From,

DR, SUJATA.V

Preliminary M.S. (Ayu) Scholar.

Department of Post Graduate Studies in Prasooti Tantra and Stree Roga.

N.K.J.A.M.C & P.G CENTER

Bidar 585403

To,

THE REGISTERAR,

Rajiv Gandhi University of Health Science

Bangalore, Karnataka

Through,

The Principal & H.O.D PG, studies in Prasooti Tantra and Stree Roga.

N.K.J.A.M.C P.G CENTER

Bidar -585403

SUBJECT:-Submission of completed Performa for registration of synopsis of dissertation.

Respected sir,

I request you to kindly register the below mentioned subject in my name for the submission of dissertation to the Rajiv Gandhi University of Health Science,Banglore, for the partial fulfillment of M.S(AYU) in Prasooti Tantra & Stree Roga.

THE TITLE OF DISSERTATION

“ROLE OF LASUNA GHRITA IN FEMALE INFERTILITY W.S.R TO ANOVULATION.”

I am enclosing completed Performa for registration of subject of dissertation

Thanking you,Yours Faithfully

Date:

Place:-BIDAR (DR.SUJATA.V)

RAJIV-GANDHI UNIVERSITY OF HEALTH SCIENCE BANGLORE –KARNATAKA

ANNEXURE- II

PROFORNMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

1. Name of the Candidate:- DR..SUJATA

D/O (LATE) VEERANNA CHITNLLIKAR

ROSE- NIVAS. PLOT NO.14

KUMBARWADA ROAD

BIDAR-585403(K.S)

2. Name of Institution :- N.K.J AYURVEDIC MEDICAL COLLEGE

& P.G.CENTER.

BIDAR-585403

KARNATAKA.(INDIA)

3. Course of Study & Subject:- M.S(PRASOOTI TANTRA & STREE ROGA)

4. Date of Admission to Center- 16/OCT /2012

5. TITLE OF THE TOPIC

“ROLE OF LASUNA GHRITA IN FEMALE INFERTILITY W.S.R TO ANOVULATION.”

6.BRIEF RESUME OF THE INTENDED WORK:

INTRODUCTION

“Failure to achieve conception by a couple of mature age having normal coitus, during appropriate period of menstrual cycle regularly at least for one year is termed as Infertility”. It develops due to faults in either partner or both.

Female infertility is usually more or less a combination of Nature & Nurture i.e. in an advanced time females are affected & attracted towards luxurious & prevalent hectic life style. Stress, anxiety,anorexia, unhealthy schedule of diet & habits, non- observance of Rajaswala- charya etc, are capable for hormonal imbalance leading the women in a state of infertility.

6.1 NEED FOR THE STUDY

As conception depends on multiple factors i.e. healthy reproductive organs. Ovarianfactor is one among them(1). But nowadays there is noticeable decline in ability to achieve conception beyond the age of 35 years,due to drastic changes in Quantity & Quality of Ovum, leading tomenstrual abnormality & Infertility.

According to Ayurveda –Acharyas mentioned “Beeja” among Garbha sambava samagri, & any abnormality of this may lead to failure to get progeny.

In the present era the periodical investigations & treatments of infertility by allied systems may be troublesome because of its high cost & adverse effects(unbalancing the hormones).

As the formulations explained in our system are easily available,much potent,low cost & without such adverse effect.

Among them Acharya Kashyapa has been explained about the various uses of Lasuna in the form of “LASUNA–GHRITA,” in the treatment of infertility. Hence the Present drug is selected for the study on basis of its multiple actions.

6.2 REVIEW OF LITERATURE

1. All our Acharyas explained about the importance of Arthava (Beeja) in the formation of Garbha, Any deformities to Arthava (arthavadusti) if not treated or treated improperly may lead to Abeejatwa (2,3).

2. The women who is habitual to vatakara ahara vihara, then vrudda vata can spoil the Beeja & Beejabhaga(4) & any injury or obstruction of the Arthava Vaha Srotas leads to Vandhyatwa(5).

3. Atyusna ahara & teeksna virechana in mrudu kosta women can vitiates Arthava, Beeja , Pushpopaghata & Beejopaghata respectively (7a.b).

4. In Puspagni jataharini though the women is menstruating regularly but unable to conceive due to fruitless menses. (7c).

5. Lasuna is indicated in all the Arthava dusti Chikitsa, and the women who consumes lasuna regularly, she will never been Infertile or ugly look. It is as true as stone-line ((7d, e, f).

LIST OF PREVIOUS RESEARCH WORK DONE.

1. Jadhav.S.S-Role of Prajastapana gana siddha ghrita uttarabasti & oral prayoga in the management of Vandhyatwa w.s.r Beejotsarga(ovulation)-P.G.T & R.A GujaratAyurvedicUniversity -L-2726(1885) Jamnagar-2002

2.Vijay kumar-Management of Primary Infertility w.s.r.to.Kalyanaka Guda.Govt.Ayurvedic college.Kerala.Trivendrum.2003.

3.Kongi Hemalata-Clinical management of stree-vandhytwa with ashwagandha ksheerapaka.N.K.J.A.M.C.Bidar.2004.

4. Savaliya Hetal C-Comparative study of Shatapushpa choornaS and Shatapushpa taila uttarabasti in Vandhya w.s.r Viphala artava.(anovulation factor).I.P.G.T & R.A Gujarat Ayurveda University Jamnagar, 2005.

6.3 OBJECTIVES OF THE STUDY

  • To assess the efficacy of ‘Lasuna Ghrita’ in infertility inthe management of ‘ANOVULATION’.

7.MATERIALS AND METHODS

7.1. SOURCE OF DATA

  • Patients will be selected from OPD of PTSR department of ShriSiddharooda charitable teaching hospital ofN.K.J.A.M.C Bidar.
  • Ayurvedic classics, Books of Medicine, Pharmacology.
  • Pharmacy attached to college for preparation of medicine.
  • Raw drugs are collected from the local market & prepared under the supervision of Rasa shastra & bhaishaijya kalpana & dravya guna specialist.

7.2METHODS OF COLLECTIONS OF DATA:-

1. Patients are collected with simple random sampling method by inclusioncriteria.

2. Separate case sheet will be prepared monitoring the signs & symptoms of infertility, treatment chart & follow up study will be carried out regularly

3.Proceduresare conducted under the supervision of guide, co-guide & expert dept, staff

RESEARCH DESIGNS

  • 30 patients will be selected by randomized method for single study.
  • Lasuna ghrita will be administered to the patients selected according to inclusion criteria.
  • Before starts the treatment thoroughcounseling of patients will be done.

DRUG REVIEW (7d)

DRUG / RASA / GUNA / VIRYA / VIPAKA / KARMA
Lasuna / Pancharasa / Snigdha / Usna / Madura / Vatakaphahara
(Allium sativum) / Tikta(+) / Pichila / Deepana
Madura(+) / Guru / Vrushyam
Kashaya / Sara / Srotas vishodanam
Lavana / Teekshna / Shonita jananam
Katu / Garbha jananam

SELECTION OF CHIKITSA.

  • ORAL MEDICATIONLASUNA GHRITA.
  • DOSAGE20ML, TWICE DAILY IN AN EMPTY STOMACH.
  • DURATION3 CONSECUTIVE CYCLE. (FROM 3rd DAY OF LMP).
  • ANUPANALUKE WARM WATER.

FOLLOW-UP:-Everymonthfor follicular study 3-cycles.

SELECTION CRITERIA:-

A.INCLUSION-CRITERIA

1. Married women age group between 20-35 years.

2. Primary & secondary infertilitywith anovulation.

B.EXCLUSION CRITERIA

  1. Age group above 35 years with pelvic pathology.
  2. Thyrotoxicosis,hypothyroidismand other sever systemic disorders.
  3. Congenital abnormalities of genital organs.

ASSESMENT CRITERIA

A)SUBJECTIVE PARAMETER

1. Primary & secondary infertility.

B) OBJECTIVE PARAMETER

1.Follicular study.

2. Endometrial thickness.

STATISTICAL ANALYSIS

Subjective & objective parameters will be assessed based on before & after treatment with appropriate statistical analysis.

7.3 INVESTIGATION REQUIRED

  • USG pelvis with follicular study.
  • CBP with ESR.
  • Urine routine.
  • Hormonal assay-if necessary.

7.4. HASCLINICAL ETHICAL CLEARANCE BEEN OBTAINED FROM YOUR INSTITUTE?

YES, Obtained.

8. LIST OF REFERENCES:-

1. Textbook of Gynaecology, D.C.Datta- Calcutta. New Central Book Agency (P) Ltd.

West Bengal.4th edition, 2005. (Chptr-15-214,215pp).

2. SUSHRUTA Sushruta samhita .Kaviraj Dr.Ambikadatta.Chaukamba Sanskrit samstan.Varanasi.8th edition1993.(Sharir sthana- 2/5,9pp).

3. VRUDHA VAGBHATAAstanga Sangraha.Prof.Jyothi mitra. Varanasi, Chaukamba Sanskrit series.UP.Reprint-2006. (Sharir sthana-1/23,268pp).

4. VAGBHATA Astanga Hrudaya .Prof.K.R.Shrikanta murthy.Krisnananda Academy. Varanasi .2nd edition.1994. (Sharir sthana 1/10.361pp).

5. SUSHRUTASushruta samhita. Prof.Shastri Ambikadatta.Chaukamba Sanskrit samstan.Varanasi.8th edition.1993. (Sharir sthana 9/12.72pp).

6.Ayurvediya Prasuti tantra evum Stree roga.Premavati Tivari.Chaukamba Orientalia.Reprint

2012.(Chptr-5.274pp).

7. KASHYAPA Kashapa Samhita.P.V.Tivari.Chaukamba Vishva Bharati. Varanasi.Reprint-2002.

a) K.S.Siddi sthana-3/20..282-283 pp. b) K.S.Kalpa sthana -7/32..381pp.

c) K.S.Kalpa sthana-6/33-34..357pp. d) K.S.Kalpa sthana-2/13-22..327pp.

e) K.S.Kalpa sthana-2/26..328pp. f) K.S.Kalpa sthana-2/97..335pp.

9. SIGNATURE OF CANDIDATE:

10. REMARKS OF THE GUIDE:

11. NAME & DESIGNATION OF:

(In block letters)

11.1 GUIDE: Dr SUKHADADEVI, M.D. H.O.D

Associate Professor

P.G. Dept. Prasuti Tantra & Stree Roga,

N.K.J.A.M.C & P.G Centre, Bidar.

11.2 SIGNATURE:

11.3 CO-GUIDE Dr MANISHA.K, M.S.

Reader

P.G Dept. Prasuti Tantra & Roga,

N.K.J.A.M.C & PG Centre,Bidar

11.4 SIGNATURE:

11.5 HEAD OF DEPARTMENT: Dr SUKHADADEVI, M.D. H.O.D

Associate Professor

P.G. Dept. Prasuti Tantra & Stree Roga,

N.K.J.A.M.C & P.G Centre, Bidar.

11.6 SIGNATURE:

12.1 REMARKS OF THE CHAIRMAN &

PRINCIPAL/DEAN : Dr.K.V.L NARASIMHACHARYULU

PROF. M.D (AYU)

12.2 SIGNATURE: