Common Reproductive Tract Abnormalities in Women Exposed to DES in Utero

Common Reproductive Tract Abnormalities in Women Exposed to DES in Utero

Vaginal adenosis - development of glandualar cells, normally only found in the cervix, present in the vagina

Cervical intraepithelial neoplasia – lesion within the epithelium of the cervix.

Leukoplakia – white, thickened patches which have a pronounced tendency to become malignant

Mosaicism – inteconnecting capillaries in the stromal papillae form a coarse, tile-like pattern that is viewed from the surface through a very thin layer of epithelium.

Clear cell adenocarcinoma – an uncommon vaginal cancer; cell appearance is due to abundant glycogenation of the cytoplasma. Commonly found in upper third of the vagina.

DES Resources

DES Action USA DES Cancer Network

610 16th Street 514 10th St., NW, Suite 400

Oakland, CA 94612 Washington DC 20004-1403

(800)DES-NET4 or (202) 628-6330

http://www.desaction.org

DES Sons Network American Cancer Society

10 Sleepy Hollow Place 1599 Clifton Road NE

Cherry Hill, NJ 08003 Atlanta, GA 30329

(609) 795-1658 (800) ACS-2345

www.cancer.org

National Cancer Institute

Cancer Information Service

M-F 9:00 am – 7:00 pm local time

(800) 4-CANCER or (800) 422-6237

TTY: (800) 332-8615

www.cancer.gov

Registry for Research on Hormonal Transplacental Carcinogenesis

University of Chicago – Dept. of Obstetrics and Gynecology

5841 S. Maryland Ave, MC 2050

Chicago, IL 60637

http://obgyn.bsd.uchicago.edu/registry.html

This is an international research registry of cancer patients who may or may not have been exposed to DES or other synthetic hormones in utero. Eligible candidates for the registry include women who were born during or after 1948 and have been diagnosed with clear cell adnenocarcinoma of the vagina and/or cervix, regardless of DES exposure. Women who have been exposed to DES and have nucoinous carcinoma of the vagina, primary endometrial carcinoma, and/or carcinoma of the fallopian tube are also candidates.