22/01/10
AGENDA FOR ANNUAL REVIEW MEETING 2010
UNIVERSITY OF NAIROBI STD/AIDS COLLABORATIVE GROUP
MAYFAIR COURT HOLIDAY INN, NAIROBI
Monday, January 25, 2010
8:00– 9:00Registration
9:00–9:30OPENING CEREMONIES
Chair: Omu Anzala
Opening remarks – Prof. I. Kibwage – Principal, College of Health Sciences, Univ. Nairobi
Reflections on the 30th Anniversary of the Univ. Manitoba / Univ. Collaboration – Prof. F. Plummer – Public Health Agency of Canada / Univ. Manitoba
Greetings from the University of Manitoba – Prof. D. Barnard – President, Univ. Manitoba
Official opening – Prof. G. Magoha – Vice-Chancellor, Univ. Nairobi
9:30 – 9:40Break
Session I:Special Presentations
Co-Chairs: Omu Anzala
Joanne Embree
9:40 – 10:00Unraveling the mysteries of HIV resistance -- progress to date (Frank Plummer – Public
Health Agency of Canada / Univ. Manitoba)
10:00 – 10:20The Thailand HIV Vaccine trial – what have we learned? Estimating the potentialimpact of an AIDS vaccine (Omu Anzala – KAVI / Univ. Nairobi)
10:20 – 10:40The debate about the importance of concurrency as a driver of the epidemic (Martina Morris – Univ. Washington)
10:40- 11:00Coffee/tea
Session II:Epidemiology, Transmission, Risk Factors I
Co-Chairs:Nelly Mugo
Stephen Moses
11:00 – 11:15Risk factors and potential intervention targets in HIV-1 discordant couples (Brandon Guthrie – Univ. Washington / Univ. Nairobi)
11:15 – 11:30Status disclosure amongst HIV-infected adults at Kilifi District Hospital 2009 (Davies Kimanga – NASCOP / Jomo Kenyatta Univ. / Wellcome Trust / KEMRI)
11:30 – 11:45Widow inheritance and HIV infection/transmission: where does the inheritor fit in the risk puzzle? (Kawango Agot, Jacob Odhiambo – Impact-RDO / Univ. Washington / Univ. Nairobi)
11:45- 12:00Correlates of HIV infection among young adults in Kisumu 2007-2008 (Anne Gumbe – CDC / KEMRI)
12:00 – 12:15Determining the best strategies to use to find persons at high risk of HIV infection for HIV prevention studies in Kisumu (Anne Adega – CDC / KEMRI)
12:15 – 12:30A cross-sectional behavioural survey of male sex workers who have sex with men and
women in Nairobi (Anna Seifried, Mary Gichuhi - Univ. Manitoba / Univ. Nairobi)
12:30 – 12:45To be or not to be a sex worker: perception of female sex workers and non-sex workers regarding HIV prevention and contraceptive practices (Elizabeth Ngugi – Univ. Washington / Univ. Nairobi)
12:45- 1:00The impact of family support on HIV prevention knowledge and practices by infected youth: The Tuungane Youth Project (Kawango Agot – Impact-RDO / CDC)
1:00 – 2:00Lunch
Session III: Interventions I – Male circumcision
Co-Chairs: Jeckoniah Ndinya-Achola
Robert Bailey
2:00 – 2:15Male circumcision for HIV prevention in Nyanza: one year and counting (Kawango Agot, Walter Obiero - Impact-RDO / Nyanza Reproductive Health Soc. /CDC)
2:15 – 2:30Male circumcision for HIV prevention in Nyanza: results and lessons from the rapid results initiative (RRI) (Walter Obiero, June Odoyo, Kawango Agot - Nyanza Reproductive Health Soc / Impact-RDO /CDC/ FHI)
2:30 – 2:40Examining the capacity of the private sector health providers to support male circumcision scale-up in Kenya (Mwende Mbondo – Male Circumcision Consortium/ FHI)
2:40 – 2:50Assessing the effectiveness of male circumcision outreach services in Kenya (George Odingo – Male Circumcision Consortium/ EngenderHealth)
2:50 – 3:00Results of a baseline random household survey on male circumcision and HIV in Kisumu Municipality (Cosam Angwana – Univ. Illinois Chicago/Male Circumcision Consortium / Univ. Nairobi)
3:00 – 3:10Voluntary Medical Male Circumcision: An Assessment of Adverse Events (Amy Herman-Roloff - Univ. Illinois Chicago/Male Circumcision Consortium / Univ. Nairobi)
3:10 – 3:20Factors associated with the circumcision decision: baseline results from the risk compensation study in Nyanza Province (Nelli Westercamp – Univ. Illinois Chicago/Male Circumcision Consortium / Univ. Nairobi)
3:20 – 3:30 Pilot study of the Shang Ring: a novel male circumcision device for HIV prevention (Frederick Ndede – EngenderHealth / NASCOP / CornellUniv.)
3:30 – 3:40 Discussion
3:40 – 4:00 Coffee / tea
4:00 – 5:30 SATELLITE SESSION – ROLLING OUT AND SCALING-UP OF MALE CIRCUMCISION SERVICES IN KENYA – ISSUES ARISING AND LESSONS BEING LEARNED (Conveners – Kawango Agot, June Odoyo)
6:00 – 9:00 RECEPTION – Holiday Inn Mayfair Court – co-hosted by Prof. G. Magoha, Vice-Chancellor, Univ. Nairobi and Dr. D. Barnard, President, Univ. Manitoba; all conference participants invited to attend
Tuesday, January 26, 2010
Session IV: Interventions II
Co-Chairs:Kishor Mandaliya
Craig Cohen
8:30 – 8:50Update on the Pre-Exposure Prophylaxis (PrEP) Clinical Trial: Parallel comparison of Tenofovir and Embricitabine/Tenofovir pre-exposure prophylaxis to prevent HIV-1 acquisition within HIV-1 discordant couples study Kenya and Uganda (Connie Celum – Univ. Washington / Univ. Nairobi)
8:50 – 9:05Pre-exposure prophylaxis (PrEP) research: a quantitative ethics appraisal (Madzouka Kokolo – Univ. Ottawa)
9:05 – 9:25Phase III multi-center double-blind randomised placebo-controlled effectiveness and safety study to assess the role of Truvada® in preventing HIV acquisition in women (Fred Owino, Kawango Agot – Impact-RDO /FHI)
9:25 – 9:40Secondary HIV prevention: translation and transfer of evidence-based interventions (Ben Jarabi – Univ. Washington / New YorkUniv. / Univ. Nairobi)
9:40 – 9:55HIV-infected males – a neglected lot? (John Mungai – Univ. Manitoba / Univ. Nairobi)
9:55 – 10:15Evaluating the impact of a large-scale HIV prevention program in Karnataka, South India (Stephen Moses – Univ. Manitoba)
10:15 – 10:30Rapid, large-scale mass HIV counselling and testing, malaria and diarrhoea prevention program in rural Kenya: report on the initial campaign (Alexandre Doyen – Vestergaard Frandsen / Kenya MOH / CHF)
10:30 – 11:00 Coffee/tea
Session V:Bacterial and Viral STIs
Co-Chairs:Carey Farquhar
King Holmes
11:00 – 11:15Prevalence, sensitivity of syndromic diagnosis and risk factors for sexually transmitted
infections within a Kenyan HIV incidence cohort study (Fred Otieno – CDC / KEMRI)
11:15 – 11:30High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections among HIV-1 negative MSMs in Coastal Kenya (Eduard Sanders - Wellcome Trust / KEMRI)
11:30 - 11:45Quinolone resistance to Neisseria gonorrhoeae in a cohort of young men in Kisumu 2002-2009 (Supriya Mehta – Univ. Illinois Chicago / Univ. Manitoba / Univ. Nairobi)
11:45 – 12:00Factors associated with prevalent and incident HSV-2 in high-risk Kenyan men (Haile Okuku – Wellcome Trust / KEMRI)
12:00 – 12:15HSV-2 incidence, GUD and HIV among circumcised and uncircumcised men in Kisumu (Robert Bailey – Univ. Illinois Chicago / Univ. Nairobi)
12:15 – 12:30Relative HIV resistance in Kenyan sex workers is not due to an altered prevalence or mucosal immune impact of HSV-2 infection (H. Baltzer – Univ. Toronto / Univ. Manitoba / Univ. Nairobi)
12:30 – 12:45Prevalence and correlates of cervical precancerous lesions among women in HIV-1 discordant couple relationships in Nairobi (Anne Rositch – Univ. Washington / Univ North Carolina / Univ. Nairobi)
12:45 – 1:00Risk factors associated with colposcopy-detected penile lesions in Kenyan men (Danielle Backes – Univ. North Carolina / Univ. Illinois Chicago / Univ. Manitoba / Univ. Nairobi)
1:00 – 2:00 Lunch
Session VI:Symposium on Zoonotic Diseases
Co-Chairs:Benson Estambale
Michael Drebot
2:00 – 2:15Zoonotic diseases, the Kenyan experience (Rosemary Sang-KEMRI)
2:15 – 2:30From outbreak responses to the development of preventative measures: Ebola and H1N1 experiences (Garry Kobinger-National Microbiology Laboratory, Public Health Agency of Canada / Univ. Manitoba)
2:30 – 2:45Understanding Periodic Outbreaks of Rift Valley Fever Outbreaks in East Africa (Kariuki Njenga-CDC)
2:45 – 3:00 Diagnostic considerations for the identification and characterization of emerging or under recognized zoonotic pathogens(Michael Drebot –National Microbiology Laboratory, Public Health Agency of Canada / Univ. Manitoba)
3:00 – 3:15Changes in livestock systems and their impacton zoonoses and how these are linked to a one health approach (John McDermott – International Livestock Research Institute ILRI).
3:15 – 3:30Risk factors, disease transmission dynamics and predictive potential for early warning on zoonoses in East Africa. (Philip Nyaga – Univ. Nairobi)
3:30 – 3:45 Investigation of a mysterious disease outbreak in Western Kenya (Omu Anzala – Univ. Nairobi)
3:45 – 4:00Coffee / tea
4:00 – 5:30 SATELLITE SESSION - CAPACITYBUILDING FOR THE UNIV. NAIROBI LEVEL 3 ENHANCEDLABORATORY- training, service delivery, sustainability (Convener – Julius Oyugi)
Wednesday, January 27, 2010
Session VII: Resistance and Susceptibility to HIV Infection and Disease
Co-chairs: Keith Fowke
Kristina Broliden
8:30 – 8:45The role of mucosal immunology and protection against HIV transmission at the female genital tract(Blake Ball – Univ. Manitoba / Univ. Nairobi)
8:45 – 9:00Setting up multiple barricades along the HIV infection pathway – learning from the genetic pathway profile of HIV-resistant sex workers (Ma Luo – Univ. Manitoba / Univ. Nairobi)
9:00 – 9:10The difference in polyfunctional HIV-specific CD4 responses in HIV-1 exposed seronegative commercial (ESN) versus newly negative commercial sex workers (Marion W. Kiguoya– Univ. Manitoba / Univ. Nairobi)
9:10 – 9:20Identifying specific HIV epitopes responsible for polyfunctional HIV-1 immune responses that could accord protective immunity in exposed seronegative commercial sex workers (James Mwanjewe – Univ. Manitoba / Univ. Nairobi)
9:20 – 9:35HIV viral set point and T cell responses in individuals with naturally-induced virus-specific CD8+ T cell responses prior to HIV acquisition (Rupert Kaul – Univ. Toronto / Univ. Manitoba / Univ. Nairobi)
9:35 – 9:45Characterisation of IL-17-secreting cervical CD4+ T cells in female sex workers (Lyle McKinnon – Univ. Toronto / Univ. Manitoba / Univ. Nairobi)
9:45 – 9:55Abundant expression of HIV target cells and C-type lectin receptors in the foreskin tissue of young Kenyan men (Taha Hirbod – Karolinska Inst / Univ. Illinois Chicago / Univ. Manitoba / Univ. Nairobi)
9:55 – 10:05Cervical vaginal environment and the epigenetic controls (Ruey-Chyi Su – Univ. Manitoba / Univ. Nairobi)
10:05 – 10:20Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa (Craig Cohen – UCSF / KEMRI)
10:20 – 10:35Does abstinence make the immune response grow fonder? Exploring the immunological effects of a break from regular sex work (Keith Fowke – Univ. Manitoba / Univ. Nairobi)
10:35 – 11:00 Coffee/tea
Session VIII:Treatment and Care I
Co-Chairs:Dorothy Mbori-Ngacha
Elizabeth Bukusi
11:00 – 11:20PEPFAR in 2009 – annual report (Lynn Adrian – CDC / KEMRI)
11:20 – 11:35Longitudinal screening for peripheral neuropathy among patients initiating antiretroviral therapy in Mombasa(Aabid Ahmed - BomuMedicalCenter /New YorkUniv.)
11:35 – 12:20The HIV Neurology in Kenya (THINK) study:
-Utility of a diagnostic tool for HIV-associated cognitive impairment in Western Kenya: pilot testing (Judith Kwasa – UCSF / KEMRI)
- Pattern of neuropsychological performance among HIV-positive patients in Kenya (Edwin Omondi – UCSF / KEMRI)
-Utility of HIV-associated neuropathy screening tools in Western Kenya: pilot testing (Deanna Cettomai – UCSF / KEMRI)
- Utility of quantitative sensory testing in characterising HIV-associated peripheral neuropathy in Western Kenya: pilot testing (Deanna Cettomai - UCSF / KEMRI)
-Measuring antiretroviral adherence in HIV-infected individuals with and without cognitive impairment in Western Kenya: pilot testing (Judith Kwasa - UCSF / KEMRI)
12:20 – 12:35Effect of antiretroviral therapy on liver and kidney parameters among HIV-infected women and their infants in Kisumu (Nicholas Polle – CDC / KEMRI)
12:35 - 12:50Effects of post-election violence on Kenya’s HIV response and the potential emergence of HIV drug resistance (Irene Mukui – NASCOP)
12:50 – 1:00Effect of gender of voice in responding to sensitive sexual behaviour questions using Audio Computer-Assisted Self-Interview (ACASI) in an HIV incidence cohort study in Kisumu (Isaiah Oloo – CDC / KEMRI)
1:00 – 2:00Lunch
Session IX: Interventions III
Co-Chairs: James Kiarie
Barbara Lohman-Payne
2:00 – 2:15Free-listing and service mapping reveals gender differences in reproductive and sexual health service perceptions and access(Mercy Owuor – Univ. Washington / Univ. Nairobi)
2:15 – 2:30Widow inheritance and sexual networks in Siaya District: developing culturally-appropriate interventions in the context of evolving traditions: baseline results (Kawango Agot, Rena Otieno - Impact-RDO / Univ. Illinois Chicago / Univ. Nairobi)
2:30 – 2:45“She’s my sister-law, my visitor, my friend:” Experiences of home follow-up in HIV research and intervention in Western Kenya (Philister Madiega – CDC / KEMRI)
2:45 – 3:00Spatial sampling using GPS for a community-enrolled prospective cohort study(Francis Njiri - Univ. Washington / Univ. Nairobi)
3:00 – 3:15Barriers in the delivery of HIV and AIDS services to people with disabilities (Sarah Nduta – Liverpool VCT)
3:15 – 3:45The HAART Cell Phone Adherence Study:
- Preliminary RCT results (Richard Lester – Univ. Manitoba / Univ. British Columbia / Univ. Nairobi)
-Use of mobile phones for health care – a qualitative analysis (Sarah Karanja – Univ. Manitoba / Univ. Nairobi)
- Baseline measures of health-related quality of life (Paul Ritvo – YorkUniversity / Univ. Manitoba / Univ. Nairobi)
3:45 – 4:00Coffee / tea
4:00 – 5:30 SATELLITE MEETING – CELL PHONE STUDY END-OF-PROJECT REPORT – RESULTS, SCALE-UP ISSUES, FUTURE DIRECTIONS (Convener – Anna Seifried)
Thursday, January 28, 2010
Session X: Perinatal transmission and HIV/AIDS in children
Co-chairs: Ruth Nduati
Lisa Avery
8:30 – 8:45Update on the Kesho Bora Clinical Trial: Triple antiretroviral (ARV) prophylaxis during pregnancy and breastfeeding compared to short-ARV prophylaxis to prevent mother-to-child transmission of HIV-1 (M. Mwaura – ICRH / Univ. Ghent / Univ. Nairobi)
8:45 – 9:00Infant and young child feeding in the context of HIV (Mildred Mudany – CDC / KEMRI)
9:00 – 9:15Evaluation of response to treatment among women exposed to anti-retrovirals for prevention of mother-to-child HIV transmission: a follow-up of the Kisumu Breastfeeding Study (KiBS) (Frank Angira – CDC / KEMRI)
9:15 – 9:30Antiretroviral treatment outcomes among HIV-infected infants exposed to maternal antiretroviral therapy for prevention of mother-to-child HIV transmission (Lilian Nafisa – CDC / KEMRI)
9:30 – 9:40Audit of outcomes of HIV-infected children admitted to the paediatric wards at KilifiDistrictHospital with early commencement of anti-retroviral therapy (Helen Nabwera – Wellcome Trust / KEMRI)
9:40 – 9:50Characteristics of paediatric patients lost to follow-up in an HIV care and treatment clinic in Kisumu (C. Kidiga – FACES / KEMRI / UCSF)
9:50 – 10:00Successful outcomes following decentralisation of tertiary paediatric HIV care to a community-based paediatric antiretroviral treatment network, Chiang Rai, Thailand (Abraham Katana – OxfordUniv. / CDC)
10:00 – 10:10Long- term treatment outcomes and predictors of mortality in HIV-infected children in Northern Thailand 2002-2008 (Abraham Katana – OxfordUniv. / CDC)
10:10 – 10:20Health system factors are more important than stigma in PMTCT interventions uptake (John Kinuthia – Univ. Washington / Univ. Nairobi)
10:20 – 10:30Prevention of mother-to-child transmission of HIV-1: from unmet need to unused service – a new study in Nyanza (John Okanda – CDC / KEMRI / Univ. Washington)
10:35– 11:00coffee/tea
11:00 – 11:15HSV-2 suppression to reduce maternal HIV-1 RNA levels during pregnancy and breastfeeding: a randomised clinical trial (Alison Drake – Univ. Washington / Univ. Nairobi)
11:15 – 11:30Is population-based HIV prevalence data able to accurately estimate the number of women needing PMTCT services? (Ruth Nduati – Univ. Nairobi)
Session XI: Molecular epidemiology
Co-Chairs: Walter Jaoko
Blake Ball
11:30 – 11:45 Multidrug resistant HIV-1 and recombination between variants from the genital tract and plasma: a longitudinal analysis (Barbara Weiser - Wadsworth Center NY State Dept of Health, AlbanyMedicalCollege)
11:45 – 12:00 Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy (Harold Burger – Wadsworth Center NY State Dept of Health, AlbanyMedicalCollege)
12:00 – 12:15Prospective associations of HIV-specific CD8+ T cell proliferation and IFN-γ ELISPOT responses with clinical outcome in HIV+ Kenyans (Lyle McKinnon – Univ. Toronto / Univ. Manitoba / Univ. Nairobi)
12:15 – 12:25PASER monitoring studies in Kenya to establish HIV drug resistance among adults using Highly Active Anti-Retroviral Therapy (HAART) (Millicent Olulo – ICRH / Univ. Ghent / Univ. Nairobi)
12:25 – 12:35Low-level HIV-1 drug resistance is prevalent in women and children taking antiretrovirals for prophylaxis and treatment in Kenya (Dara Lehman – Univ. Washington / Univ. Nairobi)
12:35 – 12:45Virologic outcomes and drug resistance mutations among HIV-1 positive pregnant women who received zidovudine, lamivudine and nevirapine for PMTCT (Alex Kasembeli (CDC / KEMRI)
12:45 – 1:00Long peptides induce polyfunctional macaque T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines (Tomas Hanke – Oxford Univ)
1:00 – 2:00lunch
Session XII: Treatment and Care II
Co-Chairs:Christina Mwachari
Rupert Kaul
2:00 – 2:15Preliminary findings from Kenya’s pilot study on early warning indicators for HIV drug resistance (Sarah Masyuko – NASCOP / CDC / KEMRI)
2:15 – 2:25Evaluation of nucleic acid testing on dried blood spots for HIV screening of blood bank units in Kenya (Julie Okonji – CDC / KEMRI)
2:25–2:35Evaluation of HIV-1 viral load measurement from dried blood spots versus plasma samples in Kenya (Kenneth Ndiege – CDC / KEMRI)
2:35 – 2:50Evaluation of a real-time in-house methodology for Mycobacterium tuberculosis detection from patient samples (Meenu Sharma – Canadian National Reference Centre for Mycobacteriology / Univ. Manitoba)
2:50 - 3:00QASI – an international quality assurance program for CD4 enumeration (Blake Ball – Univ. Manitoba / Univ. Nairobi)
3:00 – 3:10WHO stage 4 conditions in an HIV-positive cohort in Western Kenya (Patrick Oyaro – FACES / KEMRI / UCSF)
3:10 – 3:20Case fatality due to cryptococcal meningitis in a retrospective cohort in Kenya (C. Kendi - FACES / KEMRI / UCSF)
3:20 – 3:30 Factors associated with quality of life (QoL) in HIV treatment and care clinics in Western Kenya (Arbogast Oyanga – FACES / UCSF / KEMRI)
3:30 – 3:40Integration of HIV care with primary health care services: impact on patient knowledge, satisfaction and stigma in Suba District (Patrick Mbullo – FACES / KEMRI / UCSF)
3:40 – 4:00Coffee / tea
4:00 – 5:30 SATELLITE MEETING –ICT TECHNOLOGIES FOR HIV SCREENING, CARE AND PREVENTION (Conveners – Ann Kurth, Tony Kariri)
4:00 – 5:30SATELLITE MEETING – ICRH BRIEFING –ACTIVITIES AND PROGRAMMES – PAST, PRESENT AND FUTURE (Convener – Fiona Mbai)
Friday, January 29, 2010
Session XIII: Interventions IV
Co-Chairs: Elizabeth Ngugi
Lisa Mills
8:30 – 8:45Baseline survey of hospitals preparedness to provide medical and psychosocial care for gender-based violence survivors in sampled sites in Kenya (Jane Wakahe – GTZ / Univ. Nairobi)
8:45 – 9:00 Gender-Based Violence and Recovery Centre, Coast Provincial General Hospital – providing comprehensive care (Christine Katingima – UCSF / ICRH / Univ. Ghent / Univ. Nairobi)
9:00 – 9:15Interactive group counseling can change harmful intravaginal practices among female sex workers (F. Kashonga – Univ. Washington / Univ. Nairobi)
9:15 – 9:30Scaling up “Families Matter!”: supporting organisations in Kenya to deliver and sustain a parent-based intervention to prevent HIV in pre-teens (Juliet Ochura – Inst of TropMed / KEMRI
9:30 – 9:45 Disclosing HIV test results: experiences of HIV-discordant couples in Thika and Nairobi Districts (Kenneth Ngure – Univ. Washington / Univ. Nairobi)
9:45 – 10:00Introduction to the CPGH-ICRH Clinical Laboratory (Sammy Wambua - – ICRH / Univ. Ghent / Univ. Nairobi)
10:00 – 10:15Community-researcher partnership creation to improve clinical research outcomes (Jacqueline Naulikha – Univ. Washington / Univ. Nairobi).
10:15 – 10:30Overcoming structural challenges to ensure high retention in clinical trials: experiences among HIV-discordant couples enrolled in an HIV prevention study in Kenya (Josephine Odoyo – UCSF / KEMRI)