Table S3: PU.1 Target Genes
Database of confirmed PU.1 target genes, including validated binding sites and location relative to transcription start site.
Description / Reference(s) / Location / Species / Gene Name / Expression / Representative Binding Site Sequence / Site / # SitesAdipose Differentiation Related Protein / (1) / promoter / murine / Adrp / myeloid / CAAGAGGAAGTGAC / -2045 / 1
arginase I / (2) / enhancer / murine / Arg1 / myeloid / AATAAGGAAGTCAG / NA / 3
m-globin IVS2 / (3) / enhancer / murine / Hbb-b1 / erythroid / AAAGGGGAAGCGAT / NA / 1
BPI (bactericidal/ permeability increasing protein) / (4) / promoter / human / BPI / myeloid / AAGAAGGAAGGAAC / -98 / 1
Btk / (5) / promoter / human / BTK / lymphoid / AAAAGGGAACTGAG / -50 / 1
Cathepsin K / (6) / promoter / murine / Ctsk / myeloid / TGCATGGAATCCAG / -1108 / 1
Cathepsin S / (7) / promoter / murine / Ctss / myeloid / AAATTGGAACTTGTC / -48 / 10
CD11b / (8, 9) / promoter / human / ITGAM / myeloid / AAAGGAGAAGTAGG / -18 / 1
CD16 (FcRIII) / (10) / promoter / human / FCGR3 / myeloid / AAAGAGGAAGGAAA / -45 / 1
CD18 / (11) / promoter / human / ITGB2 / myeloid / TGAGAGGAACAGGA / -23 / 2
CD1D1 / (12) / promoter / murine / Cd1d1 / lymphoid/myeloid / AACCCGGAAGGACG / -30 / 1
CD20 / (13) / promoter / human / MS4A1 / lymphoid / TTTCAAGAAGTGAA / -159 / 1
CD32 (FcRIIb) / (14) / promoter / murine / Fcgr2b / lymphoid/myeloid / AATGGGGAAGTGAA / -94 / 2
CD33 / (15) / promoter / human / CD33 / myeloid / GAAGAGGAACCTCA / 403 / 1
CD45 / (16) / promoter / murine / Ptprc / lymphoid/myeloid / ATTAAGGAAGTAAG / -117 / 1
CD64 (FcRI) / (17-19) / promoter / human / FCGR1 / myeloid / AAAGAGGAAGGAAA / -93 / 1
CD68 / (20) / promoter / human / CD68 / myeloid / AAGGAGGAAATGAA / -88 / 3
CD68 (macrosialin) / (21) / promoter / murine / Cd68 / myeloid / TTAAGGGAAGTGAG / -97 / 1
CD72 / (22) / promoter / murine / Cd72 / lymphoid / AAAGAGGAAGAAGG / -146 / 1
c-fes / (23, 24) / promoter / human / FES / myeloid / GAGGAGGAAGCGCG / -18 / 2
CHI3L1 / (25) / promoter / human / CHI3L1 / myeloid / ATAAAGGAAGTACA / -102 / 1
CIITA / (26) / promoter / human / CIITA / lymphoid/myeloid / AGTAAGGAAGTGAA / -296 / 1
c-myb / (27) / promoter / human / MYB / lymphoid/myeloid / GAGGAGGAAACAGG / 19 / 1
c-rel / (28) / promoter / murine / Rel / lymphoid / GGAGGGGAAGTGCG / -474 / 3
DC-SIGN / (29) / promoter / human / CD209 / myeloid / AAACAGGAAGTTGG / -77 / 2
Defensin-1 / (30) / promoter / human / DEFA1 / myeloid / ATAGGGGAAGTCCA / -21 / 2
Early B Cell Factor / (31) / promoter / murine / Ebf1 / lymphoid / AAAGAGGAAGGGGG / 165 / 1
Early B Cell Factor / (32) / enhancer / murine / Ebf1 / lymphoid / AAAGAGGAAGGGGG / NA / 1
eosinophil granule MBP / (33, 34) / promoter / human / PRG2 / myeloid / TGAGAGGAAGCAAA / -7 / 3
eosinophil-derived neurotoxin / (35) / enhancer / human / RNASE2 / myeloid / TTAAGGGAAGTGAG / 178 / 2
F4/80 / (36) / promoter / murine / Emr1 / myeloid / GAAAGGGAAAGAGA / -265 / 9
FcRI / (37) / proximal promoter / human / FCER1A / mast cell / AAAGCAGAAGGAAA / -47 / 1
FcRI / (38) / distal promoter / human / FCER1A / mast cell / GAGAAGGAAGCACT / -21 / 2
Fibroleukin / (39) / promoter / murine / Fgl2 / myeloid / TTCTGGGAAACTCA / -65 / 1
GANP / (40) / promoter / murine / Mcm3ap / lymphoid / GAGCCGGAAGCCGG / -126 / 1
G-CSFR / (41) / promoter / human / CSF3R / myeloid / TTTCAGGAACTTCT / 1 / 1
Glucocorticoid Receptor / (42) / promoter / human / NR3C1 / lymphoid / CCAACGGAAGCACT / 265 / 1
GM-CSFR / (43, 44) / promoter / human / CSF2RA / myeloid / ACAGAGGAACTCTG / -3 / 1
gp91phox / (45-49) / promoter / human / CYBB / myeloid / ATGGAGGAAATGAA / -52 / 1
I-A / (50) / promoter / murine / Rmcs2 / lymphoid/myeloid / AGTGAGGAACCAAT / 1
Ig J chain / (51) / promoter / human / IGJ / lymphoid / AAAGCAGAAGCAGC / -52 / 1
Ig V19 / (52) / promoter / human / IGKV19 / lymphoid / AATAAGGAAGTAAA / -85 / 1
IgH 3' regulatory region (HS1,2) / (53) / enhancer / murine / Igh / lymphoid / AACTGGGAAACACG / NA / 1
IgH 5' Regulatory Region / (54) / enhancer / murine / Igh / lymphoid / CAAGAGGAAGTGAG / NA / 1
IgH intronic enhancer / (55) / enhancer / murine / Igh / lymphoid / TTTGGGGAAGGGAA / NA / 1
Ig / (56) / promoter / human / IGE / lymphoid / CAGAGAGAAAAGGG / -77 / 1
Ig 3' / (57) / enhancer / murine / Igk / lymphoid / TTTGAGGAACTGAA / NA / 1
Ig 2-4 / (58) / enhancer / murine / Igl / lymphoid / TAAAAGGAAGTGAA / NA / 1
IL-12 p40 / (59, 60) / promoter / human / IL12B / myeloid / TAAGAGGAAATGAC / -210 / 1
IL-18 / (61) / promoter / human / IL18 / myeloid / AATGAGGAAGAAGG / -25 / 1
IL-18 / (62) / promoter / murine / Il18 / lymphoid/myeloid / AATGAGGAAGAACC / -31 / 1
IL-3R c / (63) / promoter / human / CSF2RB / myeloid / AATGAGGAAGTTGC / -65 / 2
IL-3R / (44) / promoter / human / IL3RA / myeloid / AGGGAGGAAACACA / -375 / 3
IL-4 / (64) / intronic enhancer / murine / Il4 / mast cell / AAACAGGAACTGAA / NA / 1
IL-7R / (65) / promoter / murine / Il7ra / lymphoid / AAACAGGAAGTCTG / 759 / 1
IL-8R (CXCR1) / (66) / promoter / murine / Il8ra / myeloid / AATAAGGAAACCAC / -12 / 1
ILT-2 / ILT-4 (CD85) / (67) / promoter / human / LILR / lymphoid/myeloid / AAAGGGGAAGTTAA / -103 / 1
Interferon Regulatory Factor-4 / (68) / promoter / human / IRF4 / lymphoid/myeloid / AAAGAGGAACTTTTA / -9 / 1
ISG15 (IFN-stimulated gene 15) / (69) / promoter / murine / Isg15 / myeloid / GAAAGGGAACCGAA / 1
JunB / (70) / promoter / murine / Junb / myeloid / GAAGAGGAACCTCG / -1400 / 1
Leukocyte Elastase / (71) / promoter / human / ELA2 / myeloid / GGAGAGGAAGTTTT / -114 / 1
Lyl1 / (72) / promoter / murine / Lyl1 / lymphoid/myeloid / AAAGAGGAACTAGG / -408 / 5
lysozyme / (73, 74) / enhancer / chicken / LYS_CHICK / myeloid / TATTTGGAAATAAT / NA / 1
macrophage mannose receptor / (75) / promoter / murine / Mrc2 / myeloid / CAGGAGGAAGGGGA / -163 / 1
macrophage mannose receptor / (76) / promoter / rat / Endo180 / myeloid / AAACAGGAATTCAA / -102 / 1
macrophage scavenger receptor / (77) / promoter / human / MSR1 / myeloid / AAAAGAGAAGTGAA / -191 / 1
mb-1 / (78) / promoter / murine / Cd79a / lymphoid / GAACAGGAAGTGAG / -53 / 1
M-CSFR (c-fms) / (79) / promoter / human / CSF1R / myeloid / AAAGGGGAAGAAGA / -124 / 4
M-CSFR (c-fms) / (80) / promoter / murine / Csf1r / myeloid / CAGGAGGAAGAGGA / -128 / 4
MIP-1 / (81) / enhancer / murine / Ccl3 / myeloid / GATGAGGAAATGGA / NA / 1
monocyte/ neutrophil elastase inhibitor / (82) / promoter / human / SERPINB1 / myeloid / CAAGAAGAAGTGAG / -125 / 1
opioid receptor / (83) / promoter / murine / Oprm1 / myeloid / TTTGAGGAACTAAA / -699 / 1
Neurofibromin-1 / (84) / promoter / human / Nf1 / myeloid / CCACCGGAAGTGGG / -377 / 1
Neutrophil Elastase / (85) / promoter / human / ELA2 / myeloid / GGAGAGGAAGTGGA / -87 / 1
OSCAR / (86) / promoter / human / OSCAR / myeloid / TGGGAGGAAGAAAA / -97 / 3
p15-Ink4B / (87) / promoter / murine / Cdkn2b / myeloid / AGAGTGGAAGATCT / -320 / 1
P2Y10 / (88) / promoter / murine / P2ry10 / lymphoid / AAAGAGGAAGTAGA / -10 / 1
p40phox / (89) / promoter / human / NCF4 / myeloid / ATTGAGGAAGTGGA / -97 / 3
p47phox / (90) / promoter / human / NCF1 / myeloid / AAAGAGGAAGTCGC / -42 / 1
p67phox / (47, 91) / enhancer / human / NCF2 / myeloid / CCACAGGAATGTCC / NA / 3
pDP4 / (92) / promoter / murine / Pdp4 / myeloid / AAAGAGGAAGTAGC / -75 / 1
platelet binding protein / (93) / promoter / murine / Ppbp / megakaryocyte / AAGGAGGAAGTGAG / -75 / 1
pro-IL-1 / (94) / promoter / human / IL1B / myeloid / AAAGCAGAAGTAGG / -44 / 3
prophenin-2 / (95) / promoter / porcine / PF2 / myeloid / AACTAGGAACTGGC / -484 / 1
proteinase-3/ myeloblastin / (96, 97) / promoter / human / PRTN3 / myeloid / AAGGAGGAAGTGGG / -99 / 1
PU.1 / (98) / promoter / human / SPI1 / lymphoid/myeloid / AATCAGGAACTTGT / 17 / 2
PU.1 / (99) / promoter / murine / Sfpi1 / lymphoid/myeloid / CTACAGGAAGTCTC / -101 / 1
PU.1 / (100) / enhancer / murine / Sfpi1 / lymphoid/myeloid / AAAGAGGAAGCGGC / NA / 1
RANK / (101) / promoter / murine / Tnfrs11a / myeloid / CTTCAGGAAGAAAT / -1205 / 4
RANTES / (102) / promoter / murine / Ccl5 / myeloid / TTTGTGGAAACTCC / -87 / 1
SCL/Tal-1 / (103) / silencer / human / TAL1 / lymphoid/myeloid / AAAGCAGAACTTTG / 665 / 1
SCL/Tal-1 / (104) / promoter / murine / Tal1 / lymphoid/myeloid / AAAGGGGAAGGAAG / 267 / 3
secretory IL-1R / (105) / promoter / human / IL1R1 / myeloid / GAAGCGGAAATACC / -84 / 2
SHP-1 / (106) / promoter / human / Ptpn6 / lymphoid/myeloid / AAACGAGAAGTACA / -74 / 1
tec / (107) / promoter / murine / Tec / lymphoid/myeloid / TAAGCGGAAGTGGT / -349 / 1
TFEC / (108) / promoter / murine / Tcfec / myeloid / ATTCAGGAAATAGT / -377 / 6
Toll-Like Receptor 4 / (109) / promoter / human / TLR4 / myeloid / TGAGAGGAAGTGAA / 23 / 1
Toll-Like Receptor 4 / (110) / promoter / murine / Tlr4 / myeloid / CAAGAGGAAGCTGG / -112 / 1
Toll-Like Receptor 9 / (111) / promoter / murine / Tlr9 / lymphoid/myeloid / ATTGAGGAAGTGAC / -3 / 2
TRAP / (112) / promoter / murine / Acp5 / myeloid / TCTGGGGAAGTCCA / ? / 1
vav / (113) / promoter / human / VAV / lymphoid/myeloid / GAAGAGGAAGTGGT / -11 / 1
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