AGENDA FOR ANNUAL REVIEW MEETING 2012
UNIVERSITY OF NAIROBI STD/AIDS COLLABORATIVE GROUP
MAYFAIR COURT SOUTHERN SUN, NAIROBI
Monday, January 23, 2012
8:00– 9:00Registration
9:00–9:20OPENING CEREMONIES
Chair: Omu Anzala
Opening remarks – Prof. I. Kibwage – Principal, College of Health Sciences, Univ. Nairobi
Official opening – Prof. L. Irungu – Deputy Vice-Chancellor (Research), Univ. Nairobi
Session I:Treatment as Prevention – “the end of AIDS” or this year’s magic bullet?
Co-Chairs: Omu Anzala
Frank Plummer
9:20 – 9:50ABCC plus ARVs for HIV prevention: Do we have enough tools to end the HIV/AIDS Epidemic? Review of recent trial results (Nelly Mugo, Lisa Mills)
9:50 – 10:05Policy and implementation considerations in rolling out ARV-based prevention (Peter Cherutich)
10:05 – 10:20Issues and lessons learned from scaling-up male circumcision in Nyanza (Kawango Agot)
10:20 – 10:35Discussion
10:35- 11:10Coffee/tea
Session II:Epidemiology, Transmission, Risk Factors I
Co-Chairs:Benson Estambale
Rupert Kaul
11:15 – 11:30National geographic mapping of populations most-at-risk of HIV (MARP) in Kenya: preliminary results (Willis Odek – Univ. Manitoba/Univ.Nairobi)
11:30 – 11:45Enumeration of female sex workers in CoastProvince – implication for policy and programming for most at risk populations (Nzioki Kingola – ICRH / Univ. Nairobi)
11:45 – 12:00Factors associated with HIV seroconversion in the Nairobi-based female sex worker cohort 2008-2011 (Lyle McKinnon – Univ. Toronto/Univ.Nairobi)
12:00 – 12:15Evaluation of the validity of self-reported condom use with prostate-specific antigen biomarker (Fred Mose – Univ.Washington / Univ.Nairobi)
12:15 – 12:30Typologies of migration and mobility and contexts of HIV risk among women in the Kisumu area (Carol Camlin – UCSF / KEMRI)
12:30 – 12:45Sexual behaviour patterns among HIV-negative partners in HIV discordant relationships attending Pumwani MCH Clinic, Nairobi (Nelly Muturi – Univ.Manitoba / Univ.Nairobi/KEMRI))
12:45- 1:00Demographic, geographic and immune-virologic correlates of study follow-up interruption among Kenyan HIV-1 discordant couples (Jeanne Conley - Univ. Washington / Univ. Nairobi)
1:00 – 2:00Lunch
Session III: Interventions I
Co-Chairs:Scott McClelland
Lisa Mills
2:00 – 2:15HPTN052 early findings release: treating HIV-infected people with antiretrovirals significantly reduces transmission to partners (Victor Akelo – CDC/KEMRI)
2:15 – 2:25Evaluation of community recruitment approaches for the HPTN052 clinical trial in Asembo and Karemo, Kenya (Kenneth Ondenge – CDC/KEMRI)
2:25– 2:35Conducting clinical drug trials in rural Africa: identifying and addressing community issues (J. Onyango – Impact Research and Development Org)
2:35 – 2:50Acceptability of novel ARV-based HIV prevention methods in a rural Kenyan Health and Demographic Surveillance community (Lisa Mills – CDC/KEMRI)
2:50 – 3:00Road map towards the development of a client biometric identification system among MARPS populations in Kenya (Antony Kariri – Univ.Manitoba/Univ.Nairobi)
3:00– 3:10Provision of integrated services and capacity-building as a strategy: alternative livelihood for female sex workers in Kilifi District (Janet Musimbi – ICRH/Univ.Nairobi)
3:10 – 3:20Prevention with positives: findings from a community-based intervention study in Mombasa (Wilkister Ombidi – ICRH/Univ. Nairobi)
3:20 – 3:30The PMTCT cell phone intervention study – methodology and study population (Mary Gichuhi – Univ. Manitoba / Univ. Nairobi)
3:30 – 3:40A randomized controlled trial of text messaging to improve attendance at post-operative clinic visits and reduce early resumption of sex after adult male circumcision (Thomas Odeny – Univ. Washington / Univ. Illinois Chicago / KEMRI)
3:45 – 4:00 Coffee / tea
Session IV: Molecular epidemiology and lab science
Co-Chairs:Ephantus Njagi
Bhavna Chohan
4:00 – 4:10Long-term non-progressors, viraemic, and elite controllers among women infected with non-subtype B HIV-1 in Mombasa (Vernon Mochache – Univ.Washington / Univ.Nairobi)
4:10 – 4:20CYP2B6 pharmacogenetics and nevirapine clinical outcomes in HIV-1 seropositive Kenyan women receiving antiretroviral therapy (Margaret Oluka – Univ.Washington/Univ. Nairobi)
4:20 – 4:30Baseline viral characteristics among participants with recent and established HIV infections (Newton Otecko CDC/KEMRI)
4:30 – 4:40Evolution of rare K-65R mutation among HIV-1 infected and exposed infants: secondary analysis of the Kisumi breastfeeding study (Seth Inzaule – CDC/KEMRI)
4:40 – 4:50Development of a cost-effective, integrated, tagged, pooled pyrosequencing method for HIV drug resistance testing on dried blood spots (James Brooks – National Microbiology Lab Canada / Univ. Manitoba)
4:50 – 5:00Validation of locally-derived reference intervals for haematology and biochemistry parameters in Western Kenya (Julie Okonji – CDC/KEMRI)
5:00 – 5:10Pooled HIV-1 RNA viral load testing: efficient and cost-saving strategy for monitoring antiretroviral treatment in Kenyan children (Bhavna Chohan – Univ. Washington / Univ.Nairobi)
5:10 – 5:20External quality assurance for your lab: an analysis of EQA programs (John Gatimu – Univ.Washington/Univ.Nairobi)
5:20 – 5:30A case study of quality control in a flow cytometry lab (John Gatimu – Univ. Washington/KEMRI / Univ.Nairobi)
6:00 – 9:30 Cocktail party and reception – MayfairCourtHotel poolside – all participants invited
Tuesday, January 24, 2012
Session V: Bacterial and Viral STIs
Co-chairs: Joshua Kimani
King Holmes
8:30 – 8:45Prevalence of reproductive tract infections (RTI) in woman targeted for microbicide trials: the Microbicide Safety Markers in Kenya, Rwanda, Tanzania and South Africa (Mary Mwaura – ICRH/Univ.Nairobi)
8:45 – 8:55Human papillomavirus prevalence in HIV-positive women from HIV-discordant couples (Joy Cooper – Univ. N. Carolina / Univ.Washington / Univ.Nairobi)
8:55 – 9:05Prevalence of human papillomavirus infection in HIV-infected women (Mary Mwaura – ICRH/Univ.Nairobi)
9:05 – 9:20Multiple human papillomavirus infections, type competition and future HPV acquisition (Anne Rositch – Univ.Illinois Chicago /Univ.N.Carolina/Univ.Nairobi)
9:20 – 9:35Male circumcision dramatically reduces the incidence and persistence of HPV infection among men in Kisumu (Jennifer Smith – Univ. N. Carolina / Univ. Illinois Chicago / Univ. Manitoba / Univ. Nairobi)
9:35 – 9:50Microbial diversity of genital ulcer disease in men enrolled in a randomized trial of male circumcision in Kisumu (Supriya Mehta – Univ. Illinois Chicago / Univ. Manitoba / Univ. Nairobi)
9:50 –10:00Disproportionate HIV and HSV-2 prevalence and incidence among women and adolescent girls in Western Kenya: preparation for female-centred prevention trials (Frederick Otieno – CDC/KEMRI)
10:00 – 10:10Does incident HSV-2 influence episodes of bacterial vaginosis? (Linnet Masese - Univ.Washington / Univ.Nairobi)
10:10 – 10:20Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and post-partum: a randomized trial (Alison Drake – Univ.Washington/Univ.Nairobi)
10:20 – 10:30Valacyclovir for herpes suppression in HIV-1/HSV-2 co-infected women improves HIV disease progression markers but does not reduce T-cell immune activation (Alison Drake – Univ.Washington/Univ.Nairobi)
10:30 – 11:00Coffee / tea
11:00 – 11:10Periodic presumptive treatment for preventing vaginal infections in HIV-negative women: update from an ongoing randomized clinical trial (Griffins Manguro – Univ. Washington / Univ. Nairobi)
11:10 – 11:25Knowledge of cervical cancer and acceptability of screening methods among Kenyan women (Anne Rositch – Univ. Washington / Johns Hopkins Univ. / Univ. Nairobi)
11:25 – 11:35Cervical cancer screening and treatment procedures are not associated with increased HIV-1 genital shedding among women on HAART (Victoria Woo – UCSF / KEMRI)
11:35– 11:45Prevalence, characteristics and outcomes of HIV+ women diagnosed with invasive cancer of the cervix at FACES, Kisumu (Chemtai Mungo – UCSF / KEMRI)
Session VI:Epidemiology, Transmission, Risk Factors II – Men Who Have Sex With Men (MSMs)
Co-Chairs:Nicolas Muraguri
Eduard Sanders
11:45 – 12:00Sexual risk behavior changes in MSM in Coastal Kenya 2006-2011 (Haile Okuku - KEMRI-Wellcome Trust)
12:00 - 12:15HIV care provision among MSM in Coastal Kenya (Peter Mugo - KEMRI-Wellcome Trust)
12:15 – 12:30Expanding test and treat and PreP for HIV prevention in MSM in Kenya (Robert Bailey – Univ.Illinois Chicago /Univ.Nairobi
12:30 – 12:45A novel approach to identifying MSM and female sex workers with acute HIV-1 infection (Peter Mugo - KEMRI-Wellcome Trust)
12:45 – 1:00Men who have sex with men in Kisumu (Duncan Okal – CDC/KEMRI)
1:00 – 2:00 Lunch
Session VII: Family Planning and Reproductive Health
Co-Chairs:Craig Cohen
Marleen Temmerman
2:00 – 2:15A call for a family planning surge (Marleen Temmerman – Univ. Ghent /ICRH / Univ. Nairobi)
2:15 – 2:30Characteristics and HIV-1 incidence among a cohort of pregnant women in NyanzaProvince (Daniel Matemo – Univ. Washington / Univ. Nairobi)
2:30 – 2:45Prevalence and co-factors of sexually transmitted diseases during pregnancy in Nyanza Province (John Kinuthia – Univ. Washington / Univ. Nairobi
2:45 – 3:00Contraceptive method and pregnancy incidence among African women in HIV-1 serodiscordant partnerships (Kenneth Ngure – Univ. Washington / Kenyatta Univ.)
3:00 – 3:15Barriers and motivations of condom use by HIV-serodiscordant couples in Nairobi (Leila Ben-Youssef – Univ. Washington / Univ. Nairobi)
3:15 – 3:30Contraceptive use and HIV/AIDS among female sex workers (Wanjiru Gichuhi – Univ. Nairobi)
3:30 – 3:45Unintended pregnancies in the KEMRI-CDC HDSA in rural Western Kenya: comparison of the frequency and associated factors among HIV positive versus HIV negative women (Isabel Nyangau – CDC/KEMRI)
3:45 - 4:00Coffee / tea
4:00 – 4:15Concomitant use of antiretroviral therapies and a levonorgestrel subdermal implant for contraception: prospective cohort study to monitor changes in CD4 counts (Marsden Solomon – FHI360)
4:15 – 4:30Prevalence and determinants of self-reported spontaneous abortion among pregnant women in rural areas, Western Kenya (George Olilo – Univ. Washington / Univ. Nairobi / KEMRI)
4:30 – 4:45Reducing maternal and newborn mortality and morbidity in the year after birth through combined facility and community-based interventions (Christine Katingima – ICRH / Univ. Nairobi)
4:45 – 5:00A case for vaginal insemination as a safer method of conception in HIV-discordant couples (female positive, male negative) desiring conception in Kisumu (Okeoma Mmeje – UCSF / KEMRI)
Wednesday, January 25, 2012
Session VIII: Resistance and Susceptibility to HIV Infection and Disease
Co-chairs: Keith Fowke
Kristina Broliden
8:30 – 8:45IRF-1 polymorphisms and the role in resistance to HIV Infection (Aida Sivro – Univ.Manitoba/Univ.Nairobi)
8:45 – 9:00The expression of the glucose transporter protein in immune cells of commercial sex workers in the Pumwani CSW cohort, Nairobi (Winnie Apidi - Univ.Manitoba/Univ.Nairobi)
9:00 – 9:15Evaluation of T cell responses to TLR stimulation in HESN women in Nairobi (Robert Were Omange - Univ.Manitoba/Univ.Nairobi)
9:15 – 9:30Increased epithelial thickness and reduced HIV receptor expression in the ectocervical mucosa is associated with relative HIV resistance (Kristina Broliden – Karolinska Inst / Univ.Nairobi)
9:30 – 9:45The immune correlates of HIV susceptibility in the foreskin (Jessica Prodger – Univ. Toronto
9:45 – 10:00CD8+ cells in early and chronic HIV infection: evolution of polyfunctional responses and proliferative capacity (Meika Richmond – Univ.Manitoba/Univ.Nairobi)
10:00 – 10:10Delayed progression to AIDS: a potential role for HIV-specific CD8+ T cells (Melissa Herman – Univ.Manitoba / Univ. Nairobi)
10:10 – 10:20Reduced cellular susceptibility to in vitro HIV-1 infection is associated with immune quiescence (Catherine Card – Univ.Manitoba/Univ. Nairobi)
10:20 – 10:30Impact of sex work on the female genital tract mucosal immune system (Julie Lajoie – Univ.Manitoba/Univ.Nairobi)
10:30 – 11:00Coffee / tea
Session IX: Interventions II – Male circumcision
Co-Chairs: Robert Bailey
Kawango Agot
11:00 – 11:15Results of CIRCIS1 and 2: population changes in prevalence of circumcision and HIV risk behaviours in Kisumu (Matthew Westercamp – Univ. Illinois Chicago / Univ.Nairobi)
11:15 – 11:30Time to wound healing and resumption of sex following medical circumcision of adult males in Kisumu (Elijah Odoyo-June – Nyanza Reprod Health Society / Univ. Illinois Chicago / Univ. Nairobi)
11:30 – 11:45Infant male circumcision services for HIV prevention in NyanzaProvince: factors associated with uptake by mother and fathers (Marisa Young – Univ. Illinois Chicago / Univ.Nairobi)
11:45 – 12:00Behavioural risk compensation 12 months after circumcision: interim results from a prospective cohort study of circumcised and uncircumcised men in NyanzaProvince (Nelly Westercamp – Univ. Illinois Chicago / Univ.Nairobi)
12:00 - 12:10Knowledge and attitudes related to male circumcision among female partners of recently circumcised men in NyanzaProvince (Timothy Okeyo – Nyanza Reprod Health Society / Univ. Illinois Chicago / Univ. Nairobi)
12:10 – 12:20We too are shareholders: why women must be meaningfully involved in VMMC rollout (Kawango Agot – Impact Research and Development Org)
12:20– 12:30Male circumcision provides “partial protection” against HIV: what does this mean to women in NyanzaProvince? (Mores Loolpapit – FHI360-Kenya)
12:30 – 12:45 Top up to 100%: communicating about HIV protection following voluntary medical male circumcision in Nyanza (Mores Loolpapit – FHI360-Kenya)
12:45 – 1:00Randomised controlled trial of the Shang Ring versus conventional surgical techniques for adult male circumcision in Kenya and Zambia (Quentin Awori – EngenderHealth / FHI360)
1:00 – 2:00Lunch
Session X: Treatment and Care
Co-Chairs:Lucy Wanjiku
Rose Bosire
2:00 – 2:15PEPFAR in Kenya 2011 – Annual update (Katherine Perry – PEPFAR Country Coordinator, U.S. State Dept.)
2:15 – 2:30The SWOP clinic expansion – MARPS prevention and care in Nairobi Province (Charles Wachihi, Gloria Gakii – Univ. Manitoba / Univ. Nairobi)
2:30 – 2:45Retention and virologic failure in a Nairobi-based ART program (Lyle McKinnon – Univ. Toronto / Univ. Nairobi)
2:45 – 3:00Enhancing adherence to ARVs through intensified health education and adherence counseling: a case study of Baba Dogo CCC, Nairobi (John Mungai – Univ. Manitoba / Univ. Nairobi)
3:00 – 3:15Assessment of functional status in Kenya: HIV infection, depression and cognitive impairment (Ana-Claire Meyer – UCSF / KEMRI)
3:15 – 3:30Improving the quality of HIV care at health facility level in Kenya: a case of Coast Province (John Wanyungu – NASCOP / CDC)
3:30– 3:40Migrant fisherfolk and factors associated with HIV clinic attendance in Suba District (Lindah Otieno – UCSF / KEMRI)
3:40 – 4:00 Coffee / tea
4:00 – 4:15Nothing for us without US: meaningfully involving people living with HIV in linking those who test positive to care and treatment (M. Akoko – Impact Research and Development Org)
4:15 – 4:30 Strengthening intra-facility referrals and linkages of HIV-positive patients (Kenneth Mutoka - Centre for Health Solutions)
4:30 – 4:40Levels, trends and differentiation in cohort survival rates in Central Province 2006-2011: what lessons can be learned (John Njenga – Centre for Health Solutions)
4:40 – 4:50 Strengthening intra-facility referrals and linkages of HIV-positive patients (Kenneth Mutoka - Centre for Health Solutions)
4:50 – 5:00Retention of ART and pre-ART patients at high and low volume facilities in Central Province: a cohort analysis (Frida Njogu - Centre for Health Solutions)
Thursday, January 26, 2012
Session XI:Perinatal transmission and HIV/AIDS in children
Co-Chairs:Ruth Nduati
Grace John-Stewart
8:30 – 8:45Towards the elimination of mother-to-child transmission of HIV: the impact of a rapid results initiative in NyanzaProvince (V. Ndege – UCSF/KEMRI)
8:45 – 9:00 Barriers to uptake of prevention of mother-to-child transmission (PMTCT) services: results from a community-based study in NyanzaProvince (Pamela Kohler – Univ. Washington / Univ. Nairobi)
9:00 – 9:15A community-based evaluation of predictors of facility delivery among HIV-infected mothers in Nyanza Province (John Kinuthia - Univ. Washington / Univ,Nairobi)
9:15 – 9:30Strengthening prevention of mother-to-child transmission of HIV services in Homa Bay and Rachuonyo Districts by training peer counselors (Jennifer Oyieke –RATN / NARESA)
9:30 – 9:40Integration of ARVs into MCH to strengthen PMTCT services in Central Province (Lulu Ndapatani – Centre for Health Solutions)
9:40 – 9:50Using roving clinicians to support PMTCT services in low volume facilities (Lulu Ndapatani – Centre for Health Solutions)
9:50 – 10:05Linking women who test HIV-positive in pregnancy-related services to HIV-related services in Naivasha District – missed opportunities (Laura Ferguson – London School of Trop Med / Univ. Nairobi)
10:05 – 10:15Evaluating the impact of interventions on child nutritional status in Mombasa (Daniel Lango – ICRH/Univ.Nairobi)
10:15 – 10:30Determinants of infant feeding practices among HIV-positive and HIV-negative women: a survey in the HDSS, Siaya County (John Okanda – Univ.Washington/Univ.Nairobi/KEMRI)
10:30– 11:00 coffee / tea
11:00 – 11:15Exclusive breastfeeding: is it for HIV positive women only? (Florence Kagwaini – KenyattaUniv. / KEMRI)
11:15 – 11:30 Peptide-specific responses by infant CD8 cells and HIV-1 acquisition from breast milk (Marie Reilly – Karolinska Inst / Univ. Washington / Univ. Nairobi)
11:30 – 11:45Adverse events in Kenyan infants born to HIV-infected mothers taking triple ARVs for prevention of mother-to-child transmission (Francis Angira – CDC/KEMRI)
11:45 – 12:00Correlates of neurological development in Kenyan HIV-infected infants who initiated early empiric antiretroviral therapy (Hellen Okinyi – Univ. Washington / Univ. Nairobi)
12:00 – 12:15 Similar virologic, immune and growth outcomes of HIV-1 in infants receiving nevirapine (NVP) versus lopinavir-boosted-ritonavir (LPV/r) based antiretroviral therapy (ART) in Kenya (Vincent Otieno - Univ. Washington / Univ. Nairobi)
12:15 – 12:30Prevalence and co-factors of viral suppression among infants receiving early antiretroviral therapy (ART) in Kenya (Ken Tapia – Univ. Washington/ Univ. Nairobi)
12:30 – 12:45Prevalence and correlates of nevirapine resistance among HIV-1 infected infants receiving early antiretroviral therapy (ART) in Nairobi (Bhavna Chohan – Univ. Washington / Univ. Nairobi)
12:45 – 1:00 Sustainable responses to measles re-vaccination among HIV-1 infected children in Kenya: baseline characterstics (Ann Gatuguta – Univ. Washington / Univ. Nairobi)
1:00 – 2:00lunch
Session XII: Counselling and Testing
Co-Chairs:Nduku Kilonzo
Judith Wasserheit
2:00 – 2:20 HIV testing and counseling into the future: what are the imperatives? (Nduku Kilonzo – Liverpool VCT Care and Treatment)
2:20 – 2:35Improvement of HTC services for the deaf and hearing impaired (Solomon Otieno – Kenyan Assoc of Professional Counsellors)
2:35 – 2:50Integrated HIV testing and counseling: an HIV response imperative (Gladys Nyasuna-Wanga – Liverpool VCT Care and Treatment)
2:50 – 3:05Use of task-shifting approach to improve coverage of provider initiated testing and counseling (PITC) in out-patient settings: case study of four district hospitals in Eastern Province (Michael Kiragu - Liverpool VCT Care and Treatment)
3:05 - 3:20 Effects of defaulter counseling on subsequent default rates among patients in HIV care in Kisumu (Dan Okumu – UCSF/KEMRI)
3:20 – 3:30 “A woman without religion is nothing”: preliminary findings from an exploratory qualitative study on the influence of Pentecostalism on women’s decision to seek HIV testing in Mombasa (George Wanje – Univ.Washington / Univ.Nairobi)
3:30 – 3:45 Coffee/tea
Session XIII: Other Infectious Diseases
Co-Chairs: Kishor Mandaliya
Julius Oyugi
4:00 – 4:15Novel cytokines as biomarkers for the diagnosis of tuberculosis (Julius Oyugi – Univ.Manitoba/Univ.Nairobi)
4:15 – 4:30Mycobacterium tuberculosis- specific interferon gamma responses among HIV-exposed Kenyan infants (Mercy Kanyugo – Univ.Washington/Univ.Nairobi)
4:30 – 4:45Impact of recent ART guidelines on incidence of tuberculosis (TB) in children with HIV in Kenya: re-evaluating the need for pre-exposure preventive therapy (Lisa Dillabaugh – UCSF/KEMRI)
4:45 – 5:00Reduced time to initiation of anti-retroviral therapy at integrated TB/HIV sites compared to non-integrated sites: a retrospective study in rural Kenya (M. Seii – UCSF/KEMRI)