From,
SOWMYA.C. NAIR
Preliminary MD (Ayu) Scholar,
Department of Post-Graduate Studies in Swasthavritta,
S. D. M. College of Ayurveda and Hospital,
Hassan – 573 201.
To,
The Registrar,
RajivGandhiUniversity of Health Sciences, Bangalore.
Karnataka
Through,
The Principal,
S.D.M.College of Ayurveda & Hospital, Hassan-573201
.
Subject: Submission of completed proforma for registration of subject for dissertation.
Respected Sir,
I request you to kindly register the below mentioned subject against my name for the submission of the dissertation to Rajiv Gandhi University of Health Sciences, Bangalore for partial fulfillment of M.D. (Ayurveda) in Swasthavritta.
Title Of Dissertation:
“A STUDY ON THE EFFECT OF AMALAKADI COMPOUND IN PREVENTION OF DIABETES.”
Herewith I am enclosing a completed proforma of synopsis for registration of subject for dissertation.
Thanking you,
Place: Hassan, Yours faithfully,
Date: (SOWMYA. C. NAIR)
RAJIVGANDHIUNIVERSITY OF HEALTH SCIENCES,
BANGALORE, KARNATAKA.
ANNEXURE – II
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION.
- NAME OF THE CANDIDATE : SOWMYA. C. NAIR
AND ADDRESS PRELIMINARY MD AYURVEDA,
(IN BLOCK LETTERS) DEPARTMENT OF PG STUDIES IN SWASTHAVRITTA, S.D.M.C.A & H. HASSAN - 573201.
PERMANENT ADDRESS : D/O K.CHANDRASEKHARAN.
PANAPURAYIL
FORT
MAVELIKARA PO
ALAPUZHA ,KERALA -690101
02. NAME OF THE INSTITUTE : S.D.M.COLLEGE OF AYURVEDA & HOSPITAL, HASSAN – 573 201.
03. COURSE OF STUDY : M.D.(AYURVEDA), SWASTHAVRITTA.
& SUBJECT
04. DATE OF ADMISSION TO : 01st JUNE 2007.
THE COURSE
05. TITLE OF DISSERTATION : “A STUDY ON THE EFFECT OF AMALAKADI COMPOUND IN PREVENTION OF DIABETES.”
0.6 BRIEF RESUME OF THE STUDY.
6.1 NEED FOR THE STUDY.
The purpose of the human life is the achievement of the Chaturvidha Purushartha i.e.Dharma, Artha, Kama, Moksha. Ayurveda advocates that excellence of health is the basic need for achieving these Purusharthas.1
Diabetes is an ice- berg disease. It’s growing at an alarming rate all over the world2, especially in India. As the prevalence of diabetes is increasing dramatically since past few years, certain slogans were declared by different associations. As‘Targeting people with pre- diabetes.’– American diabetic association.
Pre-diabetes is a stage between normal and diabetes.It’s an alarming sign for the upcoming diabetes.It can also be termed as the Borderline diabetes, chemical diabetes, touch of diabetes etc. The term pre-diabetes was given by the American diabetic association and U.S Department of Health and Human sciences on 27th march 2002 3.
Pre-diabetes is a condition when the blood glucose level is high but not high enough to be diagnosed as diabetes. Risk of conversion of pre-diabetes into diabetes is ten times higher in people with IFG and IGT than in people with normoglycemia.People with pre-diabetes can prevent the development of type-2 diabetes by making changes in their diet and increasing their level of physical activity. Onset of type 2 diabetes can be prevented upto 58 percent through exercise, diet control and drug4.
In classics before the manifestation of Prameha variousPoorvaroopa’s are explained 5,6. Various kinds of Pathya Dravyas are explained in the classics for Prameha. Among theseDravyas Amalaki, Haridra, Karavallaka are famous for its anti-diabetic effects 7 these are cost effective and easily available. Hence an attempt is made through this work to analyze the combined effect of Amalakadi Compound in patients of pre- diabetic stage.
6.2 REVIEW OF LITERATURE.
All the Disorders are grossly classified into two categories i.e.Santarpanajanya and Apatarpanajanya Vikaras. When a person gets indulged in consumption ofGuru , Sheeta , Snigdha Ahara etc it leads to various Santarpanjanya Vikaras like Prameha,Kotha, Kusta, Jwara etc.8 Detailed description about the Nidanas and Poorvaroopa’s of Prameha is explained9.
Pre-diabetes is also known as ‘Impaired glucose tolerance’ is a health condition with no symptoms. It’s almost always present before a person develops the more serious type 2 diabetes. Pre-diabetes is defined as per American diabetic association as either impaired fasting glucose [IFG] or impaired glucose tolerance [IGT]which is characterized by reduced tissue sensitivity to the action of the insulin leading to a compensatory increasing glucose level and insulin secretions.10
A person in his pre- diabetic stage is prone to develop diabetes within few years. So identification and control with diet and exercise at this stage can prolong the time of getting diabetes or can prevent from getting diabetes.
Those Ahara which are good for Prameha are explained asPathya11. These have important role in the control of the disease.Amalaki, Haridra, Karavallaka aretold under Pathya Dravyas forPrameha12.Amalaki has been proved to act as Immuno modulator, anti-oxidant, anti-diabetic and hypo-cholesteraemic agent. Haridra has Tikta-Katu Rasa, Kapha-Vatahara, Lekhana and it’s useful in Prameha. It has got hypo-cholesteraemic effects. Karavallaka has Tikta Katu Rasa, Laghu Guna, Kapha Pitta hara and useful in Prameha. It has got hypoglycemic effects13.
6.3.OBJECTIVES OF THE STUDY.
1)To study the effect of Amalakadi Compound in patients of pre- diabetes stage.
2)To observe if there is any benefits after the use of this compound.
07. MATERIALS AND METHODS.
7.1 SOURCE OF DATA :
Patients from OPD and IPD of SDM College of Ayurveda and Hospital, Hassan will be selected for this study.
7.2 METHOD OF COLLECTION OF DATA :
30 patients who are fulfilling the criteria for diagnosis and inclusion will be selected irrespective of sex, occupation, religion etc for the present clinical study.
DIAGNOISTIC CRITERIA :
Diagnosis will be established on the basis of Poorvaroopa’s seen in the patients, history, symptoms and laboratory investigations.
INCLUSION CRITERIA :
1)Patients showing any of the Poorvaroopa’s Of Prameha.
2)Patients having impaired fasting glucose ( IFG = 100mg/dl – 125 mg/dl )
3)Patients with BMI > 30 along with fulfillment of any one of the following criteria.
4)Family h/o type 2 diabetes and people with high B.P
5)High triglycerides level (more than 150 mg/dl) and low HDL level (<40 mg/dl in men and < 50 mg/dl in women.)
EXCLUSION CRITERIA :
1)Patients with known type-2 Diabetes.
2)Patients on steroids or oral hypoglycemic drugs.
3)Patients with other systemic disorders and complications of D.M will be excluded from the study.
STUDY GROUPS :
It will be a clinical study with two groups, each group comprising of 15 patients.
GROUP A - Patients will be advised to take regular exercise (brisk walking for 20 minutes) for 2 months along with placebo.
GROUP B- Patients will be advised to take Amalakadi Compound made in tablet form 2 tablets each 3 times a day, for 2 months.
Diet chart is kept uniform for both the groups. Assessment is conducted once in 15 days for one month.
ASSESSMENT CRITERIA :
Improvements of both the groups will be noted and the data will be analyzed by ‘t’ – test.
1)The findings will be subjected to analysis between the groups, before and after the treatment in each group.
2)Improvement in the signs and symptoms of pre-diabetes
3)Improvement in the laboratory investigations.
a)F.B.S
b)LIPID PROFILE.
A Self formulated scoring scale will be used to assess rest of the symptoms.
FOLLOW UP STUDY :
The patients will beadvised to report for the follow once in 15 daysfor one month. After this study period during whichonly diet control will beadvised to all the patients in both the groups.
7.3.LABORATORY INVESTIGATIONS :
1)HB %
2)FASTING PLASMA GLUCOSE TEST ( FPG )
Normal - less than 100 mg/dl
Pre-diabetes- between 100 and 125 mg/dl
Diabetes - greater than 126.
3)TOTAL CHOLESTROL- HDL AND TRIGLYCERIDES.
4)URINE – SUGAR
7.4Has ethical clearance been obtained from your institution : YES
0.8. LIST OF REFERENCES.
1)Vagbhata – Astanga Samgraha, English translation by Prof K.R.Srikantha Murthy, Volume 1, Published by: Chaukambha Orientalia , Varanasi , 9thEdition, 2005, Sutrasthana, chapter 1/3, Page No – 2.
2)K.Park –Park Text Book of Preventive and Social Medicine, Banarsidas Bhanot Publishers, Prem-nagar, Jabalpur. 18th edition, Page No – 311.
3)
4)
5)Agnivesa- Charaka Samhita, based on Chakrapanidatta’s Ayurveda Dipika,English Translation by Dr.Ram Karan Sharma,Volume 3, Chaukambha Press, Varanasi, 5th edition 1998, Nidanasthana, 4/47. Page No-65.Chikitsasthana, 6/13-14, Page No-303
6)Sushrutha- Sushrutha Samhita , English Translation by Prof K.R.Srikantha Murthy, Volume 1, Charu Printers, Golghar, Varanasi, 2nd edition 2004, Nidanasthana 6/5.Page No – 503.
7)Sri Vishwanath – Pathyapathya Vinirnaya, Hindi Translation by Dr Brahmananda Tripathy,Chaukambha Press , Delhi, 1st edition 1998. Page No-72.
8)Agnivesa – Charaka Samhita, based on Chakrapanidatta’s Ayurveda Dipika, by Vaidya Yadavji Trikamji Acharya, Chaukambha Sanskrit Samsthan, Varanasi, 4th edition 1994, Sutrasthana 23/4, Page No-122.
9)Astanga Hridaya , English Translation by Prof. K.R.Srikantha Murthy, Volume 2, Chaukambha Press, Varanasi, 3rd edition 1998, Nidanasthana 10/ 38-39. Page No- 99.
10)Jonathan Pinkney – Prevention and Cure of Type-2 diabetes, Published in BMJ South Asian edition Nov 2002, volume 325, page no- 784,785.
11)Acharya Priyavrita Sharma- Kaiyedeva Nighantu, Chaukambha Orientalia, Varanasi, 1st edition 1979, Aushadi varga , page no- 45,107.
12)Madanapala- Madanapala Nighantu, with Hindi Tika, by Khemaraja Sri Krishnadas, Sri Venketeshwara Press Bombay, Sakavarga 7/264.
13)J.L.N Sastry – Dravya Guna Vijnana- Chaukambha Orientalia, Varanasi, 2nd Edition 2005, Page No- 220,791,513.
9. SIGNATURE OF CANDIDATE :
10. REMARKS OF GUIDE :
11.NAMES AND DESIGNATION OF
11.1 GUIDE : DR. T.B .TRIPATHY
PROFFESOR AND HOD,
DEPT. OF PG STUDIES IN SWASTHAVRITTA,
SDMCA & H, HASSAN.
11.2 SIGNATURE :
11.3 CO-GUIDE : DR.KAVITHA.M.B.
ASSISTANT PROFFESOR,
DEPT. OF PG STUDIES IN SWASTHAVRITTA,
SDMCA & H, HASSAN.
11.4 SIGNATURE :
11.5. H.O.D. :DR. T.B .TRIPATHY
PROFFESOR AND HOD,
DEPT. OF PG STUDIES IN SWASTHAVRITTA,
SDMCA & H, HASSAN.
12 SIGNATURE :
12.1 REMARK OF CHAIRMAN :
& PRINCIPAL:
12.2 SIGNATURE :
1