1
SDC1. Table 1 Single nucleotide polymorphisms genotyped with genome-wide association study sourceChromosome / BP / Gene / Genotyped SNP / Replaced SNP LD=1 / Basis for selection
54331671 / NLRP12 / rs11671984 / Candidate gene for inflammation*
1 / 10799577 / CASZ1 / rs12046278 / Blood pressure regulation [1]
1 / 11862778 / MTHFR / rs17367504 / Blood pressure regulation [7, 8]
1 / 63590954 / ATG4C, FOXD3 / rs10493339 / rs10493340 / Blood pressure regulation [2]
1 / 63591129 / ATG4C, FOXD3 / rs10493340 / Blood pressure regulation [2]
1 / 63591224 / ATG4C, FOXD3 / rs11578482 / rs10493340 / Blood pressure regulation [2]
1 / 63602535 / ATG4C, FOXD3 / rs11583678 / rs10493340 / Blood pressure regulation [2]
1 / 113216543 / MOV10 / rs2932538 / Blood pressure regulation [8, 9]
1 / 163111066 / RGS5 / rs2841993 / Candidate gene for inflammation**/dbGaP
1 / 163163777 / RGS5 / rs7513108 / Candidate gene for inflammation**/dbGaP
1 / 163260844 / RGS5 / rs16852030 / Candidate gene for inflammation*
1 / 239436542 / RYR2, M3, ZP4 / rs2820037 / Blood pressure regulation [18]
1 / 247600301 / NLRP3 / rs1539019 / Candidate gene for inflammation** [15]
1 / 247601595 / NLRP3 / rs12239046 / Candidate gene for inflammation [12]
10 / 18708798 / CACNB2 / rs11014166 / Blood pressure regulation [1]
10 / 18727959 / CACNB2 / rs12258967 / Blood pressure regulation [8]
10 / 63467553 / C10orf107 / rs4590817 / Blood pressure regulation [8]
10 / 63524591 / C10orf107 / rs1530440 / Blood pressure regulation [7]
10 / 95895940 / PLCE1 / rs932764 / Blood pressure regulation [9]
10 / 104594507 / CYP17A1 / rs1004467 / Blood pressure regulation [1]
10 / 104846178 / NT5C2 / rs11191548 / Blood pressure regulation [7-9]
10 / 115781527 / ADRB1 / rs2782980 / Blood pressure regulation [8]
11 / 10350538 / EF537580 / rs7129220 / Blood pressure regulation [8, 9]
11 / 16917219 / PLEKHA7 / rs11024074 / Blood pressure regulation [1]
11 / 100593538 / ARHGAP42 / rs633185 / Blood pressure regulation [8, 9]
11 / 116649135 / ZNF259 / rs11823543 / Blood pressure regulation [11]
11 / 116660686 / APOA5, ZNF259 / rs2266788 / Blood pressure regulation [11]
11 / 130273230 / AX747213, ADAMTS8, BC144419, BC144418 / rs11222084 / Blood pressure regulation [8]
12 / 45930973 / ANO6 / rs10785581 / Candidate gene for inflammation* [38]
12 / 90060586 / ATP2B1 / rs17249754 / Blood pressure regulation [8]
12 / 111884608 / SH2B3 / rs3184504 / Blood pressure
regulation [1, 9]
12 / 115352731 / TBX5, TBX3 / rs2384550 / Blood pressure regulation [1, 8]
14 / 76613678 / c14orf179, C14orf118 / rs935334 / Blood pressure regulation [2]
14 / 76650764 / GPATCH2L / rs2121070 / Blood pressure regulation [2]
15 / 75077367 / CSK / rs1378942 / Blood pressure regulation [7-9]
15 / 75125645 / CPLX3 / rs6495122 / Blood pressure regulation [1]
15 / 91437388 / FES / rs2521501 / Blood pressure regulation [8, 9]
16 / 20365654 / UMOD / rs13333226 / Blood pressure regulation [13]
16 / 50739582 / NOD2 / rs17221417 / Candidate gene for inflammation [18]
16 / 50755709 / NOD2 / rs10521209 / Candidate gene for inflammation** [5]
16 / 50756774 / NOD2 / rs5743289 / Candidate gene for inflammation [26-29]
16 / 82642651 / MPHOSPH6, CDH13 / rs11646213 / Candidate gene for inflammation, blood pressure regulation** [10]
16 / 83764204 / CDH13 / rs3096277 / Blood pressure regulation [2]
17 / 43208121 / PLCD3, ACBD4 / rs12946454 / Blood pressure regulation [7]
17 / 45013271 / GOSR2 / rs17608766 / Blood pressure regulation [8, 9]
17 / 47402807 / ZNF652 / rs12940887 / Blood pressure regulation [8]
17 / 47440466 / ZNF652 / rs16948048 / Blood pressure regulation [7]
18 / 57963117 / MCAR / rs17773430 / Blood pressure regulation [17]
19 / 54332061 / NLRP12, MYADM / rs7259148 / Candidate gene for inflammation*/dbGaP
19 / 54332311 / NLRP12, MYADM / rs7258592 / rs11671984 / Candidate gene for inflammation*/dbGaP
2 / 27742603 / GCKR / rs780093 / Blood pressure regulation [11]
2 / 34284984 / LOC344371, MYADML, FAM98A, RASGRP3 / rs6711736 / Candidate gene for inflammation, blood pressure regulation** [31, 32]
2 / 83292565 / Intergenetic -not mapped to gene / rs10496288 / Candidate gene for inflammation* [38]
2 / 133189239 / GPR39 / rs10188442 / Candidate gene for inflammation*
2 / 164915208 / FIGN / rs13002573 / Blood pressure regulation [8]
2 / 164963486 / FIGN / rs1446468 / Blood pressure regulation [8]
2 / 169041386 / STK39 / rs6749447 / Blood pressure regulation [33]
2 / 228715375 / CCL20, TDGF1P2 / rs7591163 / Blood pressure regulation [2]
20 / 10969030 / JAG1 / rs1327235 / Blood pressure regulation [8, 9]
20 / 15599531 / MACROD2 / rs200752 / Candidate gene for inflammation*
20 / 57758720 / ZNF831, EDN3 / rs16982520 / Blood pressure regulation [1]
3 / 2654691 / CNTN4 / rs4370013 / Blood pressure regulation [2]
3 / 27537909 / SLC4A7 / rs13082711 / Blood pressure regulation [8, 9]
3 / 41877414 / ULK4 / rs3774372 / Blood pressure regulation [8]
3 / 138903985 / MRPS22 / rs7638110 / Blood pressure regulation [17]
3 / 169165888 / MECOM / rs1918974 / Blood pressure regulation [7]
4 / 38802751 / TLR1 / rs5743594 / Candidate gene for inflammation*/dbGaP
4 / 38820986 / TLR1, TLR6 / rs7696175 / Candidate gene for inflammation*/dbGaP
4 / 54799245 / PDGFRA / rs871606 / Blood pressure regulation [8]
4 / 81164723 / FGF5 / rs1458038 / Blood pressure regulation [8, 9]
4 / 81184341 / PRDM8/FGF5 / rs16998073 / Blood pressure regulation [7]
4 / 100322445 / ADH1C, ADH7 / rs991316 / Candidate gene for inflammation, blood pressure regulation** [37]
4 / 103188709 / SLC39A8 / rs13107325 / Candidate gene for inflammation, blood pressure regulation** [8, 9]
4 / 156645513 / GUCY1A3 / rs13139571 / Blood pressure regulation [8, 9]
5 / 32815028 / NPR3, C5orf23 / rs1173771 / Blood pressure regulation [8, 9]
5 / 36425593 / RANBP3L / rs12522034 / Candidate gene for inflammation* [38]
5 / 82433781 / XRCC4 / rs6452524 / Candidate gene for inflammation*
5 / 110772404 / CAMK4 / rs10491334 / Blood pressure regulation [2]
5 / 157845402 / MARK2P11, EBF1 / rs11953630 / Blood pressure regulation [9]
6 / 26091179 / HFE / rs1799945 / Blood pressure regulation [9]
6 / 31616366 / BAG6 / rs805303 / Blood pressure regulation [9]
6 / 32151443 / AGER/RNF5/PBX2 / rs2070600 / Candidate gene for inflammation/dbGaP [19, 20]
6 / 43757896 / VEGFA, C6orf223 / rs998584 / Candidate gene for inflammation*
6 / 43758873 / VEGFA, C6orf223 / rs6905288 / Candidate gene for inflammation** [34]
6 / 43791897 / VEGFA, C6orf223 / rs6902871 / rs943072 / Candidate gene for inflammation** [24]
6 / 43793391 / VEGFA, C6orf223 / rs6940798 / rs943072 / Candidate gene for inflammation** [24]
6 / 43795968 / VEGFA, C6orf223 / rs943072 / Candidate gene for inflammation** [24]
6 / 43796146 / VEGFA, C6orf223 / rs4273687 / rs943072 / Candidate gene for inflammation** [24]
6 / 43804571 / VEGFA / rs729761 / Candidate gene for inflammation**/dbGaP, [30, 35]
6 / 43811762 / AK097853 / rs9472138 / Candidate gene for inflammation** [36]
6 / 43886159 / LOC100132354 / rs721640 / Candidate gene for inflammation*/dbGaP
6 / 43897727 / LOC100132354 / rs9472155 / Candidate gene for inflammation** [25]
6 / 43919695 / VEGFA, C6orf223 / rs9472159 / rs4513773 / Candidate gene for inflammation** [25]
6 / 43925526 / VEGFA, C6orf223 / rs4513773 / Candidate gene for inflammation** [25]
6 / 43925607 / VEGFA, C6orf223 / rs6921438 / rs4513773 / Candidate gene for inflammation** [25]
6 / 43927050 / VEGFA, C6orf223 / rs7767396 / rs4513773 / Candidate gene for inflammation** [25]
6 / 43951656 / VEGFA, C6orf223 / rs910609 / Candidate gene for inflammation*/dbGaP
6 / 76552563 / MYO6 / rs3798441 / rs3798440 / Candidate gene for inflammation*
6 / 76553836 / MYO6 / rs12210386 / rs3798440 / Candidate gene for inflammation*
6 / 76556619 / MYO6 / rs3798440 / Candidate gene for inflammation* [38]
6 / 76559909 / MYO6 / rs12211735 / rs3798440 / Candidate gene for inflammation*
6 / 76560498 / MYO6 / rs9350602 / rs3798440 / Candidate gene for inflammation*
6 / 88652580 / AKIRIN2, SPACA1 / rs2509458 / Blood pressure regulation [2]
7 / 30419853 / NOD1 / rs6946944 / Candidate gene for inflammation*/dbGap
7 / 30499575 / NOD1 / rs2906766 / Candidate gene for inflammation*/dbGaP
7 / 30513159 / NOD1 / rs932272 / Candidate gene for inflammation*/dbGaP
7 / 106411858 / AF086203 / rs17477177 / Blood pressure regulation [8]
8 / 19824667 / LPL / rs15285 / Blood pressure regulation [11]
8 / 73106916 / TRPA1, RNA5SP271 / rs1963982 / Blood pressure regulation [2]
8 / 120353267 / NOV / rs2469997 / Candidate gene for inflammation* [38]
8 / 120435812 / NOV / rs2071518 / Blood pressure regulation [8]
8 / 126493746 / TRIB1 / rs2954033 / Blood pressure regulation [11]
8 / 135567046 / ZFAT / rs1372662 / Candidate gene for inflammation*
9 / 36969205 / PAX5 / rs16933812 / Candidate gene for inflammation, blood pressure regulation** [17]
9 / 120462253 / TLR4 / rs10513308 / Candidate gene for inflammation** [3]
9 / 120601806 / TLR4, DBC1 / rs628926 / Candidate gene for inflammation** [30]
9 / 120608720 / TLR4 / rs10513311 / Candidate gene for inflammation** [4]
9 / 120657906 / TLR4 / rs1399431 / Candidate gene for inflammation**, [14]
9 / 120913104 / TLR4/DBC1 / rs2806117 / Candidate gene for inflammation** [21, 22]
9 / 121278291 / TLR4, DBC1 / rs4132476 / Candidate gene for inflammation** [23]
9 / 121339090 / TLR4 / rs10984096 / Candidate gene for inflammation** [6]
9 / 121346417 / TLR4, DBC1 / rs1572299 / Candidate gene for inflammation** [16]
9 / 121546987 / TLR4, DBC1 / rs1571093 / Candidate gene for inflammation, blood pressure regulation** [2]
9 / 121718918 / TLR4 / rs10984338 / Candidate gene for inflammation*
BP base pair,LD linkage disequilibrium, PheGenI the database Phenotype-Genotype Integrator, SNP single nucleotide polymorphism
*PheGenI/No publication
** PheGenI
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SDC2. Table 2Quality control of samples
Sample exclusions / Total (n) / Cases (n) / Controls (n)Samples originally included in study cohort / 2187 / 1055 / 1130
Controls excluded due to other complicationsa / 109 / 0 / 109
Excluded due to unusable DNAb / 125 / 9 / 116
Excluded due to >5% missing genotypes / 37 / 17 / 20
Excluded due to lack of phenotypic information on
pregnancies and births / 92 / 23 / 69
Final samples included in association analysis / 1822 / 1006 / 816
n numbers, SNP single nucleotide polymorphism.
aPregnancies with gestational hypertension, stillbirths, placental abruption, or pre-pregnancy health conditions: chronic hypertension, heart disease, or renal disease.
bSamples failed all SNP assays.
SDC3. Table 3 Quality control of single nucleotide polymorphisms
SNP Exclusionsa / SNPs (n)SNPs originally selected for genotyping / 115
SNPs excluded due to poor designability (n=10) / 10
SNPs added to replace those with poor designability (n=17)b / 17
Excluded from analysis due to missingness >2% (n=3) / 3
Excluded due to deviance from HWE in controls (n=0) / 0
Final SNPs inlcuded in the association analysis, average call rate 99.8% / 119
LD linkage disequilibrium, n numbers, SNP single nucleotide polymorphism, HWE Hardy Weinberg Equilibrium
aOf the 115 SNPs, 12 failed designability. These were replaced by every available SNP that fitted the requirements of the Sequenom MassARRAY system and were in linkage disequilibrium (r2 =1) with any of the failing SNPs according to database SNAP [1], Hapmap release 21. This resulted in the addition of 23 replacement SNPs. Only one of the original twelve SNPs which failed designability, rs319690, could not be substituted, as no surrogate SNP was identified.
bAll SNPs in LD (r2=1) with any SNP of poor designability were originally considered (n=23), 6 of these failed designability and the remaining 17 were genotyped.
References:
[1] Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics. 2008;24: 2938-2939.
SDC4. Table 4 All results from the association analysis against phenotype preeclampsia
Chrom / Gene / Base pair / SNP / P-value / Rank / Odds ratio / Lower CI 95% / Upper CI 95%
1 / CASZ1 / 10799577 / rs12046278 / 0.4407 / 53 / 0.9472 / 0.825189639 / 1.08725049
1 / MTHFR / 11862778 / rs17367504 / 3.52E-05 / 1 / 0.6499 / 0.529878743 / 0.797106914
1 / ATG4C/FOXD3 / 63590954 / rs10493339 / 0.1286 / 18 / 1.134 / 0.964216475 / 1.333679763
1 / ATG4C/FOXD3 / 63591224 / rs11578482 / 0.1508 / 25 / 1.127 / 0.957387886 / 1.326660823
1 / ATG4C/FOXD3 / 63602535 / rs11583678 / 0.1644 / 26 / 1.123 / 0.953591488 / 1.322504464
1 / MOV10 / 113216543 / rs2932538 / 0.3427 / 43 / 0.928 / 0.795266613 / 1.082887155
1 / RGS5 / 163111066 / rs2841993 / 0.9155 / 115 / 0.9915 / 0.846856927 / 1.160848095
1 / RGS5 / 163163777 / rs7513108 / 0.7644 / 99 / 0.9712 / 0.802252699 / 1.175726104
1 / RGS5 / 163260844 / rs16852030 / 0.4541 / 55 / 0.9046 / 0.695744671 / 1.176151532
1 / RYR2, CHRM3, ZP4 / 239436542 / rs2820037 / 0.6323 / 78 / 1.045 / 0.872593782 / 1.251470068
1 / NLRP3 / 247600301 / rs1539019 / 0.8891 / 110 / 1.01 / 0.878173912 / 1.161615013
1 / NLRP3 / 247601595 / rs12239046 / 0.5356 / 64 / 1.047 / 0.905391741 / 1.210756571
2 / GCKR / 27742603 / rs780093 / 0.5216 / 62 / 0.9531 / 0.82288256 / 1.10392376
2 / LOC344371, MYADML,
FAM98A, RASGRP3 / 34284984 / rs6711736 / 0.3604 / 46 / 1.068 / 0.927561872 / 1.229701257
2 / Intergenetic
-not mapped to gene / 83292565 / rs10496288 / 0.8603 / 107 / 1.019 / 0.826303344 / 1.25663415
2 / GPR39 / 133189239 / rs10188442 / 0.6194 / 76 / 1.044 / 0.880861526 / 1.23735226
2 / FIGN / 164915208 / rs13002573 / 0.866 / 109 / 0.9858 / 0.834917163 / 1.16394977
2 / FIGN / 164963486 / rs1446468 / 0.3162 / 40 / 0.9307 / 0.808754808 / 1.071032261
2 / STK39 / 169041386 / rs6749447 / 0.7002 / 90 / 0.9696 / 0.828601546 / 1.134591366
2 / CCL20/TDGF1P2 / 228715375 / rs7591163 / 0.198 / 28 / 1.106 / 0.948710065 / 1.289367579
3 / CNTN4 / 2654691 / rs4370013 / 0.2097 / 30 / 1.123 / 0.936830041 / 1.346166267
3 / SLC4A7 / 27537909 / rs13082711 / 0.08196 / 8 / 0.8593 / 0.724333533 / 1.019415029
3 / ULK4 / 41877414 / rs3774372 / 0.08596 / 11 / 1.172 / 0.977799397 / 1.404770758
3 / MRPS22 / 138903985 / rs7638110 / 0.6577 / 83 / 0.9434 / 0.729060848 / 1.220753471
3 / MECOM / 169165888 / rs1918974 / 0.3004 / 38 / 1.076 / 0.936703732 / 1.236010876
4 / TLR1 / 38802751 / rs5743594 / 0.6727 / 86 / 0.9642 / 0.814156849 / 1.141895006
4 / TLR1, TLR6 / 38820986 / rs7696175 / 0.8056 / 100 / 0.9827 / 0.855187103 / 1.129225741
4 / PDGFRA / 54799245 / rs871606 / 0.9069 / 113 / 1.015 / 0.790859487 / 1.302665034
4 / FGF5 / 81164723 / rs1458038 / 0.1419 / 23 / 1.112 / 0.965115997 / 1.281238736
4 / PRDM8/FGF5 / 81184341 / rs16998073 / 0.1367 / 21 / 1.114 / 0.966353058 / 1.284205591
4 / ADH1C/ADH7 / 100322445 / rs991316 / 0.8348 / 103 / 0.9854 / 0.858186676 / 1.131470794
4 / SLC39A8 / 103188709 / rs13107325 / 0.3555 / 45 / 0.8566 / 0.616853512 / 1.189526437
4 / GUCY1A3 / 156645513 / rs13139571 / 0.4712 / 57 / 0.9406 / 0.79627018 / 1.11109066
5 / NPR3/C5orf23 / 32815028 / rs1173771 / 0.1308 / 20 / 0.8955 / 0.776042317 / 1.033346033
5 / RANBP3L / 36425593 / rs12522034 / 0.8219 / 102 / 1.019 / 0.864968305 / 1.200461328
5 / XRCC4 / 82433781 / rs6452524 / 0.5583 / 67 / 1.042 / 0.907906039 / 1.195899083
5 / CAMK4 / 110772404 / rs10491334 / 0.107 / 13 / 0.8579 / 0.71202428 / 1.033661957
5 / MARK2P11/EBF1 / 157845402 / rs11953630 / 0.9057 / 112 / 0.9914 / 0.859383088 / 1.143697117
6 / HFE / 26091179 / rs1799945 / 0.4759 / 58 / 0.9263 / 0.750485794 / 1.143301707
6 / BAG6 / 31616366 / rs805303 / 0.4897 / 60 / 1.051 / 0.912658507 / 1.210311405
6 / AGER/RNF5/PBX2 / 32151443 / rs2070600 / 0.8982 / 111 / 0.9786 / 0.702546393 / 1.363124158
6 / VEGFA/C6orf223 / 43757896 / rs998584 / 0.6537 / 82 / 1.032 / 0.899321146 / 1.184253262
6 / VEGFA/C6orf223 / 43758873 / rs6905288 / 0.2796 / 34 / 0.9264 / 0.806514078 / 1.064106608
6 / VEGFA/C6orf223 / 43791897 / rs6902871 / 0.4175 / 50 / 1.104 / 0.869146075 / 1.402314335
6 / VEGFA/C6orf223 / 43793391 / rs6940798 / 0.6149 / 75 / 1.063 / 0.837841745 / 1.348666387
6 / VEGFA/C6orf223 / 43796146 / rs4273687 / 0.5638 / 69 / 1.073 / 0.844682124 / 1.363032278
6 / VEGFA / 43804571 / rs729761 / 0.4243 / 51 / 0.9388 / 0.804065886 / 1.096110972
6 / AK097853 / 43811762 / rs9472138 / 0.6386 / 79 / 0.9642 / 0.828118481 / 1.122643271
6 / LOC100132354 / 43886159 / rs721640 / 0.2825 / 36 / 0.9174 / 0.783927614 / 1.073597542
6 / LOC100132354 / 43897727 / rs9472155 / 0.5309 / 63 / 1.054 / 0.89412675 / 1.242459192
6 / VEGFA/C6orf223 / 43919695 / rs9472159 / 0.6041 / 74 / 0.9647 / 0.84215984 / 1.105070612
6 / VEGFA/C6orf223 / 43925607 / rs6921438 / 0.4585 / 56 / 0.9493 / 0.827293736 / 1.089299303
6 / VEGFA/C6orf223 / 43927050 / rs7767396 / 0.4303 / 52 / 0.9459 / 0.823789972 / 1.086110345
6 / VEGFA/C6orf223 / 43951656 / rs910609 / 0.07415 / 7 / 0.856 / 0.721698535 / 1.015293733
6 / MYO6 / 76552563 / rs3798441 / 0.1371 / 22 / 0.8636 / 0.711784846 / 1.047795503
6 / MYO6 / 76553836 / rs12210386 / 0.1031 / 12 / 0.8509 / 0.700746668 / 1.033227618
6 / MYO6 / 76559909 / rs12211735 / 0.1302 / 19 / 0.8615 / 0.710231287 / 1.044986702
6 / MYO6 / 76560498 / rs9350602 / 0.1142 / 16 / 0.8557 / 0.705252048 / 1.038242274
6 / AKIRIN2/SPACA1 / 88652580 / rs2509458 / 0.5544 / 66 / 0.9295 / 0.729429444 / 1.184446635
7 / NOD1 / 30419853 / rs6946944 / 0.5406 / 65 / 0.9199 / 0.704040999 / 1.20194138
7 / NOD1 / 30499575 / rs2906766 / 0.6655 / 84 / 0.9683 / 0.836729815 / 1.120558719
7 / NOD1 / 30513159 / rs932272 / 0.3815 / 48 / 0.94 / 0.818358483 / 1.079722418
7 / AF086203 / 106411858 / rs17477177 / 0.1976 / 27 / 1.114 / 0.945281998 / 1.312831517
8 / LPL / 19824667 / rs15285 / 0.8551 / 105 / 0.9859 / 0.846527958 / 1.148218202
8 / TRPA1-RNA5SP271 / 73106916 / rs1963982 / 0.85 / 104 / 1.013 / 0.886081862 / 1.158097286
8 / NOV / 120353267 / rs2469997 / 0.06166 / 6 / 1.192 / 0.991458949 / 1.433104217
8 / NOV / 120435812 / rs2071518 / 0.2665 / 32 / 1.096 / 0.93236884 / 1.288348504
8 / TRIB1 / 126493746 / rs2954033 / 0.8598 / 106 / 1.014 / 0.869033376 / 1.183149034
8 / ZFAT / 135567046 / rs1372662 / 0.08412 / 10 / 1.131 / 0.983549817 / 1.300555373
9 / PAX5 / 36969205 / rs16933812 / 0.04031 / 3 / 0.8546 / 0.735426558 / 0.993085104
9 / TLR4 / 120462253 / rs10513308 / 0.861 / 108 / 0.9553 / 0.572577175 / 1.593842944
9 / TLR4/DBC1 / 120601806 / rs628926 / 0.9314 / 117 / 1.006 / 0.877901225 / 1.152790281
9 / TLR4 / 120608720 / rs10513311 / 0.7351 / 96 / 0.9768 / 0.852612143 / 1.119076532
9 / TLR4 / 120657906 / rs1399431 / 0.4826 / 59 / 1.05 / 0.916302749 / 1.203204947
9 / TLR4/DBC1 / 120913104 / rs2806117 / 0.6532 / 81 / 1.063 / 0.81431335 / 1.387634133
9 / TLR4/DBC1 / 121278291 / rs4132476 / 0.08257 / 9 / 0.8134 / 0.64421769 / 1.027012406
9 / TLR4 / 121339090 / rs10984096 / 0.2021 / 29 / 0.8899 / 0.743878203 / 1.064585583
9 / TLR4/DBC1 / 121346417 / rs1572299 / 0.303 / 39 / 1.076 / 0.93600367 / 1.236935322
9 / TLR4/DBC1 / 121546987 / rs1571093 / 0.8119 / 101 / 0.9834 / 0.856752071 / 1.128769445
9 / TLR4 / 121718918 / rs10984338 / 0.1092 / 14 / 0.7964 / 0.602772015 / 1.052226952
10 / CACNB2 / 18708798 / rs11014166 / 0.7038 / 91 / 1.03 / 0.884419457 / 1.19954394
10 / CACNB2 / 18727959 / rs12258967 / 0.6248 / 77 / 1.041 / 0.886162747 / 1.222891624
10 / C10orf107 / 63467553 / rs4590817 / 0.6416 / 80 / 1.044 / 0.870873912 / 1.25154283
10 / C10orf107 / 63524591 / rs1530440 / 0.296 / 37 / 0.9106 / 0.763917193 / 1.085447962
10 / PLCE1 / 95895940 / rs932764 / 0.5083 / 61 / 0.9535 / 0.828032709 / 1.097978667
10 / CYP17A1 / 104594507 / rs1004467 / 0.9238 / 116 / 1.011 / 0.80796322 / 1.265058823
10 / NT5C2 / 104846178 / rs11191548 / 0.9075 / 114 / 1.015 / 0.789574668 / 1.304784768
10 / ADRB1 / 115781527 / rs2782980 / 0.56 / 68 / 1.045 / 0.901221106 / 1.211717073
11 / EF537580 / 10350538 / rs7129220 / 0.7225 / 95 / 0.9566 / 0.74881782 / 1.222037638
11 / PLEKHA7 / 16917219 / rs11024074 / 0.1095 / 15 / 0.8825 / 0.757240284 / 1.028479686
11 / ARHGAP42 / 100593538 / rs633185 / 0.711 / 93 / 0.9722 / 0.837497179 / 1.128568386
11 / ZNF259 / 116649135 / rs11823543 / 0.3305 / 41 / 1.155 / 0.864035228 / 1.543947464
11 / APOA5/ZNF259 / 116660686 / rs2266788 / 0.708 / 92 / 0.9494 / 0.723502772 / 1.245828482
11 / AX747213/ADAMTS8/
BC144419/BC144418 / 130273230 / rs11222084 / 0.05473 / 5 / 0.8678 / 0.750912847 / 1.002881816
12 / ANO6 / 45930973 / rs10785581 / 0.9837 / 119 / 1.002 / 0.827223035 / 1.213704113
12 / ATP2B1 / 90060586 / rs17249754 / 0.02206 / 2 / 0.7993 / 0.659804625 / 0.968287377
12 / SH2B3 / 111884608 / rs3184504 / 0.1268 / 17 / 1.112 / 0.970331953 / 1.274351521
12 / TBX5, TBX3 / 115352731 / rs2384550 / 0.6929 / 89 / 1.029 / 0.892889877 / 1.185858444
14 / c14orf179, C14orf118 / 76613678 / rs935334 / 0.5991 / 73 / 1.054 / 0.866326827 / 1.282328984
14 / GPATCH2L / 76650764 / rs2121070 / 0.5909 / 72 / 1.056 / 0.865721784 / 1.288099734
15 / CSK / 75077367 / rs1378942 / 0.3938 / 49 / 0.9399 / 0.815100204 / 1.083807862
15 / CPLX3 / 75125645 / rs6495122 / 0.1451 / 24 / 0.9014 / 0.783923652 / 1.036480986
15 / FES / 91437388 / rs2521501 / 0.7613 / 98 / 1.024 / 0.878704717 / 1.193320099
16 / UMOD / 20365654 / rs13333226 / 0.6691 / 85 / 1.041 / 0.865806622 / 1.251643233
16 / NOD2 / 50739582 / rs17221417 / 0.3521 / 44 / 1.082 / 0.916501091 / 1.277384187
16 / NOD2 / 50755709 / rs10521209 / 0.6791 / 88 / 1.029 / 0.898655941 / 1.178249596
16 / NOD2 / 50756774 / rs5743289 / 0.7225 / 94 / 1.038 / 0.844889334 / 1.27524867
16 / MPHOSPH6/CDH13 / 82642651 / rs11646213 / 0.2697 / 33 / 0.9238 / 0.802514196 / 1.063416004
16 / CDH13 / 83764204 / rs3096277 / 0.3712 / 47 / 1.079 / 0.913363983 / 1.274673648
17 / PLCD3/ACBD4 / 43208121 / rs12946454 / 0.04585 / 4 / 0.8524 / 0.728725756 / 0.997063372
17 / GOSR2 / 45013271 / rs17608766 / 0.9786 / 118 / 1.003 / 0.805830478 / 1.248412696
17 / ZNF652 / 47402807 / rs12940887 / 0.7539 / 97 / 1.023 / 0.887428654 / 1.179282408
17 / ZNF652 / 47440466 / rs16948048 / 0.6778 / 87 / 1.031 / 0.892708823 / 1.190714119
18 / MCAR / 57963117 / rs17773430 / 0.5887 / 71 / 0.9608 / 0.831153488 / 1.110669272
19 / NLRP12/MYADM / 54332061 / rs7259148 / 0.5818 / 70 / 1.04 / 0.904515859 / 1.195777818
19 / NLRP12/MYADM / 54332311 / rs7258592 / 0.2317 / 31 / 1.1 / 0.940931524 / 1.285959679
20 / JAG1 / 10969030 / rs1327235 / 0.4517 / 54 / 1.054 / 0.919084451 / 1.208720263
20 / MACROD2 / 15599531 / rs200752 / 0.3321 / 42 / 1.109 / 0.899770981 / 1.36688227
20 / ZNF831/EDN3 / 57758720 / rs16982520 / 0.2803 / 35 / 1.108 / 0.919775452 / 1.334743167
Chrom chromosome, CI 95% 95% confidence interval
SDC5 Table 5 Variables included evaluated as possible covariates in the preeclampsia association analysis. P-values from the generalized linear model
Variable / P-value for association with preeclampsiaTotal number of times a woman gave birth / <0.00001a
Smoking ever / <0.00001a
Average BMI at participation in HUNT / <0.00001a
Number of prior births / <0.00001a
The year the birth took place / <0.00001a
Maternal age at time of birth / <0.001a
Twin pregnancies / <0.01a
Pre-pregnancy diabetes mellitus b / 0.92
Having had a pregnancy resulting in stillbirth / 0.95
Pre-pregnancy chronic kidney disease / 0.97
Pre-pregnancy chronic hypertension / 0.97
BMI body mass index, HUNT The HUNT Study
a Statistically significant association
b Including both diabetes mellitus type 1 and type 2
SDC6. Figure 1 QQ-plot of association p-values demonstrating a linear pattern suggesting the observed p-values in this study to be distributed mainly as expected by chance with one outlier