Amendments to Proof
Amendments to Proof
Author(s) Name(s): Marc Lavoie, Kieron O’Connor
Chapter Title: Neurocognitive aspects of Tourette Syndrome and Related Disorders
Page No. / Section / Paragraph / Line No. / Delete / Add/amend1 / 1 / 1 / 5 / Cognitive and Social Psychophysiology Laboratory
1 / 1 / 1 / 6 / FRSQ Research team on obsessive-compulsive spectrum
1 / 1 / 1 / 9 / Department of Psychiatry
1 / 1 / 1 / 10 / University of Montreal
1 / 29 / Different levels of
2 / 1 / 5 / E. / Shapiro & Shapiro, 1986
2 / 7 / The / Tics appear…
3 / 2 / 24 / multiply / are additive
3 / 3 / 37 / This / Large…
3 / 3 / 38 / study / studies
3 / 3 / 39 / …GTS patients (Alsobrook & Pauls, 2002; Freeman, 2007; Freeman et al., 2000)
4 / 1 / 3-8 / Although prevalence rates vary considerably across 3 studies, it is recognized that comorbidities differ between children and adults with GTS. In 4 adults these tend to be social phobia and OCD (50-60%), whilst in children the problem is 5 more attention deficit hyperactivity (ADHD) (21-90%), and rage syndrome also called 6 explosive behavior (35-70%), plus other behavioral problems (Alsobrook & Pauls, 2002; 7 Freeman, 2007; Freeman et al., 2000).
4 / 2 / 26 / can
5 / 3 / 16 / 1.9 Clinical and phenomenological aspects of comorbidity in GTS
5 / 3 / 24 / 40% of / In half of GTS (Apter et al., 1992)
5 / 26-33 / The complicated cases of GTS+ often come with social and behavioral 26 consequences. For instance, conduct disorder (Stephens & Sandor, 1999) and poorer social 27 adaptation (Carter et al., 2000) are more prevalent in children with GTS+ than those with 28 GTS only or unaffected controls. Interestingly, tic severity was not associated with social, 29 behavioral, or emotional functioning, even after stratifying by medication status, thus, 30 providing evidence that aggressive behavior observed in GTS is associated with 31 comorbidity, independently of tic severity. Overall, these results confirm that comorbid 32 diagnoses often trigger more severe social distress than GTS alone.
6 / 1 / 5 / B.S.
6 / 3 / 29 / M.E.
8 / 2 / 9 / As demonstrated
8 / 3 / 30 / compensation
9 / 1 / 18 / G. / Thibault, O’Connor, Stip, & Lavoie, 2008
9 / 2 / 29 / symptomatic
9 / 3 / 43 / GTS+ADHD and/or the OCD
9 / 3 / 44 / Thus, / Again, the comorbidity
10 / 2 / 6 / 2.6 Inhibitory function and attention in dissociating GTS and OCD
10 / 2 / 30 / J. Towey et al., 1990; J. Towey et al., 1993; J. P. Towey et al., 1994) / (Towey et al., 1990; Towey et al., 1993; Towey et al., 1994)
10 / 3 / 34 / in separate
10 / 3 / 35 / studies
10 / 3 / 36 / G. / One of our recent study (Thibault et al., 2008)
10 / 3 / 43 / P. Morault, Guillem, Bourgeois, & Paty, 1998; P. M. Morault, Bourgeois, Laville, Bensch, & Paty, 1997 / Morault, Guillem, Bourgeois, & Paty, 1998; Morault, Bourgeois, Laville, Bensch, & Paty, 1997
11 / 1 / 2 / G. Thibault et al., 2008; J. P. Towey et al., / Thibault et al., 2008; Towey et al.,
11 / 3 / 36 / …compatible with current cognitive…
11 / 3 / 38 / cognitive-behavioral treatment (CBT)
12 / 2 / 5 / first line of attack and represent the..
12 / 2 / 8 / variable response ,
12 / antagonistic / antagonist
12 / 37 / showed
13 / 25 / 52% of the adult patients
13 / 29 / who are
13 / 30 / CT / GTS or chronic tic
13 / 38 / (TD)
14 / 1 / 1 / (K.P. O’Connor, 2005) / (O’Connor, 2005)
14 / 1 / 2 / /TD
14 / 2 / 7 / …of planning that prevents
14 / 2 / 11 / cognitive-behavioral treatment / CBT package
14 / 2 / 12 / …motor activation who will…
14 / 2 / 16 / a forty…
14 / 2 / 17 / TD / chronic tic
14 / 2 / 19 / HD
14 / 2 / 26 / TD with one principal tic,
14 / 2 / 25-26 / The majority of participants in this study were diagnosed with light to moderate symptoms.
14 / 4 / 40 / the…
14 / 4 / 40 / the…
14 / 4 / 40 / tics
15 / 1 / 4 / This type of association has not been examined with a GTS population
15 / 1 / 5 / but OCD shares several common points with GTS
15 / 3 / 40 / motor symptoms and inhibition
16 / 2 / 6 / reconstruction / management
16 / 2 / 7 / …front lines
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