Davis 241 Immune System Objectives Chapter 22

  1. Name the components of the lymphatic system and their general functions.
  2. What is the role of the lymphatic system in regulating the volume of interstitial fluid?
  3. Describe the formation, composition, and circulation of lymph.
  4. Relate the functions of the lymphatic system to that of the blood vascular system.
  5. What is edema? What might favor the development of edema (e.g. What changes would favor the transfer of liquid from tissues to plasma across capillary walls) ?
  6. What is the fundamental difference between specific and nonspecific immunity?
  7. Describe non-specific immunity details.
  8. What are complement, interferon and how do they function?
  9. What happens during inflammation? Draw a stylized diagram if the process of inflammation. Label with Structure and FUNCTION.
  10. What is the role of Natural Killer cells in immune surveillance.
  11. Explain humoral and cell mediated immunity (How do T cells, B cells and natural killer cells function?)
  12. What is an antigen, antibody?
  13. What is the difference between active (acquired) and innate immunity?
  14. What is the difference between a primary and secondary immune response?
  15. What is meant by the concept of memory in the immune system?
  16. Describe the structural similarities and differences between an antibody and a T-cell receptor.
  17. What is the importance of antigen presentation in the specific immune response?
  18. How is the ability to differentiate self from nonself, and memory important in the immune system?
  19. Understand figures 22-23, 24 and 25, IP exercises and handout study questions.
  20. What are the advantages of the cascade of complement reactions activated by antibody binding?
  21. People with type I diabetes who have been treated with insulin may develop antibodies to insulin; those without diabetes do not make such antibodies. Explain.
  22. What is the role of the immune system in preventing cancer? Could aging in the immune system contribute to the fact that cancer is much more frequent in older individuals? Explain.
  23. In most cases, transfusion reactions are the result of the recipient’s antibodies attacking the transfused cells. In what situations is an attack of donor antibodies on the recipient’s cells possible? Such reactions are usually not a problem – can you figure out why?
  24. What is an autoimmune disease? List THREE examples of autoimmune diseases.

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  1. Helper - initiate immune response
  2. Cytotaxic - lyse viral infected cells
  3. Inducer - oversee the development of T cells
  4. Suppressor - terminate immune response
  5. Proliferation - lymphokines cause stimulated T cells to multiply, increase the number of cells able to recognize antigens
  6. Activation - macrophages migrate to area of infection
  7. Induction - triggers the maturation of immature thymus lymphocytes into T cells
  8. Attack - cytotaxic cells bind and disrupt cell membrane of viral infected celllyse cell
  9. Suppression - suppressor cell multiply more slowly than cytotaxic but eventually outnumber then and shut them down
  10. Memory - generation of a population of memory T cells, provide accelerated response to later infection
  11. Proliferation - B receptors bind to antigens recognized by helper T cells, which further bind antigen and MHC -II on B cells, releasing lymphokines and causing B cells to multiply
  12. Differentiation and Secretion - B plasma cells secrete M (primary) and G (secondary) Ab’s
  13. Attack - M Ab’s activate compliment, which bursts Ab coated cells, macrophages ingest G-coated cells, and killer cells attack Ab-coated cells
  14. Suppression - response shut down by suppressor T cells
  15. Memory - B cells that do not become plasma cells circulate as memory B cells to provide accelerated response