An Improved Synthesis of Sunitinib Malate Via a Solvent Free Decarboxylation Process

An improved synthesis of sunitinib malate via a solvent free decarboxylation process

Ge Meng• Chunyan Liu • Shidong Qin • Mengshu Dong •Xiaomi Wei • Meilin Zheng •

Liwen Qin • Huihui Wang • Xiaoshuang He • Zhiguo Zhang

Some of the original spectra of the intermediates and the final product were shown in the following:

Figure 1. 1H NMR spectrum of Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate(9)

Figure 2. Mass spectrum of 5-Formyl-2,4-dimethyl1H-pyrrole-3-carboxylic acid(3)

Figure 3. 1H NMR spectrum of N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide (10)

Figure 4. Mass spectrum of Sunitinib (1)

Figure 5. 1H NMR spectrum of Sunitinib (1)

Figure 6. 1H NMR spectrum of Sunitinib Malate