CURRICULUMVITAE
ChandraK.Mittal,B.S.,M.S., Ph.D.,FCP
Professor, Scientist, Columnist
(CellPhone:713-398-6175)
Office E-Mail:
Personal E-Mail:
------EDUCATION:
B.S.,Biology/Chem/Geology(1967)First Class, Univ.of Lucknow, India
M.S.,Biochemistry(1969)First Class, Univ.of Lucknow, India
Ph.D.,Pharmacology(1974)All-IndiaInstitute ofMedicalSciences, NewDelhi,Postdoc,ClinicalPharmacology(1974-1977) Univ.ofVirginiaMed. Center, Charlottesville, Va ElectedFellow(1987) AmericanCollegeof ClinicalPharmacology(FCP)
Certificate in Distance Education (2017)Canvas-Eagle Online LMS
Credentialed to TeachBiology, Biotechnology, Anatomy & Physiology, Pharmacology, Pathophysiology
SIGNIFICANTSCIENTIFICCONTRIBUTIONS:
1998 NobelPrizein MedicineorPhysiology:Co-Discoverand Lead author ofNitric Oxide-Cyclic GMPSignalingsystemincollaborationwithDr. FeridMuradwhowasawardedthe1998NobelPrizeinMedicine forthisdiscovery.
NitricOxide-Cyclic GMP SystemhasDiagnostic, Therapeuticand Nutritional implications in Cardio-vascular health, sexual health, erectiledysfunction,etc.
PROFESSIONALAPPOINTMENTS:
2015-ProfessorofBiological &Bio-Medical Sciences-HCC
2002-2015Professor of Biotechnology– HCC-NE
2011-2013Biotechnology ProgramCoordinator–HCC-NE
2003-2011AssociateChairof Biology–HCC-NE
1996-PresentFounder ScientificDirector,HerichsonBiotech,Inc.Texas,USA
1992-1995ResearchProfessor (Pharmacology),TSUCollege of Pharmacy,Houston, Texas, USA
1992Supervisor,Division of Immunodiagnostics,NHL (now LabCorp) Houston,USA1991-1992 Drug Discovery Consultant, Abbott Laboratories, Inc.,USA
1987-1991Director -BiomedicalResearch,EscortsHeartInstitute, New Delhi,
1980-1987Assistant Professor of Pharmacology,Univ.ILColl. Med., Peoria,Illinois,USA
1977-1980Instructor inPharmacology,Univ.VirginiaSch.Med. Charlottesville, Virginia, USA
1974-1977ResearchAssociatein Pharmacology,Univ.VirginiaSch.Med. Charlottesville, Virginia,
AWARDSHONORS:
Editor, Global Vaccine & Vaccination Journal (2016 – Present)
Member, Advisory Board – Healthline Magazine, Voice of Asia Group Publication, Houston (2016-Present)
Editor,Journal of Microbiology Experimentation(2014 – Present)
SpecialRecognitionAward,(1999): ASIOA,USA -for contributionto1998Nobel-Prize in Medicine (1998)
Dr. Mrs.G.P.Talwar OrationAward (2007),AssociationofClinicalBiochemists ofIndia
ExcellenceAward,2005,NationalInstituteforStaffOrganizationalDevelopment(NISOD),USA
Member(adhoc)–NIH,CardiovascularIRG,Hypertension MicrocirculationStudySection(2004-Present)
Member(adhoc)–NationalScienceFoundation,AdvTech Education ReviewGroup
ExpertConsultant– NationalInstitutesofHealth-RCMIReview Panel(1994),ElectedFellow,AmericanCollegeofClinicalPharmacology,USA (1987)ManuscriptReviewer - BBA,Life Sci.,JMCC, etc (1977-1996)
ResearchGrant Reviewer,Am. Heart Assoc.(1981-1986)
ResearchFellowship,Govt.of India,(1969-1974)
MeritBursaryScholarship,UniversityofLucknow,India(1966-1967)
UndergraduateMeritoriousStudentStipend,Govt.ofU.P.India (1965-66)HighSchoolMeritScholarship,Govt.ofU.P.India(1961-1963)
ADMINISTRATIVEASSIGNMENTS:
BiotechnologyProgramCoordinator,HCC(2011-2013)
Associate Chair,DepartmentofBiotechnology,Houston Community CollegeSystem(2003-2007)Directorof Research Training,EscortsHeart Res.Institute,India(1987-1991)
Ex-Officio Member– BiotechnologyAdvisory Board–HCC (2002–Present)Member,InstitutionalPolicy ProceduresCommittee-HCC2013)
Member,InstitutionalPolicy ProceduresCommittee–HCC(2011)Member,ProcessTechnologyFacultySearch Committee–HCC(2012)
Member,PetroleumEngineering TechnologyFacultySearchCommittee-HCC2012)
Chair,Instrumentation TechnologyFacultySelection Committee,HCC(2005)
Member,Committee onInternationalPrograms, HoustonCommunityCollegeSystem(2002-Present)Member,Committee on Ph.D.CurriculumDevelopment,TexasSouthernUniv.(1994)
Member,ScientificAdvisoryBoard,EscortsHeartRes.Institute,NewDelhi,India (1987-1991)Chairman, ExecutiveCommittee,Dept. Biomed. Sci,UnivILL.Coll.Med.(1980-1985)Chairman,Committee of Research, University of Illinois.Coll. Med. (1980-87)
Member,CommitteeonPharmacologyCurriculum, UnivILL.Coll. Med. (1983-1985)Member, CommitteeonStudent Appraisal, Univ ILL.Coll.Med.(1985– 1987)Member, Committee onGrad.Med.Edu., Univ IL. Coll.Med. (1981-1982)
ADVISOR/CONSULTANT:
Ortho Pharmaceuticals, Inc.Raritan,New Jersey(1984)AbbottLaboratories,Inc.Abbott Park,Illinois (1989-1992)LifeCellCorporation,The Woodlands,Texas(1990)
AronexPharmaceuticals,Inc., The Woodlands,Texas (1999)
NeogenisLabs,Inc.Austin,Texas,USA(2013-Present)
COMMUNITYSERVICES
Co-Founder,Indo-AmericanAssociation,Houston,TX,USA(1993)
President,IndianAssociation ofPeoria,Peoria,Illinois,USA(1983)
FoundingMember,SocietyofYoung Scientists,AIIMS,NewDelhi,India(1973)
Co-Founder & President,Naveen TarunSangh,Lucknow,India(1968-69)
MEDIAFEATURES
1.IndianJ.Pharmacology 30:347-350(1998)
2.Lancet,October,1998
3.ExpressPharma Pulse,December10,1998
5. TimesofIndia,October 28,1998
8.DeccanHerald,October22,1998
9.The Telegraph,October25,1998
10.The Economics Times, January10,1999
11.TimesofIndia, January24,1999
12.Hindustan(Hindi),March,2000
MEDIAINTERVIEWS
1.IGNOU-TV,NobelPrizewinning DiscoveryofNitricOxide,1999
2.InventionIntelligence,March-April,1999
3.Biospectrum, May, 2005(pp,18-19):Academic andworkforce trackaretwomodels of biotecheducationin US.
4.Biospectrum India, September, 2006 (pp,22-24): The potential forbiotechnologybusiness in India.
PROFESSIONALEXPERIENCE
Teaching Experience inHealthSciences:
All-IndiaInstituteofMedicalSciences. / B.S.MedTech Prog / 5 years / (1969-1974)UniversityofVirginiaSch.Med. / M.D. Nursing Prog / 3 years / (1977-1980)
UniversityofIllinoisColl.Med. / M.DProgram / 7 years / (1980-1987)
UniversityofIllinoisColl.Med / GraduateMed. Ed / 7 years / (1980-1987)
TexasSouthernUniv.Coll.Pharm
HoustonCommunityCollege / Pharm.D
Biotech/Med.Sci / 3 years
15years / (1992-1995)
(2002-Present)
ScholarlyLeadership: Ihavehada successful careerinacademiaasdemonstrated byresearchpublicationsin thepeer-reviewed nationaland internationaljournals;supervision of research students, post-docs, technicians, fellows.Ihavewonmanymeritorious scholarships,andreceived nationalandinternationalhonors andrecognitionsformy leadershipinresearchand managementcapabilities, includingthe2005Excellence Awards fromthe NationalInstituteforStaffOrganizationalDevelopment (NISOD).Myoriginalresearch workwithdiscoveryofNitricOxide-Cyclic GMP SignalingconductedattheUniversityof Virginiawasrecognizedbythe1998 Nobel Prize inMedicine orPhysiology.
HigherEducationAdministration:Participated inadministrativefunctionsatuniversities, medicalinstitutions,andGovernment Panels.Served asChairmanand Memberofvarious institutional committeesas listedabove. AsAssociateChairof Biotech program,developedProgramStudentLearning Outcomes(PSLOs) andStudent Learning Outcomes(SLOs) and setcriteria forprogramevaluations.Created new coursesfor HCC’sbiotechnologyprogram.TheseincludedPrinciplesofBiochemistry(BITC-1403),MedicalBiotechnology(BITC-2445),ImmunologicalTechniques (BITC-2472)forAASdegree. Thesecourseshavebeennow adopted bytheTexasHigher Education Coordinating Board initsWorkforceEducation Curriculum Manual(WECM). As Coordinatorof HCC’sBiotechnologyProgram,carriedout5-yearly ProgramReviewof BiotechnologyProgramin2012, and maderecommendationto strengthen Biotechprogramat HCC.
Developednew curricula and coursedescriptionsfor Advanced TechnicalCertificates(ATCs)inClinical ResearchTechnologyinvolvingdrugtrials, Biomedical ResearchTechnologyandClinicalMolecular Diagnostics forHCCColemanCollegeof Health Sciences.These skillsare inhigh demandat theTexasMedicalCenter (TMC)institutionsandotherhealthcareindustrywithlargeemploymentopportunities.
Clinical DiagnosticsServicesAdministration: For1987to1992, servedasDirectorofClinicalLaboratoriesattheEscortsHeartInstitute,NewDelhi, and wasresponsiblefordesigning andestablishingthepatientservice labs,recruitmentof medicaltechnologists,procurement ofequipmentand materials,developingStandardOperatingProcedures(SOPs),Quality Controlguidelineasper GoodLaboratory Practices(GLP),andcreating complete documentationsystems.Theservice laboratoriesearnedrecognition from European International Standard Organization(ISO)
WorkedasManager/Supervisor of Immunodiagnosticsdivision atthe NationalHealth Laboratories,Inc.(PresentlycalledLabCorps)at Houston.Supervised 9medical lab technologistsconducting2000clinical testsdaily. Managed laboratoryoperationsandcertifiedQCand reportedclinicalreportsto physicians.
MedicalResearchAdministration:AsDirectorof ResearchatEscortsHeartInstitute,NewDelhi prepared institutionalresearchreportsfor Govt.approval,organized and directedanepidemiological study incollaborationwithUniversity of TexasMedicalBranch,Galveston(UTMB) ontheincidenceofcoronaryarterydisease(CAD) amongAsian-Indians.Createdacomprehensive cardiaccheck-up(CCC) andgenerated anomnibusdatabase on the ST-segmentanalysis duringexercise-EKG,physical exam, lipid,profile,familyhistory, dietary inputs,andtheincidenceofCAD. Comparisonswere madebetweentheCADpatternsbetween Asian-Indians andtheir Caucasian counterparts.Thescreening program resultedin detectionofhighlevelofCADdetectionamongAsian-Indiansatayoungerage.
MedicalDiagnosticsBusiness Management:Founded, Directed& Managed as CEO for7 yearsa Medical Product business(HerichsonBiotech,Inc.)inInVitroDiagnostic (IVD) biotechnologyin theUnitedStates.The productsincludedCoagulation products,Clinical BiochemistryreagentsELISA productsforthe diagnosis of endocrinedisorders,cardiovasculardisease, cancerand infectiousdiseases.Workedindependentlyas well as inalliancewithothercorporatebodies,managedallaspectsofbusinessoperationsincludingcompliance withUS-FDAregulations, product registrationwithGovt.of India.Established abio-manufacturingfacilityaspercGMPguidelines toproduceIn VitroDiagnostic (IVDs)devicesin Houston. CreatedmarketinginfrastructureinIndia forproduct distribution andcustomer support, recruitedpersonnelforbusinessprocessing,marketing,sales, and technicalsupport.
ClinicalResearchServices:Organizedand createdworkinginfrastructureto conductclinical trialsonnewtherapeuticentities (NTEs).Clients includedAronex Pharmaceuticals, Inc. USA andPharm-OlamInternational,a Houston-basedCRO,foranti-fungaldrugtrials onAIDS patients.Identified clinicaltrial Siteswithsuitablepatientpopulation, recruitedqualified physicianinvestigators,and organizedlogistics forGovernmentregulatory compliance.Fullyaware andexperiencedwithInstitutional ReviewBoard (IRB) forpatientsafetyissuesandInformed Consentin Clinical Trials.
GovernmentFoundationPanels: IserveontheExpertPanelsof theNationalInstitutesofHealth(CardiovascularSciences) and NationalScience Foundation(NSF), both Federalgovernment agency, for the scientificreviewandrecommendationsontheallocation ofresourcesfor researchinvestigators andinstitutions.Previously, Ialsoserved onspecial NationalPanelfor Site Visit toCharlesDrew Medical School,LosAngeles,CA for review of a$ 5.0Milliongrant forinstitutionaldevelopment.Ihavealsoservedon theExpert Panelof theAmericanHeart Association.
MinorityDiseaseResearch:Atthe TexasSouthernUniversity (1992-1995)conductedNIH-RCMI (ResearchCentersinMinority Institutions)fundedresearchprojectson Hypertension inAfrican-Americanpopulation.The disproportionatelyhigher incidence ofthe disease wasinvestigated atmolecular levelsin animal models. Received federalgrantsfromNIH-MBRS (Minority BiomedicalResearchSupport),andtrainedstudentsandscientistsbelongingto the minoritycommunity. Ihave supervisedresearchpresentationsby African-Americanstudents atthenational scientificmeetings.
ScientificEditorial Panels: Have servedoneditorialboards of national and internationalmedicalandbiomedicaljournalsto review scientific researchmanuscripts.Havealso writtenResearchReviewarticles, monographs,research reportsandcommentaries.
JournalisticEndeavors:Writeessays, Op-Edsandanalytical columnsinnewspapers,magazinesoncurrentnationalandinternationalaffairs relatedwithpolitical developments,governanceand religion.These arelistedinresume.
MEDICALRESEARCHGRANTS:
1.“Vascularsignaltransductioninhypertension”
PrincipalInvestigator: ChandraK. Mittal,Ph.D, National Institutesof Health, $287,424(9/94–8/98)
2.“Actionsofatriopeptin(ANP)onvascularsmoothmuscleinhypertension”
PrincipalInvestigator:ChandraK. Mittal,Ph.D., Am.Heart Assoc., $ 30,000 (7/85– 6/87)
3.“Regulationofmyocardialcyclic GMP synthesis”
PrincipalInvestigator: Chandra K. Mittal, Ph.D., Am. HeartAssoc., $ 30,000 (7/81 –6/83)
4.“Cholinergicmodulationofmyocardialcyclic GMP”
PrincipalInvestigator: ChandraK. Mittal,Ph.D., Univ.ILRes.Board, $ 10,000(7/81–8/82)
5.“Cyclicnucleotidemetabolismduringsenescence”
PrincipalInvestigator:Chandra K.Mittal,Ph.D., NIH80417(6/80–8/81)
6.“PharmacologicalmodulationofcyclicGMPmetabolism”
PrincipalInvestigator: ChandraK. Mittal,Ph.D.,Am. Heart Assoc.$ $16,000(7/78– 12/79)
7.“MechanismofphysiologicalmodulationofcyclicGMPsynthesis”
PrincipalInvestigator: Chandra K. Mittal,Ph.D.,PharmaceuticalManufacturersAssociation Foundation.$16,000 (1/78–12/79)
MEDICALRESEARCHSUPERVISION
JohnHeimanz,B.S.Medical Research Fellow (1975)
RobertAldred,B.S.ResearchAssistant(1975-78)
Kikuo Ichihara,M.D.ResearchAssociate(1977-78)
MahmoudEl-Zayat,Ph.DUNESCOFellow(1977-78)
WilliamP.Arnold, M.D.ClinicalFellow(1977-78)
J.MarkBraughler,Ph.DPostdoctoralFellow(1977-78)
AkihikoWada,M.D.ResearchAssociate(1978-80)
JuliaRuffin, B.S.ResearchAssistant(1978-80)
Rose Duffield,M.S.ResearchTechnologist(1980-87)
Mohammad Gabr,B.S.ResearchAssistant(1981-83)
John Groch,B.S.Medical ResearchFellow (1983)
Sharon Murnan,M.S.Research Technologist(1983-84)
JeffHallet,B.S.Medical Research Fellow(1984)
ValerieGrondin, M.S.ResearchSpecialist (1985-86)
AnuradhaSureka,M.D.ResearchFellow(1985-86)
MarkRichman,B.S.ResearchScientist(1988-91)
ShelleyVerma,M.A.ResearchAssistant(1987-90)
ArunRaizada,M.S.ResearchBiochemist (1987-91)
S.K. Jha,M.S.ResearchAssistant(1988-91)
RitaSinghal,Ph.D.ResearchFellow (1994-95)AndrewOAnugwom,B.Pham.ResearchAssistant(1994-95)Igeoma‘Robin’Okpara ResearchAssistant(1994-95)
JamesGeorge,B.S.ResearchAssistant(1995)
INVITEDSCIENTIFICLECTURES
1.All-IndiaInstituteofMedicalSciences,New Delhi,India(1976)
2.SmithKlineFrenchLaboratories.USA (1979)
3.MedicalCollege ofVirginia,Richmond,VA (1979)
4.Indiana University School ofMedicine,Evansville, IN (1979)
5.UniversityofIllinoisCollege ofMedicine,Peoria,IL(1979)
6.All-IndiaInstituteofMedicalSciences,New Delhi,India(1982)
7.PatelChestInstitute, University of Delhi,Delhi,India(1982)
8.Ciba-GeigyPharmaceuticals,Summit, N.J (1882)
9.R.W.JohnsonInstitute,N.J.Raritan,N.J. (1983)
10.TexasTechUniversitySchool ofMedicine,Lubbock,Texas(1984)
11.HoffmannLaRochePharmaceuticals,Nutley,N.J.(1984)
12.CentralDrugResearchInstitute,Lucknow,India(1985)
13.Indian Institute of Technology,New Delhi,India(1985)
14.JawaharlalNehruUniversity,New Delhi, India(1986)
15.UniversityofIllinoisCollege of Medicine,Chicago, IL. (1986)
16.Indian ToxicologyResearchCenter,Lucknow,India(1986)
17.MahatmaGandhiMedical College,Indore,India(1987)
18.CentralDrugResearchInstitute,Lucknow,India(1988)
19.DefenseInstituteofPhysiologyAlliedSciences,Delhi,India (1989)
20.UniversityofHouston CollegeofPharmacy, Houston,TX (1990)
21.BaylorCollegeofMedicine,Houston,TX(1990)
22.Henry FordHeartResearchInstitute,Detroit,MI(1991)
23.TexasSouthern University, Houston, TX(1992)
24.UniversityofPuerto Rico,SanJuan,PuertoRico(1995)
25.Ministry of ScienceTechnology,Govt.of India,Delhi(1998)
26.HamdardUniversity,Delhi,India (1998)
27.All-IndiaInstituteofMedicalSciences,NewDelhi,India(1999)
28.TorrentPharmaceuticals,Ahmedabad,India(1999)
29.Dr.ReddyResearchFoundation,Hyderabad,India(1999)
30.IndianOilCorporationResearchCenter,Faridabad,India(1999)
31.India MedicalAssociation, RoorkeeChapter,Roorkee, India(2000)
32.UniversityCollegeofMedical Sciences,Delhi,India(1999)
33.MalhotraHeartInstitute,NewDelhi,India(2000)
34.DepartmentofBiochemistry,UniversityofLucknow,Lucknow, India (2001)
35.Dept. of Biotechnology,AIIMS,NewDelhi,India(2001)
36.KingGeorgeMedicalUniversity,Lucknow,India(2003)
37.Biophex2004, SanFrancisco, CA(2004)
38.InternationalConferenceonDrugDevelopment,AIIMS,Feb2007
39.AmityInstituteofBiotechnology,AmityUniversity,NOIDA,India,May,2007
40.Dr. Mrs.G.P.TalwarOrationAward,AssociationofClinicalBiochemistsofIndia(2007)
41.ApeejayInstitute ofManagement,NewDelhi,India(2008)
42.ShardaUniversity,GreaterNoida,India(2009)
43.ApeejayInstitute ofManagement,NewDelhi,Inda(2009)
44.ShardaUniversityResearchDevelopmentTechnology Center,GreaterNoida,India(2010)
45.AmityInstituteofMicrobialTechnology,AmityUniversity,NOIDA,India,August,2012
SCIENTIFICPUBLICATIONS
Peer-ReviewedArticles:
1.Mittal, CK: Studies onadenylatecyclaseandcyclic AMPphosphodiesterasein chick brain.Ph.D. Thesis,All-IndiaInstituteofMedicalSciences,New Delhi, India(1974)
2.Kimura,H.,Mittal, CK andMurad,F: Activationof guanylatecyclase fromratliverand othertissuesbysodium azide. J.Biol.Chem.250,8016-8022(1975)
3.Mittal, CK., Kimura, HandMurad,F: Requirementofamacromolecularfactor forsodium azideactivationof guanylatecyclase. J.Cyclic Nucl.Res.1, 261-269(1975)
4.Kimura, H.,Mittal,CK andMurad,F: IncreasesincyclicGMPlevels in brain and liverwithsodiumazide-an activator ofguanylatecyclase.Nature257,700-702(1975)
5.Kimura, H.,Mittal, CKandMurad,F: Appearance ofmagnesiumguanylatecyclaseactivity after sodiumazideactivation.J.Biol.Chem.251,7769-7773(1976)
6.Mittal, CKandMurad, F:Formationof adenosine3’,5’-monophosphatebypreparations ofguanylatecyclase from rat liverandother tissues. J.Biol. Chem.252, 3136-3140(1977)
7.Mittal, CK, Kimura, H, andMurad,F: Purificationandproperties ofa proteinfactorrequired for sodiumazideactivation ofguanylatecyclase. J.Biol. Chem.252, 4384-4390(1977)
8.Murad,F.,Kimura,H.,Mittal, CK and Arnold, WP: Guanylatecyclase-Propertiesand regulation.EndocrinologyV Int. Cong. VolI, 507-511(1977)
9.Katsuki,S., Arnold,WPMittal, CK and Murad, F: Stimulationofguanylatecyclase by sodiumnitroprusside, nitroglycerine and nitricoxidein varioustissuesandcomparisontoeffectsof sodiumazidseand hydroxylamine.J.Cyclic Nucl.Res.3, 23-35(1977)
10.Mittal, CK andMurad, F:Activation ofguanylatecyclase by superoxidedismutaseand hydroxyl radical-a physiologicalregulatorofguanosine3’,5’-monophosphateformation. Proc.Nat. Acad. Sci,US74,4360-4364(1977)
11.Mittal, CK andMurad, F:Propertiesandoxidativeregulation ofguanylatecyclase.J. Cyclic Nucl. Res.3,381-391(1977)
12.Arnold, WP.,Mittal, CK.,Katsuki,SandMurad, F:Nitric oxideactivatesguanylatecyclase andincreasescyclic GMP levels in various tissues. Proc. Nat.Acad.Sci,US74,3203-3207(1977)
13.Katsuki,S.,Arnold,WP.,Mittal, CK and Murad,F: Stimulationofformationandaccumulationof cyclic GMPbysmoothmusclerelaxants. Proc. 2nd Cyclic Nucleotide Conference, Japan.Pp45-51(1977)
14.Mittal, CK. Arnold,WPandMurad, F: Characterization of proteininhibitorsof guanylatecyclaseactivation from ratheartheartandbovinelung.J. Biol.Chem.253,1266-1271(1978)
15.Mittal, CK and Murad, F: Formation of cyclic AMP byguanylatecyclaseafter activationwithazide, nitro-and nitroso-compounds. Adv.Cyclic Nucle. Res.9,742, (1978)
16.Muard, F.,Mittal, CK., Arnold,WP.,Katsuki,S.,andKimura, H: GuanylateCyclase: Activationby azide,nitro compound,nitricoxide andhydroxyl radicalandinhibitionbyhemoglobinandmyoglobin.Adv.CyclicNucl. Res.9,145-158(1978)
17.Murad,F., Mittal, CK., Arnold,WP.,Ichihara,K., andBraughler, JM:Propertiesandregulationofguanylate cyclase:Activationby azide,nitro-compounds and hydroxyl radicaland effect ofhemecontaining proteins.Mol. Biol Pharmacol.(Cyclic Nucleotides) pp.33-42 (1978),Elsevier Press.
18.Mittal, CK., Braughler, JM., Ichihara, K andMurad,F:Synthesis ofadenosine3’,5’-monophosphateby guanylatecyclase:Anew pathwayfor itssynthesis.Biochim.Biophys.Acta.585,333-342(1979)
19.Braughler, JM., Mittal, CKandMurad, F:Purificationofsolubleguanylatecyclasefromratliver.Proc.Nat. Acad. Sci, US76,219-222 (1979)
20.Ichihara,K.,El-Zayat., Mittal,CK and Murad, F: Fattyacidactivation ofguanylatecyclasefromfibroblastandrat liver. Arch. Biochem. Biophys. 197, 44-51(1979)
21.Murad, F., Arnold, WP.,Mittal,CK andBraughler, JM:Propertiesand regulation and role ofguanylatecyclase and cyclicGMP.Adv.CyclicNucle.Res. 11, 175-204(1979)
22.Murad,F.,Mittal, CK., Arnold,WPandBraughler, JM:Effect of nitro-compounds, smoothmusclerelaxatsand othermaterialsoncyclic GMP metabolism. Adv.Pharmacol.Therp.3,123-132(1978)
23.Braughler, JM.,Mittal, CKandMurad,F:Effectof thiols, sugars andproteinson nitricoxideonactivationof guanylatecyclase. J.Biol.Chem.254,12450-12454 (1979)
24.Murad,F., Lewicki, JA.,Brandwein,HJ.,Mittal,CK andWaldman, SA:Guanylatecyclase: Guanylatecyclase: Purification,properties,free-radical activation,radiolabelingandpreparation of hybridomamonoclonalantibodies.Adv.CyclicNucl. Res.14, 229-240(1981)
25.Mittal, CK andMurad, F: Guanylatecyclase: Regulation of Cyclic GMPmetabolism.HandbookExptl.Pharmacol.58/I,225-260(1982)
26.Lewicki,JA., Brandwein, HJ.,Mittal, CK and Murad, F:Propertiesof purifiedsolubleguanylatecyclaseby nitricoxideandsodiumnitroprusside.J.CyclicNucle. Res.8,17-25(1982)
27.Mittal, CK: PhospholipaseA2modulation ofcyclic GMPmetabolism: Activationofguanylate cyclase.Int. J. Biochem. Biophys.21, 44-46, (1984)
28.Mittal,CK:Cholinergic-muscarinic receptorsin myocardium:Propertiesof(3-H)quinuclidinylbenzilatebinding. Int.J.Exptl.Biol. 23,300-305 (1985)
29.Mittal,CK: PhospholipaseA2-modulation ofcyclic GMP metabolism: Characteristicsof guanylatecyclaseactivation.LifeSci.37, 2143-2149(1985)
30.Mittal, CK: Molecularinteraction of vasodilators: Modulationof cyclic GMPby nitro-drugs andatrialnatriureticfactor (ANF). Ind.J.Heart Res.2,21 (1985)
31.Mittal, CK: AtriopeptinIIandnitrovasodilator-mediatedshifts incyclic GMPin rat thoracic aorta: Evidencefor involvementof distinct guanylatecyclasepools.Eup.J. Pharmacol.115, 127-128(1985)
32.Mittal, CK: ScienceinIndia. Nature,311,8 (1984)
33.Mittal, CK: Determination of guanylatecyclaseand adenylatecyclaseactivitiesincells of immunesystem.MethodsinEnzymol.132,422-428(1986)
34.Mittal, CK: Measurement ofcyclicAMPand cyclicGMPlevels inpolymorphonuclearleukocytes, macrophagesandlymphocytes. Methodsin Enzymol.132,428-434(1986)
35.Mittal, CK, Actionsofatrialnatriuretic peptideson cyclicGMP system invascularsmoothmuscle.Int. J. Exptl.Biol.25,24-28(1987)
36.Mittal, CK: Interaction of atrialnatriureticpeptides inhypertension. Ind. J. Physiol.Pharmacol.31,5-6(1987)
37.Mittal, CK: Management ofScienceinIndia.Timesof India(Feature),May(1988)
38.Mittal, CK: Membranereceptors forcatecholaminesandatrial peptidesinhypertension. ProcInt. Symp.Biomemb.Dis.(1989), Raven Press,N.Y
39.Mittal,CK and Jadhav,AL:Renalatrialnatriuretic peptide (ANP receptorsduringsodium-loading.Clin.Pharmacol.Therap.53,234(1993)
40.Mittal, CK: Nitric oxidesynthase:Involvementof oxygen-radicals inconversionofL-argininetonitric oxide.Biochem. Biophys. Res.Commun.193,126-132(1993)
41.Mittal, CK:Decrease atrialpeptidereceptors in adrenalglandinspontaneouslyhypertensiverats(SHR)Am. J.Hyperten. 6,431-433(1993)
42.Dayal.HH., Ui-hwei Li.,Dayal, V.,Mittal, CKandSnodgrass, W. On utility ofmedicationdataincommunity-basedsymptomsprevalencestudies.Arch.Environ. Health49, 93-97(1993)
43.Mittal, CK: Characterization of L-arginineeffect oncyclic GMP systeminneuroblastomacells.Proc. TexasAcad. Sci. p. 35, (1994)
44.Mittal, CK and Jadhav,AL:Calcium-dependent inhibition of constitutivenitric oxidesynthase.Biochem.Biophys.Res.Commun. 203,8-15 (1994)
45.Mittal, CK and Jadhav,AL:Calcium-dependent regulation ofbrainconstitutiveNOsynthase:MechanismofNOgenerationanditsdualcontrolbycalciumion. Proc. Int. Conf.Biochem. Mol.Biol.NitricOxide, p.71 (1994)
46.Mittal, CK: Oxygen-radicals/nitric oxidemediatecalcium-dependent actionsof hormones on cyclic GMPsystem: A novel concept insignaltransduction. Mol.Cell. Biochem.149,257-262(1995)
47.Mittal,CK., Houston,DE.,Harrell, WB and Mehta, CS:Interactionofheavymetaltoxicantswithbrainnitric oxidesynthase. Mol.Cell.Biochem.149,263-265(1995)
48.Mittal, CK and Mehta, CS:Regulation of nitric oxidesynthase: Role of oxygen-radicals and cationsinnitric oxideformation.Adv. inPharmacol.34,235-250(1995)
49.Mittal, CK: NOsynthase-independentconversion ofL-arginine toL-citrulline: A potentialsourceof error inNOSactivitydetermination.FASEBJ.9,681 (1995)
50.Anugwom,AO., Singhal,RandMittal,CK: ReversalofNO-activatedguanylatecyclase byhemoglobinand methyleneblue. FASEB.J9,676 (1995)
51.Mittal, CK: Nitricoxideand oxygen-radicals insignaltransductionmechanisms- Implicationincardiovasculardisorders. Proc. CurrentTrendsin Cardiovas.Res., SanJuan, PuertoRico(1995)
52.Mittal,CK., Mittal, RandGaliotos, J.A: NitricOxide: Regulation and Clinical Relevance. TrendsinClinicalBiochem,pp 577-580(2003),Assoc.Clin.Biochem. India
53.Mittal, CK:Oxygen-Radicals asBio-Regulators:ANovelConcept in Physiology, Proc. Am. Assoc. PhysiciansofIndian Origin,December22-23, (2003)
54.Mittal,CK: Anatomy ofDiscoveryof NitricOxide-CyclicGMPSignaling System: ANovelPlatformforNewDrugs Diagnostics.IndianJ. Clin.Biochem, 22,19-20 (2007)
55.Mittal,CK:PhysiologicalRegulation byOxygen-Radicals(in preparation)
56.Mittal,CK and Raizada, A:MolecularPathologyof Hypertension. (Invited, in preparation)
57.Richa Chandra, Birgit Mellis, Kyana Garza, Samee A. Hameed a, James M. Jurica, Ana V. Hernandez,
Mia N. Nguyen, Mittal, CK: Remnant lipoprotein size distribution profiling via dynamic light
scattering analysis. Clinica Chimica Acta 462, 6-14 (2016)
Abstracts:
2.Mittal,CKand Sharma,SK:Adenylatecyclaseindeveloping chick brain. Symp.Mol.Mech. DrugAct. CDRI,India(1970)
3.Mittal,CKandSharma,SK: Ontogenetic development ofadenylatecyclase. Proc. 40the Soc.Biol.Chem. India,1971
4.Mittal,CKand Sharma,SK: Adenylatecyclaseand cyclic AMP-phosphodiesterasein development. Proc. Int.Symp.BrainBehav. India (1972)
5.Mittal, CK., Joshi,AandSharma, SK:Adenylatecyclasein nerve cellbodiesandglialcells fromrat cerebralcortex.Proc.41st Soc.Biol. Chem.India(1972)
6.Kimura, H.,Mittal, CKand Murad,F:Activation ofguanylatecyclase bysodiumazide.Clin.Res. 23,324(1975)
7.Kimura, H.,Mittal, CKandMurad,F:Sodiumazideactivation of guanylatecyclase.Proc. VIInt. Cong. Pharmacol. P.392 (1975)
8.Mittal, CK., Kimura, HandMurad,F:Activation ofguanylatecyclasebysodiumazide.GordonConf. “CyclicNucleotides”(1975)
9.Kimura, H.,Mittal, CKandMurad, F: Magnesium-dependent guanylatecyclaseafter sodium azideactivation.Fed.Proc.
35, 434 (1976)
10.Mittal, CKand Murad, F:Formationofcyclic AMPbyguanylatecyclasepreparationafter activationwithsodiumazide.Clin.Res.25,49 (1977)
11.Mittal, CK., Kimura, HandMurad,F:Propertiesofaproteinfactorrequired forsodium azideactivation ofguanylate cyclase.Fed. Proc.36,737(1977)
12.Katsuki,S.,Arnold,WP.,Mittal, CKandMurad,F:Stimulation ofguanylatecyclaseinvarioustissuesbynitroprusside, nitroglycerine,hydroxylamine andsodiumazide.Clin.Res. 25, 58(1977)
13.Braughler, JM.,Mittal, CKand Murad,F:Purification andpropertiesof guanylatecyclase. GordonConf. “CyclicNucleotides”(1978)
14.Arnold,WP., Katsuki,S.,Mittal, CK and Murad,F:Stimulation ofguanylatecyclase by nitric oxide. Adv. CyclicNucle.Res.9, 743(1978)
15.Ichihara,K.,El-Zayat,M.,Mittal,CK andMurad, F:Activation of guanylatecyclasefromfibroblast andliverbyfatty acids.Fed.Proc. 37, 390(1978)
16.Arnold,WP., Braughler,JM.,Mittal, CK and Murad,F:Activation ofguanylatecyclase bythiols. Fed,Proc.37,390(1978)
17.Mittal, CKand Murad,F: Effect of phospholipase A2andlipoxigenaseonguanylatecyclase. Fed.37,1689(1978)
18.Mittal, CKand Murad, F:Cyclic AMPformation byguanylatecyclase. Clin.Res.26,531 (1978)
19.Braughler, JM.,Mittal, CKand Murad, F:Purificationof solubleguanylatecyclase from rat liver toapparent homogeneity. Clin.Res. 27,788 (1979)
20.Mittal, CK., Braughler,JMand Murad,F:Modulation of purifiedguanylatecyclase by proteins.Fed.Proc.38,318(1979)
21.Wada,A.,Mittal, CK andMurad, F:Cyclic GMP levelsand B-glucuronidase fromhumanpolymorphonuclearleukocytes.
Clin. Res.28,498 (1980)
22.Mittal,CK: Guanylate cylcase:analternatepathwayforcyclicAMP formation. Proc.AsianOceanianBiochem(1981)
23.Mittal, CK: Clonidineandprazosinreceptorsinneurogenic hypertension.Fed.Proc.42, 647(1983)
24.Mittal, CK., Duffield, RandLuqman, GA: Nitrendipine,prazosin,clonidineand QNBbindinginbrainmemebranesfrom normotensive andhypertensiverats.Pharmacologist25,240(1983)
25.Mittal, CK: Age-dependentalterationsincholinergic-muscarinic receptorsandcyclic GMPmetabolism. Fed.Proc.43,624 (1984)
26.Ho, A.,Mittal, CK andHjelle,JT: Subcellular distribution of calmodulinandguanylatecyclaseinkidneyproximaltubules. Fed.Proc.43,766 (1984)
27.Mittal, CK., Groch,JSandKalyan-Raman, U:Guanylatecyclase andcholinergicreceptorssitesinhumanbraintumors.
Clin. Res.32,419 (1984)
28.Mittal,CK., Hallet,JFandKalyan-Raman, K:Ca2+modulation of RBCcyclic GMPinmusculardystrophypatients.Clin.
Res.33,(1985)
29.Mittal, CKand Duffield, R: Interaction of atriopeptinewith thoracicaortaand renalmembranes. Proc.Int. HeartSoc(1986)
30.Mittal, CK: AtriopeptinandphospholipaseA2dependent modulation ofcyclicGMP-guanylatecyclasesystem.Fed.Proc. 46,192 (1986)
31.Mittal,CK: Atrial natriureticprotein(ANP)receptor in vascular smoothmuscle:Characterisitcs andproperties> Pharmacologist28,93(1986)
32.Mittal, CK: Effect ofcationsonatrial natriuretic protein(ANP)receptorsin vascularsmoothmuscle. Fed. Proc.47,(1987)
33.Mittal,CK:Atrial natriureticpeptide(ANP)receptorsingenetichypertension. FASEB J.6,(1992)
34.Mittal,CK: Formation ofnitric oxidebyNO synthaserequires oxygen-radicals. Pharmacologist 35,162 (1993)
35.Mittal, CKand Jadhav,AL: Effect of cationsonnitric oxidesynthase. FASEBJ.8,362(1994)
36.Mittal, CK: Oxygen-radicalsand nitric oxidemediatehormonalregulationof cyclicGMPsystem.Proc. Int.Symp. Sec.Messengers,Trinidad, June, 1994
37.Mittal, CKand Houston, D:Differentialmodulatoryeffects ofheavy-metaltoxicants on constitutiveNO synthaseactivity.TheToxicol.15,10 (1995)
38.Mittal,CKand Mehta, CS: Nitricoxidesynthase-A new target forenvirnmentaltoxicants.Proc. Am.Chem. Soc.(1995)
39.Mehta,CSandMittal,CK: Roleof cyclic GMPintheneurotoxicityof trimethyltininrats.Int. Cong.Toxicol.P.12(1995)
40.Mittal, CK: Phospholipid-phospholipaseA2dependentactivationof particulateguanylatecyclase.9th Int. Conf.2nd.MessengerPhosphoproteins (1995)
41.Mittal, CK: DiscoveryofNitricoxidesignalingsystem:A novel conceptinsignaltransduction.Ind.J.Pharmacol. Dec1998
42.Mittal,CK: NitricOxide:DiscoveryImportancein Cardiovascular Diseases. Proc.9th AsianPac. CongressClin.Biochem(2002)
43.Mittal,CKandGaliotos,J.A:BiotechnologyEducation at Houston CommunityCollege.Am. Chem.Soc.(in press,2003)
44.Mittal,CK, TheresaL.SpainandGaliotos, J.K: “Development of Enzyme-Linked ImmunosorbentAssay(ELISA) kit –An Importantbiotechnological toolfor medicaldiagnostics and therapeutics.Am. Chem. Soc. (2003)
45.Mittal,CKandGaliotos,J.K:BiotechnologyEducation atCommunity Colleges-An Emerging Challenge.Am.Soc.BiochemMol. Biol.(2003)
46.Mittal,CK: CommunityCollegesasBusinessIncubators–A NovelConceptfor SmallBusinessesinBiotechnology.Biophex2004Conference,San Francisco,CA,September 28-30,2004.
47.Mittal,CK, Galiotos, JKandHernandez, KJ:Structuring a Workforce TrainingProgramfor Global BiotechnologyIndustry,FASEBJ. 2005
48.Mittal,CK,Sen,P, Spain, T, Galiotos, G, and Hernandez, K:AModel Curriculumfor TraininginMolecularDiagnostics.Proc.XIXInternationalClinicalChemistry(2005)Am.Assoc. Clin. Chem(2005)
NewspaperArticles and Op-Ed Columns
1. Sciencein India.Nature, vol. 311, p8(1984)
2. ManagementofScienceinIndia. Times ofIndia(May,1988)
3. Is Indian Prime Minister Narendra Modi, Ronald Reagan of India?Voice of Asia, Vol. 27, No 28 (2014)
4. Is Indian Prime Minister Narendra Modi, Ronald Reagan of India?India Tribune, Chicago, August 15, 2014
5. Narendra Modi – A Transformative Leader for 21st Century India.India Tribune, Chicago, August 22, (2014)