Cell Tissue Bank Supplementary Table S2 Grünblatt et al. 2010 Email:

Supplementary Table S2:Correlation of various variables to high and low tryptophan (TRP) levels

High TRP (n=6) / Low TRP (n=6)
Mean / Minimum / Maximum / Mean / Minimum / Maximum
TRP level (M) / 213.630.7* / 177.0 / 252.0 / 31.316.6 / 15.7 / 58.0
Storage (Month) / 94.020.7** / 60.0 / 120.0 / 40.223.7 / 9.0 / 73.0
PMI (hours) / 46.530.4 / 21.0 / 100.0 / 21.215.9 / 5.0 / 48.0
Age (year) / 59.85.6 / 54.0 / 69.0 / 62.519.1 / 32.0 / 84.0
PFK (nmol fructose-1,6-bisphosphate/mg protein/min) / 98.528.5 / 69.9 / 149.0 / 83.666.2 / 27.0 / 206.8
GAD (nmol/mg protein/h) / 1.30.6 / 0.4 / 2.1 / 2.63.1 / 0.1 / 8.5
pH Value / 6.00.3 / 5.5 / 6.3 / 6.20.3 / 5.9 / 6.6
RIN / 4.71.7 / 2.8 / 7.1 / 4.71.4 / 2.8 / 6.0
RAB3A / 1.71.0 / .9 / 3.2 / 1.00.7 / 0.2 / 2.1
Synaptophysin / 1.60.5 / 0.8 / 2.2 / 1.11.0 / 0.0 / 2.3
-Synuclein / 2.12.3 / 0.3 / 4.9 / 4.70.1 / 0.1 / 11.9
GFAP / 3.02.6 / 0.3 / 5.8 / 2.32.0 / 0.6 / 5.9
TAU46 / 0.30.3 / 0.0 / 0.7 / 0.81.2 / 0.1 / 3.2
TAU-P-ser262 / 0.60.9 / 0.1 / 2.3 / 3.53.3 / 0.4 / 8.1
CamK-II / 0.61.1 / 0.0 / 2.6 / 0.40.6 / 0.0 / 1.5
-Tubulin / 1.90.7 / 1.2 / 2.8 / 2.20.7 / 1.2 / 2.9
-Tubulin / 0.70.4 / 0.4 / 1.3 / 0.70.3 / 0.3 / 1.3
mGlu R2/R3 / 1.41.2 / 0.2 / 3.0 / 0.90.9 / 0.0 / 2.1
TrkB / 0.30.4 / 0.0 / 1.0 / 0.60.6 / 0.0 / 1.7
BDNF / 1.80.5 / 1.3 / 2.7 / 1.70.4 / 1.1 / 2.2
Acetyltransferaseactivity (RFU) / 5.21.9 / 3.1 / 8.4 / 3.2.13 / 2.0 / 5.5
Methyltransferase activity (RFU) / 1.40.4 / 1.1 / 1.9 / 1.60.7 / 0.9 / 2.4

One-way ANOVA * p<0.0001; ** p=0.002; Nominal significant p=0.058; p=0.094;  p=0.101

Phosphofructokinase (PFK) was measured in nmol fructose-1,6-bisphosphate/mg protein/min, Glutamate decarboxylase (GAD) in nmol/mg protein/h, tryptophan (TRP) in M, RNA concentration in ng/ml, RNA integrity number (RIN), RAB3A, Synaptophysin, -synuclein, glial fibrillary acidic protein (GFAP), TAU46, TAU-P ser262, calcium/calmodulin-dependent protein kinase II- (CamK-II), -Tubulin, -Tubulin, glutamate receptor metabotropic 2/3 (mGlu R2/R3), Neurotrophic tyrosine kinase, receptor, type 2 (NTRK2; TrkB) and brain-derived neurotrophic dactor (BDNF) were measured in density and normalized to -actin, Acetyltransferase activity and Methyltransferase activity were measured in RFU

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