BIO-DATA

DR. A. Rathinavel, MS., M.Ch., Ph.D

(General Surgery, Cardiothoracic and Vascular Surgery, Molecular Cardiology)

Course / Institution / Year of Passing
Ph.D., / School of Biological Sciences, MaduraiKamarajUniversity, Madurai / 2001-2007
M.Ch., Cardiothoracic & Vascular Surgery / MaduraiMedicalCollege & RajajiGovernmentHospital, Madurai / 2004
M.S., General Surgery / MaduraiMedicalCollege & RajajiGovernmentHospital, Madurai / 1993-1995
M.B.B.S., / MaduraiMedicalCollege & RajajiGovernmentHospital, Madurai / 1989

Ph.D Research: Investigation of Cardiac Isoform of Alpha 2 Macroglobulin (CA2M), as a novel diagnostic marker for cardiac diseases (June 2001 - Feb., 2007)

Cardiothoracic Surgery:Fourteen Years

Vascular Surgery : Nineteen Years

General surgery : Twenty years

Operations performed independently:

General Surgery : Capable of doing any General surgery cases

Coronary : Harvesting LIMA, Radial & SVG harvest, top end and distal anastomosis

,Done 1200 cases Individually.

Congenital : ASD, VSD, PS, PDA interruption.

Valvular : Mitral and Aortic valve replacement, Open mitral/tricuspid closed mitral commissurotomy.More than 2000 cases done .

Miscellaneous : LA/RA myxoma, Pericardiectomy

Thoracic : Lung resection, Decortication, Thoracoplasty,Muscle

transfers Resection of small Mediastinal tumors

Vascular : Fem-Pop, Thoracic outlet surgery, 1500 A.V. Fistula and

250,Brachial A.V. Fistula

Aneurysm : Peripheral vessel aneurysms

Trauma : Very good experience in poly trauma, chest and abdominal trauma.

Coronary : CABG ( off-pump) 800 cases ,on pump 200 cases

Congenital : Ostium primum ASD,CAVC,Swiss cheese VSD,AP

window,PA banding, DORV

Valvular : Mitral valve repair, Bentall's surgery

Aneurysm :Thoracic/Abdominal aortic aneurysm surgery.

Done 700 cases of open Heart surgery in Tamilnadu chief minister,s comprehensive Health Insurance scheme, in Private Hospitals.

Done Two thousand cases individually in Govt Hospitals.

Multi organ Transplantation

Cardiac Transplantation;

Assisted Donor Heart harvesting,in CADAVAR.

Assisted Receipient Heart surgery.

In Very small Numbers as Cardiac Transplantation is a rare surgery.

Renal transplantation :

LIVE: Assisted 120 Donor Nephrectomys.

Assisted 60 Transplant Recipients.

Done125 Recipients Vascular Anastomosis,Individually.

Done Minimal Numbers of cadaveric Renal Transplantation Receipients.

RESEARCH & ACADEMIC POSITION:

ICMR Chaturvedi kalawati Jagmohan Das Memorial award 2011.

Ph.D Guide The Tamilnadu Dr.M.G.R Medical university.

Med EJ Reviwer, Dr.M.G.R Medical university.

Examiner in Dr.MGR Medical university.

Ph.D Guide Madurai kamaraj university.

Visiting Faculty, Madurai kamaraj university.

Co-Investigator , Research projects, Madurai kamaraj university.

Professor & Head, Dept of cardio-Thoracic surgery,

14-11-2014—to till date. Madurai Medical college.

Professor Dept of Cardio Thoracic surgery

06-12-2014.To 14-11-2014. Madurai Medical college.

Professor & Head Dept of cardio thoracic surgery

24-9-11 To 05-12-2014 Thanjavur Medical college

Professor.
12-05-11—23-09-11 / Dept of cardio thoracic surgery
Stanley Medical college.
Senior Assistant Professor
(October 2004 – 06-05-11 ] / Department of Cardiothoracic Surgery,
Madurai Medical College, Madurai
Tutor in Cardiothoracic Surgery
April 2004 – September 2004 / Chennai Medical College,
Chennai
Assistant Professor
October 1996 – May 2001 / Department of General Surgery
Madurai Medical College, Madurai.
Medical Officer
June 1991 – February 1993 / Rural Primary Health Centre
Tamilnadu.
House Officer
March 1988- March 1989 / GovernmentRajajiHospital,
Madurai
Senior House Officer
April 1989 – April 1990 / Department of General Surgery,
Medical Medical College., Madurai.

Awarded GC Sharma Fellowship 2005 by Indian Association of Cardio vascular - Thoracic Surgeons Conference in Kochi 2005. India.

TECHNICAL EXPERTISE

Molecular Biology

  • Isolation of plasmid DNA, genomic DNA and RNA from blood samples and
  • mammalian tissues
  • Estimation of nucleic acids, electrophoresis techniques, electro elution and recombinant DNA techniques

Protein Purification Techniques

  • Expression and Isolation of proteins using animal serum tissue
  • Raising polyclonal antibody
  • Isolation and purification of protein using Gel filtration column
  • SDS-PAGE and Agarose gel electrophoresis
  • Western blotting, Autoradiography

Immunology

  • Immunization of rabbit and mice
  • Antibody production and Ammonium sulphate precipitation
  • ELISA
  • Basic microbiological techniques

Other Technical skills

Proficiency in computers: Impact – CS software solution Integrated Ltd., SSIL Madurai.

Operating system : MS-DOS, MS-Windows

Front End Tool : Developer 2000, Power Builder 5.0, Visual Basic 5.0

Back End Tool : ORACLE (7.x)

Language : C, C++ (concept level)

RESEARCH PUBLICATIONS

2015.

Int J Pharm Bio Sci 2015 Oct; 6(4): (B) 647 - 651

This article can be downloaded from

B - 647

Research Article Allied Science

International Journal of Pharma and Bio Sciences ISSN

0975-6299

COMPREHENSIVE CARE PROGRAM ON PAIN, FUNCTIONAL RECOVERY,

NUTRITIONAL STATUS AND OCCURRENCE OF COMPLICATION AMONG

PATIENT WITH HIP SURGERY

T.VIJAYAPRIYA MSC (N)*1, DR.A.RATHINAVEL MS.Mch, Ph.D2,

DR. MANGALAGOWRI Ph.D (N) 3 AND DR.S.J.NALINI MSC (N), PH.D4

1 Ph.D Scholar, Saveetha University, Thandalam, Chennai, Tamilnadu, India - 602105

2 Professor of Cardio - Thoracic surgery, Madurai Medical College, Madurai -20 India.

3Professor & Principal Saveetha college of nursing, Saveetha University, Thandalam, Chennai India.

4 Professor&Vice-principal, Sri Ramachandra University, Porur, Chennai-600116, India

2014

NATURE GENETICS

RAF1 mutations in childhood-onset dilated cardiomyopathy

Perundurai S Dhandapany1–3, Md Abdur Razzaque4,5, Uthiralingam Muthusami6,7, Sreejith Kunnoth6, Jonathan J Edwards3, Sonia Mulero-Navarro3, Ilan Riess3, Sherly Pardo8, Jipo Sheng9, Deepa Selvi Rani10, Bindu Rani11, Periyasamy Govindaraj10,12, Elisabetta Flex13, Tomohiro Yokota14, Michiko Furutani14,15, Tsutomu Nishizawa14, Toshio Nakanishi14,15, Jeffrey Robbins4, Giuseppe Limongelli16, Roger J Hajjar9, Djamel Lebeche9, Ajay Bahl11, Madhu Khullar11,

Andiappan Rathinavel17

,

Kirsten C Sadler18–20, Marco Tartaglia13, Rumiko Matsuoka14,15,21, Kumarasamy Thangaraj10,21 & Bruce D Gelb1–3,21

2014

PLOS ONE.

Elevated Levels of Circulating DNA in Cardiovascular,Disease Patients: Metagenomic Profiling of Microbiome,in the Circulation

Vasudevan Dinakaran1, Andiappan Rathinavel2, Muthuirulan Pushpanathan1,

Ramamoorthy Sivakumar1, Paramasamy Gunasekaran1, Jeyaprakash Rajendhran1*

1 Department of Genetics, Center for excellence in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India, 2 Department

of Cardiothoracic Surgery, Madurai Medical College & Government Rajaji Hospital, Madurai, Tamilnadu, India.

2013

Dinakaran V, Shankar M, Jayashree S,Rathinavel A, Gunasekaran P and Rajendhran J (2012)Genome Sequence of Staphylococcus arlettae strain CVD059 isolated from the circulation of a cardiovascular disease patient.Journal of Bacteriology194: 6615–6616

Ramprasath T, Murugan PS, Kalaiarasan E, Gomathi P, Rathinavel A, Selvam GS. Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes. Mol Cell Biochem. 2012. 361(1-2):143-50.

Dinakaran V, John L, Rathinavel A, Gunasekaran P and Rajendhran J (2012) Prevalence of bacteria in the circulation of cardiovascular disease patients, Madurai, India. Heart, Lung and Circulation. 21: 281–283.

Ramprasath T, Senthil Murugan P, Prabhakaran AD, Gomathi P, Rathinavel A, Selvam GS. (2011). Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes. Biochem. Biophy. Res. Comm.407(1): 49-53.

Ramasamy S, Vipindas C, JD Clifton, Rathinavel A, A Bidulescu, Ramprasath Tharmarajan, and Govindan S. Selvam. (2010) Cardiac Isoform of Alpha 2 Macroglobulin and Its Reliability as a Cardiac Marker in HIV Patients. Heart, Lung and

Circulation19:93–95.

Nature Genetics

A common MYBPC3 (cardiac myosin binding protein C),variant associated with cardiomyopathies in South Asia

Perundurai S Dhandapany1, Sakthivel Sadayappan2, Yali Xue3, Gareth T Powell3, Deepa Selvi Rani4,Prathiba Nallari5, Taranjit Singh Rai6, Madhu Khullar6, Pedro Soares7, Ajay Bahl6, Jagan Mohan Tharkan8,Pradeep Vaideeswar9,

Andiappan Rathinavel10,

Calambur Narasimhan11, Dharma Rakshak Ayapati12,

Qasim Ayub13,18, S Qasim Mehdi13,18, Stephen Oppenheimer14, Martin B Richards7, Alkes L Price15,

Nick Patterson16, David Reich16,17, Lalji Singh4, Chris Tyler-Smith3 & Kumarasamy Thangaraj4

Pitchai Balakumar, Rajeshkumar U. Koladiya, S Ramasamy,A Rathinavel and Manjeet Singh (2008). Pharmacological Interventions to Prevent Vascular Endothelial Dysfunction: Future Directions.J. Health Sci.54 (1): 1-16.

Ramasamy S,Rathinavel A, Balakumar P, Singh M, Rathinavel A, Anandamurthy K, Ramprasath D and Selvam GS. (2007) “Functional Characterization of Cardiac Isoform of alpha 2 macroglobulin (CA2M): Identification of Non-Hypetrophic Domain. The Cardiology. 3(2): 20-23.

Ramasamy S, Omnath R, Rathinavel A, Kannan P, Dhandapany PS, Annapoorani P, Balakumar P, Singh M, Ganesh R, Selvam GS (2006). Cardiac isoform of alpha 2 macroglobulin (CA2M), an early diagnostic marker for cardiac manifestations in AIDS patients. AIDS.20(15): 1979-1981.

Annapoorani Ponnambalam, Perundurai S.Dhandapany, ARathinavel, SRamasamy, Govindan Sadasivam Selvam (2006).Cardiac isoform of alpha 2 macroglobulin: a novel biomarker for myocardial infarcted diabetic patients. Atherosclerosis.186(1):173-176.

Andiappan Rathinavel, Perundurai S. Dhandapany, Ponnambalam Annapoorani, Subbiah Ramasamy, Govindan Sadasivam Selvam (2005). Cardiac Isoform of Alpha 2 Macroglobulin (CA2M), as a novel diagnostic marker for cardiac diseases. Eur J Cardiovasc Prev Rehabil. 12(6): 601-603.

AY919611 - Rattus norvegicus alpha 2 macroglobulin cardiac isoform mRNA, partial cds

AY921651 - Rattus norvegicus alpha 2 macroglobulin cardiac isoform mRNA, partial cds

AY887133 - Rattus norvegicus alpha 2 macroglobulin cardiac isoform mRNA, partial cds -

  1. A. Rathinavel, S. Dhandapany S. Ramasamy and G. S .Selvam. cardiac isoform of Alpha 2 macroglobulin (182kDa) protein as a novel marker for cardiac diseases. Int. Con. on Biotechnology and Neurochemistry. Dec 29-31, 2004
  1. Ramasamy S. Rathinavel A, and G.S.Selvam “CA2M is a Novel Vehicle for Targeted Gene Delivery into Myocardium” XIX World Congress of the ISHR - Bologna, Italy. 22-25 June 2007.
  1. Subbiah Ramasamy, Perundurai S. Dhandapany, Ponnambalam Annapoorani, Andiappan Rathinavel, and Govindan Sadasivam Selvam. “Functional Characterization of cardiac isoform of Alpha 2 Macroglobulin (CA2M) during induction of cardiac hypertrophy “ Internal society of heart Research by Indian section, Chennai-2006 Jan 6-9, Tamilnadu, India
  1. International conference on Biotechnology and Neuroscience Dec 29-31. Kochi-2005, India.
  1. National symposium on “frontiers in biotechnology” Bharathiyar University Coimbatore oct-27-28, 2004, Tamilnadu, India.
  1. International conference on New Horizons in Biotechnology (NHBT)- April 18-21 –2001, RRL CSIR Trivandrum, India

Ongoing Research projects in MaduraiKamaraj University

S. No. / Title of the Project / Funding Agency / Amount (Rs.) / Date of Sanction and Duration
01. / Circulating human microbiome and cardiovascular diseases / DBT
Govt of India / 40,05,000/- / April 2010 to June 2013
3Years Six Months
02. / Thiamin responsive megaloblatic anemia (TRMA) in Indian populations: Identification and functional characterization of SLC19A2 mutations and microRNAs / DBT
Govt of India / 27,73,000 / March 2011 to Feb 2014
3 Years
03 / Identification of Novel Biomarker in Cardiac Arrhythmia Induced rats and its significance on Human Serum / ICMR, Govt. of India / 27,00,000 / Dec 2012- Nov 2015
3 years
  • As Assistant professor of surgery, I am regularly taking theory classes for MBBS students, MS Post Graduates and M.Ch Post Graduates.
  • Regularly taking classes in Clinical demonstration.
  • Regularly taking classes in Cardio thoracic care and critical care for Nurses in GovtRajajiHospital.

Life member in International Society of Heart Research

Life member in Indian Association of Cardio Thoracic and vascular surgeons

Life member in vascular society of India

Life member in Association of surgeons of India

Life member in Indian Medical Association

Organising Joint Secretary National IACTS Cardiac CME 2014 Madurai.

Presently Secretary Madurai cardio-Vascular & Thoracic Surgeons Forum , having 14 South Districts of Tamilnadu, CTS surgeons & cardiac Anaesthetists 54 Numbers.

Vice-chairman Madurai city Chapter ASI.

SergeantNational Cadet Corps - Madurai Medical College

Secretary Blood Donors Club -MaduraiMedicalCollege

General SecretaryStudents council, MaduraiMedicalCollege

State President Tamilnadu Postgraduates Association

[Includes Eleven Medical Colleges]

Joint SecretaryTamilnadu Govt Doctors Association

Madurai Medical College

CAREER INTERESTS

  • To work towards obtaining experience in technical skills and the overall management of all types of cardiac surgical conditions with special interest in CABG, OPCABS and aortic surgery. To excel in the areas of interest and apply the same in India.
  • Oriented towards research and publication and professional development with in the

field of cardiothoracic surgery.

Name : Andiappan Rathinavel

Date of Birth :12-04-.1964

Marital Status: Married

Spouse Name : R.Punitha B.A (House wife)

Permanent Address: Dr. A. Rathinavel MS., M.Ch., Ph.D

743-1, viswa shanthi bhavan main road,

Narayanapuram, MADURAI-625017.