CAMB 708: HIV Virology/Pathogenesis/Cure Seminar/Journal Club

CAMB 708: HIV Virology/Pathogenesis/Cure Seminar/Journal Club

Directors: Ronald Collman and Katharine Bar

Prereqs: Strong background in cell biology, immunology or virology fulfilled by 1st yr CAMB Courses. Course is limited to graduate students. Instructor permission required for non-CAMB graduate students.

Description: This will be a year-long class, held every other week, that is paper-based utilizing the current literature in HIV virology, pathogenesis and cure research. The class will have a journal club format with attendance and participation open to the full Penn student & postdoc community (teach-your-peers). Enrolled students will be responsible for approximately 4-5 presentations over the duration of the course, as well as for bi-weekly paper selection in conjunction with the instructors and coordinating the presentations by other participants.

Sylabus 2016 is shown below (2017 will follow similar format)

Class / Student / Paper for discussion
1 / Brenda Salantes / Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.
Ndhlovu ZM, Kamya P, Mewalal N, Kløverpris HN, Nkosi T, Pretorius K, Laher F, Ogunshola F, Chopera D, Shekhar K, Ghebremichael M, Ismail N, Moodley A, Malik A, Leslie A, Goulder PJ, Buus S, Chakraborty A, Dong K, Ndung'u T, Walker BD.
Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. PMID: 26362266
2 / Son Nguyen * / Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection.
Lynch RM, Boritz E, Coates EE, DeZure A, Madden P, Costner P, Enama ME, Plummer S, Holman L, Hendel CS, Gordon I, Casazza J, Conan-Cibotti M, Migueles SA, Tressler R, Bailer RT, McDermott A, Narpala S, O'Dell S, Wolf G, Lifson JD, Freemire BA, Gorelick RJ, Pandey JP, Mohan S, Chomont N, Fromentin R, Chun TW, Fauci AS, Schwartz RM, Koup RA, Douek DC, Hu Z, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE; VRC 601 Study Team. Sci Transl Med. 2015 Dec 23;7(319):319ra206. doi: 10.1126/scitranslmed.aad5752.
PMID: 26702094
3 / Colby Maldini * / Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions.
Schultz BT, Teigler JE, Pissani F, Oster AF, Kranias G, Alter G, Marovich M, Eller MA, Dittmer U, Robb ML, Kim JH, Michael NL, Bolton D, Streeck H.
Immunity. 2016 Jan 19;44(1):167-78. doi: 10.1016/j.immuni.2015.12.011.
PMID: 26795249
4 / Ronnie Russell * / Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.
Matheson NJ, Sumner J, Wals K, Rapiteanu R, Weekes MP, Vigan R, Weinelt J, Schindler M, Antrobus R, Costa AS, Frezza C, Clish CB, Neil SJ, Lehner PJ.
Cell Host Microbe. 2015 Oct 14;18(4):409-23. doi: 10.1016/j.chom.2015.09.003.
PMID: 26439863
5 / Christopher Chung * / Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W.
Science. 2015 Oct 30;350(6260):563-7. doi: 10.1126/science.aab2749.
PMID: 26429886
6 / Ronnie Russell * / HIV-1 evades innate immune recognition through specific cofactor recruitment.
Rasaiyaah J, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ.
Nature. 2013 Nov 21;503(7476):402-5. doi: 10.1038/nature12769.
PMID: 24196705
7 / Shilpa Iyer / SERINC3andSERINC5restrictHIV-1infectivityand recounteractedbyNef.
Usami Y, Wu Y, Göttlinger HG.
Nature. 2015 Oct 8;526(7572):218-23. doi: 10.1038/nature15400.
PMID: 26416733
8 / Chris Chung * / Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.
Sung JA, Pickeral J, Liu L, Stanfield-Oakley SA, Lam CY, Garrido C, Pollara J, LaBranche C, Bonsignori M, Moody MA, Yang Y, Parks R, Archin N, Allard B, Kirchherr J, Kuruc JD, Gay CL, Cohen MS, Ochsenbauer C, Soderberg K, Liao HX, Montefiori D, Moore P, Johnson S, Koenig S, Haynes BF, Nordstrom JL, Margolis DM, Ferrari G.
J Clin Invest. 2015 Nov 2;125(11):4077-90. doi: 10.1172/JCI82314.
PMID: 26413868
9 / Pia Dosenovic / Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.
Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, Pietzsch J, Gray MD, Cupo A, van Gils MJ, Yao KH, Liu C, Gazumyan A, Seaman MS, Björkman PJ, Sanders RW, Moore JP, Stamatatos L, Schief WR, Nussenzweig MC.
Cell. 2015 Jun 18;161(7):1505-15. doi: 10.1016/j.cell.2015.06.003.
PMID: 26091035
10 / Colby Maldini * / Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells.
Lichinchi G, Gao S, Saletore Y, Gonzalez GM, Bansal V, Wang Y, Mason CE, Rana TM.
Nat Microbiol. 2016 Feb 22;1:16011. doi: 10.1038/nmicrobiol.2016.11.
PMID: 27572442
11 / Son Nguyen * / Banga R, Procopio FA, Noto A, Pollakis G, Cavassini M, Ohmiti K, Corpataux JM, de Leval L, Pantaleo G, Perreau M. PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Nat Med. 2016 Jul;22(7):754-61. doi: 10.1038/nm.4113. PubMed PMID: 27239760.
12 / Son Nguyen * / Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Science. 2016 Oct 14;354(6309):197-202. PMID: 27738167
13 / Ronnie Russell * / Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction. Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, Kellam P, Finzi A, Borrow P, Hahn BH, Neil SJ. Cell Host Microbe. 2016 Oct 12;20(4):429-442. doi: 10.1016/j.chom.2016.08.006.
PMID: 27640936
14 / Mary Margaret Addison / HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4⁺ T Cells.
Vermeire J, Roesch F, Sauter D, Rua R, Hotter D, Van Nuffel A, Vanderstraeten H, Naessens E, Iannucci V, Landi A, Witkowski W, Baeyens A, Kirchhoff F, Verhasselt B. Cell Rep. 2016 Oct 4;17(2):413-424. doi: 10.1016/j.celrep.2016.09.023. PMID: 27705790
15 / Natania Field / Macrophages sustain HIV replication in vivo independently of T cells. Honeycutt JB, Wahl A, Baker C, Spagnuolo RA, Foster J, Zakharova O, Wietgrefe S, Caro-Vegas C, Madden V, Sharpe G, Haase AT, Eron JJ, Garcia JV. J Clin Invest. 2016 Apr 1;126(4):1353-66. doi: 10.1172/JCI84456. PMID: 26950420
16 / Ryan Roark / Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, van Gils MJ, Sanders RW, Wang LX, Seaman MS, Burton DR, Gazumyan A, Walker BD, West AP Jr, Bjorkman PJ, Nussenzweig MC.
Sci Transl Med. 2017 Jan 18;9(373). pii: eaal2144. doi: 10.1126/scitranslmed.aal2144.
PMID: 28100831