David Sainsbury Fellowshipoutline Form

David Sainsbury FellowshipOutline Form

1. Email address

1. Institutional address

1. Sponsor name (incl., title)

1. Institutional address (if different from above)

Title of the Project

1. Details of collaborations or time that will be spent in labs outside of your home institution during the course of the Fellowship.(maximum ~ 150 words)

1. Scientific Background (maximum ~ 250 words)

1. Objectives of the project and experimental plan (maximum ~ 300 words)

1. Does your project seek to replace, reduce, or refine the use of animals in research?

Replacement Reduction Refinement

1. Describe the current animal models/protocols that are in use in the area of interest, including the severity of harm, and the species and numbers of animals used. Then detail which of these models/protocols your project would seek to replace, reduce, or refine, and the species and potential numbers of animals that would be affected locally, and in the wider scientific community. (maximum ~ 300 words)

Please provide realisticmetrics quantifying the scale of animal use and 3Rs impact.

Estimates can be made by, for example, searching literature databases to see how many papers are published each year reporting use of the particular animal model(s) and the typical number of animals used per experiment in the published papers.Consider answering the following questions:

Replacement/Reduction:

• How many experiments/procedures/tests of this type are conducted in your laboratory/company? How many laboratories/companies worldwide conduct these tests? How many animals would no longer be used per experiment/procedure/test? What is the percentage reduction in animal use that could be achieved?

Refinement:

• What is the evidence that animal suffering will be reduced/animal welfare improved? What objective indicators will be used to assess animal welfare? Is the severity limit for the procedure/protocol likely to be downgraded as a result of the proposed refinement technique? How many animals are likely to benefit per year both locally and in the wider scientific community?

1. If you are developing a new model, tool, or protocol, explain how it will improve on the existing models, tools, or protocols, from both scientific and 3Rs perspectives. (maximum ~ 200 words)Preliminary data and realistic 3Rs metrics should be included where possible.

1. If you are further characterising, validating, or otherwise improving on an existing model, tool, or protocol, or utilising an existing one for a novel application, describe what the additional scientific and 3Rs impact of the work would be beyond what had already been achieved in the initial development of the model/tool/protocol. (maximum ~ 200 words)Preliminary data and realistic 3Rs metrics should be included where possible.

1. Discuss the barriers you might face in achieving widespread community uptake of your model/tool/protocol, and posit solutions to overcome them. (maximum ~ 150 words)

1. What would be the continuing 3Rs impact of your work beyond the lifetime of the project? (maximum ~ 150 words)