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BIOL 404 ImmunologySpring Term 2008
TIME: MWF 9:00 a.m. – 9:50 a.m. lectures in Chichester Science Center 222
W 1:00 p.m. – 2:40 p.m. laboratories in Chichester 222
INSTRUCTOR: Dr. David W. Buckalew
OFFICE: Room 305A
PHONE:395-2586 (or 2586 from campus)
OFFICE HOURS: As posted or by appointment
M 1:00 – 3:00 p.m.
R9:00 – 10:00 a.m.
Course description: This course focuses on the specific and non-specific immune responses with particular emphasis on the human system. Relative to each category of immune response, the interplay between immune signaling molecules and relevant cells, tissues, and organs are discussed. Specific topics include: antigen recognition, processing, and presentation, T/B lymphocyte maturation, activation, and differentiation, humoral immunity, cell-mediated immunity, inflammation, hypersensitivity, acute and chronic disease responses, vaccines, and the immunology of cancer.
Three lectures and one 2-hour lab period per week. 4 credits.
REQUIRED TEXTBOOKS: Kindt, T.J., Goldsby, R.A., and Osborne, B.A.. 2007.
Immunology (6th ed.). W.H. Freeman (Lecture)
COURSE OBJECTIVES:
- To learn the distinctions between the innate and the adaptive immune response and to appreciate the collaboration between the two systems.
- To learn the distinctions between aspects of humoral and cell-mediated immunity and their many manifestations.
- To gain an appreciation for the complexity and diversity of cellular and chemical components at work to defend and rid the body of foreign cells and chemicals.
- To become aware of the health affects that may occur when select component(s) of these systems fail.
- To become aware of how problems relating to immunology are studied and interpreted
- Analyze and interpret information acquired from primary literature sources, then organize and communicate it in oral and written form.
- Demonstrate in writing and orally, a capacity for critical analysis of a specialized or topical issue in immunology.
- Demonstrate the potential for life long learning, the ability to use information technology, and effective time management skills
COURSE REQUIREMENTS:
THERE WILL BE NO "MAKE-UPS" FOR EXAMS, TESTS OR QUIZZES. ALL TESTS WILL BE GIVEN AT THE TIME AND DATE SCHEDULED.
Course grading will be comprised of:
A)three tests given approximately every four (4) weeks ……
B) final examination (comprehensive) scheduled for Friday, May 2 between 11:30 am – 2:00 pm in the lecture classroom
C)in-class quizzes
D)article reviews
E) laboratory component (incl. term paper and presentation)
Tardiness and Absences:
Class attendance and punctuality are strongly emphasized, as there is a high correlation between course performance and attendance in this class. Attendance will be taken at the beginning of class. Any student not present when roll is taken will be considered absent. If a student arrives after roll is called, it is the responsibility of the student to personally inform the instructor of his/her presence as soon as class is over. The instructor will adhere to Longwood’s policy of applying an “F” grade for any student who misses more than 25% (11 absences) of the class meetings (lecture and/or lab combined). An absent or tardy student will also be held accountable for all materials missed during absence(s).
The instructor assumes all students taking Immunology are seriously interested in attending graduate or professional school and desire to tailor their priorities pursuant to that goal.
COURSE EVALUATION:
The final grade will be determined as follows:
approx. %
three tests @ 100 pts. each300 points (33%)
the final examination200 points (22%)
ten quizzes @ 10 pts each 100 points (11%)
five review articles @ 5 pts each 25 points (3%)
the laboratory component 275 points (31%)
total points possible 900 points (100%)
Grading Scale:
Points/Percentage and Final Grade
The instructor will adhere to a strict 60/70/80/90% scale in determining grades for this course. All points are weighed equally from the lecture and lab quizzes, papers, and test scores.
Honor Code Policy:
I strongly support the Longwood University Honor System and expect you to do likewise. All written work is to be pledged in full and signed. Any student found responsible for an Honor Code violation in this course will receive an “F” grade.
COURSE OUTLINE AND SCHEDULE:
Some of the topics as well as the sequence of those topics are subject to change. Exams may include more or less material than is listed in the schedule depending on how closely we adhere to this outline......
Week of:Topic: Chapter
Jan 14Overview of the Immune System 1
Jan 21“ ” 1
*******Article #1 due Friday 1/25
Jan 28Cells and Organs of the Immune System 2
******Article #2 due Friday 2/1
Feb 4“” 2
*************TEST ONE**********Friday, Feb 8 ********************
Feb 11Innate Immunity – Inflammation processes 3
Feb 18Antigens 4
*****Article #3 due Friday 2/22
Feb 25Immunoglobulins: Structure and Function 4
Mar 3 Antigen Processing and Presentation and MHC Antigens 8
*************TEST TWO********Friday, Mar 7 ********************
Mar 10Spring Break – no classes
Mar 17B/T cell Maturation, Activation, Differentiation 10/11
Mar 24 Hypersensitivity 15
******Article #4 due Friday 3/28
Mar 31 Hypersensitivity 15
Apr 7 Immune Response to Infectious Disease 18
*************TEST THREE********Friday, April 11 **************
Apr 14 Vaccines 19
*******Article #5 due Friday, 4/18
Apr 21 Cancer and the Immune System 21
Apr 25Last day of classes
May 2Final Exam (Friday, May 2, 11:30 am – 2:00 pm)