Appendix.Search strategy of the three main database.
Ovid MEDLINE
Search # / Search Parameters1 / exp Lipid Regulating Agents/ae [Adverse Effects]
2 / expantidepressive agents/ae
3 / exp narcotics/ae
4 / exp Adrenergic beta-Antagonists/ae [Adverse Effects]
5 / exp Angiotensin-Converting Enzyme Inhibitors/ae [Adverse Effects]
6 / exp hypoglycemic agents/ae
7 / exp respiratory system agents/ae
8 / exp anti-ulcer agents/ae
9 / exp proton pump inhibitors/ae
10 / exp diuretics/ae
11 / exp anticonvulsants/
12 / exp tranquilizing agents/ae
13 / expantithyroid agents/ae
14 / exp calcium channel blockers/ae
15 / expantirheumatic agents/ae
16 / exp contraceptives, oral, hormonal/ae
17 / exp contraceptives, postcoital, hormonal/ae
18 / exp angiotensin II/ae
19 / exppenicillins/ae
20 / exp macrolides/ae
21 / exp vitamins/ae
22 / exp "Hypnotics and Sedatives"/ae [Adverse Effects]
23 / exp analgesics/ae
24 / exp histamine antagonists/ae
25 / 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24
26 / (antidepressive agents or antidepressants or thymoanaleptics or thymoleptics).mp.
27 / (lipid regulating agents or hypolipidemic agents or anticholesteremic agents).mp.
28 / (narcotics or marcotic* or Analgesics, opiod).mp.
29 / (adrenergic beta-antagonists or beta-blockers or beta blockers).mp.
30 / (angiotensin-converting enzyme inhibitors or ACE inhibitors).mp.
31 / (hypoglycemic agents or antidiabetics).mp.
32 / (respiratory system agents or respiratory agents or bronchodilator agents or anti-asthmatic agents or antiasthmatic*).mp.
33 / (anti-ulcer agents or antiulcerant*).mp.
34 / proton pump inhibitor*.mp.
35 / (diuretics or diuretic effect).mp.
36 / (anticonvulsants or antiepileptics or anti-epileptics).mp.
37 / (tranquilizing agents or tranquilizer* or antaractics or anti anxiety agents or anti-anxiety agents or antimanic agents or antispychotic agents).mp.
38 / (antithyroid agents or thyroid prep* or goitrogens).mp.
39 / (calcium channel blockers or calcium antagonists).mp.
40 / (antirheumatic agents or antirheumatic* or DMARD or anti-inflammatory agents, non-steroidal or antiinflammatory agents, non-steroidal or anti-inflammatory agents, nonsteroidal or antiinflammatory agents, nonsteroidal).mp.
41 / (hormonal contraceptives or contraceptives, hormonal).mp.
42 / angiotensin II.mp.
43 / (penicillin* or antibiotics).mp.
44 / (macrolides or anti-biotics).mp.
45 / ("hypnotics and sedatives" or hypnotic* or sedative*).mp.
46 / (analgesic* or anodynes or antinociceptive agents).mp.
47 / (histamine antagonists or antihistamine*).mp.
48 / 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43 or 44 or 45 or 46 or 47
49 / "drug related side effects and adverse reactions".mp. or exp "Drug-Related Side Effects and Adverse Reactions"/
50 / (adverse reactions or adverse drug events or side effects).mp.
51 / 49 or 50
52 / 48 and 51
53 / exp Lichen Planus, Oral/ci, et [Chemically Induced, Etiology]
54 / lichen planus, oral.mp.
55 / expLichenoid Eruptions/ci, et [Chemically Induced, Etiology]
56 / (lichenoid eruptions or lichenoid lesions or lichenoid reaction).mp.
57 / (medication induced or drug induced or chemically induced or etiology).mp.
58 / (oral or oral cavity).mp.
59 / exp Mouth/
60 / 25 or 52
61 / 58 or 59
62 / 56 and 57
63 / 55 or 62
64 / 54 and 57
65 / 53 or 64
66 / 61 and 63
67 / 65 or 66
68 / 60 and 67
69 / limit 68 to (english or spanish)
Scopus
Search # / Search Parameters1. / ( ( TITLE-ABS-KEY ( oral lichen planus ) OR TITLE-ABS-KEY ( ( lichenoid eruptions OR lichen* eruption* OR lichenoid lesions OR lichen* lesion* OR lichenoid reaction OR lichen* reaction* ) AND ( oral OR oral cavity OR mouth OR lip OR cheek ) ) ) )
2. / ( ( TITLE-ABS-KEY ( lipid regulating agent* OR hypolipidemic agent* OR anticholesteremic agent* OR antidepressive agent* OR antidepressant* OR thymoanaleptic* OR narcotic* OR opioid analgesic* ) OR TITLE-ABS-KEY ( adrenergic bets-antagonist* OR beta blocker* OR angiotensin-converting enzyme inhibitor* OR ace inhibitor* OR hypoglycemic agent* OR antidiabetic* OR respiratory system agent* OR bronchodilator* OR anti asthma* ) OR TITLE-ABS-KEY ( anti ulcer agent* OR antiulcerant* OR proton pump inhibitor* OR diuretic* OR diuretic effect OR anticonvulsant* OR antiepileptic* OR anti epileptic* OR tranquilizing agent* OR tranquilizer* OR antactic* OR anti anxiety agent* OR antimanic agent* ) OR TITLE-ABS-KEY ( antipsychotic agent* OR antithyroid agent* OR thyroid prep* OR goitrogen* OR calcium channel blocker* OR calcium antagonist* OR antirheumatic agent* OR antirheumatic* OR dmard ) OR TITLE-ABS-KEY ( anti inflammatory agent* OR nonstroidal anti inflammatory agent* OR oral hormonal contraceptive* OR postcoital hormonal contraceptive* OR angiotensin ii ) OR TITLE-ABS-KEY ( penicillin* OR antibiotic* OR macrolide* OR antiinfective* OR anti infective* OR vitamin* ) OR TITLE-ABS-KEY ( "hypnotic* and sedative*" OR hypnotic* OR sedative* OR analgesic* OR anodyne* OR antinociceptive agent* OR histamine antagonist* OR antihistamine* ) ) )
3. / #1 AND #2
Embase
Search # / Search Parameters1. / 'antithyroid agent'/exp OR 'antithyroid agents' OR 'thyroid prep*' OR 'thyroid antagonist*' OR 'antithyroid drug*'
2. / 'antiulcer agent'/exp OR 'antiulcer agent' OR 'anti-ulcerant*' OR 'antiulcerant*' OR 'anti-ulcer drug*' OR 'antiulcer drug*' OR 'anti
ulcer drug*'
3. / 'respiratory tract agent'/exp OR 'respiratory tract agent' OR 'respiratory system agent*' OR 'respiratory agent*' OR 'bronchodilator*' OR 'bronchodilator agent*' OR 'respiratory stimulant*' OR 'bronchodilator drug*' OR 'respiratory drug*'
4. / 'antilipemic agent'/exp OR 'antilipemic agent' OR 'lipid regulating agent*' OR 'lipid regulating drug*' OR 'hypolipidemic agent*' OR 'hypolipidemic drug*' OR 'anticholesteremic agent*' OR 'anticholesteremic drug*'
5. / 'antidepressant agent'/exp OR 'antidepressant agent' OR 'antidpressant*' OR 'antidepressant drug*' OR 'thymoanaleptic*' OR 'thymolepitic*'
6. / 'narcotic agent'/exp OR 'narcotic agent*' OR 'narcotic*'
7. / 'beta adrenergic receptor blocking agent'/exp OR 'beta adrenergic receptor blocking agent' OR 'adrenergic beta-antagonist*' OR 'beta-blocker*'
8. / 'dipeptidylcarboxypeptidase inhibitor'/exp OR 'dipeptidylcarboxypeptidase inhibitor' OR 'angiotensin-converting enzyme inhibitor*' OR 'angiotensin converting enzyme inhibitor*' OR 'kininase*' OR 'ace inhibitor*'
9. / 'antidiabetic agent'/exp OR 'antidiabetic agent*' OR 'hypoglycemic agent*' OR 'hypoglycemic drug*' OR 'antidiabetic drug*' OR 'anti-diabetic agent*' OR 'anti-diabetic drug*'
10. / 'proton pump inhibitor'/exp OR 'proton pump inhibitor'
11. / 'diuretic agent'/exp OR 'diuretic agent' OR 'diuretic*' OR 'diuretic drug*'
12. / 'anticonvulsive agent'/exp OR 'anticonvulsant*' OR 'anti-epileptic*' OR 'antiepileptic*'
13. / 'tranquilizer'/exp OR 'tranquilizer' OR 'tranquilizing agent*' OR 'tranquilizing drug*'
14. / 'calcium channel blocking agent'/exp OR 'calcium channel blocking agent' OR 'calcium channel blocking drug*' OR 'calcium channel blocker*' OR 'calcium antagonist*'
15. / 'antirheumatic agent'/exp OR 'antirheumatic agent' OR 'antirheumatic*' OR 'anti-rheumatic*' OR 'dmard'
16. / 'contraceptive agent'/exp OR 'contraceptive agent' OR 'contraceptive*' OR 'hormonal contraceptiv*'
17. / 'angiotensin ii'/exp
18. / 'penicillin derivative'/exp OR 'penicillin derivative' OR 'penicillin*'
19. / 'macrolide'/exp OR 'macrolide' OR 'vitamin'/exp
20. / 'hypnotic sedative agent'/exp OR 'hypnotic
21. / 'analgesic agent'/exp OR 'analgesic agent' OR 'analgesic*' OR 'antinociceptive agent*' sedative agent' OR 'hypnotic*' OR 'sedative*' OR 'vitamin'
22. / 'antihistaminic agent'/exp OR 'antihistaminic agent' OR 'histamine antagonist*' OR 'antihistamine*'
23. / 1 OR 2 OR 3 0R 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22
24. / 'adverse drug reaction'/lnk OR ('adverse drug reaction'/exp OR 'adverse reaction*')
25. / 23 AND 24
26. / 'lichen planus'/exp OR 'lichen planus' OR 'lichenoid eruption'/exp OR 'lichenoid eruption'
27. / 'mouth'/exp OR 'mouth' OR 'mouth mucosa'/exp OR 'mouth mucosa' OR 'cheek'/exp OR 'cheek' OR 'lip'/exp OR 'lip' OR 'mouth cavity'/exp OR 'mouth cavity' OR 'palate'/exp OR 'palate' OR 'tongue'/exp OR 'tongue' OR 'oral cavity'/exp OR 'oral cavity' OR 'cheek mucosa'/exp OR 'cheek mucosa' OR 'gingiva'/exp OR 'gingiva' OR 'mouth epithellum cell'
28. / 26 AND 27
29. / 25 AND 28