Bureau of Infectious Disease and Laboratory Sciences

Bureau of Infectious Disease and Laboratory Sciences

2016 Statewide Antibiogram Report

Bureau of Infectious Disease and Laboratory Sciences

Massachusetts State Public Health Laboratory Requests for additional data can be emailed to:

305 South Street

Jamaica Plain, MA 02130

Tel: (617) 983-6550

Fax: (617) 983-6925 Acknowledgements:

Kerri Barton, MPH

Scott Troppy, MPH

To speak to the on-call epidemiologist: Jessica Cotter, MPH

(617) 983-6800 Quynh Vo, MPH

Jessica Leaf, MPH

Evan Caten, MS

Alfred DeMaria, Jr., MD

In 2016, antibiogram data representing 62 (89%) acute-care hospitals was reported and is included in this statewide report. Each

page of this eleven page report displays the average percent susceptibility (red dots) and standard deviation (red bars) of bacterial

isolates to relevant antibiotics. These data are representative of antibiotic susceptibility data for 204,166 inpatient and outpatient

bacterial isolates, and does not represent the full extent of antibiotic resistance in Massachusetts.

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**Page 1**

The graph on page 1 displays the average percent susceptibility of Acinetobacter baumannii to various antibiotics in 2016. The standard deviationfor the average percent susceptibility for each antibioticis also displayed. The x-axis displays antibiotics that were tested against Acinetobacter baumannii, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was ertapenem (0%). The antibiotic with the highest average percent susceptibility was tobramycin (98%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 2**

The graph on page 2 displays the average percent susceptibility of Pseudomonas aeruginosa to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Pseudomonas aeruginosa, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was ertapenem (0%). The antibiotic with the highest average percent susceptibility was amikacin (95%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 3**

The graph on page 3 displays the average percent susceptibility of Enterobacter aerogenes to various antibiotics in 2016. The standard deviation, for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Enterobacter aerogenes, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was cefoxitin (0%). The antibiotic with the highest average percent susceptibility wasamikacin (100%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 4**

The graph on page 4 displays the average percent susceptibility of Enterobacter cloacae to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Enterobacter cloacae, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility wascefoxitin(1%). The antibiotic with the highest average percent susceptibility was amikacin (98%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 5**

The graph on page 5 displays the average percent susceptibility of Escherichia coli to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Escherichia coli, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was cephalothin (44%). The antibiotics with the highest average percent susceptibility were amikacin (100%), ertapenem (100%) and imipenem (100%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 6**

The graph on page 6 displays the average percent susceptibility of Klebsiella pneumoniae to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Klebsiella pneumoniae, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was cephalothin (81%). The antibiotics with the highest average percent susceptibility were amikacin (100%), cefotetan (100%) and imipenem (100%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 7**

The graph on page 7 displays the average percent susceptibility of Stenotrophomonasmaltophilia to various antibiotics in 2016. The standard deviation for the reported average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Stenotrophomonasmaltophilia, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was ertapenem (0%). The antibiotic with the highest average percent susceptibility was trimethoprim/sulfamethoxazole (94%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 8**

The graph on page 8 displays the average percent susceptibility of Serratiamarcescens to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Serratiamarcescens, and the y-axis displays percent susceptibility. The antibiotics with the lowest average percent susceptibility wereamoxicillin/clavulanate(0%) and cefuroxime (0%). The antibiotic with the highest average percent susceptibility was amikacin (100%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 9**

The graph on page 9 displays the average percent susceptibility of Klebsiellaoxytocato various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Klebsiellaoxytoca, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was ampicillin/sulbactam (66%). The antibiotics with the highest average percent susceptibility were amikacin (100%), cefotetan (100%), ertapenem (100%) and imipenem (100%). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 10**

The graph on page 10 displays the average percent susceptibility of Staphylococcus aureus to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Staphylococcus aureus, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was erythromycin (46%). The antibiotics with the highest average percent susceptibility were daptomycin (100%) and quinupristin/dalfopristin (100%). The average percent susceptibility to oxacillin was 63%, which means that 37% of Staphylococcus aureus isolates included in this report could be defined as MRSA (methicillin-resistant Staphylococcus aureus). It is important to note that the data displayed may or may not include duplicate isolates.

**Page 11**

The graph on page 11 displays the average percent susceptibility of Streptococcus pneumoniae to various antibiotics in 2016. The standard deviation for the average percent susceptibility for each antibiotic is also displayed. The x-axis displays antibiotics that were tested against Streptococcus pneumoniae, and the y-axis displays percent susceptibility. The antibiotic with the lowest average percent susceptibility was erythromycin (64%). The antibiotics with the highest average percent susceptibility were amoxicillin/clavulanate (100%), linezolid (100%) and vancomycin (100%). It is important to note that the data displayed may or may not include duplicate isolates.Average percent susceptibilities for ceftriaxone, cefotaxime, and penicillin are reported for MIC breakpoints according to recommendations made by the Clinical and Laboratory Standards Institute (M100-S26, 2015).