Table S1: Univariate Probability of Outcomes for (a) recipientand (b) donorAFR admixture

(a)

<=0.14 / > 0.14 / Pointwise
Outcome / N / Prob(95%CI) / N / Prob(95%CI) / p-value
Overall Survival / 1215 / 34 / 0.054a
@ 1 year / 60 (57-63) / 47 (31-64) / 0.136
@ 3 years / 51 (48-53) / 35 (20-52) / 0.065
@ 5 years / 46 (44-49) / 24 (10-40) / 0.004
Disease-Free Survival / 1205 / 34 / 0.111a
@ 1 year / 52 (49-55) / 44 (28-61) / 0.370
@ 3 years / 44 (41-47) / 26 (13-42) / 0.023
@ 5 years / 40 (38-43) / 17 (5-34) / 0.002
TRM / 1205 / 34
@ 1 year / 25 (22-27) / 44 (28-61) / 0.025
@ 3 years / 29 (26-31) / 47 (31-64) / 0.033
@ 5 years / 31 (28-33) / 51 (34-68) / 0.023

(b)

<=0.228 / > 0.228 / Pointwise
Outcome / N / Prob(95%CI) / N / Prob(95%CI) / p-value
Overall Survival / 1229 / 24 / <0.001a
@ 1 year / 61 (58-63) / 29 (13-49) / <0.001
@ 3 years / 51 (48-54) / 17 (5-34) / <0.001
@ 5 years / 47 (44-49) / 13 (3-28) / <0.001
Disease-Free Survival / 1219 / 24 / <0.001a
@ 1 year / 53 (50-55) / 21 (7-39) / <0.001
@ 3 years / 44 (41-47) / 13 (3-28) / <0.001
@ 5 years / 40 (38-43) / 8 (1-22) / <0.001
TRM / 1219 / 24
@ 1 year / 24 (22-27) / 63 (43-80) / <0.001
@ 3 years / 28 (26-31) / 63 (43-80) / <0.001
@ 5 years / 30 (28-33) / 67 (47-84) / <0.001

Abbreviations: Prob = Probability (%); CI = Confidence interval

a Log-rank p-value.

Table S2: Donorsof AFR admixture > 23% and recipientsof AFR admixture > 14% driving the studyfinding (high-risk group). a) All recipients with AFR admixture >14% and the AFR admixture of the donors they received graft from as well as both donor and recipient self-identified race/ethnicity. Only 19 out of the 34 recipients (56%) received grafts from donors with AFR admixture > 23%. b) All donors with AFR admixture >23% and the AFR admixture of the recipients they donated to as well as both donor and recipient self-identified race/ethnicity. All donors with AFR admixture > 23% donated to recipients with AFR admixture > 14%. Shaded cells indicate high-risk donors or recipients. AFR- African genetic admixture, AFA – African-American race, CAU – European Caucasian race, HIS – Hispanic ethnicity, MLT – Multiethnic, NAM – Native-American race.

(a)

Recipient race / Donor race / Recipient AFR admix / Donor AFR admix
AFA / AFA / 89.00% / 98.70%
AFA / AFA / 78.30% / 98.50%
AFA / AFA / 74.90% / 98.40%
AFA / AFA / 84.60% / 92.30%
AFA / AFA / 78.10% / 89.70%
AFA / CAU / 73.70% / 88.20%
AFA / AFA / 92.70% / 87.20%
AFA / AFA / 81.10% / 86.70%
AFA / AFA / 78.60% / 84.80%
AFA / AFA / 79.80% / 84.40%
AFA / AFA / 81.60% / 81.30%
AFA / AFA / 87.20% / 79.90%
AFA / AFA / 97.40% / 77.60%
AFA / AFA / 83.80% / 77.50%
AFA / AFA / 90.10% / 74.50%
CAU / AFA / 74.60% / 73.40%
AFA / AFA / 95.50% / 73.20%
AFA / MLT / 99.50% / 54.00%
HIS / HIS / 27.20% / 32.80%
AFA / MLT / 86.10% / 16.90%
AFA / MLT / 74.00% / 6.70%
AFA / CAU / 37.70% / 1.00%
HIS / HIS / 28.10% / 0.80%
CAU / CAU / 25.10% / 0.60%
AFA / CAU / 51.20% / 0.30%
HIS / CAU / 30.20% / 0.30%
CAU / NAM / 14.60% / 0.30%
AFA / HIS / 87.60% / 0.20%
AFA / CAU / 68.30% / 0.20%
AFA / CAU / 29.70% / 0.20%
CAU / CAU / 14.40% / 0.20%
AFA / CAU / 97.90% / 0.10%
CAU / CAU / 43.40% / 0.10%
AFA / AFA / 76.70% / N/A

(b)

Recipient race / Donor race / Recipient AFR admix / Donor AFR admix
AFA / MLT / 99.50% / 54.00%
AFA / AFA / 97.40% / 77.60%
AFA / AFA / 95.50% / 73.20%
AFA / AFA / 92.70% / 87.20%
AFA / AFA / 90.10% / 74.50%
AFA / AFA / 89.00% / 98.70%
AFA / AFA / 87.20% / 79.90%
AFA / AFA / 84.60% / 92.30%
AFA / AFA / 83.80% / 77.50%
AFA / AFA / 81.60% / 81.30%
AFA / AFA / 81.10% / 86.70%
AFA / AFA / 79.80% / 84.40%
AFA / AFA / 78.60% / 84.80%
AFA / AFA / 78.30% / 98.50%
AFA / AFA / 78.10% / 89.70%
AFA / AFA / 74.90% / 98.40%
CAU / AFA / 74.60% / 73.40%
AFA / CAU / 73.70% / 88.20%
HIS / HIS / 27.20% / 32.80%
HIS / HIS / 0.60% / 28.70%
CAU / AFA / 0.30% / 69.10%
CAU / HIS / 0.30% / 29.70%
HIS / HIS / 0.30% / 26.60%
CAU / HIS / 0.20% / 24.80%

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