Motivation, Perception, and Treatment Beliefs in the Myocardial Infarction Genes (MI-GENES) Randomized Clinical Trial
Sharma Kattel1*, Tochukwu Onyekwelu2*, Sherry-Ann Brown1, Hayan Jouni1, Erin E. Austin1, Iftikhar J Kullo1
Short Title: Motivation, perception and treatment beliefs in MI GENES
1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN;
2Medical University of South Carolina, School of Medicine, Charleston, SC
* Dr.sKattel and Onyekwelu contributed equally as first authors of this work.
Correspondence
Iftikhar J Kullo, MD
Division of Cardiovascular Diseases
Mayo Clinic, 200 First Street SW
Rochester, MN, 55905, USA
Tel: 507-266-3964
Fax: 507-266-1617
Supplemental Table 1: Motivation survey- How much of a role did the factors listed below influence your decision to participate in this study?
- Curiosity about my genes
- Desire to find out my risk of heart attack
- Desire to find out what I can do to improve my health
- Participate in research to help others
- No cost to me to participate
- Desire for information about risk of health conditions for children and grandchildren
- Adopted and want information about genetics
- Study remuneration
Strongly disagree / Disagree / Neutral / Agree / Strongly agree
- Would you consider paying out of pocket for genetic testing for heart attack?
- Would you recommend genetic testing to other members of your family?
- Would you recommend genetic testing to your friends?
- Clinical trials are research studies that involve people. They are designed to test the safety and effectiveness of new treatments and to compare new treatments with the standard care that people currently get. Have you ever heard of a clinical trial?
Supplemental Table 2: Perception Survey
Strongly agree / Agree / Disagree / Strongly disagree
1.A person can have a gene for a condition (like diabetes or cancer) and not develop that condition. / 1 / 2 / 3 / 4
2.Common health conditions are caused by genes in combination with lifestyle and environmental factors. / 1 / 2 / 3 / 4
3.The information in the study will tell me definitely whether or not I will get heart disease. / 1 / 2 / 3 / 4
4.The study will tell me about my risk for:
a) All genetic diseases / 1 / 2 / 3 / 4
b) Side effects from drugs / 1 / 2 / 3 / 4
c) Risk for having a heart attack / 1 / 2 / 3 / 4
- This study will help researchers learn about genes and disease.
- The results of this study will help me change my behaviors and reduce risk.
- The results will help me seek medical attention and reduce disease risk.
- The results will tell me what medications to avoid.
- The results will teach me about risk of heart disease in my children.
- The results will tell me what medications to take.
- I can have gene therapy to reduce my risk.
- There are no benefits to being in this study.
- There are no risks to being in this study.
- The results of this study may make me worry.
- I will learn about risks that I did not want to know about.
- I may not be able to get insurance if results get out.
- I will learn about risks I can do nothing about.
Supplemental Table 3: Treatment beliefs survey
The following questions ask about how likely these breakthroughs are in the future regarding finding a cure, better prevention, and advanced symptom relief for heart attack.
Not likely at all / Somewhat not likely / Neutral / Somewhat likely / Very likely
- Cure in next 5 years
- Cure in your lifetime
- Further advances in prevention within next 5 years
- Further advances in prevention in your lifetime
- Further improvement in symptom relief within the next 5 years
- Further improvement in symptom relief within your lifetime