BIOM 600: Cell Biology and Biochemistry--Fall 2014
Director:Richard Assoian~898-7157 ~ Office: 805 BRB II/III
Co-Directors:
Theme I: Mickey Marks ~ 215-590-3664~
Mark Lemmon ~ 898-3072 ~
Theme II:John Weisel ~ 898-3573 ~
Theme III:Toshinori Hoshi ~ 573-7305 ~
Theme IV:Xiaolu Yang ~ 573-6739 ~
BGS Coordinator: Colleen Dunn ~ 898-2792 ~
TAs:Kurt Engleka ~
Megan Fisher ~
Jamie Lemon ~
TA Office hours/location:
Megan: Wednesday 12-2PM(Smilow Rm. 9-143)
phone: 267-426-7378
Jamie: Thursday 8:30-10:30AM (Johnson Pavilion Rm 401/Lab: Johnson Pavilion 403)
Phone: 215-573-3510
Kurt: Thursday 3-5PM (Office:Smilow Rm. 9-143)
Phone: 215-898-0252
Lectures:Monday, Wednesday and Friday from 10:30 AM – 12:00PM
Austrian Auditorium
Textbook:Molecular Biology of the Cell, Eds. Alberts, et al. 5th edition
REQUIRED introductory lectures (prerecorded; available via MediaSite On-Line)
Protein Purification(9-4-13)M. Ostap
Immunological Techniques (9-6-13)M. Marks
Basics of Protein Structure and Folding (9-9-13)K. Ferguson
DATETOPICLECTURER
THEME I: COMPARTMENTATION
W Sept 3Course introductionR. Assoian
Themes in CompartmentationM.Marks
Membrane StructureM. Lemmon
F Sept 5Cellular Quality ControlP. Oliver
M Sept 8Protein Biogenesis and TranslocationJ. Wilusz into the Endoplasmic Reticulum
W Sept 10Protein Folding and Assembly in theM. Marks
Endoplasmic Reticulum
DATETOPICLECTURER
F Sept 12ImagingA. Stout
M Sept 15Imaging continued (10:30-11am)A. Stout
Biochemistry Quiz (11am-12pm)
W Sept 17Mechanisms of Vesicular TransportM. Marks
F Sept 19Golgi Function and Protein Sorting inC. Giraudo
the Secretory Pathway
M Sept 22Endocytosis and Lysosomal DegradationM. Marks
W Sept 24Exocytosis and SecretionC. Giraudo
FSept 26Mitochondria Function and BiogenesisA. Dancis
M Sept 29Nuclear Architecture and Nucleocytoplasmic B. Black
Transport
W Oct 1Protein-Protein Interactions R. Marmorstein
W Oct 1Exam review *3:30 – 5:00 pmTAs/Faculty
F Oct 3Exam ReviewTAs/Faculty
THEME II: CELL MOTILITY AND ADHESION
M Oct 6 Exam 1(Dunlop Auditorium)
W Oct 8 Microtubules E. Holzbaur
F Oct 10 Microtubule-Based Motility E. Holzbaur
M Oct 13Actin Cytoskeleton R.Dominguez
W Oct 15 Actin-Based Motility M. Ostap
F Oct 17 Adhesion J. Weisel
M Oct 20Cell Extracellular InteractionsJ. Weisel
W Oct 22Mitosis and CytokinesisE. Bi
THEME III: MEMBRANES AND SOLUTE TRANSPORT
MediaSite On-LineIntroduction to Kinetics (Prerecorded 10-11-13)R. Kohli
F Oct 24Principles of Ion TransportK. Foskett
M Oct 27Ion Channels 1T. Hoshi
W Oct 29Membrane Problem Set Help SessionK. Foskett
F Oct 31Ion Channels 2T. Hoshi
M Nov 3Integrated Functions of Ion ChannelsK. Foskett
M Nov 3Exam Review*3:30 – 5:00 pmTAs/Faculty
W Nov 5Exam ReviewTAs/Faculty
F Nov 7Exam 2 (Austrian Auditorium)
DATETOPICLECTURER
THEME IV: SIGNAL TRANSDUCTION
M Nov 10Introduction to Signal TransductionM. Lemmon
W Nov 12G-Protein Coupled Receptors and G-ProteinsD. Manning
FNov 14 Signaling by Small GTPasesM. Chou
Phosphoinositides
M Nov 17Tyrosine Kinases and PhosphatasesM. Lemmon
W Nov 19Calcium Signaling & PhospolipasesK. Foskett
F Nov 21Serine and Threonine PhosphorylationF. Lee
MNov 24Signaling and MetabolismK. Wellen
W Nov 26AutophagyS. Cherry
FNov 28No Class--Thanksgiving Break
M Dec 1Nuclear Receptor SignalingM. Lazar
WDec 3Cell CycleF. Luca
FDec 5Rb-E2F/Cell cycleR. Assoian
M Dec 8ApoptosisX. Yang
W Dec 10Integration of Signaling and Disease by p53X. Yang
F Dec 12Exam ReviewTAs/Faculty
M Dec 15Exam ReviewTAs/Faculty
W Dec 17Exam 3 (Dunlop Auditorium)
Faculty Lecturers
Richard Assoian – – 898-7157
Erfei Bi – – 573-6676
Ben Black – – 898-5669
Sara Cherry – – 746-2384
Margaret Chou – – 267-426-9228
Andy Dancis – – 573-6275
Roberto Dominguez – – 573-4559
Kevin Foskett – – 898-1354
Claudio Giraudo – – 267-425-2124
Erika Holzbaur – – 573-3257
Toshi Hoshi – – 573-7305
Rahul Kohli – – 573-7523
Frank Lee – – 898-4701
Mitch Lazar – – 898-0198
Mark Lemmon – – 898-3072
Frank Luca – – 573-5664
Ronen Marmorstein – – 898-7740
Dave Manning – – 898-1775
Mickey Marks – – 898-3204
Paula Oliver – – 267-426-2839
Mike Ostap – – 573-9758
Andrea Stout – – 573-3942
John Weisel – – 898-3573
Katy Wellen – – 746-8599
Jeremy Wilusz–– 898-8862
Xiaolu Yang – – 573-6739