Cases Submitted for Detailed Study, in Which Minimumavailable Data of Individual Patients

Cases Submitted for Detailed Study, in Which Minimumavailable Data of Individual Patients

Supplementary Table 1. Cases of intraductal oncocytic papillary neoplasms of the pancreas described in the literature (including 4 previously not reported cases).#
No / Year of publication and authors / Age / Gender / Signs and symptoms / Preoperative diagnostics / Tumor markers / Surgery / Location / Type / Size / Grade of dysplasia / presence of invasion / Invasion / Type of invasive carcinoma / Margins involved / Metastases
at the time of surgery or presentation / Survival
1# / 1989
Morohoshi et al.
[29] / 77 / M / No / NG / CEA and CA19-9 within normal limits / Distal subtotal pancreatectomy / Body / MDT / 2.5 cm / Lower than high / - / - / - / - / Alive, without disease at 18 months
2# / 1996
Adsay et al.
[17] / 52 / M / Abdominal pain, diabetes / NG / NG / Subtotal pancreatectomy / Head / NG / 1.6 cm / High-grade / - / - / - / - / Alive, without disease at 36 months
3# / 1996
Adsay et al.
[17] / 78 / F / Diarrhea, diabetes / NG / NG / Total pancreatectomy / Head, body and tail (2 separate neoplasms) / NG / 4 cm and 10 cm / High-grade / - / - / - / - / Death on 12th postoperative day
4# / 1996
Adsay et al.
[17] / 73 / F / Bloating, diabetes / NG / NG / Pancreaticoduodenectomy, completion pancreatectomy after recurrence / Head / NG / 6 cm / High-grade / - / - / Pancreatic margin / - / Local recurrence (24 months), death without disease at 60 months
5# / 1996
Adsay et al.
[17] / 69 / M / No / NG / NG / Distal pancreatectomy / Tail / NG / 6 cm / High-grade / - / - / Yes (type of involved margin not precised) / Liver (detected by CT, no biopsies were taken) / Death on 15th postoperative day
6# / 1996
Adsay et al.
[17] / 62 / F / Gastric ‘pressure’, nausea, high glucose blood level / NG / NG / Pancreaticoduodenectomy / Head, body / NG / 7 cm / High-grade / - / - / Yes (type of involved margin not precised) / - / Alive, without disease at 7 months
7# / 1996
Adsay et al.
[17] / 65 / M / Obstruction of vena cava, diabetes / NG / NG / Pancreaticoduodenectomy / Head / NG / 13 cm / High-grade / - / - / No / - / Death without disease at 30 months
8# / 1996
Adsay et al.
[17] / 39 / M / Pancreatitis / NG / NG / Pancreaticoduodenectomy / Head / NG / 4 cm / High-grade / - / - / No / - / Alive, without disease at 36 months
9# / 1996
Adsay et al.
[17] / 66 / M / Pancreatitis / NG / NG / Distal pancreatectomy / Body, tail / NG / 15 cm / High-grade / - / - / No / - / Alive, without disease at 5 months
10# / 1996
Adsay et al.
[17] / 74 / M / Pancreatitis / NG / NG / Pancreaticoduodenectomy / Head / NG / 2.5 cm / Microinvasive carcinoma / Stroma adjacent to the cysts / Tubular / No / No / Alive, without disease at 1 month
11# / 1996
Adsay et al.
[17] / 64 / F / Epigastric discomfort / NG / NG / Pancreaticoduodenectomy / Head / NG / 5.5 cm / Invasive carcinoma / Pancreatic parenchyma, vascular invasion / Tubular / No / No / Alive, without disease at 1 month
12# / 1996
Adsay et al.
[17] / 43 / F / Epigastric discomfort / NG / NG / Pancreaticoduodenectomy / Head / NG / 2 cm / High-grade / - / - / Yes (type of involved margin not precised) / - / Alive, without disease at 1 month
13# / 1998
Jyotheeswaran et al.
[30] / 69 / F / Epigastric discomfort / In CT multilocular cyst, dilatation of mid and distal main pancreatic duct,
in ERCP dilatation of main pancreatic duct, excretion of mucin / CEA and CA19-9 within normal limits
1 year prior surgery / Pancreaticoduodenectomy / Head / NG / 5.8 x 4.7 x 3.7 cm / High-grade with single focus suspicious for invasion / Stroma / Tubular / No / No / Alive, without disease at 12 months
14# / 1998
Thompson et al.
[31] / 37 / M / Weight loss, early satiety, malaise, abdominal discomfort, palpable mass / In CT multiloculated mass,
core biopsy of pancreatic mass / NG / No surgery, evaluation for abdominal transplant surgery / Head / NG / 12 x 10 x 8 cm / Invasive carcinoma / NG / NG / - / Liver / NG
15# / 1999
Nobukawa et al.
[32] / 51 / M / No / In ERCP dilatation of main pancreatic duct, tumor extending from the orifice to the duodenum / NG / Pancreaticoduodenectomy / Head / accessory pancreatic duct / NG / Invasive carcinoma / Duodenal invasion / Mixed / NG / Lymph nodes / Death in postoperative period
16 - 24
(9 cases) / 2001
Luttges et al.
[8] / 43-72 (mean 58) / 4M,
5F / NG / NG / NG / NG / 7 x Head,
2 x Head and body / NG / 2.1 -5.5 CM (mean 4 cm) / High-grade dysplasia / - / - / NG / - / NG
25 - 26 (2 cases) / 2001
Luttges et al.
[8] / 66 and 77 / 1M,
1 F / NG / NG / NG / NG / 2 x tail / NG / 9.8 and 11 cm / Invasive carcinoma / NG / NG / NG / NG / NG
27# / 2002
Patel et al.
[33] / 73 / M / Recurrent pancreatitis / In ERCP cystic dilatation of main pancreatic duct in body and tail;
in MRCP irregular pancreatic duct and cystic mass in tail, in
brushings of the pancreatic duct adenocarcinoma / CA19-9:
44 U/ml (normal < 37) / Distal pancreatectomy, splenectomy / Tail / MDT / 2.5 cm / Invasive carcinoma / pancreatic parenchyma / Tubular / Invasive carcinoma within 1 mm of radial margin / No / Alive, with disease at 48 months; local recurrence and liver metastases at 42 months, adjuvant chemotheraphy (5-Fu) and radiation therapy
28# / 2002
Noji et al.
[34] / 68 / F / Fatty liver / In US, CT, MRI multilocular cystic mass, dilatation of main pancreatic duct, in ERCP communication of lesion and main pancreatic duct / NG / Distal pancreatectomy / Tail / NG / 12 x 6.5 x 4.9 cm / High-grade dysplasia / - / - / NG / - / Alive, without disease at 15 months
29 - 33 (5 cases / 2004
D’angelica et al.
[50] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG
34 - 52
(19 cases) / 2005
Chung et al.
[21] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG
53 - 55 (3 cases) / 2005
Albores-Saavedra et al.
[51] / NG / NG / NG / NG / NG / NG / NG / NG / 3.3 - 5.1 cm / Invasive carcinoma / NG / NG / NG / NG / NG
56# / 2005
Shima et al.
[35] / 79 / F / Epigastralgia / In CT multiloculated mass with mural nodule, in ERCP mildly dilated main pancreatic duct with a filling defect, cytology with no signs of malignancy / Tumor markers within normal limits / Pancreaticoduodenectomy / Head / BDT / 2.8 x 2.1 cm / Moderate grade dysplasia / - / - / NG / - / Alive, without disease at 36 months
57 / 2006
Chetty et al.
[52] / 64 / F / NG / NG / NG / NG / NG / NG / NG / Moderate grade dysplasia / - / - / NG / - / NG
58 / 2006
Zen et al. [14] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / High / - / NG / - / NG
59 - 67
(9 cases) / 2006
Khayyata et al.
[23] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG
68 - 72
(5 cases) / 2006
Ban et al. [22] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / Borderline / NG / NG / NG / NG
73 / 2007
Ohike et al.
[53] / NG / NG / NG / NG / NG / NG / NG / NG / NG / IPMN with oncocytic component / NG / NG / NG / NG / NG
74 - 87
(14 cases) / 2007
Andrejevic-blant et al.
[28] / NG / NG / NG / NG / NG / NG / NG / NG / NG / 4 cases of invasive carcinoma and 5, 1, and 4 cases with low-grade, moderate grade and high-grade dysplasia, respectively / NG / NG / NG / NG / NG
88 / 2007
Yamaguchi et al.
[54] / NG / NG / NG / NG / NG / NG / NG / NG / NG / High-grade dysplasia / NG / NG / NG / NG / NG
89 / 2007
Yamaguchi et al.
[54] / NG / NG / NG / NG / NG / NG / NG / NG / NG / Invasive carcinoma / NG / NG / NG / NG / NG
90# / 2007
Oku et al.
[36] / 76 / F / Nausea / In US, CT, MRI, EUS monocular cystic mass with mural nodule and calcification, in ERCP segmental stenosis and dilatation of main pancreatic duct, no communication with a cyst, no secretion of mucin / CEA: 2.4 ng/ml (normal <5), CA19-9:
11.7 U/ml (normal <37) / Distal pancreatectomy, splenectomy / Body / NG / 7.5 x 5.5 x 5 cm / Low-grade / - / - / NG / - / Alive, without disease at 9 months
91 / 2007
Ishida et al.
[6] / 55 / M / NG / NG / NG / NG / NG / BDT / NG / High / - / - / NG / - / Alive, without disease at 18 months
92# / 2007
Hibi et al.
[9] / 46 / M / Abdominal pain / ERCP with collection of pancreatic juice for cytological analysis after secretion stimulation / NG / NG / Head / MDT / NG / Invasive carcinoma / NG / NG / NG / NG / Died of disease at 7 months
93# / 2007
Hibi et al.
[9] / 64 / M / No / ERCP with collection of pancreatic juice for cytological analysis after secretion stimulation / NG / NG / Head / MDT / NG / Invasive carcinoma / NG / NG / NG / NG / Alive, with disease at 20 months
94# / 2007
Hibi et al.
[9] / 68 / M / No / ERCP with collection of pancreatic juice for cytological analysis after secretion stimulation / NG / NG / Head / MDT / NG / Invasive carcinoma
(mixed pancreaticobiliary and oncocytic) / NG / NG / NG / NG / Died of disease at 6 months
95# / 2008
Kato et al.
[37] / 69 / F / Right hypochondriac pain / In ERCP dilation of main pancreatic duct, communication with a cysts, no excretion of mucin, in US, CT, MRI cystic lesion with mural nodules, hypervascular septa, thick wall and no invasion, very strong uptake in FDG-PET / CEA and CA19-9 almost normal / Pancreaticoduodenectomy / Head / NG / 9.1 x 7.5 x 4.5 cm / High-grade dysplasia / - / - / NG / - / Alive, without disease at 18 months
96# / 2008
Sanada et al.
[38] / 63 / F / Back pain / NG / NG / Distal pancreatectomy / Body / MDT / 3 cm / Invasive carcinoma / NG / Mixed / NG / NG / NG
97 / 2008
Fukushima et al.
[55] / 69 / M / NG / NG / NG / NG / NG / NG / 2.5 cm / High-grade dysplasia / NG / NG / NG / NG / NG
98 / 2008
Fukushima et al.
[55] / 74 / M / NG / NG / NG / NG / NG / NG / 1.5 cm / High-grade dysplasia / NG / NG / NG / NG / NG
99- 118
(20 cases) / 2009
Chen et al.
[24] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG
119 -125
(7 cases) / 2009
Furukawa et al.
[25] / NG / NG / NG / NG / NG / NG / NG / MDT – 4 cases, BDT - 3 cases / NG / 5 cases with high-grade dysplasia, 2 invasive carcinomas / NG / NG / NG / NG / NG
126 - 132
(7 cases) / 2009
Hsu et al.
[26, 27] / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG / NG
133# / 2009
present study / 74 / M / Epigastric discomfort / In CT pancreatic mass in main pancreatic duct / NA / Pancreaticoduodenectomy / Head / MDT / 4 cm / Invasive carcinoma / Pancreatic parenchyma, duodenum / Tubular / No / Lymph nodes / Died with disease at 12 months
134# / 2009
present study / 66 / F / Abdominal pain / NA / NA / Pancreaticoduodenectomy / Head / MDT / 2.5 cm / Invasive carcinoma / Pancreatic parenchyma / Tubular / No / No / NA
135# / 2009
present study / 63 / F / Abdominal pain / NA / NA / Pancreaticoduodenectomy / Head / MDT / 3 cm / Invasive carcinoma (focal gastric-foveolar differentiation in non-invasive component) / Pancreatic parenchyma, duodenum / Tubular / No / No / NA
136# / 2009
present
study / 60 / F / Abdominal pain, cholestasis / In US, CT, and MRI multilocular cystic mass / NA / Pancreaticoduodenectomy / Head / MDT / 6 cm / Invasive carcinoma / Pancreatic parenchyma, duodenum / Mixed / No / No / Alive with disease (liver metastases) at 30 months,
palliative chemotherapy

# cases submitted for detailed study, in which minimumavailable data of individual patients (patient’s age and gender, tumor localization and grade of dysplasia/presence of invasion) were described

US – ultrasonography, CT – computed tomography, MRI – magnetic resonance imaging, ERCP – endoscopic retrograde cholangiopancreatography, FDG-PET - 18F-fluorodeoxyglucose positron emission tomography, NG – not given, NA – not available

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