneuploidy testing: analytical validation and retrospective clinical evaluation.

10:30 AMCoffeebreak and Trade Exhibition

11:00 AMArray-CGH: New cytogenetic epidemiology, new chromosome rearrangements

- Anadolu Auditorium (300)

Chaired by A. Schinzel, O. Zuffardi

O. Zuffardi: Frequency and types of unbalanced chromosome rearrangements combining new and old data.

M.C.Bonaglia: The history of chromosome 22q distal deletions: actual frequency and related phenotype.

J.Vermeesch: “Balanced” complex rearrangements: how many are really balanced?

G. Hobson: Triplication and more than triplication rearrangements.

R.Redon: Normal copy number variation in the human genome.

01:00 PM Discussion of difficult clinical cytogenetic cases– Topkapı B (50)

02:00 PMClosing session - Anadolu Auditorium

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