Supplementary Data Table 3 Genes downregulated by HOXA1
Gene name / Genbank accession / HOXA1Over-expression / HOXA1
Kncokexpression
apoptosis
serum/glucocorticoid regulated kinase / NM_005627 / 0.52 / 1.96
BCL2-interacting killer (apoptosis-inducing) / NM_001197 / 0.54 / 2.17
biosynthesis
ribosomal protein L18a / Y11162 / 0.62 / 1.53
methionine-tRNA synthetase / NM_004083 / 0.61 / 1.57
tyrosinase-related protein 1 / NM_000550 / 0.40 / 2.44
asparagine synthetase / NM_001673 / 0.55 / 1.62
cell adhesion
KIAA0848 protein / NM_014926 / 0.34 / 1.63
carcinoembryonic antigen-related cell adhesion molecule 6 / NM_002483 / 0.51 / 2.25
NEL-like 2 (chicken) / NM_006159 / 0.66 / 1.61
cadherin 6, type 2, K-cadherin (fetal kidney) / NM_004932 / 0.64 / 1.53
mucin 5, subtypes A and C, tracheobronchial/gastric / AF043909 / 0.65 / 1.68
activated leukocyte cell adhesion molecule / NM_001627 / 0.44 / 2.59
desmocollin 2 / X56807 / 0.53 / 1.65
laminin, gamma 2 / NM_005562 / 0.64 / 1.51
tenascin C (hexabrachion) / NM_002160 / 0.53 / 1.68
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) / NM_004598 / 0.44 / 1.96
cell cycle
stromal antigen 2 / L08437 / 0.58 / 1.61
S100 calcium binding protein A6 (calcyclin) / NM_014624 / 0.52 / 2.05
betacellulin / NM_001729 / 0.31 / 2.29
protein kinase (cAMP-dependent, catalytic) inhibitor alpha / NM_006823 / 0.64 / 1.51
hypothetical protein MGC10765 / AK026854 / 0.61 / 1.61
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 / AF263541 / 0.56 / 1.60
development
forkhead box N1 / NM_003593 / 0.53 / 1.96
sema domain, seven thrombospondin repeats (type 1 and type 1-like) / AK022877 / 0.60 / 1.65
esophagus cancer-related gene-2 / U47646 / 0.32 / 3.01
spermatogenesis associated 6 / NM_019073 / 0.31 / 1.56
echinoderm microtubule associated protein like 1 / NM_004434 / 0.66 / 1.78
matrilin 3 / AJ224741 / 0.64 / 1.56
neuronal Shc adaptor homolog / AB001451 / 0.61 / 1.75
asporin (LRR class 1) / NM_017680 / 0.50 / 1.66
chromosome 4 open reading frame 6 / NM_005750 / 0.46 / 1.50
S100 calcium binding protein A7 (psoriasin 1) / NM_002963 / 0.45 / 1.95
patched homolog 2 (Drosophila) / NM_003738 / 0.60 / 1.74
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) / NM_005461 / 0.41 / 2.45
neuronal thread protein / NM_014486 / 0.58 / 1.83
brain expressed, X-linked 1 / NM_018476 / 0.58 / 1.71
zinc finger protein 238 / NM_006352 / 0.65 / 1.56
calmegin / NM_004362 / 0.51 / 1.53
sialyltransferase 8D (alpha-2, 8-polysialyltransferase) / NM_005668 / 0.66 / 1.58
glypican 6 / NM_005708 / 0.58 / 1.52
bone morphogenetic protein 7 (osteogenic protein 1) / NM_001719 / 0.53 / 2.15
DNA/RNA processing
RNA binding motif protein, Y-linked, family 1, member A1 / NM_005058 / 0.56 / 1.66
testes-specific heterogenous nuclear ribonucleoprotein G-T / NM_014469 / 0.65 / 1.66
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2 / X15624 / 0.57 / 1.69
immune response
major histocompatibility complex, class I, F / NM_018950 / 0.62 / 1.64
serine (or cysteine) proteinase inhibitor, member 3 / NM_001085 / 0.53 / 2.00
CD1C antigen, c polypeptide / NM_001765 / 0.67 / 1.52
metabolism
ring finger protein 150 / AB033040 / 0.47 / 1.99
phospholipase A2, group IIE / NM_014589 / 0.64 / 1.65
phospholipase A2, group III / NM_015715 / 0.49 / 1.99
phospholipase D1, phophatidylcholine-specific / NM_002662 / 0.58 / 2.40
hydroxyprostaglandin dehydrogenase 15-(NAD) / NM_000860 / 0.63 / 1.78
carbonic anhydrase II / NM_000067 / 0.55 / 1.93
monoglyceride lipase / NM_007283 / 0.55 / 1.93
aldo-keto reductase family 1, member C1 / NM_001353 / 0.58 / 1.88
creatine kinase, brain / NM_001823 / 0.59 / 2.00
matrix metalloproteinase 3 (stromelysin 1, progelatinase) / NM_002422 / 0.65 / 1.54
UDP-N-acetyl-alpha-D-galactosamine (GalNAc-T12) / AK024865 / 0.59 / 1.70
others
sialyltransferase / NM_006456 / 0.60 / 2.05
natriuretic peptide precursor B / NM_002521 / 0.48 / 2.55
protein S (alpha) / NM_000313 / 0.56 / 1.74
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 / NM_002639 / 0.66 / 1.57
benzodiazapine receptor (peripheral) / NM_000714 / 0.63 / 1.59
signal transduction
dual specificity phosphatase 6 / NM_001946 / 0.56 / 1.66
PFTAIRE protein kinase 1 / NM_012395 / 0.32 / 2.13
DIRAS family, GTP-binding RAS-like 2 / NM_017594 / 0.37 / 2.01
signal peptide, CUB domain, EGF-like 2 / AF086390 / 0.61 / 1.72
olfactory receptor, family 1, subfamily D, member 5 / NM_014566 / 0.30 / 1.50
dickkopf homolog 3 (Xenopus laevis) / NM_013253 / 0.61 / 1.64
N-myc (and STAT) interactor / NM_004688 / 0.65 / 1.65
Traf2 and NCK interacting kinase / AF172264 / 0.43 / 1.99
G protein-coupled receptor 50 / NM_004224 / 0.54 / 1.56
calcitonin receptor / NM_001742 / 0.37 / 1.95
G protein-coupled receptor 64 / NM_005756 / 0.57 / 1.57
arginine vasopressin receptor 1A / NM_000706 / 0.54 / 1.66
G protein-coupled receptor 30 / NM_001505 / 0.43 / 1.81
chemokine (C motif) ligand 1 / NM_002995 / 0.57 / 1.85
annexin A1 / NM_000700 / 0.41 / 1.66
LIM domain binding 3 / AL359621 / 0.62 / 1.65
neurotrophic tyrosine kinase, receptor, type 1 / X06710 / 0.42 / 2.47
amphiregulin (schwannoma-derived growth factor) / NM_001657 / 0.21 / 4.98
interleukin 18 (interferon-gamma-inducing factor) / NM_001562 / 0.60 / 1.63
tumor necrosis factor receptor superfamily, member 9 / NM_001561 / 0.57 / 1.54
immunoglobulin superfamily, member 3 / NM_001542 / 0.45 / 2.55
mitogen-activated protein kinase 13 / NM_002754 / 0.61 / 1.56
interleukin 4 receptor / NM_000418 / 0.44 / 1.53
KIAA0644 gene product / NM_014817 / 0.49 / 2.52
phosphatidic acid phosphatase type 2A / NM_003711 / 0.62 / 1.82
fibroblast growth factor 11 / NM_004112 / 0.48 / 2.38
fibroblast growth factor 12 / NM_004113 / 0.44 / 2.07
guanylate cyclase 1, soluble, alpha 3 / NM_000856 / 0.62 / 1.69
RAS protein activator like 1 (GAP1 like) / NM_004658 / 0.65 / 1.65
calmodulin-like skin protein / NM_017422 / 0.36 / 2.86
S100 calcium binding protein A14 / AY007220 / 0.40 / 2.42
S100 calcium binding protein P / NM_005980 / 0.36 / 3.15
fibroblast growth factor 13 / NM_004114 / 0.44 / 2.18
Rho guanine nucleotide exchange factor (GEF) 4 / NM_015320 / 0.66 / 1.59
thioredoxin interacting protein / NM_006472 / 0.61 / 1.80
dopamine receptor D2 / NM_000795 / 0.28 / 2.32
endometrial bleeding associated factor / NM_003240 / 0.48 / 2.12
prostate differentiation factor / NM_004864 / 0.51 / 2.19
glutamate decarboxylase 1 (brain, 67kDa) / NM_000817 / 0.39 / 1.61
stress response
serine protease inhibitor, Kazal type, 5 / AF147363 / 0.53 / 2.32
trefoil factor 3 (intestinal) / NM_003226 / 0.65 / 1.73
immunoglobulin superfamily, member 4 / NM_014333 / 0.52 / 2.06
glutathione peroxidase 2 (gastrointestinal) / NM_002083 / 0.59 / 1.63
fibrinogen, gamma polypeptide / NM_000509 / 0.48 / 2.31
structral/cytoskeleton
abhydrolase domain containing 2 / AL109729 / 0.67 / 1.65
microtubule-associated protein 1B / Y09836 / 0.61 / 1.51
myristoylated alanine-rich protein kinase C substrate / AB020968 / 0.40 / 2.79
Usher syndrome 2A (autosomal recessive, mild) / NM_007123 / 0.45 / 2.13
laminin, beta 3 / NM_000228 / 0.62 / 1.53
microfibrillar-associated protein 2 / NM_017459 / 0.57 / 1.70
tubulin, epsilon 1 / NM_016262 / 0.47 / 2.11
SH3 and multiple ankyrin repeat domains 1 / AF163302 / 0.56 / 1.54
kinesin family member 5C / NM_004522 / 0.54 / 1.66
amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) / NM_001635 / 0.50 / 1.85
mucin 1, transmembrane / NM_002456 / 0.67 / 1.58
transcription regulation
eukaryotic translation initiation factor 4E binding protein 1 / NM_004095 / 0.66 / 1.62
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) / NM_005360 / 0.49 / 1.94
hypothetical protein FLJ20156 / NM_017691 / 0.29 / 2.94
core promoter element binding protein / NM_001300 / 0.67 / 1.62
zinc finger protein 22 (KOX 15) / NM_006963 / 0.67 / 1.52
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) / NM_005378 / 0.47 / 2.11
KIAA1305 protein / AB037726 / 0.57 / 1.59
trinucleotide repeat containing 9 / AK027006 / 0.66 / 1.63
homeo box B9 / AK026084 / 0.55 / 1.93
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related / AF131817 / 0.40 / 1.81
transport
RAB3B, member RAS oncogene family / AK002107 / 0.65 / 1.59
solute carrier family 8 (sodium/calcium exchanger), member 1 / X91221 / 0.39 / 2.30
six transmembrane epithelial antigen of the prostate / NM_012449 / 0.51 / 1.53
chloride intracellular channel 3 / NM_004669 / 0.43 / 2.17
solute carrier family 43, member 1 / NM_003627 / 0.47 / 1.89
lactotransferrin / NM_002343 / 0.54 / 1.52
low density lipoprotein-related protein 1B (deleted in tumors) / NM_018557 / 0.54 / 1.60
solute carrier family 21 (prostaglandin transporter), member 2 / NM_005630 / 0.62 / 1.52
FXYD domain containing ion transport regulator 3 / NM_005971 / 0.44 / 2.53
solute carrier family 2 (facilitated glucose transporter), member 9 / NM_020041 / 0.67 / 1.80
solute carrier family 22 (organic cation transporter), member 15 / AL353933 / 0.50 / 1.78
apolipoprotein D / NM_001647 / 0.43 / 2.70
Unknown
hypothetical protein FLJ12987 / AK024079 / 0.48 / 1.50
sister-of-mammalian grainyhead / AL137763 / 0.65 / 1.72
Homo sapiens mRNA; cDNA DKFZp566E183 (from clone DKFZp566E183) / AL049354 / 0.64 / 1.88
hypothetical protein DKFZp434J1015 / AL133055 / 0.58 / 1.68
Homo sapiens full length insert cDNA clone ZD83D05 / AF086453 / 0.65 / 1.52
Homo sapiens cDNA FLJ44318 fis, clone TRACH3000780 / AF007153 / 0.56 / 2.08
Homo sapiens clone 24405 mRNA sequence / AF070632 / 0.62 / 1.61
Homo sapiens cDNA: FLJ20869 fis, clone ADKA02377 / AK024522 / 0.60 / 1.77
Homo sapiens cDNA clone IMAGE:5286266, partial cds / AL049461 / 0.52 / 1.51
hypothetical protein DKFZp761K1423 / NM_018422 / 0.62 / 1.55
juxtaposed with another zinc finger gene 1 / AK000711 / 0.60 / 1.50
Homo sapiens cDNA FLJ11041 fis, clone PLACE1004405. / AK001903 / 0.23 / 2.44
Homo sapiens similar to chromosome 6 open reading frame 188 (LOC221299), mRNA / AF086130 / 0.57 / 1.80
Homo sapiens cDNA FLJ14142 fis, clone MAMMA1002880. / AK024204 / 0.46 / 2.24
Homo sapiens mRNA similar to nuclear localization signals binding protein 1 / AF075040 / 0.58 / 1.51
Homo sapiens cDNA FLJ44354 fis, clone TRACH3006589 / AL390167 / 0.65 / 1.54
Homo sapiens cDNA FLJ45011 fis, clone BRAWH3013049 / AL137513 / 0.36 / 1.54
Homo sapiens mRNA; cDNA DKFZp434N144 (from clone DKFZp434N144) / AL080161 / 0.56 / 1.54
Homo sapiens clone 24974 mRNA sequence / AF131841 / 0.64 / 1.78
Homo sapiens cDNA: FLJ21036 fis, clone CAE09578 / AK024689 / 0.55 / 1.52
Homo sapiens similar to adaptor-related protein complex 1 sigma 2 subunit / AF086204 / 0.33 / 3.26
Homo sapiens cDNA: FLJ21341 fis, clone COL02653 / AK024994 / 0.31 / 1.71
Homo sapiens cDNA FLJ11473 fis, clone HEMBA1001712. / AK021535 / 0.63 / 1.58
Homo sapiens cDNA FLJ11555 fis, clone HEMBA1003078. / AK021617 / 0.42 / 1.62
Homo sapiens cDNA FLJ10946 fis, clone PLACE1000005. / AK001808 / 0.64 / 1.60
Homo sapiens cDNA FLJ14096 fis, clone MAMMA1000752. / AK024158 / 0.58 / 1.96
Homo sapiens cDNA FLJ11419 fis, clone HEMBA1000985. / AK021481 / 0.53 / 1.90
six transmembrane epithelial antigen of prostate 2 / AK026813 / 0.48 / 1.96
hypothetical protein FLJ14957 / AK027025 / 0.67 / 1.62
hypothetical protein LOC201895 / AK023351 / 0.67 / 1.54
Homo sapiens full length insert cDNA clone ZD78D09 / AF086421 / 0.54 / 2.05
Homo sapiens full length insert cDNA clone ZD73H04 / AF086391 / 0.56 / 1.79
PRO1073 protein / AF130094 / 0.63 / 1.78
chromosome 5 open reading frame 4 / NM_016348 / 0.44 / 2.28
Homo sapiens cDNA FLJ41603 fis, clone CTONG3000657 / AK023814 / 0.60 / 1.59
hypothetical protein FLJ13081 / AK023143 / 0.33 / 1.73
cytochrome P450, family 19, subfamily A, polypeptide 1 / S85075 / 0.66 / 1.54
uncharacterized hypothalamus protein HT011 / NM_018472 / 0.66 / 1.59
hypothetical protein FLJ23186 / AK026839 / 0.64 / 1.78
Homo sapiens cDNA FLJ12825 fis, clone NT2RP2002800. / AK022887 / 0.40 / 1.50
hypothetical protein FLJ10901 / NM_018265 / 0.60 / 1.74
hypothetical protein FLJ38984 / AF086190 / 0.61 / 1.72
Homo sapiens cDNA FLJ13457 fis, clone PLACE1003343. / AK023519 / 0.42 / 1.77
Homo sapiens clone IMAGE 23915 / AF090101 / 0.29 / 1.55
putative NFkB activating protein 373 / AK026744 / 0.39 / 2.00
Homo sapiens full length insert cDNA YO61A08 / AF075056 / 0.60 / 1.66
hypothetical protein DKFZp434L142 / NM_016613 / 0.60 / 1.55
chromosome 20 open reading frame 39 / AK024282 / 0.43 / 2.15
adipose specific 2 / NM_006829 / 0.34 / 3.18
hypothetical protein FLJ20200 / NM_017708 / 0.50 / 1.91
KIAA0649 gene product / U90903 / 0.54 / 1.64
Homo sapiens cDNA FLJ10586 fis, clone NT2RP2003986. / AK001448 / 0.66 / 1.60
ARF protein / AK024178 / 0.56 / 1.99
Homo sapiens cDNA: FLJ23050 fis, clone LNG02639 / AK026703 / 0.64 / 1.71
Homo sapiens cDNA FLJ26234 fis, clone ADG09627 / M34428 / 0.59 / 1.56
Homo sapiens mRNA, chromosome 1 specific transcript KIAA0493. / AB007962 / 0.64 / 1.50
unc-5 homolog B (C. elegans) / AL049370 / 0.60 / 1.51
phosphodiesterase 8B / AF079529 / 0.34 / 1.73
hypothetical protein FLJ32810 / AK023666 / 0.50 / 1.55
LL5 beta / AL137663 / 0.58 / 1.93
ring finger protein 39 / AF238315 / 0.63 / 1.59
likely ortholog of mouse hypoxia induced gene 1 / NM_014056 / 0.61 / 1.88
placenta-specific 1 / AF234654 / 0.41 / 1.72