Background of the Invention

-1-

CLAIMS

1. Compounds of the formula

wherein

Ais O and B is -CR8R9-; or

Bis O and A is -CR8R9-;

R1is selected from the group consisting of hydrogen, C1-7-alkyl and C3-7-cycloalkyl;

R2is selected from the group consisting of hydrogen, C1-7-alkyl and C3-7-cycloalkyl;

R3is selected from the group consisting of hydrogen, halogen, C1-7-alkyl and C3-7-cycloalkyl;

R4is selected from the group consisting of hydrogen, halogen, C1-7-alkyl and C3-7-cycloalkyl;

R5is C1-7-alkyl or C3-7-cycloalkyl;

or R3 and R5 together with the C atom to which they are attached form a cyclopropyl ring;

R6a, R6b, R6c and R6d independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, halogen and halogen-C1-7-alkyl;

R7is -(CO)-R10 or R11, wherein

R10is selected from the group consisting of

aryl, said aryl being unsubstituted or substituted by one, two or three groups selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy, cyano, hydroxy-C1-7-alkyl, oxo and phenyl,

heteroaryl, said heteroaryl being unsubstituted or substituted by one, two or three groups selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy, cyano, hydroxy-C1-7-alkyl, oxo and phenyl,

C1-7-alkyl,

halogen-C1-7-alkyl,

C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen or halogen-C1-7-alkyl, and

C1-7-alkoxy-C1-7-alkyl;

R11is selected from the group consisting of

C1-7-alkyl, and

C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen and halogen-C1-7-alkyl,

R8 and R9 are independently from each other selected from hydrogen, C1-7-alkyl and C3-7-cycloalkyl;

or pharmaceutically acceptable salts thereof.

2. Compounds of formula I according to claim 1, wherein A is O and B is -CR8R9-.

3. Compounds of formula I according to claim 1, wherein B is O and A is -CR8R9-.

4. Compounds of formula I according to any one of claims 1 to 3, wherein R1 and R2 are independently from each other selected from hydrogen or C1-7-alkyl.

5. Compounds of formula I according to any one of claims 1 to 4, wherein R1 and R2 are hydrogen.

6. Compounds of formula I according to any one of claims 1 to 5, wherein R3 and R4 are independently from each other selected from the group consisting of hydrogen, halogen, C1-7-alkyl.

7. Compounds of formula I according to any one of claims 1 to 6, wherein R3 and R4 are independently from each other hydrogen or fluoro.

8. Compounds of formula I according to any one of claims 1 to 7, wherein R3 and R4 are fluoro.

9. Compounds of formula I according to any one of claims 1 to 8, wherein R5 is methyl or ethyl.

10. Compounds of formula I according to any one of claims 1 to 6, wherein R3 and R5 together with the C atom to which they are attached form a cyclopropyl ring.

11. Compounds of formula I according to any one of claims 1 to 10, wherein R6a is hydrogen or fluoro and R6b, R6c and R6d are hydrogen.

12. Compounds of formula I according to any one of claims 1 to 11, wherein R7 is
-(CO)-R10 and R10 is selected from the group consisting of

C1-7-alkyl,

halogen-C1-7-alkyl,

C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen or halogen-C1-7-alkyl, and

C1-7-alkoxy-C1-7-alkyl.

13. Compounds of formula I according to claim 12, wherein R10 is selected from the group consisting of

halogen-C1-7-alkyl,

C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen or halogen-C1-7-alkyl, and

C1-7-alkoxy-C1-7-alkyl.

14. Compounds of formula I according to claim 12, wherein R10 is heteroaryl, said heteroaryl being unsubstituted or substituted by one, two or three groups selected from the group consisting of C1-7-alkyl, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy, cyano, hydroxy-C1-7-alkyl, oxo and phenyl.

15. Compounds of formula I according to claim 12, wherein R10 is C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen or halogen-C1-7-alkyl.

16. Compounds of formula I according to claim 12, wherein R10 is halogen-C1-7-alkyl or C1-7-alkoxy-C1-7-alkyl.

17. Compounds of formula I according to any one of claims 1 to 11, wherein R7 is R11 and is selected from the group consisting of C1-7-alkyl and C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen and halogen-C1-7-alkyl.

18. Compounds of formula I according to claim 17, wherein R11 is C3-7-cycloalkyl, said cycloalkyl being unsubstituted or substituted by one, two, three or four groups selected from the group consisting of C1-7-alkyl, halogen and halogen-C1-7-alkyl.

19. Compounds of formula I according to any one of claims 1 to 18, wherein R8 and R9 are hydrogen.

20. Compounds of formula I according to any one of claims 1 to 19, selected from the group consisting of

5-Chloro-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-4-fluoro-phenyl]-amide,

R)-5-(5-Cyclopentylamino-2-fluoro-phenyl)-6-fluoro-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine,

(5R,6R)-5-(5-(cyclopentylamino)-2-fluorophenyl)-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine,

(R)-5-(5-(cyclopentylamino)-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-amine,

(R)-ethyl 6-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenylcarbamoyl)nicotinate formate,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)picolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloropicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-(trifluoromethyl)picolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-cyanopicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropyrimidine-2-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)pyridazine-3-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3,5-dichloropicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloro-5-fluoropicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-methyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-methyloxazole-4-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-ethyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-ethyl-4-methyl-1H-pyrazole-5-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-methyl-1H-imidazole-4-carboxamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-fluoro-3-methylpicolinamide,

(R)-N-(3-(3-amino-5-ethyl-6,6-difluoro-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5,7,7-trimethyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5,7,7-trimethyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-cyanopicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-fluoropicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-cyanopicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloro-3-methylpicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3,5-difluoropicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloropicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-(trifluoromethyl)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3,5-dichloropicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloro-5-fluoropicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-methyl-1H-pyrazole-3-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2-methyloxazole-4-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-1-(difluoromethyl)-1H-pyrazole-3-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(difluoromethoxy)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(2,2,2-trifluoroethoxy)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(2,2,3,3-tetrafluoropropoxy)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(ethoxymethyl)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-(2,2,2-trifluoroethoxy)picolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(2,2-difluoroethoxy)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2-chlorothiazole-4-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-isopropoxypicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(2-fluoroethoxy)pyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4,5-dichlorothiophene-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloro-1,2,4-thiadiazole-3-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(2,2-difluoroethoxy)pyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-fluoro-5-(trifluoromethyl)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-6-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-methoxypicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-methylpicolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-ethyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-methyloxazole-4-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-ethyloxazole-4-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(trifluoromethyl)pyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-methylisoxazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-ethyl-4-methyl-1H-pyrazole-5-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-(difluoromethyl)picolinamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide formate,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2-methyl-5-(trifluoromethyl)oxazole-4-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide,

(R)-N-(3-(5-amino-3-methyl-2,3,6,7-tetrahydro-1,4-oxazepin-3-yl)-4-fluorophenyl)-5-chloropicolinamide,

(R)-N-(3-(5-amino-3-methyl-2,3,6,7-tetrahydro-1,4-oxazepin-3-yl)-4-fluorophenyl)-3-chloro-5-(trifluoromethyl)picolinamide,

(R)-N-(3-(5-amino-3-methyl-2,3,6,7-tetrahydro-1,4-oxazepin-3-yl)-4-fluorophenyl)-5-cyanopicolinamide,

(R)-N-(5-(3-amino-6,6-difluoro-5,7,7-trimethyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-2,4-difluorophenyl)-5-cyanopicolinamide,

(R)-N-(5-(3-amino-6,6-difluoro-5,7,7-trimethyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-2,4-difluorophenyl)-5-chloropicolinamide,

[3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

1-Trifluoromethyl-cyclobutanecarboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

1-Trifluoromethyl-cyclopropanecarboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

1-Trifluoromethyl-cyclopropanecarboxylic acid [3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide formate,

1-Trifluoromethyl-cyclopropanecarboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

2,2-Difluoro-cyclopropanecarboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

2,2-Difluoro-cyclopropanecarboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3,5-Dichloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3,5-Dichloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((1S,7R)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-phenyl]-amide; trifluoro-acetate salt,

3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-Fluoro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide (formate salt),

5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-4-fluoro-phenyl]-amide,

5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-phenyl]-amide,

5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Chloro-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-phenyl]-amide,

5-Chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Chloro-pyridine-2-carboxylic acid [3-((5S,7S)-3-amino-5-methyl-7-phenyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-2,2,5-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide (formate salt),

5-Chloro-pyrimidine-2-carboxylic acid [3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Difluoromethoxy-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Fluoro-pyridine-2-carboxylic acid [3-((5S,7S)-3-amino-5-methyl-7-phenyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Fluoro-pyridine-2-carboxylic acid [3-((S)-3-amino-2,2,5-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Fluoro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-Fluoro-pyridine-2-carboxylic acid [3-(3-amino-2,2,5-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

N-(3-((5R,6R)-3-amino-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide,

N-(3-((5R,6R)-3-amino-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide,

N-(3-((5R,6R)-3-amino-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-cyanopicolinamide,

N-(3-((5R,6R)-3-amino-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-(2,2,2-trifluoroethoxy)picolinamide,

N-(3-((5R,6R)-3-amino-6-fluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide,

N-(3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2,2-difluorocyclopropanecarboxamide formate,

N-(3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2-methoxypropanamide formate,

N-[3-((S)-3-Amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-3,3,3-trifluoro-propionamide, and

Pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide.

21. Compounds of formula I according to any one of claims 1 to 20, selected from the group consisting of

5-chloro-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-4-fluoro-phenyl]-amide,

5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-4-fluoro-phenyl]-amide,

5-chloro-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-phenyl]-amide,

5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((1SR,7RS)-3-amino-5-oxa-2-aza-bicyclo[5.1.0]oct-2-en-1-yl)-phenyl]-amide,

5-chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-fluoro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3,5-dichloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

[3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-difluoromethoxy-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-fluoro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3,5-dichloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-ethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

1-trifluoromethyl-cyclopropanecarboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

2,2-difluoro-cyclopropanecarboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

1-trifluoromethyl-cyclopropanecarboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

N-[3-((S)-3-amino-5,7,7-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-3,3,3-trifluoro-propionamide,

2,2-difluoro-cyclopropanecarboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

1-trifluoromethyl-cyclobutanecarboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-fluoropicolinamide,

5-fluoro-pyridine-2-carboxylic acid [3-(3-amino-2,2,5-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-cyanopicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloro-3-methylpicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3,5-difluoropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-1-(trifluoromethyl)cyclopropanecarboxamide,

N-(3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2,2-difluorocyclopropanecarboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)picolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-(trifluoromethyl)picolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-5-chloropyrazine-2-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3,5-dichloropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-3-chloro-5-fluoropicolinamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-4-chloro-1-methyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-2-methyloxazole-4-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxamide,

(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-1-(difluoromethyl)-1H-pyrazole-3-carboxamide,

5-chloro-pyridine-2-carboxylic acid [3-((R)-5-amino-3-methyl-2,3,6,7-tetrahydro-[1,4]oxazepin-3-yl)-4-fluoro-phenyl]-amide,

5-chloro-pyrimidine-2-carboxylic acid [3-((R)-3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,

5-chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-2,2,5-trimethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide,