SFS
1. ------IND- 2007 0044 S-- EN- ------20070130 ------PROJET
Swedish Collection of Statutes
SFS
Published on
1
SFS
Order
amending the Order (1999:58) prohibiting certain products hazardous to health;
issued on x April 2007.
The Swedish Government stipulates[1] that the Annex to the Order (1999:58) prohibiting certain products hazardous to health is to have the following wording.
______
This Order shall come into force on 1 May 2007.
On behalf of the Swedish Government
MARIA LARSSON
Björn Reuterstrand
(Ministry of Health and Social Affairs)
Annex[2]
List of products that must be considered hazardous to health under the Act prohibiting certain products hazardous to health
N-methyl-1-(3,4-methylene dioxyphenyl)-2-butylamine (MBDB)
1-(3,4-methylene dioxiphenyl)-2-butylamine (BDB)
N-benzylpiperazine
4-chloro-2,5-dimethoxyamphetamine (DOC)
5-methoxy-N,N-dimethyl tryptamine (5-MeO-DMT)
5-methoxy-N,N-diisopropyl tryptamine (5-MeO-DIPT)
5-methoxy-alphamethyl tryptamine (5-MeO-AMT)
2,5-dimethoxy-4-ethyl phenethylamine (2C-E)
alpha-methyl tryptamine (AMT)
2,5-dimethoxy-4-chlorophenethylamine (2C-C)
2,5-dimethoxy-4-methyl phenethylamine (2C-D)
4-acetoxy-N,N-diisopropyl tryptamine (4-AcO-DIPT)
4-hydroxy-N,N-diisopropyl tryptamine (4-HO-DIPT)
gamma butyrolactone (GBL)
1,4-butane diol (1,4-BD)
3,4-methylene dioxy metcatinone (Methylon)
4-acetoxy-N,N-methylisopropyl tryptamine (4-AcO-MIPT)
4-hydroxy-N,N-methylisopropyl tryptamine (4-HO-MIPT)
4-acetoxy-N,N-diethyl tryptamine (4-AcO-DET)
4-hydroxy-N,N-diethyl tryptamine (4-HO-DET)
1-(3-trifluoromethyl phenyl)piperazine (TFMPP)
2,5-dimethoxy-4-isopropyl thiophenethyl amine (2C-T-4)
bromobenzodifuranyl isopropyl amine (Bromo-Dragonfly)
salvinorin A
all parts of the plant Salvia divinorum from which salvinorin A has not been extracted and regardless of the designations under which they are present
Salts of the substances where these may be present.
/CLASSIFICATION DOCUMENT
for products hazardous to health:Act 1999:42
Order 1999:58
/ Ref. no.: 830-06-0886Proposal submitted on:
06/12/2006
RELATES TO
2C-T-41. Name, common name, synonyms, CAS no.
2C-T-42,5-dimethoxy-4-isopropyl thiophenethyl amine
CAS no.: 207740-25-8
2. Empirical formula, chemical structure
C13H21NO2S2C-T-4 is a synthetic substance belonging to the group of phenethyl amines. Its chemical structure resembles substances such as 2C-B, 2C-T-7, meskaline and MDMA, which are all regulated as narcotics (LVFS 1997:12).
3. Physical data
Physical stateOccurs as powder, capsules and tablets. Has been encountered in Denmark as light yellow tablets, weight 31 mg, diameter 4 mm. In Sweden, 2C-T-4 has been encountered as beige and also white tablets. In the United Kingdom, as capsules containing 90 mg 2C-T-4, cream-coloured powder. (EDND; SKL; the National Board of Health; UK NFP)
Molecular weight
255.37 g/mol (chemfinder.com)
4. Preparation
Information is lacking.5. Mechanism of action
2C-T-4 is a phenethyl amine derivative which, like other 2C-T-derivates (e.g. 2C-T-2 and 2C-T-7) and 2C-B, etc., acts mainly by stimulating 5HT2 receptors. This stimulation induces hallucinations and an altered mood. 2C-T-4 may also bind to other serotonin receptors and alpha-adrenergic receptors; however, this is not known in detail. Phenethyl amine derivatives have a certain amphetamine-like effect, which can more easily induce a circulatory effect with, for example, raised blood pressure and pulse. (Poisons Information Centre; Poisindex; Roth)6. Method of exposure, abuse dose
2C-T-4 is usually taken orally or nasally in doses of 10 – 20 mg. The effect may appear late and may last for up to 20 hours, and possibly even longer. In the case of nasal exposure, the intoxication tends to be shorter. (leda.lycaeum.org; Shulgin;7. Combined abuse
2C-T-4 is still limited in use as a substance of abuse and is found in isolated cases in combined abuse (e.g. with DXM, amphetamine and metamphetamine) (Poisons Information Centre; RMV).8. Health risks
Individual risks2C-T-4 belongs to the phenethyl amine group and has risks reminiscent of LSD (hallucinogen) and amphetamine (central stimulant). As no scientific research has been conducted on 2C-T-4, knowledge of risks relating to this substance is primarily limited to the user’s reported experience. Risks include nausea, dilated pupils and hallucinations, and the compound has effects similar to other phenethyl amines (e.g. 2C-B, 2C-T-2, 2C-T-7). Overdose may lead to a certain circulatory effect, cramps and unconsciousness. (The National Board of Health;
Public health risks
Besides the two seizures and one case of 2C-T-4 being detected in bodily fluid that have occurred in Sweden, discussion fora on various websites indicate that 2C-T-4 is used to some extent. Two seizures have been made in Europe, indicating that it is also used outside Sweden. Whether this currently limited use will increase is difficult to predict. As a result of the substance’s similarities to other controlled psychedelic phenethyl amines, there is a substantial risk of use spreading while the substance remains legal. (
Social risksNo documented social risks are linked to the use of 2C-T-4. Nevertheless, abuse of 2C-T-4 may pose a risk of accidents and mental problems (the National Board of Health). Both the individual and society are put at risk.
9. Documented occurrence
Medical and industrial use
In Sweden, there is no importation or manufacture of 2C-T-4 for industrial purposes (the Swedish Chemicals Inspectorate). No medical use of the substance is known (the Medical Products Agency; the National Board of Health).Incidence of abuse
2C-T-4 is a relatively new substance of abuse which, according to the National Institute of Public Health in Sweden, has been abused in Sweden over the last few years. Discussions of use can be found on Swedish and European websites, and in 2005 seizures were made in Sweden, Denmark and the United Kingdom. 2C-T-4 was also detected in a Swedish urine sample during 2006. That the substance is used both in Sweden and in other countries is therefore clear, but the National Institute of Public Health in Sweden and ECNN consider use for the time being to be limited. (ECNN; EDND; SKL;
Reported occurrence in Sweden
SKL
In July and September 2005, the police in Skåne made two seizures of 2C-T-4 from users. The seizures consisted of two white tablets and one beige tablet.
RMV
During 2006, 2C-T-4 was detected in a urine specimen taken from a 20-year-old man. The police in Skövde state that at the time of the arrest, the man was talking incessantly and incoherently and that he appeared confused. The urine specimen also contained 3 micrograms of amphetamine and 2 micrograms of metamphetamine per millilitre of urine.
The Swedish Customs Department laboratory
Up to October 2006, the Swedish Customs Department has not had any cases concerning 2C-T-4.
Poisons Information Centre
During 2005, 4 inquiries were received concerning 2C-T-4.
The CRD network
No occurrences have been reported up to and including October 2006.
Reported occurrence in the EU
Denmark
In 2005, the police made a seizure of 2C-T-4. The seizure consisted of a light yellow tablet, weight 31 mg, 4 mm in diameter. (DK NFP)
United Kingdom
UK Customs made one seizure of 2C-T-4 during 2005. The seizure consisted of a plastic bag containing 90 mg cream-coloured powder in capsules. The bag was marked “2C-T-4/100 mg” and the consignment seized had been imported from Japan. FHI comments: Not indicated whether 90 mg/capsule or a total of 90 mg divided between several capsules. (UK NFP)
10. Availability
Most international websites market 2C-T-4.The Swedish website Rc Drugs sells 2C-T-4 in tablet form. 20 tablets of 10 mg each cost SEK 700. ( Cyberacid previously sold 2C-T-4. In May 2006, the pricing was the same as for Rc Drugs. Cyberacid ceased selling the product in autumn 2006. (
11. Abuse profile
The lack of research on 2C-T-4 makes it difficult to draw conclusions about abuse of the substance.In the user part, the state of intoxication is described, among other things, in the following terms:“The actual experience feels like reality is shrouded in a haze, and the visual side is then gradually filled in. […] It’s like being in two worlds at once, because even when under the influence of this drug you can function relatively normally, if you make an effort. That’s not to say that those around you think you’re sober … If you let the experience come and just relax, you can get really high.” (
12. Current control status
2C-T-4 is a class B drug in Denmark (the National Board of Health). The substance is also controlled in the United Kingdom under the generic classification of phenethyl amines (ECNN).13. Conventions
2C-T-4 is not covered by the 1961 Narcotics Convention or by the 1971 Psychotropics Convention.14. Other information
2C-T-4 is monitored by the EU in accordance with Council Decision 2005/387/JHA from 10 May 2005.15. References
The CRD network, the CAN (Central Federation for Alcohol and Drug Information) regional drug reporting systemDK NFP (National Focal Point), the National Board of Health, Denmark
ECNN, the European Centre for Narcotics and Narcotics Control
EDND, European information system and database on new drugs, ECNN
The Poisons Information Centre
The Swedish Chemicals Inspectorate
LVFS 1997:12, The Medical Products Agency's regulations governing lists of narcotics
The Medical Products Agency
Poisindex Managements. © 1974 – 2006 Thomson MICROMEDEX
RMV, the National Board of Forensic Medicine’s Department of Forensic Chemistry
Roth BL et al. Savinorin A: A potent naturally occurring non-nitrogenous opioid selective agonist. Proc. Natl. Acad. Sci. USA; 2002, 99(18):11934-39
Council Decision 2005/387/JHA dated 10 May 2005
Shulgin A and A Shulgin. Pihkal. Phenethylamines I have known and loved. A chemical love story. 2003
SKL, The National Laboratory of Forensic Science
The National Institute of Public Health in Sweden
The National Board of Health. Recommendation concerning the inclusion of 2C-T-4 in the Euphoretics Order. Ref. No. 0-310-149/1/BIN. 22 November 2005
The Swedish Customs Department
The Swedish Customs Department laboratory
UK NFP (National Focal Point), Department of Health, the United Kingdom
Websites:
chemfinder.com
leda.lycaeum.org
16. Recommendation
To prevent 2,5-dimethoxy-4-isopropyl thiophenethyl amine (2C-T-4) spreading further and thus causing damage, the National Institute of Public Health in Sweden, in consultation with the authorities concerned, recommends that the substance be included in the Order prohibiting certain products hazardous to health.17. Notification of the EU Commission
If the decision under point 16 means that the product must be classified, account must be taken of the barriers to trade that a ban may entail.z
/
CLASSIFICATION DOCUMENT
for products hazardous to health:Act 1999:42
Order 1999:58
/ Ref. no.: 830-06-0886Proposal submitted:
06/12/2005
RELATES TO
Bromo-Dragonfly1. Name, common name, synonyms, CAS no.
Bromo-DragonflyBromobenzodifuranylisopropyl amine
(1-(8-bromobenzo[1,2-b;4,5-b’]difuran-4-yl)-2-aminopropane
3C-Bromo-Dragonfly, DOB-Dragonfly, Br-DF, ABDF
2. Empirical formula, chemical structure
C13H12BrNO2Bromo-Dragonfly is a synthetic phenethyl amine that resembles DOB, LSD and amphetamine.
3. Physical data
Physical stateOccurs as powder, tablets, blotters (scraps of paper for placement on the tongue) and liquid (
Molecular weight
294.15 g/mol (
Melting point
240C for the hydrochloride (
4. Preparation
Information is lacking.5. Mechanism of action
Bromo-Dragonfly has a very strong propensity to bind to the 5-HT2A receptor, a propensity approx. 60 times greater than the corresponding non-aromatic benzodifuran (Parker et al; Chambers et al; Monte et al). Bromo-Dragonfly may also bind strongly to 5-HT2B and 5-HT2C(6. Method of exposure, abuse dose
Is usually taken orally, with onset of effect after 20 – 90 minutes. Maximum effect is achieved after about 6 - 12 hours and usually persists for 12 – 24 hours. The effect may in some cases persist for 3 – 4 days. Normal abuse doses are 50 – 800 µg (7. Combined abuse
Bromo-Dragonfly is still limited in use as a substance of abuse and is found in isolated cases in combined abuse (e.g. with DOI). (SKL)8. Heath risks
Individual risksBromo-Dragonfly is an extremely potent hallucinogen. It has structural similarities to DOB, LSD and amphetamine and is a phenethyl amine with risks reminiscent of LSD (hallucinogen) and amphetamine (central stimulant). Individual differences in response may be due it being the non-aromatic form or the aromatic form, see mechanism of action, section 5. (Parker et al; Chambers et al)
A long time until onset of effect increases the risk of the user becoming impatient and therefore overdosing (
Public health risks
Only one seizure of Bromo-Dragonfly is known in Europe; this has been made in Sweden. Websites selling and discussing the use of the substance highlight the fact that the substance is in use to a certain extent. Whether this currently limited use will increase is difficult to predict. Users are stated to gain a desired effect from the substance, and there is a substantial risk of use spreading while the substance remains legal. (
Social risksNo documented social risks are linked to the use of Bromo-Dragonfly. As a result of its potent hallucinogenic effect, there is a risk of accidents and mental disorders. Both the individual and society are put at risk.
9. Documented occurrence
Medical and industrial use
In Sweden, there is no importation or manufacture of Bromo-Dragonfly for industrial purposes (the Swedish Chemicals Inspectorate). No medical use of the substance is known (the Medical Products Agency).Incidence of abuse
Bromo-Dragonfly is a new substance that was synthesised for the first time in the late 1990s. Via the internet, it has been known for a couple of years that the substance is being abused, and the seizure made by Swedish police in September 2006 confirms this assumption. This seizure also contained DOI (4-iodine-2,5-dimethoxyamphetamine). (SKL;
Reported occurrence in SwedenSKL
In September 2006, the National Laboratory of Forensic Science (SKL) had one case referred from the police in Uppsala involving the discovery of Bromo-Dragonfly. The seizure consisted of 4 white square blotters that turned out also to contain DOI (4-iodine-2,5-dimethoxy amphetamine).
RMV
As of October 2006, the National Board of Forensic Medicine (RMV) has not had any cases involving Bromo-Dragonfly.
The Swedish Customs Department laboratory
As of October 2006, the Swedish Customs Department has not had any cases involving Bromo-Dragonfly.
Poisons Information Centre
Isolated inquiries during 2006.
The CRD network
No occurrence has been reported up to and including September 2006.
Reported occurrence outside Sweden
The National Institute of Public Health in Sweden is unaware of any other country in which Bromo-Dragonfly has been seized.
10. Availability
Bromo-Dragonfly is sold on both in powder form and as blotters. 1 gram of powder costs SEK 2500 SEK. A pack of blotters contains 2 x 500 µg blotters and costs SEK 98, 20blotters (10000 µg) cost SEK 695 and 200 blotters (100000 µg) cost SEK 4 950 (as at 21/09/2006). Bromo-Dragonfly is also sold on in the form of blotters. The price is the same as for blotters from Naturensdroger. (16/11/2006)11. Abuse profile
The lack of research on Bromo-Dragonfly makes it difficult to draw conclusions about abuse of the substance.Bromo-Dragonfly is used, among other things, at parties. Users are mainly young people who use Bromo-Dragonfly to supplement or replace other drugs. (
12. Current control status
Bromo-Dragonfly is not internationally controlled. The substance may be covered by generic legislation in the United Kingdom and Eire (ECNN; EDND).13. Conventions
Bromo-Dragonfly is not covered by the 1961 Narcotics Convention or by the 1971 Psychotropics Convention.14. Other information
Bromo-Dragonfly is monitored by the EU in accordance with Council Decision 2005/387/JHA dated 10 May 2005.15. References
Chambers et al, Enantiospecific Synthesis and Pharmacological Evaluation of a Series of Super-Potent, Conformationally Restricted 5-HT2A/2C Receptor Agonists, Purude University, Indiana, Journal of Medical Chemistry, volume 44, no. 6, 2001.The CRD network, the CAN (Central Federation for Alcohol and Drug Information) regional drug reporting system
ECNN, the European Centre for Narcotics and Narcotics Control
EDND, European information system and database on new drugs, ECNN
The Poisons Information Centre
The Swedish Chemicals Inspectorate
The Medical Products Agency
Monte et al, Dihydrobenzofuran Analogues of Hallucinogens, Vanderbilt University Medical Center, Nashville, Tennessee, Journal of Medical Chemistry, volume 40, no. 19, 1997.
Parker et al, A Novel (Benzodifuranyl)aminoalkane with Extremely Potent Activity at the 5-HT2A Receptor, Purude University, Indiana, Journal of Medical Chemistry, volume 41, no. 26, 1998.
RMV, The National Board of Forensic Medicine’s Department of Forensic Chemistry
Council Decision 2005/387/JHA dated 10 May 2005
SKL, The National Laboratory of Forensic Science
The National Institute of Public Health in Sweden
The Swedish Customs Department
The Swedish Customs Department laboratory
Websites:
16. Recommendation
To prevent bromobenzodifuranylisopropyl amine (Bromo-Dragonfly) spreading further and thus causing damage, the National Institute of Public Health in Sweden, in consultation with the authorities concerned, recommends that the substance be included in the Order prohibiting certain products hazardous to health.17. Notification of the EU Commission
If the decision under point 16 means that the product must be classified, account must be taken of the barriers to trade that a ban may entail.1
[1] See Directive 98/34/EC of the European Parliament and of the Council of 22 June 1998 laying down a procedure for the provision of information in the field of technical standards and regulations and of rules on Information Society services (OJ L 204, 21/7/1998, p. 37, Celex 31998L0034), amended by Council Directive 98/48/EC (OJ L 217, 5/8/1998, p.18, Celex 31998L0048).
[2] Most recent wording of 2006:167.