Curriculum Vitae for ELAINE FUCHS
Investigator Howard Hughes Medical Institute
Rebecca C. Lancefield Professor of the Laboratory of Mammalian Cell Biology and Development
The Rockefeller University; 1230 York Avenue Box 300, NY, NY 10065-6399
Tell 212-327-7953;
EDUCATION AND TRAINING:
University of IllinoisB.S. Chemistry,1972; Highest distinction in the curriculum.
Princeton University:Ph.D., Biochemistry, 1977 (Professor Charles Gilvarg).
Massachusetts Inst. Technology:Postdoctoral Fellow, 1977-80 (Professor Howard Green).
POSITIONS:
1980-1985Assistant Professor, The University of Chicago.Department of Biochemistry.
1985-1988Associate Professor, TheUniversity of Chicago. Department of Biochemistry and Molecular Biology; Department of Molecular Genetics and Cell Biology
1988-1993Associate Investigator, Howard Hughes Medical Institute, The University of Chicago.
1989-1993Professor, The University of Chicago. Department of Biochemistry and Molecular Biology;Department of Molecular Genetics and Cell Biology; Committee on Developmental Biology; Committee on Genetics; Committee on Cancer Biology.
1993-2002Amgen Professor of Basic Sciences, The University of Chicago.
1993-2002Investigator, Howard Hughes Medical Institute, The University of Chicago.
2002-Investigator, Howard Hughes Medical Institute, The Rockefeller University.
2002-Rebecca C. Lancefield Professor, The RockefellerUniversity, Laboratory of Mammalian Cell BiologyDevelopment
HONORS and AWARDS:(* denotes special importance)
University of Illinois.1968-72:
Phi Beta Kappa
Phi Kappa Phi
Alpha LambdaDelta
Sigma Xi
Agnes Sloan Larson Award for the Outstanding Freshman Chemistry Student
Straight A Book Award
Iota Sigma Pi Award
Reynold Clayton Fuson Award in Chemistry
James Scholar
Illinois StateScholarship
Argonne National Laboratory Scholarship
Bronze Tablet (top 3% Class).
Princeton University. 1972-77:
NIH Predoctoral Fellowship.
Massachusetts Institute of Technology. 1977-79:
Damon RunyonPostdoctoral Fellow
University of Chicago.1980-01:
Andrew Mellon Fellow (‘81)
*Searle Scholar (‘81-’83)
NIH Career Development Award (‘82-’87)
*Presidential Young Investigator (‘84-’89)
Nation's 100 brightest scientists under 40 (Science Digest, ‘84)
Nation's Outstanding Scientists Lunch, White House (‘85)
R.R. Bensely Award (AmericanAssociation of Anatomists, '88)
Searle Scholar Alumnus Award Lecture (‘91)
NIH Merit Award (‘93-’03)
*Montagna Award(Society for InvestigativeDermatology, ‘95)
Keith Porter Lecture (AmericanSociety for Cell Biology ‘96)
*Senior Women's Career Achievement Award (American Society for Cell Biology ‘97)
*Harvey Lecture (Rockefeller University, ‘99)
*Hermann Pinkus Memorial Lecture Award (American Academy of Dermatopathology, ‘00)
*Richard Lounsbery Award (National Academy of Sciences, ‘01).
Rockefeller University. 2002-:
Cartwright Prize (Columbia University,‘02)
Cruikshank Memorial Lecturer (Gordon Research Conferences on Cell Adhesion, ‘02)
*Honorary Doctorate of Science Degree(Mt Sinai Sch. Medicine and New York University‘03)
*Novartis Award in Biomedical Research (shared with P. Sharp and D. Botstein, ‘03)
Distinguished Visiting Scientist (Singapore, ‘‘04)
*Dickson Prize in Medicine (’04)
*FASEB Award for Scientific Excellence (‘06)
*Honorary Doctorate of Science Degree (University of Illinois, Champaign-Urbana, ‘06)
*Beering Award (‘06)
Lecturer, College de France (by Invitation of the Assembly of Professors) (’08)
Rothschild-Yvette-Mayent Visiting Scholar of the Institut Curie (’08)
NIH MERIT Award (’09-)
** National Medal of Science (’09)
Distinguished Investigator Award (Emerald Foundation, ‘10)
Visiting Scholar of Phi Beta Kappa (‘10)
AACR-WICR Charlotte Friend Award (’10)
**L’Oreal UNESCO Award For Women in Science (’10)
*Madison Medal (Princeton University,‘11)
**Passano Award (‘11)
**Albany Prize in Medicine (’11)
Rockefeller University Teaching Award (’12)
New York Academy of Medicine (Basic Sciences and Medicine Award, November, ’12)
**March of Dimes Prize in Developmental Biology (‘12)
Lifetime Achievement Award (American Skin Association ‘13)
*Kligman-Frost Leadership Award (Society of Investigative Dermatology, ‘13)
*Pasarow Award for Cancer Research (‘13)
**Pezcoller Award for Cancer Research (to be awarded at the AACR meeting April 6, ’14).
Elected to Honorary Societies:
*American Academy of Arts and Sciences (‘94)
*Institute of Medicine of the National Academy of Sciences (‘94)
*National Academy of Sciences (‘96)
Fellow, American Academy of Microbiology (‘97)
Honorary member of the German Society of Dermatology (‘01)
The Harvey Society (‘04)
Fellow, New York Academy of Sciences (‘04)
*American Philosophical Society (‘05)
Fellow, American Association for the Advancement of Science (’08)
*EMBO Foreign Member (equivalent of the European National Academy of Sciences) (’10)
*Academy of the American Association for Cancer Research (’13).
Honorary/Named Lectures(2007-‘13):
Sokolow Lecturer (UCSF, ’07); Discovery Lecturer (Vanderbilt University,’07), Niewand Lecturer (University of Notre Dame, ’07); Blaffer Seminar (MD Anderson, ’07); Myron Levine Lecture (University of Michigan, ’07), Pittman Lecture (NIH, ’08); Dorcas Cummings Lecture (CSH Symposium on Stem Cells(’08); Chandrakant Dave Lecture (Roswell Park Cancer Institute, ’08); Distinguished Lecturer (SUNY Buffalo, ’08); Arthur Partite Lecture (Woods Hole; ’08); The Ritter Lecture (University of Georgia, ’08); Meyenburg-Stiftung Lecture (German Cancer Res. Center, ’08); Sharon Cosloy-Edward Blank Lecture (CUNY, ’08); Distinguished Lecturer (McGill University, ’09); Dean’s Lecture (Radcliffe University, ’09), Proctor & Gamble Lecture (UCincinnati, ’09); Eminent Scholar Award Lecture (MUSC, ’09); GABBA Inaugural Lecture (Porto, ’10); Bolie Lecture (University of Colorado, ‘10); Copp Lecture (University of British Columbia, ’10); Han Moo Koo (Van Andl Cancer Ctr, ’10); GABBA Inaugural Lect.(Porto’10); Danny Brower Mem. Lecture (University of Arizona, ’11); Harriott Lecture (Johns Hopkins’11); Nobel Forum Lecture (Stockholm ’11); Boxer Memorial Lecture (Robt Wood Johnson Med. School, ’11); Loren Knapp Lecture (USC, ’12); McCaskey Lecture (USC,’12); Dean’s Lecture (UTexas,’12); Benning Lecture (University of Utah, ’12); 13th Annual Cell & Developmental Biology Lecture (Stonybrook, ’12);Stem Cell Workshop (Vatican, Rome’12); Chipperfield Lecture (MIT, 2013); Mautner Lectures (UCLA, 2013); Alicia Showalter Reynolds Lecture (John’s Hopkins U, ‘13); Griem Lecture (U Chicago, ‘13); Adam Neville Lecture (U Dundee, ’13); Ann McLaren Lecture (ISSCR, ’13); Severo Ochoa Lecture (Madrid, ’13).
Keynote Lectures, Plenary Lectures at Major Scientific Meetings (2007-‘13):
American Society of Cell Biology:Keynote Address, ’13.
Gordon Conferences: Cell Adhesion (’08, ‘12); Epithelial Biology (’07, ’09, ’11, ‘13); Keynote Address, Stem Cells & Cancer Gordon Conference (Les Diablarets, Switzerland, ’13);
Keystone Symposia:Stem Cells (’07,’11);); Wnt Signaling and Cancer (Banff, ‘08); TGFβ Signaling (’08; Keynote:’11), Mouse Models of Cancer (’07); Mouse Genetics (Cologne, Germany, ’08); Micro/Small RNAs (’09; ‘10); Development (’11); Organogenesis and Stem Cells (’12), Transcription and Small Non-coding RNAs (’12); Keynote Address: Immune Plasticity (’13);.
ISSCR Annual Meetings: Presidential Symposium ISSCR (’11); Barcelona,’09; San Francisco ’10; Yokahama,‘12; Keynote Address, Regional ISSCR Meeting (Suzhou, ’11); Plenary talk, Regional ISSCR Meeting (Florence, ’13).
Cold Spring Harbor Symposia/Meetings:CSHL Symposium on Stem Cells (’08;’11); Organogenesis & Development (’12); 60th Anniversary of the Discovery of the Double Helix of DNA (’13); Stem Cells & Development (’13).
Royal Society: Genes and Development (’12); Cell Polarity (’13).
American Association for Cancer Research: Opening Session, 100th Anniversary Meeting of the AACR (’07);AACR Regional Mtg, Stem Cells & Cancer (Keynote address’11); AACR Annual Mtg Plenary Sessions: ’12, ‘13
Keynote Lectures at Other Meetings/Symposia (2007-‘13):
National Arts Association (’07), UCSD Graduate Student Retreat (’07);Soc Dev Bio Regional Meeting (Princeton, ’07); ADF Meeting (Erlangan, Gemany, ’08); American Association of Physicians and The American Society for Clinical Investigation (Chicago, ’09), Wnt Signaling, Stem Cells and Cancer Meeting (Xiamen, ’09); CRG Stem Cell Meeting. (Barcelona ’09), Oesper Symposium (UCincinnati, ’09); Bissell Symposium (LBL, ’10); British Cell Biol. Meeting (’10), Aging and Stem Cells (Harvard, ’10); National MD/PhD Student Training Program Retreat (’10); Stem Cells & Regenerative Medicine (San Antonio, 10); Walpert Symp. (Harvard’10), Notch & Stem Cells (Athens ’10); Society for Matrix Cell Biol. Meeting (’10); International Genodermatology Society Meeting (’10); Moore Cancer Symposium (UCSD, ’11); NYSTEM Stem Cell Symposium (’11), TGFβ Signaling FASEB Meeting (’11); Stem Cell Symposium (Seoul, ’11); L’Oreal-WBF Women & Science 10th Ann. (Seoul, ’11); Government’s Symposium on Cancer and Stem Cells (Mexico City, ’12); World Science Festival NYC (’12), Columbia University Graduate Student Retreat, ’12; International Society for Cell Biology (Rio de Janeiro’12); European Society for Dermatological Research (Venice’12); Cancer and Stem Cells Meeting (Heidelberg’12); International Mtg on Hair Research (Edinburgh, ’13); Stem Cell Symposium (Rutgers, ’13).
Plenary Lectures at Other Meetings/Symposia (2007-‘13):
Stem Cell Symposium (UCLA, ’07); Stem Cell Symposium (Calgary, ’07); Cancer & Stem Cells Symposium(UCSF, ’08); Developmental Biology Symposium (Institut Curie, ’08); Stem Cells Cancer Symposium (Institut National du Cancer, ’08); Australian Health and Medical Research Congress (Brisbane, ’08); CNIO Stem Cells and Cancer Symposium (Madrid, ’09); Evans Scholar Symposium (Boston University,’09); EMBO Meeting (Amsterdam, ’09), Wnt Meeting (Goettingen, ’09), AACR Meeting Cancer and Stem Cells (Boston, ’09); Miami Winter (’10); Lineberger Cancer Symposium (UNC, ’10); Nobel Forum, Regenerative Medicine (Stockholm, ’10), Notch Signaling Meeting (Athens, ’10); Broad Symposium UCSF (’11); Stem Cell Symposium (Berlin, ’11); Stem Cell Symposium (Uppsala, ’11); Stem Cells and Cancer (CNIO, ’11; Barcelona, ‘12),
Additional Seminars (2007-‘13):
UCSF, UCLA, Scripps Research Institute, University of Pennsylvania, Stanford, Cold Spring Harbor, Princeton University,National Institutes of Health, Vanderbilt University,Curie Institute (Paris), UC Davis, Tularik, Fred Hutchison Cancer Center, Dana Farber Cancer Institute, Pfizer/University Michigan, Biozentrum (Basel), UT Southwestern Dallas, University California Irvine, University New Mexico Sch. Med, Boston University,University of Southern California, Amgen, Weizmann Institute (Rehovot), Genentech, University Wisconsin, Cornell University (Ithaca), University California Riverside, University California San Diego (2X), California Institute of Technology, Salk Institute, DukeUniversity,University of North Carolina, Massachusetts Institute of Technology (2X), Harvard Medical School (X3), INSERM, Strasbourg; University of Paris; Institut Pasteur, Institut Curie, Burnham Institute, Mt. Sinai School of Medicine, University of Buffalo, University of Virginia, National Jewish Medical Center, New York University (2X), University of Massachusetts, McGill U; Stower’s Institute; Lehai U; Kenyon College; SUNY Albany, Enzon Pharmaceuticals, Johnson & Johnson, University of Pittsburgh, Yale University,Columbia University,MD Anderson, Pasteur Institut, Ohio State, Johns’ Hopkins University, Stanford U; Friday Lecture, Rockefeller University,Novartis, University of Illinois Chicago, Albert Einstein, National Cancer Institute, National Institutes of Health, Pfizer, Cold Spring Harbor.
NATIONAL/INTERNATIONAL COMMITTEES/ADMINISTRATIVE RESPONSIBILITIES:
Elected Posts in National/International Societies:
American Society for Cell Biology,‘89-’92 Council; *President, ‘01
National Academy of Sciences,Council ‘01-’04; Class II Membership Committee, ’05; ’08.
International Society for Stem Cell Research (ISSCR), Board of Scientific Directors,‘06-; Executive Committee (’08-’12); Vice President (’08); President (’10).
American Association for Cancer Research, Nominating Committee 07-’10; Awards Committees;
*NYAS Board of Governors (’11-).
Appointed Committees/Posts in National/International Organizations:
Correspondent, Committee on Human Rights of the NAS, NAE and IOM, ‘95-; Program Committee, ASBMB International Meeting, ’95; Nominating Committee, ASBMB, ‘91, ‘94; Chair, ‘95; ASCBProgram Committee,‘89; ’92; ’08; Special Reviewer: Ad-hoc, NIH site visits, and postdoctoral fellowships, ‘85-87; Organizing Committee, AACR Transcription Meeting., ’94,’97; Nominating Committee,ASCB, ‘92; Chair, ’94; Program Committee, ASCB International Meeting, ’96,’97; Selection Committee, Richard Lounsbery Award, NAS, ’97, ‘10; Chair, ‘05; Vice-Chair and Chair, Epithelial Biology Gordon Conference, ’99, ’01; Chair, Molecular Cell Biology Gordon Conference, ’99; Co-chair, Keystone Symposium on the Cytoskeleton, ’00; Selection Committee, General Motors Foundation Awards, 2004-’06; Selection Committee, Pezcoller Foundation Award (‘07);Chair, AACR OAR/Clowes Awards (’08); ASCB Program Committee (’09); Jury L’Oreal-UNESCO Award (’11); Nominating Committee ISSCR (’11); Committee Human Rights of the NYAS (’11-); Advisory Workshop to the Vatican on Stem Cells (Vatican City, ’12); Albany Prize Selection Committee (’13-); ASCB Committee to Prepare a “White Paper” advising NIH on prioritizing funding initiatives for stem cell research (’13).
Scientific Boards:
Searle Scholar Review Board, ‘93-’95; Chair, Searle Scholar Review Board, ‘96-’98;
Recruitment Board, Stower’s Institute, ‘98-’00;
Burroughs Welcome Young Investigator Review Board, ‘98-’05;
Scientific Advisory Board, RIKEN Developmental Biology Institute, Kobe, Japan, ‘01-’06;
Scientific Advisory Board, Whitehead Institute, ‘03-‘09;
Scientific Review Board, Jane Coffin Childs Foundation, ‘03-;
Board of Directors, Damon Runyon Cancer Research Foundation, ‘04-;
Scientific Review Board Cell Biology, Weizmann Institute, November, ’05;
Scientific Advisory Board, Sirna Pharmaceutical Company, ‘05-’07;
Scientific Advisory Board, CBRI Institute for Biomedical Research, Harvard Med, ‘06-;
Founding Board Member of the Rosalind Franklin Society;
External Advisory Board, NYU (’08);
Medical Advisory Board, NYSCF (’07-); Scientific Advisory Board MIT (‘09-);
Scientific Advisory Board, Johnson & Johnson (’10-13);
Scientific Review Board VIB, Belgium (’10),
Scientific Advisory Board, University of Utah Cancer Center (’12-);
Scientific Advisory Board, IMBAVienna (’12-);
Scientific Advisory Board, L’Oreal (’13).
National Institutes of Health, National Cancer Institute, Advisory Council, Scientific Review Panels, Study Sections:
Physiological Chemistry Study Section, 1983-86; *Advisory Council to the NIH Director, Dr. Harold Varmus, ‘96-’00; Scientific Review Panel to review the Intramural Program at NIAMS, ’97; Scientific Review Panel RFA on Cancer Stem Cells, ’08; NIH Special Grant Review Panel ACTS, NIAMS (’08); Scientific Special Review Panel, President’s Stimulus Package Challenge Grants (’09); RFA CA-11-011 and 012 “Research Answers to Provocative Questions” Study Section, National Cancer Institute (’11).
Editorial Positions:
Editorial Board, Journal of Cell Biology, ‘88-’92; *Associate Editor, Journal of Cell Biology, ‘93-;
Special Advisory Editor, Journal of Clinical Investigation, ‘92-’98;
Editorial Board, Genes and Development,‘00-;
Editorial Board, Developmental Cell, ‘01-;
Editorial Board, Cell, ‘01-;
Editorial Board, Cell Stem Cell, ‘07-;
Editorial Board ELife, ’12-
UNIVERSITY ADMINISTRATIVE EXPERIENCE:
The University of Chicago:
University-Wide: Council of the Senate. ‘87-90; President’s Committee to Develop a 5 Yr Plan of Intellectual Financial Priorities,’87; University Disciplinary Committee,‘96-02; Council on Research,‘97-02; Interdivisional Building Committee,‘00-’02.
Divisional: Chair, Committee to Reorganize the Basic Sciences within the Division of Biological Sciences, ‘94-95; Dean's Advisory Committee to Set Priorities for Division of Biological Sciences, ‘96-02; Chair, ACS Institutional Research Grant Committee:‘85-90; PI, Cancer Biology Training Grant, ‘88-02; PI, Molecular Biology Section, NIH Cancer Center Grant, ‘90-02; Executive Committee, Cancer Center. ‘91-02; Steering Committee, Cancer Biology Committee‘96-02; Chair, Curriculum Committee for Developmental Biology, ‘98-02; Chair, Senior Cell Biology Search Committee,‘00-02.
Departmental: Graduate Admissions Committee, MGCB ‘88-93; Faculty Recruitment Committee: BMB and MGCB; ‘84-93; Chair (MGCB), ‘93, ‘96; Chairman's Advisory Committee (MGCB), ‘92-02; Promotions and Appointments Committee (MGCB), ‘92-95; Curriculum Committees, MGCB, BMB ‘95-02.
The Rockefeller University:
Friday Lecture Series Committee Chair,‘03-05; Executive Committee of the Academic Council, ‘03-06; Tri-Institutional Stem Cell Institute Initiative, ‘04-; Faculty Recruitment Committee Chair,‘05-06; Honorary Degree Committee, ’07-; Faculty Budget Advisory Committee,’09; Postdoctoral Fellowship Awards CommitteeChair, ’10-‘14; Lecture Policy Committee Chair, ’12; Faculty Recruitment Committee, ’12-; MidCareer Hiring Committee, ’13-; Executive Committee of the Academic Council, ’11-’14; Chair, ’13-‘14.
TEACHING:
Graduate Molecular Biology II: Eukaryotic Gene Expression (MGCB 313) ‘81-’95.
Graduate Advanced Cell Biology I: (MGCB 316) ‘95-’02.
Invited Lecturer: Cell Physiology Course, Woods Hole, Mass.,’87-’89; Cell Biology Course, Northwestern Med. School, ‘87-’90; Cell Biology Course, Harvard University, ‘88; Philips Lecturer, Haverford College, ‘92; Storer Life Science Lectureship, University California Davis, ‘95; Stem Cell Course at Cold Spring Harbor, ‘04.
Graduate Cell Biology(team-taught), Sloan Kettering/Cornell Medical School, ‘04-
Graduate Cell Biology guest lecturer, Rockefeller University, ‘04-
Graduate Developmental Biology guest lecturer, Rockefeller University, ‘10-
College de France, Paris, January, 2008.
Graduate Stem Cells in Tissue Morphogenesis and Cancer Course, Rockefeller University, ’09; ’11; ’13 (co-taught with Ali Brivanlou; received Rockefeller Teaching Award for this course in 2011).
International Delegation to Provide Career Education to Top High School Students in China, ’12.
GRANTS/CONTRACTS:
NIH AR27883 (34), Cell adhesion and cytoskeletal dynamics in skin. 12/1/80-11/30/18. MERIT AWARD.
NIH AR31737 (31), Regulation of epidermal differentiation and development. 7/1/83-6/30/15.
NIH AR050452 (10), Skin stem cells: purification and characterization. 12/01/03-6/30/14 (received 2% priority score for the 7/1/14-6/30/19 period).
*Howard Hughes Medical Institute (Investigator, ‘88-).
Ellison Senior Scholar (1/1/13-12/31/16).
BIBLIOGRAPHY:Peer-Reviewed Articles (* denotes key papers).
1.Lien WH, Polak L, Lin M, Lay K, Zheng D,Fuchs E. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nature Cell Biology, in press (2014).
2.Kadaja M, Keyes B, Lin M, Pasolli HA, Genander M, Polak L, Stokes N, Zheng D, Fuchs E. SOX9: a Stem Cell transcriptional regulator of secreted niche signaling factors.Genes and Development in press (2014).
3.*Schramek D, Sendoel A, Segal JP,Beronja S, Heller E, Oristian D, Reva B and Fuchs E. In vivo RNAi screen unveils myosin-IIa as a tumor suppressor of Squamous Cell Carcinomas. Science, in press (2014).
4.*Beronja S, Janki P, Heller E, Lien W-H, Keyes B, Oshimori N, Fuchs E.Genome-wide RNAi screens identify physiological regulators of oncogene-dependent epidermal growth. Nature501:185-90 (2013).
5.Folgueras, AR, Guo, X, Pasolli, HA, Stokes, N, Polak L, Zheng, D, Fuchs E. Architectural niche organization by LHX2 Is linked to hair follicle stem cell function. Cell Stem Cell13:314-27 (2013).
6.Fuchs Y, Brown S, Gorenc T, Rodrigues J, Fuchs E@ Steller H@ (@equal contribution). Sept/ARTS regulates stem cell dependent regeneration. Science341: 286-289 (2013).
7.Keyes BE, Segal JP, Heller E, Lien W-H, Chang C-Y, Guo X, Oristian D, Zheng D, Fuchs E.Nfatc1 orchestrates aging in hair follicle stem cells, Proc. Natl Acad Sci. USA, 110:E4950-9 (2013).
8.Tatin F, Taddei A, Weston A, Fuchs E, Devenport D, Tissir F, Makinen T. Planar Cell Polarity Protein Celsr1 Regulates Endothelial Adherens Junctions and Directed Cell Rearrangements during Valve Morphogenesis.Developmental Cell26:31-44 (2013).
9.Williams S, Fuchs E. Oriented cell divisions cell fate decisions. Curr Opin Cell Biol 25: 1-10 (2013).
10.*Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E.NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature495:98-102 (2013).
11.Kulukian A, Fuchs E.Spindle orientation and epidermal morphogenesis. Philosophical Transactions of the Royal Society, 368(1629):20130016. (2013).
12.Lu C, Fuchs E.Sweat glands in homeostasis and wound repair. In skin and its diseases. Cold Spring Harbor Laboratories, in press (2013).
13.Jackson SJ, Zhang Z, Feng D, Flagg M, O'Loughlin E, Wang D, Stokes N, Fuchs E, Yi R. Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation.Development. 140:1882-91 (2013).