U01 Review Critique Template

Use this template for U01 critiques

The guidelines available here use language posted in the original funding opportunity announcement (FOA) and do not replace or modify the criteria established in the full announcement. If you have any questions, contact the Scientific Review Officer (SRO) in charge of the review panel. SRO contact information for your application can be found in eRA Commons.

Application #:

Principal Investigator(s):

Overall Impact

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following five scored review criteria, and additional review criteria. An application does not need to be strong in all categories to be judged likely to have major scientific impact.

Overall Impact

Strengths

Weaknesses

Scored Review Criteria

Reviewers will consider each of the five review criteria below in the determination of scientific and technical merit, and give a separate score for each.

1. Significance

Strengths

Weaknesses

2. Investigator(s)

Strengths

Weaknesses

3. Innovation

Strengths

Weaknesses

4. Approach

Strengths

Weaknesses

5. Environment

Strengths

Weaknesses

Additional Review Criteria

As applicable for the project proposed, reviewers will considerthe following additional items in the determination of scientific and technical merit, but will not give separate scores for these items.

Responses forProtections for Human Subjects, Vertebrate Animals, and Biohazardsare required for all applications.

A response for Inclusion of Women, Minorities and Children is required for applications proposing Human Subjects Research.

Page 1 of 4

Protections for Human Subjects

Click Here to SelectAcceptable Risks and/or Adequate ProtectionsUnacceptable Risks and/or Inadequate ProtectionsNot Applicable (No Human Subjects)

Comments (Required Unless Not Applicable):

Data and Safety Monitoring Plan (Applicable for Clinical Trials Only):

Click Here to SelectAcceptableUnacceptableNot Applicable (No Clinical Trials)
Comments (Required Unless Not Applicable):

Inclusion of Women, Minorities and Children Applicable Only for Human Subjects Research

Click Here to Select Gender CodeG1A - Both Genders, AcceptableG1U - Both Genders, UnacceptableG2A - Only Women, AcceptableG2U - Only Women, UnacceptableG3A - Only Men, AcceptableG3U - Only Men, UnacceptableG4A - Gender Unknown, AcceptableG4U - Gender Unknown, Unacceptable
Click Here to Select Minority CodeM1A - Minority and Non-minority, AcceptableM1U - Minority and Non-minority, UnacceptableM2A - Only Minority, AcceptableM2U - Only Minority, UnacceptableM3A - Only Non-minority, AcceptableM3U - Only Non-minority, UnacceptableM4A - Minority Representation Unknown, AcceptableM4U - Minority Representation Unknown,UnacceptableM5A - Only Foreign Subjects, AcceptableM5U - Only Foreign Subjects, Unacceptable
Click Here to Select Children CodeC1A - Children and Adults, AcceptableC1U - Children and Adults, UnacceptableC2A - Only Children, AcceptableC2U - Only Children, UnacceptableC3A - No Children Included, AcceptableC3U - No Children Included, UnacceptableC4A - Children Representation Unknown, AcceptableC4U - Children Representation Unknown,Unacceptable

Comments (Required Unless Not Applicable):

Vertebrate Animals

Click Here to SelectAcceptableUnacceptableNot Applicable (No Vertebrate Animals)

Comments (Required Unless Not Applicable):

Biohazards

Click Here to SelectAcceptableUnacceptableNot Applicable (No Biohazards)

Comments (Required Unless Not Applicable):

Resubmission

Comments (if applicable):

Renewals

Comments (if applicable):

Revisions

Comments (if applicable):

Additional Review Considerations

As applicable for the project proposed, reviewers will address each of the following items, but will not give scores for these items and should not consider them in providing an overall impact/priority score.

Applications from Foreign Organizations

Click Here to SelectJustifiedUnjustifiedNot Applicable (No Foreign Organizations)

Comments (Required Unless Not Applicable):

Select Agents

Click Here to SelectAcceptableUnacceptableNot Applicable (No Select Agents)

Comments (Required if Unacceptable):

Resource Sharing Plans

Click Here to SelectAcceptableUnacceptableNot Applicable (No Relevant Resources)

Comments (Required if Unacceptable):

Budget and Period ofSupport
Click Here to SelectRecommend as RequestedBudget Modifications Recommended (in amount/time)
Recommended budget modifications or possible overlap identified:

Additional Comments to Applicant

Reviewers may provide guidance to the applicant or recommend against resubmission without fundamental revision.

Additional Comments toApplicant (Optional)

Page 1 of 4